Mr. Jane: "Mr. Yuan must have some understanding of the core cell theory. Pen Fun Pavilion www.biquge.info"

Yuan Qidong: "Hmm. Core cells are found in the body's nervous system, reproductive system, and some skeletal and musculoletal tissues. It is said to have a very low number of divisions and is associated with aging. I don't know about the rest. ”

Jane: "Yes, the core cell theory is very closely related to aging, and it can be said that we are the key to solving the problem of aging. Our body is metabolizing every day, and if there is cell death, new cells must be born to replenish it, and the continuous division and replication of cells is risky. There are more than 3 billion base pairs and about 50,000 to 100,000 genes that make up the genetic material that makes up our human species. Every time our cells divide, we have to replicate such a huge amount of genetic information, and errors are almost inevitable. ”

Yuan Qidong did the math, and it was indeed the case, if you write 10 words per second, each word represents a base pair, it will take nine and a half years to copy a copy of genetic information.

Yuan Qidong: "If it's wrong, doesn't it mean a genetic mutation." Is there anything wrong with harmful mutations being eliminated under Darwinian evolution's principle of survival of the fittest, while beneficial mutations are good for us humans? ”

Xue'er: "Mr. Yuan is talking about the population, but at the individual level, this harmful variation can only be accumulated, and will not be affected by the principle of survival of the fittest. ”

Consider that survival of the fittest is the elimination of harmful mutations at the cost of the demise of individuals who do not adapt to the environment, but within each individual, it is impossible to do so. When a mistake occurs, it will not be corrected, and the replication based on that mistake will be repeated over and over again, and will be stacked with other mistakes to create more errors.

The replication of genes during cell division in the human body is like copying photos with a photocopier, and each copy is based on the previous finished product, and there is no way to correct the ambiguity above, and new blurs will be added for various reasons, and in the end, I am afraid that Xi Shi will also become Zhang Fei.

Jane: "The core cell theory is to find the most primitive cells, get the most primitive genetic information, and replace those faulty cells with a large number of copies through embedded cell technology, so that the harmful variation of the body can be corrected." ”

Yuan Qidong: "Is there any effect?" ”

Cher: "We can cure any cancer. Cancer is caused by the accumulation of harmful variants. The genes that control the normal division of cells are destroyed, causing tissue cells to divide and form malignant tumors, which is called cancer. Using embedded cell technology, we can replace cancerous cells with normal ones. ”

Yuan Qidong: "This is a very remarkable achievement, you are the ones who really deserve the Nobel Prize." ”

Jane: "It's not that simple, it's very, very complicated to treat, you need to extract the core cells first, and then accelerate the culture of the embeddings, formulate inhibitory hormones, and so on, all for the individual. Therefore, it can only be customized, not assembly line operation, even if it is a billionaire, it is not affordable. ”

Yuan Qidong: "No, what treatment will cost hundreds of millions of yuan?" Besides, hundreds of millions of dollars are just a number for some people. "In fact, for Yuan Qidong, it's just numbers.

Jane: "Because I don't have that much time. ”

Damn, it's really arrogant, it seems that this one-size-fits-all method for treating cancer, only this Mr. Jane knows.

Cher: "We're also trying to make this approach more practical, but we're doing it slowly. ”

Yuan Qidong knew that their treatment would definitely require a lot of manpower, material resources and energy, and the reason why they didn't publish this research result that could make them fame and fortune both rich and famous, was really smart.

Imagine if it is announced, how many people who have been sentenced to death by cancer will come to the door. Whether it's those rich people who spend a lot of money, or politicians who can use the power of the state, even ordinary people, they can't stand it when they come to beg you in droves. It's unimaginable how crazy people can do in the face of the threat of death.

They won't let anyone know until everything is ready. But now let yourself know that if you don't cooperate with them, will you be killed?

Yuan Qidong: "This is a great thing, I think you should put all your energy into the clinical application stage as soon as possible." ”

Jane: "We also need Mr. Yuan's cooperation in this regard, saving lives, is there a more noble cause than this?" ”

Yuan Qidong: "Is this this?" I'm not very interested. My childhood dream has been eliminated as a doctor, being pierced in the ass with a sharp steel needle, and then injecting an inexplicable potion into the body, which is my most painful memory. ”

Xue'er: "Has Mr. Yuan heard of the Immortal Lock?" ”

Yuan Qidong was stunned, was it the thing that the child was wearing around his neck? It's like that thing is called a longevity lock.

Cher: "We're breaking the immortal lock, and each of us has this immortality lock in our genes, not just humans, but all species on Earth. It is this immortal lock that limits our lifespan. ”

Yuan Qidong didn't quite understand, he really didn't know that there was such a thing.

Seeing Yuan Qidong's puzzled gaze, Jane began to explain: "Xue'er is joking with you, the immortal lock is the name we gave, of course you can't have heard of it." ”

Xue'er smiled, sat next to Yuan Qidong, peeled an orange and handed it to him.

Jane: "But we do have certain chains in our genes that limit our longevity. These chains are given to us by heaven. Jane said, gesturing to the sky.

Xue'er said: "Maybe you don't believe it, but in the process of species evolution, there have been some species that do not have immortal locks. But it's all gone. ”

This is really a strange statement, since it is a species without an immortal lock, then the lifespan is naturally endless, how can it be annihilated?

"These species have all been destroyed by themselves. It is because of their immortality. In our world, many species have a lifespan of hundreds of years, but basically within a few times the reproductive cycle, not more than 10 times. For example, the reproductive cycle of human beings is about 14 years, so the theoretical lifespan of human beings will not exceed 140 years. The same is true of other creatures. Many organisms have only one reproductive cycle and die after reproduction. ”

Yuan Qidong: "This doesn't mean anything, and the core cell theory can be used to explain this." ”

Jane: "It's true that the length of life depends a lot on the core cells. However, for those low-level life forms with a very short lifespan, such as flies, mosquitoes and other insects, their genetic replication has not gone through many generations of false superposition, and there is no need to be so short-lived. You also know that many insects only have a lifespan of a few months, and their genes are barely affected by harmful mutations. ”

Yuan Qidong: "Then is there any basis for what you said about the immortal lock?" ”

"We studied the phenomenon of oil and coal. Based on the Earth's reserves of oil and coal, we estimate the total amount of organisms needed to form these coal and oil. ”

Qi Lingjia was attentive when he listened, and expressed strong dissatisfaction with the sudden change of topic: "How did it become a problem of energy crisis again." ”

Xue'er smiled: "This sister is quite anxious, listen to me slowly." ”

Qi Lingjia was even more dissatisfied, and slandered a few words in his heart. Who's my sister, hmph, you're a little bone elf who is old. I'm a very young girl.

"Isn't it strange that under hundreds of millions of years of natural attrition, oil reserves still have the amazing scale they are now, which can be consumed and used by human beings for hundreds of years without control? In 2005, for example, we consumed 10 million tons of oil a day.

Imagine how many carcasses of organisms need to be continuously decomposed, compressed and precipitated to finally form a ton of oil, and in this process, there will be endless consumption, and only the part that is completely enclosed by the earth's crust can be found and used by us. If I say that 10,000 tons of carcasses can produce 1 ton of oil, do you think it is reliable? ”

Yuan Qidong interjected: "I think it may still be a little less." ”

Xue'er smiled, very charming: "Mr. Yuan is right, maybe one million tons, ten million tons is the right answer." ”

Qi Lingjia: "But is this related to the immortal lock you said?" ”

Cher: "The question is, where did so many corpses of living organisms come from?" ”

Qi Lingjia said: "Of course it grows on the earth." "I didn't expect anyone to ask such a strange question.

Cher: "That's the carcasses of animals as many as the ocean." The Indian Ocean can be filled with the carcasses of animals needed to form an oil field. ”

Qi Lingjia gasped, this was something she couldn't imagine no matter what.

Yuan Qidong: "You're right. I see, didn't you look for amber? Well, the age is wrong. ”

Xue'er: "Mr. Yuan still impresses me." That's it right to the point. If we assume that this or several organisms in ancient times had a long lifespan and had no natural predators in ancient times, then their populations would increase geometrically, even to the point of filling the oceans. In this case, the living space required by the individual is not compressed, and the living environment continues to deteriorate, which eventually leads to the deterioration of the environment of the entire ocean, the death of organisms in large areas, the extinction of the entire population, and the transformation of the entire ocean into a sea of death. At that time, the Decomposers were still very weak and unaccustomed to surviving in the Sea of Death, so this Sea of Death would exist for a long time. In the process, the earth's crust changes, and some of it is sequestered deep into the earth's crust, forming oil. We believe that this has happened many times, and that it is only when the immortal lock gene is formed in the living organism, limiting the lifespan of the individual living organisms, and the maturity of the decomposers makes the total number of living organisms on the earth balanced, and the Sea of Death does not reappear. Moreover, we believe that the immortal lock was formed during the period when life on earth was still marine life, so it is impossible for us to find the genes of life without immortal locks in amber. Just like Mr. Yuan said, the age is wrong. ”