Chapter 15 Penicillin and Sulfonamides

Thursday was Miss Anna Brister's 17th birthday, and John had already accepted Mrs. Brister's invitation when he was at Baron Cole's house, and even had a birthday present ready. But on Wednesday morning, he had to reluctantly cancel his plan to go in person.

Because on Wednesday morning, Professor Wolfgang recommended three patients in one go!

After some busyness, John and the others were diagnosed with acute appendicitis, and one of them may even have a perforation, so near noon, two patients were admitted to John's hospital room in one go!

This sudden change caught everyone off guard, and John couldn't help but be surprised and delighted, surprised that he couldn't go to Anna's birthday party tomorrow, and happy that with the proof of the previous surgeries, it seems that it is now much easier to convince patients to accept surgery!

Two patients, one of whom may have had a perforation, is a situation that Thomas can not handle alone.

John had no choice but to cancel his plan to take a vacation for the next few days.

“…… In short, in addition to bringing the gift, I must express my sincere apologies on my behalf! ”

Facing Hans, the housekeeper who rushed to the hospital, John said with a wry smile.

John didn't know what kind of attitude he should have towards Miss Brister. The girl is very beautiful, her figure is also very compatible with him, and the most important thing is that her temper is also similar, and it is impossible for John, as a man, not to be moved. But on the other hand, he will return to New York in the first half of the year at the latest, and the Brister family, whose roots are all in Germany, are obviously unlikely to choose the path of immigration, which has been quite tangled in John's heart.

In this era, it's not easy to find a girl who makes him feel excited!

"Don't worry, sir!"

looked at John with a tangled expression. Hans smiled secretly in his heart, but his face was firmly assured.

When he walked out of the gate of Charlotte Hospital, the corners of the housekeeper's mouth curled up slightly, and he thought happily: "My little master, it looks like he has really grown up......"

……

In the afternoon, John operated on the female patient who suspected a perforated appendix.

After exploratory laparotomy. John was sure that it was a perforated appendix, so after carefully removing the appendix and irrigating the abdominal cavity, John placed a drain and rarely stayed in the hospital.

The patient's condition is quite bad.

This woman in her thirties has been ill for some time, and she has been seeing a doctor who practices herself, and the other party has given her some yapian and some blood, but it has almost no effect. It wasn't until today that she was recommended to Charlotte Hospital, and after discovering that her condition was very serious. Professor Wolfgang didn't hesitate to push John here.

After the surgery, John didn't have any bottom of his mind. The patient's abdominal infection was extremely severe, and God knows if she could carry it without antibiotics......

Nothing was said all night.

The next morning, after examining the patient, the situation was still not optimistic, which made John a little worried. However, the others were not too worried, and although the patient's condition was not very good, it did not get worse after the operation, at least for Thomas at this time. He is more concerned about the possible gains of this operation!

After coming out of the ward, Thomas smiled with a somewhat complicated look in his eyes: "John." If this patient can recover, I am afraid that this kind of perforated surgical treatment and the use of new drainage tubes can be written in several papers, right? ”

The importance of drainage tubes in surgery is something that even ordinary people will understand in later generations, but in this era, only a very small number of surgeons will understand. After all, there are only a handful of doctors who dare to operate on human body cavities, and the type of drainage tube John uses has been heavily improved in terms of shape and material. It can be said that this technology has been taken a long step forward, and in Thomas's view, it is naturally extremely valuable.

Originally, Thomas wanted to have this operation very much, but John took over the control of the main surgery without hesitation, considering that he had never had a perforated appendectomy, which made him really disappointed. However, after watching the whole process of John's operation, Thomas had to admit it. It's one thing to understand what John wrote, but it's another thing to be able to apply it to surgery......

"Well, maybe."

Nodding, John replied somewhat absent-mindedly.

Of course, John didn't care about Thomas's little thoughts, his mind was on the lady in the hospital bed at this moment. And at this time, he was once again seriously considering whether he should invent antibacterial drugs in advance!

This is a question that haunts John more than Anna!

The best choice is naturally penicillin, two things that appear frequently in later novels, which can be said to be the great invention that changed the history of human medicine, and ushered in a new era of mankind's fight against the tiny enemy of bacteria!

But wouldn't it be too early for the world of 1885 to let it appear?

Admittedly, with enough time and effort, John could have them appear in the real yàn chamber first, which was certainly not a difficult thing for him, but just like lidocaine and procaine, how much point did the real yàn chamber produce? With the current state of technology, it is very difficult to produce it on a large scale. Later, Fleming discovered penicillin in 1928, but it was not until the beginning of World War II that the United States invested heavily in research and slowly increased production. Now, fifty years ahead, John doesn't have the bottom of his mind at all.

This is something that John had to consider.

And more importantly, if John invests heavily in research and development and can eventually successfully produce these two drugs on a large scale, will he be able to keep them?

Soft gold, is another name for penicillin.

During World War II, penicillin was a strategic material, and people were even willing to exchange a whole box of gold for a box of penicillin, it is conceivable that if John just discovered penicillin, no one would pay attention to it for many years, but once the process and method of mass production were developed, and its huge economic value was shown to people, it would inevitably usher in countless forces that were enough to swallow him alive!

Just think about the need for antibiotics in later generations to know what this thing was in the 19th century!

"Let's try to study sulfonamides first!"

After returning to his office, John finally made up his mind.

Considering the influence of various factors, he wanted to put both drugs back and talk about it, but seeing the patient's situation today, John felt that he really couldn't push it back.

Although sulfonamides have many disadvantages compared with penicillin, such as too much toxicity and too narrow application range, this antibacterial drug, which was born in the dye industry more than ten years later, is more suitable for the current technology. As for what you can't keep, if you can't do it, it's better to share some benefits when the time comes...... (To be continued......)