Because of the exemplary effect of aspirin, Dr. Berg, who was in charge of Aina, did not strongly oppose the use of sulfonamides.

In fact, he had nothing to do about Aina's condition now, except for the habitual use of Yapian and some antipyretic drugs with great adverse effects, Dr. Berg had no other way, and in just a few days he even used four bloodlettings, and if he tried a few more times, John would even wonder if the girl would survive.

Fortunately, with the support of Professor Wolfgang, Aina was able to take her first dose of sulfonamide in the afternoon.

After doubling the dose of sulfonamides, under John's guidance, Aina began to use plenty of warm water, on the one hand, to counteract the adverse effects of sulfonamides, and on the other hand, to replenish the large amount of water she had lost. In addition, measures including cooling and supplementing nutrition were also proposed by John, and Dr. Berg began to implement them.

And then......

Perhaps it was because of the lack of natural enemies of the bacteria of this era, and the fact that they had never developed drug resistance, the patient's condition began to improve after only one night, and on the morning of the third day, the girl who suddenly improved her mental state stunned Dr. Berg and caused a sensation in the internal medicine department of the entire Charlotte Hospital!

This was an outcome that John had long anticipated.

For the doctors of the 21st century, sulfonamides are not a good thing, because they have too many shortcomings, mainly too many adverse reactions, so in the late World War II, penicillin has surpassed him, and in the following decades it was gradually replaced by other antimicrobial drugs.

But for the physicians of 1886, sulfonamides were definitely a miracle drug!

Doctors in this era are unable to confront the newly discovered bacteria head-on, and they don't even know which bacteria cause meningitis, so most of the time, doctors who are confronted with bacterial infections either don't know the cause of the disease at all. Either they can only be passive defenses - using symptomatic treatments such as cooling and cough suppressants, or simply using bloodletting, yapian, etc., to make John laugh.

In a word, basically there is nothing doctors can do.

So just three or four days after the little patient Aina was given sulfadiazine, almost all the internal medicine doctors at Charlotte Hospital were agitated!

Every day, from the beginning of the morning to the end of the afternoon, there is an endless stream of doctors in the ward. The doctors on duty at night frequently inspected the ward where Aina was. They carefully observed the condition of the little patient, and Dr. Berg, who was directly in charge, was surrounded by colleagues all day long, asking about the drug!

Oh, God!

Under the action of sulfadiazine, Aina is getting better day by day at a speed that is visible to the naked eye!

"Incredible!"

"Incredible!"

"Incredible!"

On Saturday morning, looking at John, who had just come to his office, Professor Wolfgang used three incredible words in quick succession to express his excitement at this time, and then said excitedly: "Mr. Huntelaar, the patient's condition is now significantly better, and your newly invented sulfonamide drug has succeeded!" ”

"Hmm. It's just wonderful. ”

Nodding, John replied lightly.

The five days after taking the drug are very critical for the patient, so John is in the internal medicine ward almost every day, he has to supervise the patient's drug reaction, and if there is an allergy or adverse reaction, he must deal with it in time, so he doesn't know much less than Professor Wolfgang about what is going on with Aina. Just before coming to the professor's office, he went to the ward to see the little patient. I did a detailed physical examination, and the situation was very gratifying - the little girl's life must have been saved!

But on the surface, it is calm. But secretly John was also relieved.

Although Heinz Pharmaceutical Company made sulfadiazine, its purity still did not satisfy John, and because there were no sophisticated examination instruments, he could only rely on a rudimentary microscope in addition to physical examination, which made John feel very uneasy. Physicians in the 21st century have become accustomed to relying on equipment and instruments to substitute for their own diagnosis, albeit with the knowledge in their heads. John's diagnosis was still more accurate than the doctors of his time, but it still didn't put him at ease.

Fortunately, this time the luck is still good.

Rubbing his hands together, Professor Wolfgang then excitedly said, "Mr. Huntelaar, we need more new medicines. There are many patients with meningitis, pneumonia, etc. throughout Charlotte Hospital every year, and we need more sulfonamides! ”

"Of course, sir!"

Of course, John would not refuse Professor Wolfgang's request, he immediately nodded and smiled: "I will inform Mr. Nicklaus to provide you with a hundred bottles of each of the three sulfonamide drug samples for free, I think it should be enough in a short time, right?" ”

"Enough, enough."

Squinting his eyes slightly, Professor Wolfgang said happily: "Please rest assured, since you have used your free medicine, I will instruct them to record the various records of use in detail, and summarize them for you when the time comes." And I think it won't be long before I can write a paper on sulfonamide drugs for various diseases, and then send it for publication......"

……

By the time I left the medical ward and returned to my office, it was almost noon.

John hadn't been to his office for a few days because he had been worried about Aina's treatment for the past few days, and when he sat down in his chair after entering the door, he was relaxed.

After sitting quietly for a while, John casually picked up a letter on the table.

Because he might not come to the office often, John gave Thomas his keys so that he could bring in the letters he had written to him and the magazines he had subscribed to. It seems that Thomas has done a good job, with several letters from recent times neatly on the table, as well as a copy of the just-published journal German Medicine.

After reading a few letters, John was a little bored.

The letters were all from his surgical colleagues, and the content was to discuss relevant academic issues with him, covering everything from sterilization to local anesthesia, from appendectomy to blood group research. If in the beginning, John really enjoyed the process of communicating with his peers through letters, because he found it fresh and interesting. But over time, replying to all the letters became a heavy burden - without a computer, it was very tiring to have to reply by hand, and discussing academic issues with the physicians of the late 19th century, John had to not only think about what he could say and what he could not say, but also endured all kinds of problems that would later be known to any medical student, which was a real headache.

"Alas......"

Throwing a letter in his hand onto the table, John couldn't help but sigh as he picked up another letter.

If he had enough manpower in the future, or if he had brought his students, he would have been able to hand over these letters to them to deal with, but for now, he could only do it himself, with enough food and clothing.

"Huh?"

After seeing the postmark on the envelope of this letter, John suddenly sighed.

Baltimore, USA.

"That's a rarity!"

Blinking, John was slightly surprised. Although he has often received letters from his peers in the past year, it is relatively rare for him to come from the United States, and he often only has one letter for a few months, and he is quite happy to see it every time.

The sender's name was not written on the envelope, and John quickly opened the letter and read it.

John has always been enthusiastic about his American counterparts, not because they are his "compatriots," but because he may need more local partners when he returns to New York. That's why when he was at the University of Berlin, he tried to maintain a good relationship with American students.

But this time, when he read the letter in his hand, his face gradually changed.

Moments later, John? Mr. Huntelaar almost jumped up from his chair: "Baltimore? John? Hopkins School of Medicine? William? Welch? God, you're not kidding me......" (To be continued......