In the history of mankind, there have been countless crazy scientists.

In physics, chemistry, biology and many other disciplines, these crazy scientists have done many things that will make future generations jaw-dropping, such as jumping off a cliff with their arms on their wings, or deliberately exposing themselves to thunderstorms in order to do a good job......

But John is sure that there is no madder scientist in the world than the doctors!

In order to study infectious diseases, Pasteur and Koch and others traveled countless times to the most severe epidemic areas; To study flukes, Claude? Barrow swallows the worm taken from the infected; To prove that yellow fever is not a contagious disease, Stabis? Foss swallowed vomit from a yellow fever patient; In search of a better anesthetic gas, European physicians even stood at the door of the chemist's room, desperately sniffing every gas that had just been prepared......

There is no doubt that the physician of the 19th century was the craziest creature in the world.

However, it was these extremely crazy behaviors that made medicine develop by leaps and bounds in the 19th century, and discoveries that could change the history of medicine in the world were slowly discovered in these crazy behaviors, thus becoming a huge driving force for the rapid development of medicine!

In the history of anesthesia, there is no shortage of such figures.

After Floyd discovered that cocaine could numb the tongue and his colleague Kohler used it in eye surgery, two surgeons in New York had the more radical idea of injecting each other's gums and limbs with cocaine to make the area insensitive to pain. One of the two surgeons is named Richard? Hall, one is the famous William? Halstead, the future John? One of the Big Four at Hopkins School of Medicine! It's a pity that the two have been addicted to drugs since then and have never been able to get rid of it for the rest of their lives......

It was their succession that gave confidence and courage to another German physician who followed. Finally ushered in the era of local anesthesia!

"And what I'm going to do is just move this process forward."

After breaking up with Paul, John secretly thought about his plans for the future.

Medical anesthesia can be roughly divided into two types, one is general anesthesia and the other is local anesthesia. General anaesthesia means loss of consciousness and loss of pain sensation throughout the body. and a certain degree of muscle relaxation, etc., that is to say, the person does not know anything at all. The meaning of local anesthesia is clear at a glance, which refers to the meaning of making a part of the body lose the sense of pain, so that surgeons can perform surgery. For example, if you have a lipoma or cholesteatoma on your head, or if you are circumcised or something, you are doing the surgery using local anesthesia techniques, and the patient knows what the doctor is doing, and they can even hear the scalpel cutting around on their body!

Broadly speaking, neuraxial anesthesia is also a local anesthetic.

The human body is a very wonderful little world. For example, our upper body is supported by the spine, which in turn is made up of vertebrae stacked on top of each other. There is a small hole in the center of the vertebrae, called the cone hole, and all the cone holes are connected up and down to form the spinal canal.

Inside the spinal canal is the human spinal cord and three layers of membranes.

To put it simply, neuraxial anesthesia is the injection of anesthetic drugs into the spinal canal and acting on the spinal nerve roots, so that the corresponding area innervated by the nerve roots can produce an anesthetic effect, such as making the lower body unconscious.

What John wants to do now. It is to develop a new type of local anesthetic, and let the local anesthetic technology appear in front of the world more than ten years in advance. This is both for surgery. It is also an important milestone for anesthesiology to be independent in the future!

But......

Cocaine is certainly not possible to use directly, as it is too toxic as a local anesthetic, so it must be made into procaine hydrochloride and lidocaine hydrochloride, which are more common and safer in later generations. John is very confident in this, after all, he is now half an expert in chemistry, if you don't think about industrial production. There is no problem in preparing a small amount of sample in the real yàn chamber with the molecular formula known.

"The trouble is the waist wear."

Sighing softly, John pondered helplessly: "It seems that I have to go through the literature again to see if the lumbar piercing is now ......."

……

In Berlin, Europe, John and his helpers are busy preparing for the blockbuster that will follow. And on the other side of the Atlantic, in New York City, the old Huntelaar, who had just returned, found the equally busy Steve? Zola.

As the owner of a Lego toy factory, Steve has been on a smug ride lately.

No one could have imagined that the "high-end toys" business, which everyone was not very optimistic about, would be so popular, although it was not as good as the daily income of bicycles, but last year there was a profit of 11,000 US dollars in the United States alone, it was just a year, and the initial investment was almost half recovered! It is conceivable that with the construction and commissioning of European factories, the profits will inevitably be higher and higher in the future, and Steve, the original second ancestor, has become a successful person!

Therefore, after seeing the old Huntelaar who had returned to China, Steve said very enthusiastically: "Sir, is John okay in Berlin?" Did you ask you to bring me anything back? ”

"Yes, indeed."

Facing Steve's eager gaze, old Huntelaar quietly took out a stack of white paper from his bag and said lightly: "This is the drawing that John asked me to bring back, it seems to be a few new sets of toy designs......"

"Great! Thank you, Mr. Huntelaar! ”

Steve was overjoyed and nodded his head repeatedly.

In this era, John's toy design is undoubtedly the best, he only needs to occasionally remember some gadgets from his past life, and draw drawings that are the "works of art" of this era! So since opening the Lego toy factory, Steve's greatest wish is to get John back from Berlin and put him in the factory to design new toys every day......

However, after the joy, old Huntelaar immediately surprised Steve again, he took out another stack of thicker white paper from his bag and handed it over: "Steve, here are some other drawings that John asked me to bring you......"

"It can't be that building again, right?"

A bad feeling suddenly rose in his heart, and Steve almost screamed with a bitter face.

From the first time he wrote to him about the building, John has been writing an average of more than a week to the present, and the content is all about the building. Either add a few rooms to the building, or add some features on a whim, which makes Steve a little scared when he receives John's letter!

You know, John is not an architect, he just used drawings to draw the layout of some rooms in the building and the functions that need to be realized, Steve had to hire a real architect to design, and every time John changed the idea, it would add a part of the workload to the architect, and the previous design would even be invalidated because of this! Not to mention that in John's drawings, fashionable new inventions such as electric lights and telephones are almost all over the building, which undoubtedly poses a great challenge to traditional architects!

Glancing at Steve with some sympathy, old Huntelaar smiled and said, "It seems that you are really good friends, and you guessed what John meant at once." Yes, this is John's latest idea and drawing, but he also told me that this will be the last addition, and there will be no more criticism of the building's design. ”

"Hoo ......"

After hearing old Huntelaar's words, Steve finally breathed a long sigh of relief.

According to John's request, the building had to be completed by the end of 1886, but now that the foundation had not yet begun to be laid on the vacant land due to the design changes, Steve had been worried that he would not be able to complete the agreement, and now he could rest assured.

However, after taking the drawings and looking through them briefly, Steve's face became embarrassed again: "Mr. Huntelaar, John's changes this time are really not small, such as adding a separate bathroom to thirty percent of the rooms...... Is this building really a hospital? In this case, the construction cost will increase by at least $10,000! ”

"I know."

Hearing Steve's words, old Huntelaar was also quite helpless in his heart, but remembering John's entrustment and assurance before leaving, he said quietly: "Steve, build it according to John's vision, no matter how much it costs this building, I will ensure that you have sufficient funds to build its ......" (to be continued......