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"What is there to consider, how can there be rejection in a blood transfusion? There are so many cases of blood transfusion in our hospital every year, and I have never heard of any rejection, rejection only occurs when it comes to organ transplantation, and you can only say it if you don't understand medicine at all, how can I let you disturb the work of the expert group? The vice president said righteously.

At this time, a middle-aged doctor, who could only stay outside the ward, muttered in a low voice: "In essence, blood transfusion is really a type of transplantation, and hemolysis is also a type of rejection." ”

The pathology of rejection is actually very simple, because everyone has a strong immune system, and most of the abnormal changes in the body caused by various germs, viruses, and various reasons will be strangled by this immune system. Only when the immune system can't kill us will we get sick.

The immune system is very aggressive, but it does not attack randomly, it can recognize its own cells and foreign objects, and it will not attack the normal cells and organs of the body itself.

Organ transplantation is equivalent to a huge heterogeneous substance in the human body all of a sudden, and the immune system will definitely mobilize strength to attack, so the transplanted organs must be tested for matching, and only the same type can be transplanted.

However, it is impossible for the organs of two people to be exactly the same, so the rejection of the graft by the immune system must exist, and the chronic rejection cannot be reversed.

Blood transfusion is essentially a transplant, and the immune system will not accept all the blood from outside, so it must be of the same blood type before it can be transfused. Medically, though. Many components in the blood are low-risk antigens that the immune system automatically ignores, so the immune response to the same blood type is usually mild, but sometimes there is an immune transfusion reaction.

Hemolysis is an immune transfusion reaction.

In the case of this immune transfusion reaction, the panel is not undiagnosed, and the symptoms are not completely consistent.

In fact, there is another case that is the opposite of an immune transfusion reaction, not because the immune system attacks the heterogeneity, but because the immune system is defective or otherwise does not function properly. It allows allogeneic cells to multiply and grow in the body.

When the immune system is tolerant to lymphocytes contained in the transfused bloodstream. It causes the multiplication and growth of allogeneic lymphocytes, and when the allogeneic lymphocytes come into contact with the body of the blood recipient, they will feel unfamiliar and be judged to be allogeneic for immune attack. Causes disorders in the body systems of the recipient.

This is known as transfusion-associated graft-versus-host disease. General rejection refers to the host's body's resistance to grafting. In this case, the opposite is true, and the graft is in turn host-resistant.

The probability of the occurrence of this condition is very small, only 1 in 10,000. However, once born, the mortality rate is as high as more than 90 percent, and there is no effective treatment until more than ten years later.

It has only been ten years since the introduction of blood transfusion-associated graft-versus-host disease, and there were no cases reported in China until the year before last, and the medical community has not paid attention to it, and there is still very little research and understanding of this disease.

In fact, even after 20 years, many people do not know the existence of this disease, and many people think that the probability of blood type matching between relatives, especially between direct blood relatives, is very high, and mutual blood transfusion is very convenient, but in fact, direct blood relatives, especially one generation of blood relatives, transfuse blood with each other, the risk of transfusion-associated graft-versus-host disease is greater.

The pathology of transfusion-associated graft-versus-host patients can usually be divided into three categories: one is that allogeneic lymphocytes are immunoactive, and the immune system of the recipient does not kill them; One is immunodeficiency, tolerant to allogeneic lymphocytes; The third type is because the direct blood relatives are mistaken for autologous lymphocytes due to the relatively high cell approximation, and the immune system does not attack, and after the allogeneic lymphocytes multiply and grow, they in turn attack the recipient's cells.

Bao Feiyang also saw the news of prohibiting direct blood relatives from supplying blood to each other in later generations, and felt strange, but only after understanding it did he know that there was such a disease.

Nowadays, very few people know about this condition, unless they are experts who specialize in the field of graft-versus-host disease, and the disease is very rare under normal circumstances and is often overlooked.

Bao Feiyang heard Meng Shuang's noisy and fierce argument on the phone, so he said to Meng Shuang: "You go directly to Zhao Liping and ask her to tell the expert group about this possibility, the course of this rejection reaction is often very fast, if it is late, it may be too late." ”

Hearing Bao Feiyang say this, Meng Shuang hurriedly said to the doctor who had just spoken: "Could you please give my phone number to Miss Zhao, my friend will tell Miss Zhao directly." ”

The doctor looked at the vice president with a look of embarrassment on his face: "This ...... I can't go in without permission! ”

Meng Shuang had no choice but to say to the vice president again: "My friend also knows Miss Zhao, please tell me, okay?" ”

The vice dean shook his head reservedly: "You are fooling around, is your friend an expert, can your friend know what the expert doesn't know?" I don't think you'd better mess around. ”

Chen Zhiguo and Chang Mengqin, who had not yet left, also pulled Meng Shuang and said, "Shuang'er, don't listen to Bao Feiyang's nonsense, he can be more powerful than an expert!" ”

Chen Zhiguo saw Meng Shuang calling Bao Feiyang again, and he was very uncomfortable in his heart: "Yes, you see that the director of other hospitals says it's impossible, what does Bao Feiyang do, will he still see a doctor?" ”

Meng Shuang was so anxious that she was about to cry, she was worried about Guo Liqiong, and she also believed in Bao Feiyang, she pushed Chen Zhiguo away, rushed to the vice president, and handed the eldest brother over: "You go in and sue Miss Zhao immediately, just say what Bao Feiyang said, he has a way, let her answer the phone." If you delay the condition and delay the disease, you know the consequences. ”

The vice president looked at the eldest brother who stretched out in front of him, his face was red and white, if others dared to do this, he would definitely ask the security guard to kick people out, but he knew the relationship between Meng Shuang and the patient in the ward, and he had faintly heard about Guo Liqiong's origins, and knew that he really couldn't afford that kind of consequences.

He snorted angrily, didn't answer Zhao Liping's phone, and said very reluctantly to the doctor who had just spoken: "Xiao Guo, then you can go in and talk about it." ”

"Okay." The doctor, surnamed Guo, hurriedly agreed, turned around and walked into the ward.

In the consultation room, Liu Wenxuan, director of the Yuedong Provincial Department of Health, and Feng Dexian, president of the Provincial People's Hospital, had a grim face, and several medical experts were arguing about Guo Liqiong's condition, whether it was infection, cancer or other causes, each reason could not find sufficient evidence, but was overturned by other evidence.

In this case, everyone does not dare to use drugs casually, so as not to further intensify the development of the disease.

Zhao Liping hurriedly came to the consultation room from the ward, and when she heard that everyone still couldn't agree on their opinions, she couldn't help but complain loudly: "Aren't you all experts, why can't you even find out a cause now?" ”

The expressions of several medical experts are a little embarrassed, it is precisely because they are experts that they do not make a judgment lightly when they encounter this situation, if it is an ordinary doctor, when they encounter a similar situation, they must have already started to carry out treatment, and the result may be that they happen to be cured, but it is more likely that they will treat the person to death, or the wrong treatment will delay the correct treatment.

"Miss Zhao, it's not that we can't find out, but if we strictly argue, no matter what the case is, it seems to be a little wrong, the reason is insufficient, and we can't make a judgment lightly." Chen Wanjing, an expert from the capital, said cautiously.

Chen Wanjing is an expert at Yenching Union Hospital and one of the family doctors of the Zhao family, and this time Zhao Genzheng invited him to sit in Yuecheng, which shows that he trusts him very much, which makes him more careful, and he does not dare to make decisions casually without a certain situation.

Zhao Liping said angrily: "Argument and argument, my mother is not a test for you!" ”

Chen Wanjing was very embarrassed and anxious, in fact, he had already called several famous experts in the medical field to ask for advice, including experts from the United States, but everyone's views were similar to his.

At this time, Feng Dexian's phone rang, and he hurriedly answered it, with a respectful expression on his face: "Secretary Tang...... Yes, the medical team has not yet reached a clear conclusion......"

Hanging up the phone, Feng Dexian raised his head, and the expression on his face was a little ugly: "Secretary Tang of the Provincial Party Committee has rushed to the airport, and Cabinet Member Zhao will soon arrive in Yuecheng, Secretary Tang instructed us that before Cabinet Member Zhao arrives, we must not let the condition deteriorate, and Governor Ji will come to us soon......

After hearing this, everyone's faces became more serious, especially the experts in Yuedong Province, who were under great pressure in their hearts.

Chen Wanjing's pressure is not small, he has a close relationship with the Zhao family, if Guo Liqiong has an accident at this time, it will be difficult for him to feel at ease in his life.

Doctor Guo walked in accompanied by a medical staff, and saw so many experts and famous doctors gathered together, his heart was full of anxiety, he just felt that the situation that Meng Shuang said was indeed possible, but so many experts did not come to a conclusion, is it really that simple?

Under the gaze of everyone, Dr. Guo said to Zhao Liping: "Miss Zhao, Miss Meng outside asked me to bring you a message, she said, she said that there is a person named Bao Feiyang who said that he has a way to let you go and answer the phone." ”

"Bao Feiyang? What can he do? Zhao Liping was very anxious and angry, although she had a good impression of Bao Feiyang, she still subconsciously didn't believe it. Although these people in front of him are not very good, they are indeed experts in the medical field, they are all at a loss, Bao Feiyang is a small cadre, and he is thousands of miles away, what can he do?

Chen Wanjing still had some impressions of Bao Feiyang, and he couldn't help but turn dark when he heard the words. (To be continued......)