This chapter is dedicated to our birthday boy Wang Meimiao. This girl is the sun, the moon, surrounded by stars, and the angel who opens the door to heaven, which is worth cherishing.

Well, I can't make it up, all in all, a good girl. 21 years ago today, she landed on the ground, and now she has grown into a Peugeot lady, and it is not easy to go all the way.

When you say you're an ordinary girl, I stupidly believe it, but the more I get to know you, the more you find out that you're completely teasing me.

This is the malice of the winner in life. The reason why there is humility is not only to truly realize that there are people outside the sky, but also to be calm about the trajectory of one's continuous life.

Of course, the continuous life trajectories of different people are different lines, so we will find that the villains who are similar from the beginning of birth have different differentiation and have their own wonders in the melting pot of society.

Back to the topic, I still wish our beautiful and wonderful students to continue to have this calmness, and continue to fight more and more bravely on the road of life.

Happy birthday!!! Medical testing does not have to become an adjunct to clinical medicine, with today's computational processing capabilities, there is a pathway formed by the measurement of various trace components of body fluids (spectrophotometer) and the combination of these meaningful substances, which is a high-dimensional structure, we need to establish a certain projection relationship with different diseases to make a diagnosis at this level with sufficient accuracy, and theoretically it is possible to improve the test items to infinitely improve the accuracy.

This relationship can be expressed as the relationship between pathology and pathophysiology, and the expression of various mechanisms of the disease is the basis of the morphological change of the pathology, which is a specific expression in the simulation based on the Markov sequence, that is, its correlation can only be understood at the statistical level.

Therefore, the various measurement data of the one-time large pathway should theoretically be able to form a certain pattern, which is a low-dimensional hierarchical structure, which we can continue to traverse upwards, that is, form different combinations, and finally be able to build correlations with macroscopic pathological changes.

In this way, it may be possible to truly cure the disease before it occurs, that is, to detect this possibility before it causes obvious irreversible pathological damage, and then to recuperate, and use the resistance of the human network to return to a normal state.

Even if you are really sick, you can get more accurate answers and make a better diagnosis through data mining and analysis.

Because there are not many factors that doctors can consider, they pay more attention to various characteristic changes, and the topological geometry corresponding to mathematics is the fixed point, so the doctor of the cow is really good and can hit the nail on the head.

But this is a minority, and the computing power provided by computers allows us to approach the upper limits of their capabilities.

As far as I understand, the doctor's diagnosis is the operation of high-dimensional structures, which is very complicated, but we can refer to the establishment of calculus, which is to infinitely decompose complex relations into simple units that can be calculated, and then the addition of low-dimensional levels is pushed all the way up.

The Newton-Leibniz formula tells us that the addition and subtraction of higher dimensions is equal to the superposition of lower dimensions, i.e., the integral operation.

To find the amount of this kind of operation in the medical field, the current idea is based on the probability connection between different things, and then form different pathways, and there is a certain competition between the pathways, referring to game theory, it can be considered that the equilibrium that can be achieved is the equilibrium between the various levels of the organism network.

Then the game between these equilibrium forms a high-dimensional equilibrium that is what we understand as a state of health or disease.

I have an idea about testing, that is, the various proteins we generally test can obtain high-dimensional structural intrinsics (disease diagnosis) in the form of omics, that is, the data obtained through the existing testing methods can be processed to reveal the fixed point principle of mathematics, which I think is the core of the testing technology, that is, the overall situation of the high dimension can be reflected through certain low-dimensional changes.

For example, ALT/GPT alanine aminotransferase reflects liver damage, and AST/GOT aspartate aminotransferase reflects myocardial damage, and its obvious changes can indicate obvious liver damage.

This qualitative description is a fuzzy judgment of our current general technology, and I envision the use of hierarchical affiliations to unify information at all levels, just like fuzzy mathematics.

The test sheet I see is the yin and yang +- of different test items, and there may be a few more +, but this is a qualitative description, and I think that the formula that can provide mathematics is the future of the development of testing, in fact, all aspects of medicine are the pursuit of mathematical formalization as economics is to social science.

This requires us to do some modeling. Among them, the pathophysiological acid-base balance has given me a lot of inspiration, which can be regarded as an idealized level of flat, that is, the level of competition, the macroscopic pH in 7.35~7.45 is to indicate that the body is in a stable state, and then it can be divided into HCO3- and PaCO2 concentration relative proportion, and then can continue to be divided into respiratory system, urinary system and other effects, such as lung respiration and CO2 changes have a great correlation, so there may be different conditions (alveolar damage, airway blockage, inflammatory responses, etc.), which can then be coupled to various conditions of the wider body (shock, balance disorders, ischemia-hypoxia, ischemia-reperfusion, etc.).

In this process, the different pathways derived from it may have different effects, such as insulin makes blood sugar drop, and glucagon, adrenaline, glucocorticoids and other hormones make blood sugar rise, this pathway we understand as the competition of pathways, theoretically can get a certain equilibrium, that is, the body tends to form a steady state.

The relative proportions of the levels, which can be regarded as partial derivatives, can have Green's formula to transform the different integrals, which is the basis of my first operation.

One of these idealizations is a kind of limit-finding, i.e., derivation. The above is the guiding ideology of the theory, and then there are specific topics, so we need to select certain objects, and then investigate the existing pathways according to the literature to see if the coupling of the two will have new effects, such as the protective effect of neutrophil gelatinase-associated lipid carrier proteins in acute kidney injury.

But we can try to develop kits or test strips. For example, chorionic gonadotropin examination, in which the basic principle of immunological latex agglutination inhibition test, monoclonal latex agglutination test, etc., is sequence matching, that is, the structure has a certain similarity can have a relatively large probability of difference, and the protein that may be able to anchor a certain structure in the gum can be combined and adsorbed with a certain similarity.

There is also the option to develop drugs, and it is important to find the mechanism of action, such as Indelipide, which can interfere with the signals of the immune system, so that the level of TH1 cytokines in the blood decreases, thereby increasing the success rate of artificial insemination.

This is a kind of regulation of the body's internal immune system through external stimuli, by anchoring a certain level, causing a local imbalance, which is a disease for the body, but we can achieve our purpose.

The rapid enzymatic touch reaction is based on the synthesis and release of certain specific enzymes in the process of growth and reproduction of bacteria, according to the characteristics of the enzyme, the corresponding substrates and indicators are selected, and they are prepared in the relevant medium.

Based on the obvious color change that occurs after the bacterial reaction, the suspicious strains to be isolated are identified, and the results of the reaction are helpful for rapid diagnosis of bacteria.

This is a good idea, the synthesis of this dye is actually similar to the idea of immune hybridization, both of which use the specific binding of specific structures.

A point-to-surface divergent approach: the changes of a specific detection index have a certain correlation with other basic ones at the statistical level, such as chronic intravascular coagulation (DIC), deep vein thrombosis (DVT), pulmonary embolism (PE), acute myocardial infarction, cerebral infarction, malignant tumors, ovarian cancer, lung cancer, sepsis, liver disease, pregnancy-induced hypertension, preeclampsia, burns, surgery, trauma and sepsis, etc., all of which can increase D-dimer, and these basically have other effect changes. As a result, network relationships can be derived, which the human brain cannot handle.

We can only understand the relationships between macroscopic objects in terms of certain patterns (fixed points), which depend on experience, and the computing power of computers allows them to handle these relationships with a certain degree of precision.

That is, the symptomatic treatment can be more refined, and the resulting resistance changes will not be so large, that is, the changes brought to the network are in a controllable range, such as allopurinol 300mg/day for hyperuricemia, taken orally, and adequately rehydrated to maintain urine output, which may occur a series of secondary effects, such as the appearance of atopic dermatitis.

If not, then according to our understanding of fuzzy mathematics, and then the hierarchy can be selectively expressed as a linear combination of other levels (imitating the Fourier series), we can deal with these refined levels, which may go deep into the regulation of the level of insulin secretion of pancreatic B cells.

Of course, in concrete practice, we only need to extract the processing of the pattern is enough, but only in theory can we achieve 50-60% of the effect in practice.

Theoretically, the changes of different detection items can be represented by a certain matrix, and a specific combination is a certain pattern, which is of great significance for disease diagnosis.

A good marker is preferably in a homeostasis, e.g., D-dimer directly reflects thrombin and plasmin production.

As for ToCureSometimes, ToRelieveOften, ToComfortAlways, in my opinion, not enough is not enough, that's our limitation, so we have the help of computers.

We can't just use the restrictions of the past to limit the pace of today. We do not seek to cure all diseases, but to have a deeper understanding of the nature of diseases based on modern technology.

Theoretically, treatment is to restore the body's equilibrium through various means, and the effects of various drugs should be calculated in the form of microscopic changes at the cellular level, and the combination of drugs in different time domains at our end can be individualized.

Because the effect of general drugs is the result of the rest of the body's network game, such as IFN in the treatment of chronic myeloid leukemia CML, the early common side effects are fever, chills, flu-like symptoms, headache, etc., which last for about a few days to 2 months; In the late stage, there may be persistent fatigue, decreased appetite, a few cases may have anemia, liver and kidney damage, baldness, sometimes bone, muscle pain, hypothyroidism, depression, etc., and in severe cases, there may be angina, inattention, memory loss and lethargy and other neurological toxicity.

These effects can be understood in terms of different levels of drug-organism interactions, and if we can go deeper, we will be able to go beyond the existing thinking and enter the lower dimensions of computing.

Because the so-called drug use is extremely dependent on experience, it is an act of chance, and I am not denying its significance, but I think there can be a better mechanism to screen it.

I think it's a great gift to work together to complete a paper that can be submitted (young people dare to think).

Or is it a project completion experience? Specific experiments may not be possible, but a scientific simulation activity can still be done.

It's also a good idea to do a meta-analysis. I hope this gift is different, because it is not a simple acceptance, but an initiative to give and win.

Forget it, if you think too much, the above is unrealistic. Then take my brain hole as a gift. All in all, Happy Birthday Wang!