Chapter 41 Immunology

"Of course I do!"

Although a German through and through, and still Robert? A loyal supporter of Koch, but when it comes to the Frenchman Pasteur, Ehrlich is still respectful!

In this day and age, Pasteur is undoubtedly the emperor superstar of science!

This great microbiologist and chemist single-handedly pioneered microbial physiology and left a series of brilliant records: denying the theory of natural generation, inventing the pasteurization method that has been used in later generations, the theory that bacteria cause infectious diseases, bacteria can be made into vaccines after special culture, etc., and it was with his excellent work that the French saved their silk industry, Liszt ushered in a new era of surgical sterilization, and medical scientists began to prepare vaccines that could prevent infectious diseases......

In the world of microbiology, Pasteur's name is like the sun.

In fact, even in the 21st century, the Institut Pasteur in Paris is still the authoritative research structure for microorganisms, and there is also an Institut Pasteur in Shanghai, China, which is a tripartite research institute jointly established by the Institut Pasteur in France, the Chinese Academy of Sciences and the Shanghai Municipality......

As an impartial scientist, no matter how great the hatred between France and Germany is, and how deep the contradiction between the two leading figures in the microbial world, Pasteur and Koch, can not deny the greatness of Pasteur.

However, when John mentioned Pasteur, Ehrlich was still a little puzzled: "I don't quite understand, does your idea have anything to do with Mr. Pasteur?" What is he researching about? ”

"Research on attenuated vaccines against chicken cholera bacteria, anthrax, rabies!"

John smiled slightly and said softly, "Recently." I was very interested in these studies of Mr. Pasteur and had some special ideas...... Mr. Ehrlich, are you interested? ”

"You mean...... Want to research the preparation of vaccines? ”

Pupils shrank slightly. Ehrlich couldn't help but ask.

In the long process of research, Pasteur used high-temperature anthrax bacillus to inactivate the anthrax dead bacteria, said that the chicken cholera pathogens were placed at room temperature for a long time to reduce its toxicity, and the rabies source was passed through the rabbit brain to prepare a live attenuated rabies vaccine, and proved the miraculous curative effect in a little boy. And after causing a worldwide sensation. Many researchers have begun to use Pasteur's methods to study different infectious diseases and develop new vaccines, and Ehrlich is well aware of this.

"No, no. It's not that simple. ”

Waving his hand, John said with a smile: "If it's just to develop a vaccine, I'm not really interested in it, because it's the same as developing a new sulfonamide drug...... For me. It's important to study the deeper nature behind these efforts! ”

After listening to John's words. Elrich's eyes lit up!

Seeing Ehrlich's obvious "I'm interested" look, John was overjoyed, knowing that his words had already impressed the future Nobel laureate, and that he should be able to find a truly capable collaborator for his research in the field of immunology......

Immunology is a very important basic course in medicine.

The word immunity, derived from the Latin word immunis, has the meaning of freedom from epidemics, and in simple terms, immunity is actually a physiological function of the human body. Or it can be a defense mechanism: the body relies on the work of the immune system to defend against factors such as external bacteria, or certain risk factors in the body itself, such as damage from tumor cells. So in the 21st century. Many health supplements will shout slogans such as "improve immunity".

In fact, it is a very old discipline.

Hundreds of years ago, the Chinese knew how to use human pox vaccines to prevent smallpox, and hundreds of years later Zinner invented cowpox vaccines, thus saying the classic words in 1800: "Although I am not fully confident, allow me to congratulate this country and the general public that a solution will make a disease that kills people every hour, a disease considered the worst scourge of mankind, disappear from the face of the earth forever."

But at the same time, immunology is an emerging discipline.

It was not until the second half of the 19th century, after the invention of bacterial isolation and culture technology, that Pasteur and Koch began to prepare attenuated bacteria through physical, chemical and biological methods for the prevention and treatment of diseases. It was from the two of them that immunology began to truly enter the category of science and play an increasingly important role in medicine!

For people in the 21st century, immunity is a very familiar concept.

Putting aside common things such as allergies and immune systems, just a planned immunization is enough to make people familiar with it. After all, no matter where the child is, as long as he wants to go to school, he must hold the small green book issued by the state - the vaccination certificate for various infectious diseases, otherwise he will not even be able to enter the kindergarten.

But at the end of the 19th century, in 1888 to be exact, even scientists had very few of these concepts.

The understanding of immunology in this era is still extremely superficial. Even Pasteur and Koch, in fact, have only just stepped into the door of immunology, they do not yet know the existence of antigens, antibodies and complement, and of course they do not know the so-called agglutination reaction, complement binding reaction, etc., and what John and Ehrlich are talking about now is about the study of immunology.

"Give me two more weeks."

After thinking for a while, John said seriously: "I will write down my thoughts and ideas in detail, please take a look, if you are interested, I think we can start." ”

Starting two studies at the same time was not a problem for John at all.

Whether it is the introduction of vitamin theory or immunology, it is actually relatively simple, many times he only needs to put forward a theory or even a "guess", and then others can verify or implement it. In fact, if he hadn't been wrestling with the dangers of infectious disease research, he would have started the most prestigious project of his time......

"Gotcha! Get! ”

Just as Ehrlich frowned, about to ask why he had waited until two weeks later, there was a knock on his office door.

Miss Brown pushed open the door and walked in with a grimace on her face.

"What's wrong?"

Seeing Miss Brown's expression, John's brow couldn't help but furrow.

"Mr. ......"

Biting her lip, Miss Brown said cautiously, "The same Mr. Hawkins who visited you last week is here again, and he has brought with him a strange-looking gentleman......" (to be continued......