"Knock knock!"

The louder knock on the door woke both Tian Lu and Professor Locke from the heated discussion at the same time. The only difference is that Professor Locke frowned, and his face showed displeasure, while Tian Lu was shocked, and a sense of chagrin immediately surged in his heart.

"Oh no! I was so carried away just now!"

Not to mention the chagrin in Tian Lu's heart, after Locke said "Please come in", a resident doctor pushed the door and walked in.

First, he glanced at Tian Lu with a rather strange look, and the resident doctor clicked the watch on his wrist and said with some embarrassment: "Sorry to disturb the two of you!" Professor Locke, each applicant only has half an hour to interview, and you have to interview several other applicants, so 。。。。。。 ”

Under the reminder of the resident doctor, Professor Locke immediately looked at his watch, and suddenly realized: unconsciously, his conversation with Tian Lu had lasted for an hour and a half!

"What a pity!"

Professor Locke stood up and shook his head, "Tian, it was a pleasant conversation with you, and before you knew it, it had been so long. By the way, are you going back to Los Angeles today?"

"Yes, Professor, I've booked my ticket for eight o'clock in the evening. Tian Lu also stood up and replied honestly. According to the schedule sent to him in advance, he was free to leave after the afternoon interview.

After a little hesitation, Professor Locke smiled and said, "So, if it's convenient, can you postpone your plan to go back?" I'd like to invite you to dinner and continue what we just talked about, okay?"

After speaking, not only Tian Lu was slightly stunned, but the resident doctor's face also showed a hint of surprise!

"Of course, we'll cover the cost of the hotel and transportation, so we won't make you pay any more!" Professor Locke added immediately. For the applicants for residency training, the hospital is only responsible for one night's accommodation and three meals, and everything else has to be solved by themselves, and Professor Locke's attitude at this time seems to be afraid that Tian Lu will refuse.

If Tian Lu didn't know what was going on by this time, it would be too dull! Surprised in his heart, he nodded hurriedly and replied without hesitation: "Okay sir, I'll go and refund the ticket later." ”

Nodding with satisfaction, Professor Locke personally sent Tian Lu out of the office.

On the bench outside the door, there were three or four applicants waiting for Professor Locke's interview, and when they saw Tian Lu and Professor Locke walking out laughing, everyone's eyes showed surprise and at the same time, there was also a flash of vague dissatisfaction and hostility.

Tian Lu, who was happy in his heart, naturally didn't care about the hostility of these competitors, and after nodding to Professor Locke, he left the University of California, San Francisco Medical Center with brisk steps.

Walking out of the gate of the hospital, as soon as the cold wind blew, Tian Lu's head suddenly hurt a little again.

When talking to Professor Locke, Tian Lu felt relieved, and it seemed that even the cold was much better, but once the interview was over and his mood relaxed, all kinds of symptoms immediately returned to his body.

"It's still early, let's find a hotel to sleep in. ”

Because he originally planned to go back directly, and he didn't bring anything with him, Tian Lu left the room in the morning, and since he decided to stay for one more day, after thinking about it, he raised his feet and walked to the nearest hotel to the hospital。。。。。

。。。。。。。。。。。。。。。。。。。。。。。。。。。。。

"The Chinese are really smart!"

"Pinching" two chopsticks in his hand, Professor Locke tried to pick up a potsticker, but after several attempts to no avail, he reluctantly picked up the knife and fork again, and said with a smile: "This kind of tableware is a test of finger coordination. ”

"That's because you use too little, in fact, I use it pretty well!" Another white man next to Professor Locke nimbly picked up the spring roll in front of him and smiled quite smugly.

For dinner at eight o'clock, Professor Locke deliberately chose a very famous Chinese restaurant near the hospital, which made Tian Lu quite grateful: on the one hand, Tian Lu was not very familiar with the etiquette of Western food, and it was easy to make a fool of himself if he went to a high-end restaurant; on the other hand, he was unwell and now just wanted to drink a bowl of white porridge and eat some light vegetarian food, which may only be sold in authentic Chinese restaurants.

After discussing the cutlery for Chinese food, Professor Locke gradually got to the point: "Tian, after today's interview, I chatted with Professor Smith, and he is also very interested in an idea you put forward in the afternoon, can you elaborate on it more?"

Hearing Professor Locke's provocative words, Professor Smith, who had been eating with relish, immediately put down the chopsticks in his hand. Although he was suspicious of the young man from a foreign country in front of him, out of trust in his old friend Professor Locke, Professor Smith still looked at Tian Lu expectantly.

"Ugh。。。。。。 ”

After looking at Professor Smith and hesitating for a moment, Tian Lu asked with some uncertainty, "I'm sorry, Professor Smith, because I talked a lot with Professor Locke in the afternoon, I don't know what you are interested in?"

The professor in front of me is not small, he is the chief of neurology at the San Francisco Medical Center. In fact, as an independent secondary discipline, neurology does not belong to the concept of internal medicine, and is quite closely related to neurosurgery, many diseases are difficult to judge whether they belong to the category of neurology or surgery, and sometimes it requires the cooperation of two departments, so the relationship between Professor Locke and Professor Smith is also quite good.

"About the blood-brain barrier!"

Professor Smith replied without hesitation!

Tian Lu was suddenly shocked in his heart!

Suddenly, there were waves of turmoil in his heart! Tian Lu's eyes with extremely complicated emotions involuntarily drifted towards Professor Locke, who had a serious face.

Sure enough, he is a top neurological expert, with a keen sense of touch and a vicious eye!

During the interview in the afternoon, for the first time, he had the opportunity to show his understanding of neuroscience in front of top experts, and Tian Lu got a little carried away for a while, and inadvertently revealed some knowledge beyond reality in the system, including theories involving how to break through the blood-brain barrier.

Of course, even if Tian Lu's tone was quite positive at the time, Professor Locke would only think that this was his idea. After all, there are no experiments and studies to confirm it, and no one would think that the words of a young man are true!

But even so, Professor Locke was extremely shocked to find that, at least in theory, Tian Lu's idea really seemed to have a certain degree of feasibility!

The so-called blood-brain barrier, in layman's terms, is actually a defense mechanism for the human body to protect the brain.

The nutrients absorbed by the human body and the oxygen breathed by the human body are transported by the circulatory system to various tissues and parts, of course, drugs are no exception, and many drugs must be delivered to the site of action through the circulatory system. The eventual exchange of substances between the circulatory system and human tissues is mainly done by capillaries.

The blood-brain barrier is a structure in the brain that prevents certain substances from entering the brain tissue from the bloodstream.

The capillaries of the brain are different from the capillaries of other parts of the body, and there is a special set of structures, which the medical community calls the blood-brain barrier. Because of the effect of the blood-brain barrier, it is difficult and easy for substances in the blood to enter the brain tissue through the cerebral capillaries, some are easy to pass, some are difficult to pass, and some are not at all. And this selective passage cannot be controlled by human autonomy yet, the blood-brain barrier is like a solid line of defense to protect the brain, only the substances it approves of are allowed to enter, and the substances that are not approved, whether they are good or bad, whether they are beneficial to the brain tissue or not, are all rejected!

The mechanism of action of the blood-brain barrier has not been completely cracked until now, and in the past 100 years, the world's major pharmaceutical companies have been trying their best to find a way to avoid or break this defense mechanism, safely and effectively control the switch of the blood-brain barrier, so as to deliver drug ingredients to brain tissue and treat some refractory diseases.

This is a puzzle that has puzzled the scientific community for many years!

Once the blood-brain barrier is successfully broken, the treatment of some neurological diseases, such as Alzheimer's disease (Alzheimer's disease), epilepsy (epilepsy), etc., is likely to have a breakthrough development!

Eighty years later, this puzzle has long been solved, and a whole set of mature theories has been formed: from the mechanism of action of the blood-brain barrier, to the criteria and principles for the selection of substances through it, and even a detailed list of substances that can pass through the blood-brain barrier!

Of course, there are several ways to control the opening and closing of the blood-brain barrier!

In an afternoon conversation with Professor Locke, Tian Lu inadvertently revealed the general principle of one of the methods. Although this method involves a large amount of chemical, biological and neurological knowledge, it is extremely complex, arguably the most complex of the several methods, and it is also the least efficient and controllable. However, for the development level of modern medicine, it is the most appropriate! In particular, many of the previous research on this method has basically been completed in reality, that is to say, it is still based on the existing research, and most of the theoretical foundations are already there.

It is precisely for this reason that as soon as he heard Tian Lu's theory, Professor Locke sensitively discovered its value.

It has been said that only genuine interest can make a person successful in their field. Professor Locke is like this, as a neurologist, even if he knows that Tian Lu is just a rookie who has just graduated from college, but that set of theories still scratches his heart, so just a little hesitation, he contacted his old friend Professor Smith. In this regard, Professor Locke thinks that there is still a certain gap between himself and Professor Smith, so he can't wait for Smith to make a further evaluation of Tian Lu's theory!

Facing the expectant gazes of Professor Locke and Professor Smith, Tian Lu was extremely conflicted for a while.

The training of neurosurgery residency takes seven years, the first four years are for neurosurgery clinical knowledge and technical training, the fifth year is basic research, the sixth year can also choose to continue in-depth research, and the seventh year is the chief resident. And this method of breaking through the blood-brain barrier is the research topic that Tian Lu chose for himself during his fifth and sixth years of training!

In the afternoon, Tian Lu only expounded the basic theory, but did not say the final conclusion, as far as such a huge research is concerned, it takes a lot of time and energy to summarize and verify the previous theory, and that kick in the door can make a research group stuck for countless years!

It's like Edison researched the light bulb, he knew that heat-resistant materials were used in vacuum bubbles, but after trying more than a thousand materials, he invented the carbide cotton silk incandescent lamp. However, Tian Lu went one step further, and directly knew that tungsten filament was a more suitable material than carbonized cotton filament!

Therefore, Tian Lu was not worried about the adverse consequences of the afternoon conversation, in his mind, there was a complete theory and results, and it was completely possible to save countless attempts and avoid countless failures, so even if Professor Locke knew the principle, it was basically unlikely that he would be ahead of Tian Lu.

But if you elaborate further now, it is very likely that you will give more hints to the other party, and the uncontrollable factors will be greatly strengthened.

Borrowing and plagiarism in the academic world is commonplace, that is, when Edison invented the electric light, didn't he also compete with Swan in Britain for the patent? Therefore, the centenary of the invention of the electric light in Britain was in 1978, and in the United States it was in 1979.

It's not that Tian Lu is selfish and unwilling to share the knowledge of the system with others, in fact, he wishes that others could accept the theory of the system without doubt, so that he can have more room to play and be able to use the help of the system more efficiently. It's just that this research is too important for his future plans to be missed.

But in the same way, such a study is definitely not something that Tian Lu can complete alone!

It is impossible for him to directly write the final results for everyone to see, and it is impossible for such a paper to be published in journals all over the world, especially when it involves a large amount of experimental data, and it must be completely recorded. And if it is used as a theoretical inference and the basic principles are published, it can only be to make wedding dresses for others, and Tian Lu will gain nothing except for unprecedented glory!

This kind of research requires a team, a lot of advanced instruments, a rigorous experimental process, and a huge amount of data results, which ultimately comes down to money and the support of a scientific research institution!

This is also the reason why Tian Lu insisted on coming to the United States for residency training, and only here can he get all this.

"What to do? Say or not say?"