"Your Majesty! Emperor! The concubine is wrong, the emperor's concubine is really wrong, ask the emperor to forgive the concubine! "Empress Jiang crawled to the feet of the eldest grandson Yuanhong, there is no child in the middle palace, if this is the case, she will not even lose the right to take care of the **, then her position as queen is an empty shelf to watch, and anyone can step on such a kick.

When Empress Jiang married him, the two may still have some feelings, but after so many years, Jiang Guogong was arrogant and domineering, and he had already exhausted Changsun Yuanhong's patience, and he dared to threaten him at this moment, of course Changsun Yuanhong would not let it go lightly.

Angel didn't feel stunned when she heard such a canonization, and then smiled mockingly, the eldest grandson Yuanhong exchanged himself for Xiao Dianzan, not at this time it should be Yuan Jieyu, the eldest grandson Yuanhong chose the other party without hesitation between her and herself, Qin Guiren is just a decent person for himself.

After Angel knew about this, she still ate, drank and rested as if she hadn't heard anything, and took care of Qin Guiren, arranged a suitable courtyard for her, and moved there after the child was born, but at this moment, an unprecedented disaster befell in the palace - smallpox.

Smallpox is mainly transmitted by inhalation of droplets or direct contact. There are two types of smallpox virus, the virulent ones cause positive smallpox, and the weak ones cause smallpox-like ones.

The clinical manifestations of smallpox are mainly severe symptoms of poisoning blood (chills, high fever, fatigue, headache, pain in the limbs and lower back, convulsions and coma can occur when the body temperature rises sharply), and the skin appears in batches of macules, papules, herpes, pustules, and finally scabs, scabs, and acne scars. The fatality rate of smallpox in unimmunized people is 30% within 15~20 days.

When a person is infected with the smallpox virus, there is an incubation period of about 10 days, after which the patient becomes very acute, and the body temperature can be as high as 41 °C or more because of headache, back pain, chills or chills, high fever and other symptoms.

Accompanied by nausea, vomiting, constipation, insomnia, etc. Vomiting and seizures are common in children. After 3~5 days of onset, the patient had a rash on the forehead, cheeks, wrists, arms, trunk and lower limbs. At first, it is a red macule, then it becomes a papule, after 2~3 days, the papules become herpes, and then the herpes turns into a pustular rash.

2~3 days after the formation of the pustular rash, it gradually dries and shrinks into a thick scab, and the scab begins to fall off after about 1 month, leaving a scar, commonly known as "numbness". Patients with severe smallpox are often accompanied by complications, such as sepsis, osteomyelitis, encephalitis, meningitis, pneumonia, bronchitis, otitis media, laryngitis, blindness, miscarriage, etc., which are the main causes of death from smallpox.

Inhalation through the respiratory tract is the main route of transmission of smallpox. The smallpox virus adsorbs on the surface of the epithelial cells of the upper respiratory tract of susceptible people and invades, quickly reaches the lymphoid tissues such as the regional lymph nodes and tonsils, replicates in large quantities and enters the bloodstream, forming the first transient viremia. Through the bloodstream, it infects mononuclear macrophages throughout the body, and continues to replicate and release into the bloodstream, leading to the second viremia. Through the blood circulation, the virus spreads more widely to the skin, mucous membranes and internal organs and tissues of the whole body. At this point, the patient develops a high fever and general malaise. After 2~3 days of prodromal symptoms, smallpox rash appeared.

Because the smallpox virus is not heat-tolerant, viraemia lasts only briefly after fever. The day after the fever, it is generally difficult for the virus to be detected in the blood of the patient, and the virus is mainly stored in the skin and other tissues with low temperature.

After the smallpox virus invades the skin tissue cells, it first proliferates in the dermis, causing the capillaries of the dermis to dilate, the cytoplasm to appear vacuoles, the nuclei to concentrate and disappear, and the clinical appearance of macules; Subsequently, the virus invades the epidermal layer and the cells proliferate in large numbers, causing local swelling, thickening of the cortex, and the appearance of pimples. After that, the cells degenerate and die. There is fluid oozing between the cells, forming herpes.

Cells that are not completely destroyed become septated in herpes, forming many cells; Due to the traction of the deep cell wall, the central part of the herpes of smallpox is concave into an umbilical form. Under the microscope, in the cytoplasm of the epithelial cells around herpes, the inclusion body with a clear perimeter can be seen, which is round and has a diameter of 1~4 μm. When a large number of inflammatory cells penetrate into the blister, a pustular eruption is formed. When the fluid inside the pustular rash is absorbed, a hard crust forms. Due to ulceration and scratching, impetigo eruptions are prone to secondary bacterial infection, which worsens local deep skin lesions and aggravates systemic toxicity symptoms. During the pustular eruption, the liver and spleen may be enlarged.

If secondary infection occurs in the oral cavity and nasopharynx, it can lead to cervical lymphadenopathy. If the pustule invades only the epidermis, the scarring after scab removal is not obvious; If the dermis is involved or secondary infection occurs, a depressed scar that remains permanent develops. Due to the lack of stratum corneum, mucosal lesions break down more quickly than skin breakdown, and lesions of the mucous membranes tend to form ulcers of different depths rather than herpes.

The virus is easily excreted in large quantities from the ulcer; Therefore, mucosal lesions play an important role in the early infectivity of patients. The mucous membranes of the respiratory tract, digestive tract, urinary tract, and other places can be affected. Due to the significant inflammatory response around the ulcer, it can lead to symptoms of zhì strict zhòng. If the cornea is affected, it can cause corneal opacity, ulceration, or secondary bacterial infection, resulting in blindness.

The imperial physician in the palace distributed wormwood disinfection everywhere, and Angel ordered a large amount of wormwood to be sent to Qin Guiren and Liang Chonghua, after all, the two still have children at the moment, and if there is a three-long and two-short one, it is one corpse and two lives.

Let the palace maids and eunuchs prepare a lot of high-concentration liquor, and burn all the old clothes worn in the past after pouring the liquor, open the windows all day long, and the courtyard is smoked with wormwood, and everyone needs to check their bodies regularly every day, wipe their bodies with high-concentration liquor, and if they find that someone has a fever, they should be safely isolated immediately, even if they live with her, they need to be isolated.

Shaohua Palace can be regarded as the safest palace among the best, at least after a lot of people died in other places, Shaohua Palace was safe and sound, it is the place where all palace people sacrificed the least, and even the two most vulnerable pregnant women were safe and sound.

It's a pity that such comfort is a superficial phenomenon, and soon after the palace came out, Chen Guiyi, the head of the first palace of Shaohua Palace, had smallpox, and I don't know how many people are worried about it.

Although there is one less enemy in it, there will be less competitiveness, but if Angel really can't withstand this catastrophe, then** will still be one less interesting character, unconsciously, Angel's influence has long been standing side by side with the queen and others, but the queen and Concubine Jing are infamous, and Angel is indeed a thorough virtuous name.

Angel's aunt and aunt almost fainted after hearing the news, Angel is different from An Lin'er and An Meng'er, she is everyone's heart, if there is really a three-long and two-short, I'm afraid someone won't be able to live.

A gentle Concubine Zhen smashed the tea cup in her hand on the face of the imperial doctor, "Waste, the emperor raised you to let you heal, not here to ask three questions and don't know, this palace tells you, if you think about curing Chen Guiyi, forget it, if Chen Guiyi has three long and two short, this palace wants your family to be buried together!" ”

"Nuo" Imperial Doctor suddenly trembled and kowtowed, although Concubine Zhen had disappeared in the palace for more than ten years, but still no one dared to doubt the credibility of these words, although she was not favored at the beginning, but she was also a spit and nail character.

"What are you doing here, why don't you hurry up and think of a prescription?" Concubine Zhen patted the small table on one side, and her hideous face made several people present tremble.

Seeing the few people present leaving, Concubine Xiangxian also put down the teacup in her hand irritably, "I heard that all the affairs of Shaohua Palace have been taken care of by Yaliang people in recent days, and the two who are pregnant, one is stuffy in the Buddhist hall, and the other is copying Buddhist scriptures all day long, hoping that the girl's condition can get better as soon as possible." ”

Speaking of this, Concubine Zhen didn't feel angry, and said with a snort, "Even if those two people have a conscience, if I see them at this time and continue to stir up the wind and rain, then don't blame me for being unkind." It's also to blame Qi'er's girl, why should I give them a good wormwood soju, now it's okay, I know it hurts. ”

Concubine Zhen felt that the more she thought about it, the more angry she became, and she couldn't wait to slap Angel to death like this to call a willing, **This person eats people, and actually gave life-saving herbs to others at such a dangerous time, I really don't know what she thinks in her head, Angel has smallpox, and she really deserves it.

Concubine Xiangxian waved her hand, Angel is her niece, although she is not a relative, but there are still a lot of feelings in it, "Don't worry too much, that girl has always been edified, and she won't be so slumped in a small illness or pain." This time it was also the girl's kindness, but she didn't expect to be calculated, a few days ago Bing'er seemed to have found a blood scar of smallpox in her quilt. ”

"What? Is this still worth it? actually hurt people in front of us, okay, it's really good, I haven't moved my muscles and bones over the years, **There are really a lot of people in it who have forgotten about me, bullying our An family's family background, and actually calculating my niece like this, it seems that this ** is time to change blood. ”

Concubine Zhen said fiercely, she can enter the palace with a mediocre family background, climb from a concubine to the main position of the first palace, and give birth to a daughter, and adopt the young son of the emperor, so she is definitely not a simple character.

Now, this woman who has been silent for many years finally no longer continues to be silent, Angel can be regarded as the bottom line of the An family, if this bottom line is touched, then no matter how cowardly the creature is, it will show its fierce fangs.

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At this moment, in the Xiyan Palace, Angel is sitting weakly, with a high fever that does not go away, it has always been a troublesome thing, no matter how much medicine she has drunk or how many times she has wiped her body with alcohol, she has been haunted by herself like a nightmare.

Angel knows that this is just the beginning, if she can't solve the problems behind, even if she saves her life, it will be useless, if it really burns to more than forty degrees Celsius, then even if she doesn't become an idiot and fool, there will inevitably be problems in other aspects.

Tightly hold the brand-new satin quilt on her body, the quilt that was touched by someone some time ago has been taken off, but she doesn't want to die, her limbs are hot and cold, she doesn't have any strength in her body, and some places have begun to appear a slight red rash at this moment, if it becomes a blister, then it will be a huge crisis.

Thinking of this, Angel felt as if her chest was blocked by something, she kept coughing, and her little face was flushed because of the fever, and she looked extremely tired and weak at the moment.

"Master!" Bing'er walked in with a medicine bowl, and saw Angel coughing hard, so she hurriedly put down the medicine, walked to the other party's side in three or two steps, and poured a cup of warm tea.

It is true that Angel is sick, but this does not mean that even her position in Guiyi has been cut off, Bing'er is still serving in the house, Shuang'er is responsible for taking care of her trivial clothes, He Jiu and Mama Jin don't know medical skills and don't know poison, plus they are also old, so they are responsible for decoction outside.

Angel waved her hand, "I'm fine, it's just that I was out of breath just now, and I couldn't help coughing!" ”

"The little master has encountered something annoying, if this is really the case, let the slave and the maid and others go to deal with it, the doctor said, only when you keep your mood happy, the condition will get better faster." Bing'er could only try her best to appease Angel, hoping that she would not have too much emotional fluctuations, which would also be conducive to the healing of the imperial doctor.

Angel waved her hand, from the physiotherapy plan in her heart, Angel is still barely able to do that, this method of living by her own will in later generations has indeed created one miracle after another, but for her who was infected with smallpox, she lived in **, it was not useful to live.

But anyone who has smallpox, most of them are going to be destroyed from the face to the body, if this is the case, her future life must be a walking corpse, and suddenly grabbed the other party's arm, "This time the matter is you and I are careless, there are many people in the palace who expect me to die, but I can't do what they want, after this incident, you and I need to make a strong mark in this history." ”

Bing'er looked at the other party puzzled, "Little master, what are you talking about, the slave doesn't understand!" ”

"Or it's not just you, even Shuang'er won't be an ordinary palace maid in the future, I don't want to die, and I don't want to be destroyed. Bing'er, do one thing for me, if this thing can really be done, every problem can be solved. ”

"But by the master's command!" Bing'er's eyes were particularly firm, Angel was sentenced to death after she had smallpox, as a maid who grew up with her since childhood, of course she didn't want this kind of thing to happen, if there was even a glimmer of unattainable hope, she would not give up.

"Come here, you go and tell Emperor Sù, the three of us have been studying ancient medical methods recently, and we finally have a way to treat smallpox, but things have priorities, this method is inevitably a little heretical, and no one has tried it before, I want to try the medicine here, and only the two of you will serve here!" Angel calmly finished speaking, the medical conditions in this era are limited.

Although the 21st century has also had various epidemics, it has not been enough to kill people, because they were more or less vaccinated when they were young, so they are superior to the characters of this era in many ways.

For smallpox, the book also contains specific treatments. In the 9th century, smallpox was rampant in Europe, and when the Germanic army invaded France, the soldiers contracted smallpox, and the commander ordered the cruel killing of a Qiē patient. In order to prevent its contagion, smallpox was still prevalent, and in India the superstitious method of the 'smallpox goddess' was adopted, which naturally did not help.

China, on the other hand, has not only been paying attention to the treatment of smallpox for a long time, but has also actively taken preventive measures. According to the Qing Dynasty physician Zhu Chunyan recorded in the "Conclusive Theory of Pox", during the period of Song Zhenzong (998-1022 AD) or Renzong (1023-1063 AD), there was a doctor in Emeishan, Sichuan, who was known as a miracle doctor, and was later hired to Kaifeng Mansion to successfully plant pox for Wang Su, the son of Prime Minister Wang Dan.

The invention of human pox inoculation soon attracted the attention of foreign countries, and Yu Zhengxie's "Manuscript of the Records of the Emperor" contains: "During the Kangxi period, (1688 AD), Russia sent people to China to study pox medicine." This is the first country to send students to China to learn about human pox. The pox method was later transmitted to Turkey and Northern Europe via Russia.

In 1796, the Englishman E. Jenner was inspired by the Chinese pox inoculation method and successfully tried to inoculate cowpox, which gradually replaced the human pox inoculation method.

Knowing that Angel had sent all the imperial doctors and was ready to make a desperate bet, Concubine Jing was about to laugh at this moment, and held the maid's hand and said, "Langhuan, look at it, look at it, our Chen Guiyi began to go to the doctor when she was sick, and she actually sent all the imperial doctors out and asked a maid to go to the ranch to find medicine." If this smallpox is so easy to treat, the imperial doctors of the past dynasties of the Yu Kingdom who have not cured the master's illness will really die in vain. ”

Lang Huan also smiled viciously after hearing this, and she didn't think it was a bad thing when she couldn't see Angel, "Niangniang is really wise, our Chen Guiyi's life is not good, she is originally a humble body, and she actually tries to be on an equal footing with Niangniang, and wants to be promoted to Concubine Chen, which is God's retribution for her." ”

"Isn't that so!" Jin Feng supported his forehead with one hand, while enjoying Lang Huan's service, and she really looked like a rich idler, "She is a hard-tempered person, knowing that after she has smallpox, she is afraid that she will not be favored if she does not die, so she simply gives up treatment, but ** just can't tolerate this kind of hard-tempered person." ”

"What Niangniang said is, you said that we should also find some prescriptions, although it is not said that it can treat smallpox, but it can prevent smallpox, the emperor may think of Niangniang's good, and maybe Niangniang's grade will be upgraded in the future."

After hearing this, Concubine Jing stood up suddenly, and after walking back and forth in the palace twice, "You can take the palace people to deal with this matter!" ”

After hearing the news of the two palaces, the queen just smiled sarcastically.