And those small and medium-sized enterprises, because they do not have the resources of large state-owned enterprises, they have a problem buying drugs for hospitals, so they have no resources or ability to study medicine on their own, so they can only live by imitating foreign medicines. Pen | fun | pavilion www. ｂｉｑｕｇｅ。 ｉｎｆｏ

As a result, the current situation of backwardness in the field of pharmaceutical innovation in China has been created, and now it seems that this gap has not only not narrowed, but has a growing trend.

Another point is that those large domestic pharmaceutical companies, if they can only make generic drugs, forget it, but the key is that they can't even do generic drugs, which is a bit of a fuck.

"Hey, Brother Xiaojin, I won't tell you, I have a lot of friends in the field of pharmaceutical manufacturing in China, and I think I should know better than you about what kind of virtue is in domestic pharmaceutical manufacturing. So this is one of the main reasons why I am reluctant to buy domestic pharmaceutical companies, so let me tell you, I am friends with the main leaders of many well-known big pharmaceutical companies in China. We often eat and drink together when we have free time, and they tell me a lot about the domestic pharmaceutical manufacturing field. Take an example they told me about, in terms of cardiovascular disease, the most common drug we use is a vasodilator, which was developed by the Americans, and later passed the patent protection period, so many domestic pharmaceutical companies can also do it. But any professional and responsible physician will tell you that this kind of medicine is produced in China, and it is okay to eat it in summer, but in winter, it is generally not recommended for everyone to take it, or it is more reassuring to eat foreign generic drugs, why is there such a situation? Mainly because there is a very important chemical element in this drug, called raas Chinese called aldosterone, this drug, our domestic generic drug purity is not enough, so the efficacy is not up to standard, in summer, because of the high temperature, the principle of hot dirt and cold contraction, eat our domestic generic drugs, the effect is okay. However, in winter, because of cold contraction, this kind of vasodilator drug, if you eat domestic products, the effect will be very slow, and the effect of vasodilation is not particularly good, if the patient eats this domestic generic drug, not only will not save lives, and it is even likely to miss the best time for treatment. Therefore, the generally responsible physician will specifically remind the patient that some domestic drugs should not be taken indiscriminately. ”

Although he used to study pharmacology, he didn't know that in China, domestic generic vasodilators can be eaten in summer and not in winter, he never thought that domestic generic drugs would be so backward.

What the hell is going on? No wonder Wang Xueming is reluctant to buy a domestic pharmaceutical factory, our feelings are so weak.

And Jin Muchen's father, today is also the first time to hear such a statement, at this time suddenly realized, no wonder when he had a friend hospitalized in the past, other doctors tried their best to recommend foreign medicine, at that time they thought that it was those doctors who were black-hearted, just to make their money, today I know, it turns out that this domestic medicine is really special and will be fatal.

"Actually, it's not that I said that our domestic medicine is not good, but these grandsons who are engaged in this industry are really special fucked up. Most of the pharmaceutical manufacturing companies in our country are large state-owned enterprises, and they are backed by those large tertiary hospitals in China, and the relationship between them is decades on both sides, so the products they produce are not worried about selling at all, so they have no pressure to survive, and they don't have to do any research and development. You must know that the investment cycle of R&D of new drugs is long, the investment is large, the effect is slow, and there is a risk of R&D failure, so the leaders of those companies are not willing to bear such a risk at all, after all, they need political achievements, not innovation, so the leaders of general pharmaceutical companies will not advocate the research and development of new drugs, which has caused our domestic pharmaceutical manufacturing technology to be worse and worse, and now the distance pulled down by the world is also getting bigger and bigger. ”

When Wang Xueming said these words, he also felt a little sad, and Jin Muchen, a young man here, was even a little indignant when he heard these words.

"Brother Wang, I understand what you said, but even if they are unwilling to develop new drugs, how can they not even do generic drugs? That's a bit of a stretch, isn't it? ”

"Hey, that's why I told you before that I wanted to buy a foreign pharmaceutical factory. My friend also told me the main reason why even generic drugs are not doing well in China. After the drug is taken by the patient, it will be melted by the human gastric juice in the shortest possible time, and then absorbed by the capillaries of the tail, and then run to all parts of the body with the blood, and then absorbed by the sick parts of the human body, so as to achieve the purpose of treating the disease. If this small molecule compound wants to play a real role, it has a timeliness, which means that the drug is taken orally from the human to the stomach, and then digested and absorbed by the human stomach, and then reaches a certain concentration in the human blood, and then how long this concentration can last, these are the key to the so-called timeliness. In particular, the most critical question is what concentration the drug can reach in the human blood, and how long this concentration can last. ”

Jin Muchen and his father were already dumbfounded at this time, they really didn't know that Wang Xueming was so professional in this pharmaceutical manufacturing, and they had never heard of these things before.

And Wang Xueming saw that he usually learned the knowledge of medicine from his friends who were engaged in pharmaceutical manufacturing, and he was able to fool Jin Muchen and the others, and he was also very proud at this time.

After picking up the teacup at hand and taking a sip of water, he continued.

"For example, for a certain disease, these small molecule compounds must reach a certain concentration in the human blood in order to be effective against the disease. Moreover, the concentration of the drug in the blood must reach a certain period of time to fully ensure that the drug is absorbed by the body, and will not be excluded from the body because of the natural metabolic function of the human body because it has not yet played a role, so the concentration of the drug in the human blood, as well as the length of time that the concentration can be guaranteed in the human blood, has become the key to whether the drug is effective. Generally speaking, if the timeliness of a foreign-produced drug is compared to 100%, then the timeliness of our domestic drugs can reach 80% of others, which is already a good drug, and it can reach 70%, and it can also be accepted by doctors. However, at present, those generic drugs in China are more than 50 percent, and they simply cannot reach the timeliness of 70 percent of other foreign drugs, which is generally about 60 percent, and some small factories produce them even 50 percent of the timeliness. This is the main reason why many domestic patients now have obvious differences in the treatment effect after buying drugs with the same name but produced by different manufacturers. This is not necessarily because they have bought counterfeit drugs, but only that the technology of the pharmaceutical companies that produce these drugs is not up to standard, and the production capacity is not up to standard. ”

Wang Xueming explained to Jin Muchen the main reason why the generic drugs produced in China are worse than foreign drugs, but Jin Muchen still doesn't understand why we can't do these generic drugs well.

"Brother Wang, I understand what you said, but what I don't understand, those foreign drugs, haven't they already passed the patent protection period? Their formulas and everything have already been announced, and we can copy them completely, or work backwards, but why can't our domestic pharmaceutical companies even do this? ”

"Huh! Your question is just to the point, which is the key to why I am reluctant to buy domestic pharmaceutical companies. Many of these foreign pharmaceutical factories are century-old factories, and they have their own unique skills in the production and manufacture of medicines. To put it bluntly, the key is still in other people's production processes and processes, we make generic drugs, to put it bluntly, it is a process of reverse deduction of other people's production, but when we are reversed, we are not willing to spend that money and take responsibility because of the management system of those state-owned big pharmaceutical factories and the sense of responsibility of the leadership, so we will not pick out the details and reverse the processes and processes produced by others, so we will not be able to produce drugs with the same effect as others. It's like you know how other people's steamed bread is made, and you also know how much flour and yeast people use, and even you use the same pot as others, but you just can't produce the same steamed bread as others, and people steam out snow-white steamed bread, but because you don't know other people's processes and processes, you can only steam out pots of dead gnocchi, which is the main reason why we can't produce good medicine. ”

Wang Xueming gave Jin Muchen this lesson in such an easy-to-understand way, and Jin Muchen finally understood the main reason why Wang Xueming had to buy a pharmaceutical factory from abroad and go back. (To be continued.) )