A Nobel laureate once claimed: "The twentieth century is the century of genes, and the twenty-first century is the century of the brain." ”

The breakthrough achievements of molecular biology in the late twentieth century have changed the place of life sciences in the natural sciences dramatically, and the Human Genome Project is also considered one of the three greatest human science projects of the twentieth century!

In the nineties of the twentieth century, the world's major scientific and technological powers have accelerated their investment in neurobiology research, such as the "Brain Decade Plan" proposed by the United States, the "EC Brain Decade Plan" proposed by Europe, and the "Brain Science Era Plan" cross-century large-scale research program in Japan, which plans to invest huge amounts of research funds in the next ten or twenty years to focus on neurobiology research.

Of course, even with the support of the actual actions of various countries, this sentence must still be a bit exaggerated. But, in any case, there is certainly no problem with one sentence: the twenty-first century, the century of life sciences!

Nowhere is this more evident than in the top scientific journals.

I don't know when people start to talk about top scientific journals, they often use NSC, or CNS instead, referring to the three top journals "nature", "science" and "cell", it seems that as long as you can publish papers in these three journals, it must be good research.

"Cell" is a pure life science journal, while "Nature" and "Science" are comprehensive journals, but life science articles account for a very large proportion. This shows how much the world attaches importance to life sciences.

Of course, being able to publish an article in three top journals is also the dream of all life science researchers in the world, especially those countries outside the big scientific research countries, once a researcher can publish an article in three journals, it will often become their lifelong capital。。。。。。

In September 2011 and March 2012, less than half a year before and after, Nature· The journal Neuroscience has published articles from two research institutes. The content of the articles is strikingly consistent, and they are all about a century-old medical puzzle: the study of how to break through the blood-brain barrier.

For a time, these two seemingly identical, but very different studies, have caused a huge sensation in the neurobiology community, and even in many fields of life science!

The first article published in Nature came from the Department of Immunology at Cornell University in the United States, where scientists used a molecule in mice, adenine nucleoside receptors, to control the entry of large molecules into the brain, and when adenine nucleoside receptors are activated on the cells that make up the blood-brain barrier, a channel into the blood-brain barrier will be established. In their experiments, they successfully delivered glucosan-sized molecules the same size as antibodies into the brain, trying to figure out where they could get the macromolecules and whether this approach required the size of the molecules. They also succeeded in getting an β amyloid peptide antibody to cross the blood-brain barrier of transgenic mice and observed that it attached to the amyloid plaques that cause Alzheimer's disease in the mice.

The article published later is also from the United States and was completed by the Department of Neurobiology of the well-known Sprex Research Institute.

In the first author's article, signed "Tian Lu", the researchers also claim that they have successfully broken through the blood-brain barrier, but unlike the Cornell study, the results of the Splitix Institute are more explicit and systematic.

Strictly speaking, the results of the Splix Institute are not an article, but a series of three articles! In the current issue of "The Effect of Pericellular Autocrine Signaling Molecules on Endothelial Cells in the Pericyte/Endothelial Cell Co-culture System", the content of this series of articles is first briefly introduced, including the results of successfully breaking through the blood-brain barrier, and at the end of the article, the title of this series of articles in the next issue of the journal is announced: "Research on the Role of Endothelial Cells in the Defense Mechanism of the Blood-Brain Barrier"!

Unlike Cornell University's research, which only achieved the result of breaking through the blood-brain barrier, the scientists at the Sprex Institute seem to want to try to elucidate some of the mechanisms of action of the blood-brain barrier before talking about the specific methods of breaking through the blood-brain barrier. In the preview of this issue, the researchers at the Splitix Institute even listed a list of substances that they had experimented with that could successfully cross the blood-brain barrier!

The preview of this article not only made scientists around the world full of expectations, but also those multinational pharmaceutical companies were even more excited, and many people who were interested couldn't wait for the publication of the next two issues of the magazine, and got on the plane and flew to San Diego, California, USA。。。。。。

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Meanwhile, on the edge of the Sonoran Desert in California.

"Whew。。。。。。 ”

Tian Lu gasped heavily, leaned over, and with a "bang", the huge bag slipped to the ground, and he himself sat on the soft yellow sand.

"I'm so tired!"

Leaning on the backpack, Tian Lu gasped rapidly, only to feel that his whole body seemed to fall apart, and the position of the backpack was also hot and painful, presumably worn out by the heavy bag.

Seeing Tian Lu's appearance, Ye Lan hurriedly took out the kettle from her bag and handed it over: "Let's drink saliva first." ”

Gu Dong Gu Dong, tilted his neck and poured several large mouthfuls, the heat on his chest was slightly extinguished, Tian Lu looked at the endless yellow sand in front of him, suddenly shook his head, and said with a wry smile: "What kind of place does this Senior Brother Lei recommend? What else do you say is so magnificent that people can look at it and put it in their hearts! I think it's a piece of yellow sand, except for sand or sand, what is there to see?"

"I think it's pretty good. ”

Ye Lan took the kettle in Tian Lu's hand and took a few sips herself, then said with a smile: "Although I can't understand the kind of artistic conception that Senior Brother Lei said, I have always been very tolerant of the scenery that I have never seen." ”

Pouting, Tian Lu did not speak.

The location of the two of them is only the edge of the desert, but in Tian Lu's heart, he has already made up his mind that he will never take another step inside!

"Jingle bell。。。。。。 ”

During the break, the mobile phone in the small bag next to Tian Lu suddenly rang, in this empty desert, the high-pitched ringtone was unusually harsh, Tian Lu couldn't help but grab the mobile phone, and quickly pressed the answer button.

"Hey, I'm Tian Lu. ”

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"Oh, it's Lele。。。。。。 Yes, I'm on vacation, a month, didn't I just come out! I've been in the United States for so many years, and I haven't taken Lan Lan out to play!"

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"You know it all?。。。。。。 Haha, thank you!"

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"Okay, let's get back and talk, goodbye!"

After saying the last sentence, he threw the phone back into the small bag, and Tian Lu leaned back on the backpack and kicked his legs hard. After a long morning's walk, it was nice to be able to sit down and rest.

"What are Lele looking for you?"

Ye Lan casually fiddled with the pebbles in her hand and asked intentionally or unintentionally.

"What else can you do?"

Tian Lu stretched his waist, yawned and said, "Didn't you hear about my article, call to congratulate me! By the way, did you tell her?"

Ye Lan grinned, crooked into Tian Lu's arms, and said coquettishly: "Didn't I say that I leaked my mouth when I talked to her on the phone last night! Besides, it's not a bad thing, why hide it from her?"

"Huh. ”

Caressing Ye Lan's hair, Tian Lu had to laugh at his careful thoughts. But after just laughing, his brows immediately furrowed again, and he said with a bitter face: "I don't think this place is really interesting, anyway, Lei Kang has listed a lot of scenic spots, let's go to the next place!"

"Okay. ”

Seeing that Tian Lu really had no love for this place, Ye Lan nodded indifferently. She was just curious about the desert scenery in front of her, and she didn't have any special feelings, but she wasn't very nostalgic.

Merely......

"Is it really okay for you to take a month。。。。。。's leave? Ye Lan asked with some concern.

"What's the problem?"

Tian Lu's fingers played with a small strand of Ye Lan's hair, and said lightly: "It's been more than a year of hard work, and now it's just a month's vacation, who can say anything?"

After more than a year of hard work, with the assistance of more than 20 technicians, Tian Lu successfully completed his research plan ahead of schedule. And at the suggestion of Professor Bruce, he deliberately kept all the articles in his hands and sent them to the journal Nature after all the data came out. Fortunately, after getting Tian Lu's article, Nature magazine attached great importance to it and completed the publication work in a short time.

Completing the predetermined goal was enough for Tian Lu, and there was no need for him to continue to go deeper. On the one hand, he is indeed tired, he has worked hard non-stop for so many years, and he really needs an unprecedented long vacation. On the other hand, there are some things that may not be more beneficial to the field road if you go too far ahead。。。。。。

"Hehe, since we're out, we just have to have fun and relax completely! Don't think about those things, okay?" Seeing that Ye Lan was still a little worried, Tian Lu pinched her little nose and said with a smile.

As soon as Tian Lu said this, Ye Lan was only stunned for a moment, then simply nodded and said no more.

Think about it, on the edge of this desolate desert, what are the two of them doing blindly。。。。。。?

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It was released very late again, and unlike the average person, I was busier than usual on the weekend, haha.

Of course, this is the first chapter of the day, and the other chapter is less than a thousand words, so I'm afraid it will be difficult to finish before twelve o'clock, but I'll go to bed after I post it, so let's read it tomorrow morning.