(783) Coral Man
"Coral Man?" Fu Chenxue's heart sank, he knew that this disease, which is one of the world's "ten strange diseases", is really called "progressive muscular ossification" (MOP), also known as "progressive ossifying fibrodysplasia" (FOP) is a rare hereditary progressive connective tissue disease, characterized by progressive sexual mobility disorders in multiple joints and progressive rhabdomyostriated muscle heterotopic ossification. Although this is a dominantly inherited disease, most cases are caused by mutations that occur naturally and may not be traced back to the family history. The earliest documented cases of the disease date back to the end of the 16th century, and medical statistics show that the disease occurs only 1 in 2 million people, with a total of 600 cases worldwide. In history, only 2,500 people worldwide have suffered from the disease.
This strange disease is one of the rarest diseases in the world, in which the muscles of the patient's whole body gradually turn into bones, and the whole body seems to have a "second skeleton", and eventually the joints of the whole body will be unable to move, turning into a living "statue" of flesh and blood. This process is very similar to the process of coral formation. The polyps in the coral body can secrete calcareous matter, which constantly grows upwards and divides, leaving the bones behind, forming coral, so people with this rare bone disease are also called "coral people" in medicine.
"Progressive muscular ossification" causes the bones in the human body to develop in an abnormal direction, first with the deformity of the toes, then the neck and spine and shoulders, and finally the muscles gradually disappear and ossify, and gradually transform into a bone man. In other words, more and more bones accumulate outside the patient's skeleton, and eventually the body stiffens and takes shape - either in a U-shape, or with the arms folded together, or the legs crossed together, or the legs stand in a "human" shape, like a stone man, and can no longer do any movement. People with this disease are usually very fragile, like glass people, and at the slightest touch, their joints bulge like balloons, and the next step is to grow into new bones.
There are no cured cases of "progressive muscular ossification" so far, and the average life expectancy of patients is 41 years. Medical experts have spent a lot of effort studying this strange disease, and finally found out the source of the disease -- the culprit is actually a gene. They found that the gene, called "ACVR1", controls three types of bones in the human body, forming proteins (BMPs), which directly affect bone formation and repair. When the gene "ACVR1" is mutated, such as duplicating one or two more of itself, it will change the original genetic information, and the signal that leads to bone formation and repair will be disturbed, and a large number of wrong proteins will be produced. "Progressive muscular ossification" makes doctors feel helpless, because the most effective way to treat other diseases is surgery, and this disease is absolutely not operable, because surgery will cause capillary bleeding, and the abnormal protein in the blood will erode to other healthy parts of the body, resulting in worse results the more surgery. At present, this disease can only be treated with some medicines, and I will find a way to save my life first. The treatment methods of FOP, such as bone marrow transplantation and gene therapy, are in the research stage, and there is no cure.
Huo Ziyan said: "Grandpa likes Ling'er very much, since Ling'er got this disease, grandpa has never had a smile on his face. In the past two years, grandpa and dad have searched for famous doctors all over the world, and they have collected hundreds of ancient recipes and earthwork recipes, but no one has no one and no prescription can cure Ling'er's disease, watching that lovely child become a 'stone man' little by little, the whole family's heart is about to break......" As he spoke, Huo Ziyan's eyes were covered with a layer of mist, and crystal tears rolled down his cheeks. It can be seen that her feelings for that child are extremely deep. "Chenxue, you must save him, okay? As long as you can cure Ling'er's illness, whatever you want, I will give you ......" Speaking of this, she suddenly realized that her words were a little ambiguous, and her pretty face turned red again.
Fu Chenxue smiled bitterly in her heart: I want you to give it to me, the problem is that the world's famous doctors are helpless for strange diseases, and I may not be able to cure it well. Of course, he couldn't say this, he gently wiped away Huo Ziyan's tears and asked, "Ah Zi, has anyone in your family ever had this disease?" ”
"Nope! I've heard my grandfather say that no one in our immediate family or collateral family has ever suffered from 'Stone Man Syndrome'! ”
"Did anyone in your family have ever had this disease?"
"This ...... It doesn't seem to be! ”
"Like?"
"Well, because the ancestors are so old, and there is no family history left, who can know? According to Grandpa's memory, it really didn't appear. ”
Hearing Huo Ziyan say so surely, Fu Chenxue relieved her mind a little, among all diseases, the diseases that belong to the family inheritance are the most difficult to treat. As long as it's not a genetic problem, there's some hope. He looked at Huo Ziyan and said with a smile: "Ah Zi, do you believe me?" ”
Huo Ziyan was moved by Fu Chenxue's gentle movements, nodded vigorously, put her cheek on his chest again, and said, "Chenxue, I believe in you!" What others can't do, you will definitely be able to do it-because you are Fu Chenxue, you are the only one in this world! ”
Being worshiped by a beautiful woman is a pleasing thing to the eye, but being worshiped by a noble, proud, and elegant beauty like Huo Ziyan makes people honestly afraid. Fu Chenxue laughed: "Ah Zi, do you want to kiss me a few more times?" Maybe when I'm happy, I'll work harder to treat Ling'er. ”
"Villain, how dare you blackmail me...... I like it, though. Huo Ziyan sat up from Fu Chenxue's arms, first glared at him fiercely, and the next moment he smiled, hugged his neck, and pressed his small mouth frantically against his lips......
Hearing the madness in the back, the two women in front were on pins and needles, and they didn't even need to look back to know what was going on behind them. They didn't dare to make a sound, they didn't dare to cough, even though their throats itched uncomfortably...... Not only is the throat itchy, but there are a lot of small insects crawling on the body, itchy and crispy, numb...... Alas, this Miss Huo is really bad, do you forget that they are also women? So blatant, so glue-like, so ...... Shameless!
The car drove into the "Huo Mansion" like a palace, and the "Huo Mansion" was very large, so big that it was beyond imagination, at least much more magnificent than the "Zhou Mansion". The car drove on the winding mountain road for five or six minutes before stopping in front of a white house, where the bamboo trees are surrounded, the gold is splendid, the rockery waterfall, the lake and the mountains are beautiful, as if entering a fairyland, gorgeous and extravagant are amazing.
The door opened, and the bodyguard and the driver, who got out of the car first, finally let out a sigh of relief, only to realize that their backs were cold and their clothes were soaked with sweat