"Fei Fei's mother died not long after Fei Fei was born." Yang Shushan said slowly with a hint of regret.

"Sister Jing mentioned it to me, saying it was because of leukemia." Zhang Yang thought to himself, this is not a secret, what the old man wants to say should not be so simple.

Yang Shushan nodded: "It's leukemia, it must have been Jing'er who told you." ”

"Hmm!" Zhang Yang nodded.

"Fei Fei's mother has CML for chronic myeloid leukemia." Yang Shushan added.

Zhang Yangjian's eyebrows frowned slightly, he knew that chronic myeloid leukemia is a relatively rare malignant tumor, accounting for about 0.3% of all cancers and 20% of adult leukemia; In the general population, about 1 to 2 people per 100,000 people have the disease, that is, the probability of a normal person getting this disease is about 1 to 2 in 100,000, and the probability is very small.

Chronic myeloid leukemia progresses slowly, so many patients have no symptoms, especially in the early stage, it is not easy to find, but if it is found, the treatment effect is good, but once it enters the accelerated phase or blast crisis phase, it is more difficult to save it.

Yang Shushan said slowly: "When the diagnosis was made, Fei Fei's mother was still in the chronic stage, but the doctor said that it may soon enter the accelerated stage, and it is useless to just take Glenin or chemotherapy, if you want to completely get rid of this evil disease, you need to do a bone marrow transplant to have a way, but Fei Fei's mother's condition is too special." ”

Yang Shushan sighed with a hint of sighing: "The doctor deduced that she was caused by family genetics, and more coincidentally, the chronic myeloid leukemia she obtained, after examination, it was determined that the pH chromosome was generally positive, but negative." Among patients with chronic myeloid leukemia, the proportion is less than five percent, in other words, she should be regarded as the ** type of ACML, and the probability of a normal person is only one in a few million or even one in tens of millions. ”

"Familial hereditary... PH chromosome? Zhang Yang was stunned for a moment, which means that Yang Fei and Yang Jing may also inherit the risk, for a master of bioengineering medical drug engineering, PH chromosome Zhang Yang naturally knows.

PH chromosome. It was discovered in 1960 that scientists in the United States found that there is a chromosome smaller than the G group in the blood of chronic myeloid leukemia, which was named the PH chromosome because it was first discovered in the United States PH.

The cause of the disease is the translocation of the long arm of chromosome 9 and 22, which recombines the proto-oncogene ABL on the long arm of chromosome 9 (9q34) and the BCR gene on chromosome 22 (22q11) into a fusion gene, which leads to the increased tyrosine kinase activity. This is a trigger for the onset of chronic myeloid leukemia.

Although this leukemia is also a type of cancer, it is like this special leukemia, especially the leukemia in which the family genetic factors are mixed in, and the pH chromosome is still negative, which is almost equivalent to genetic mutation.

This disease, even Nanxing No. 1, can only play a temporary inhibition role, because the repair cell system in Nanxing No. 1 has no way to completely correct its chromosomes back.

Really to heal. I'm afraid I'll have to go through a Guò allogeneic bone marrow transplant.

"Yes, Fei Fei's mother is inherited from her family, and Fei Fei's grandmother also died of the same disease." Yang Shushan smiled wryly, "Originally, if chronic myeloid leukemia was detected early, there would be a chance. Even if it is negative, there is a chance to pass the means of guò bone marrow transplantation. ”

This matter is also clear, but Yang Jing didn't say it in such detail at the beginning, and now he knows that the cause of Fei Fei's mother is still so complicated. "Sister Jing also told me that my aunt just couldn't find a matching bone marrow for transplantation at that time. So in the end, I had to give birth to Teacher Fei Fei under the doctor's advice, but..."

"However, Fei Fei still couldn't match her mother, and in the end she could only watch her move from the chronic phase to the accelerated phase, and then died soon after." Yang Shushan sighed and said, "Actually, when Fei Fei was six years old, she went to check and found that the cells in her body also found the PH chromosome. ”

"What? Are you saying that Ms. Fei Fei also has leukemia? When Zhang Yang heard this, his body couldn't help but shake.

Yang Shushan nodded, but immediately shook his head again: "Fei Fei is fine, the presence of PH chromosome does not mean leukemia, but it is an important cause of leukemia." ”

"It's just that when our whole family was worried, she didn't show any abnormalities in her body, and it lasted for six years, and when she was twelve years old, she went to check again, but strangely found that the pH chromosome disappeared, and she didn't find any other abnormalities in her blood."

"Oh!" Hearing this, Zhang Yang couldn't help but breathe a sigh of relief, although if Yang Fei really got that disease, he would save her even if he needed to consume all the system points, but after all, having that disease hurt her too much, and he always hoped that Yang Fei could be safe and sound.

However, he looked at Yang Shushan's face, but he still seemed to have a sad face, right? Still have questions?

"Is there anything you haven't said?" After all, when it came to Yang Fei, he blurted out directly.

"Hmm!" Yang Shushan nodded, "Just when we thought that Fei Fei had no problem, when she was seventeen years old, her grandmother died, and the family was very messy, that year, she happened to be admitted to Meining University, and when we examined her again, we found that she had a PH chromosome on her body again, and what was even worse was that she didn't know how to know the fact that she was born to save her mother." ”

"Since then, the estrangement between her and Xiuguo has become deeper and deeper." Yang Shushan's face had a look of deep pain, "But it's nothing, we are more worried about her body, the doctor told us that she probably inherited her mother's genes to cause this situation, but Fei Fei's PH chromosome disappeared inexplicably for a while, medical experts and genetic experts told us that it is likely that Fei Fei's own immune function has repaired itself." ”

"However, the reappearance of her PH chromosome makes us very worried, but in this case, we don't dare to tell her, so we can only secretly contact Mei Da, and we monitor her physical condition at any time, fortunately, from the freshman to the senior year, she did not have any abnormalities, and when it was time for the first year of study..."

Yang Shushan sighed and paused.

"How was it when you were in the first year of study?" Although Zhang Yang knew that he must be fine, he couldn't help but worry about Yang Fei.

"When I was in my first year, the PH chromosome suddenly disappeared again." Yang Shushan shook his head and said with a blank expression, "We don't know why, but as long as her body is okay, it is more important than anything." ”

"Hmm!" Zhang Yang nodded, Yang Fei's situation, generally speaking, or her body's immune function has played a role, generally speaking, when human cells detect chromosome damage, the cell cycle control point will be automatically activated, generally there are G1/S, G2/M two control points, and ATM protein will respond to DNA double-strand damage, ATR protein will respond to DNA single-stranded damage, and the two will activate the downstream DNA repair pathway, which will repair DNA damage.

Yang Fei's situation should be that her DNA repair pathway is turned on and the damaged chromosomes are automatically repaired, but the strange thing is that since it has been repaired before, how can it happen again?

Is it because their family's recessive genetic code is strong, or is her own body's self-immune repair ability stronger?

Zhang Yang looked at Yang Shushan and asked rhetorically: "So, in the past few years, has Teacher Fei Fei's body found any abnormalities again?" ”

"No, but I'm worried that she will not happen to this again, after all, with the experience of the last time, I am still very worried, I asked those experts, the reason why Fei Fei has a pH chromosome, and there are very few cases of pH negative, it is very likely that it is caused by family genes, which means that it is very likely to appear again, and as you get older, the possibility of mutation will become higher and higher."

"Since you have decided to be with Fei Fei now, I think it is necessary for me to tell you about her situation, and you must be mentally prepared." Yang Shushan looked at Zhang Yang and asked, "Are you confident?" In fact... It's too late to regret it now. ”

"Even if the universe returns to the singularity, I will still hold Teacher Feifei's hand." Zhang Yang stared at the night sky like a piece of sunglasses, although there were not many stars, but the curved crescent moon looked unusually bright at the moment.

It's like the faint halo derived from Yang Fei's incomparably beautiful face.

"What's more, don't forget, I'm the boss of the Nuwa Group, even if the teacher really has any problems in the future, I believe I have the ability to deal with it."

"It's good to have your words." Yang Shushan nodded with satisfaction, "I believe you will be able to protect Fei Fei." ”

"Don't worry, I won't let her be wronged in the slightest."

"There's one more thing I just told you." Yang Shushan looked around, and after making sure that there was no one, he attached it to Zhang Yang's ear and said softly, "It's Feifei's mother's life experience." ”

"Teacher Feifei's mother? I've heard Sister Jing say, isn't she a rich girl? ”

"It's just one of those identities." Yang Shushan said in a low voice, "Even she may not know that her mother is from Jingshuixuan. ”

"You... Do you always know Jing Shui Xuan? ”

"How could I not know that the ancestor of the Yang family was a royal doctor, even in modern times, the Yang family is still a leader in medicine, and the relationship between the successive masters of Jingshuixuan and the Yang family is also extremely close."

"So Fei Fei's grandmother is... Could it be that she is the owner of Jingshuixuan today? ”

"Hehe, of course not, but she has a lot to do with the current owner of Jingshuixuan, if you want to count it, the owner of Jingshuixuan today is called Feifei's grandmother and aunt, Feifei's mother and her are cousins."