Chapter 59: Antitoxin Serum

The two papers in The Lancet naturally caused quite a stir on the European continent.

However, because of John's "cunning", he did not directly comment on the tragedy caused by blood group inheritance, and limited the content to the academic field, and used vague words throughout the text, so although there were many critics, it had not reached the point of chaos after all. On the contrary, many people were very interested in John's theory after reading the paper, for example, the number of people who studied blood types gradually increased......

As for the other paper, it is even more confined to a very small field of medicine. After all, the words in John's thesis, which can only be regarded as popular science in the future, are the real "frontier of science" in this era, and ordinary doctors are running around every day for food and clothing, and only a few people are willing to pay attention to them, and even fewer can understand them.

In any case, at least hundreds of people were affected, and that was enough for John.

Not to mention what will happen after the publication of the next three papers of The Lancet, John is no longer concerned about it in New York City, on the other side of the Atlantic. Perhaps in the future, medical schools and hospitals will set up relevant laboratories to continue research in the field of genetics, and the theory of vitamins has also begun to be studied in Heinz General Hospital, but John is not very interested in them, at least not for the last ten or twenty years. Modern medicine is a very large system, and there are many more important directions than them, such as immunology, which is just beginning to sprout......

In the director's office at Heinz General Hospital, John and Ehrlich sat opposite each other. Quietly look at the future Nobel laureate.

The Ehrlich in 1888 was actually quite remarkable.

For later generations of physicians and scientists, Ehrlich's most famous achievement was, of course, the founder of the sidechain theory and chemotherapy. But before he met John, Ehrlich had already achieved quite a lot of success in many fields: for example, he invented the vivirate staining method, discovered eosinophils, and distinguished leukemia from anemia. Otherwise, even with John's strong support, he would not have been able to convince so many researchers and chemists from Germany to become the head of the Heinz General Hospital Research Institute.

However, Ehrlich still knows too little about John's immunological theory.

Even in that document, John writes very simply. Basically, future medical students can come with their mouths open, but in this era, there is no corresponding theoretical support. Without the results of the laboratory as evidence, relying only on some "conjectures" and "speculations" out of thin air, it is not too easy to convince Ehrlich, who has a solid foundation, even if he was so excited when he first saw this information!

But......

"Not as well. Let's do an experiment first? ”

After a long silence. John suddenly smiled and said, "Earlier, when I was a student at the University of Berlin, I did an experiment in the laboratory, a very interesting experiment......

"What experiment?"

With a flash of his eyes, Ehrlich immediately asked.

"An experiment related to diphtheria."

After another laugh, John continued: "I was very interested in the research of Mr. Pasteur and Mr. Koch, and I thought about it for a long time, and then one day I had a whim. Since attenuated germs can be used as vaccines to prevent disease, is it possible to find a cure from sick people? So I did this experiment. Serum from rats that had diphtheria was injected into rats with new diphtheria, and then ...... A miracle happened! ”

"Miracle?"

When he heard this, Ellich's heart jumped, and his mouth suddenly became dry.

Diphtheria, a term that is very foreign to people in the 21st century, but unusually familiar to people in the late 19th century. It is an acute respiratory infection caused by diphtheria bacilli, characterized by the appearance of a white pseudomembrane in the pharynx, tonsils and surrounding tissues, and in severe cases, myocarditis and nerve palsy.

In the 21st century, diphtheria is already rare.

The use of diphtheria, tetanus, tetanus, But at the end of the 19th century, diphtheria was a dangerous infectious disease! It is one of the main killers of children, even in the 20s of the 20th century, 200,000 people fell ill and tens of thousands died every year in the United States alone, while in Europe this number increased several times!

This figure comes after the advent of "antitoxin" serum.

One can imagine how much of a threat diphtheria was to children at the end of the 19th century, and the 80s of the 19th century coincided with the diphtheria pandemic in Europe......

So after hearing what John said, Ehrlich's heart subconsciously tightened, and his whole body became stiff, and after a pause, he couldn't wait to ask: "John, what do you mean by this miracle...... Healed? ”

"Of course! Haha......"

Nodding, John laughed.

Ehrlich, who was shocked in his heart, of course, could not have discovered the emptiness hidden behind John's laughter. How could he have had the time to do this experiment? It's just that I know the process and results of the experiment, and I just take it out to bluff people. It's just that the person to bluff is the real participant in the antitoxin serum in history, and even John can't help but feel a little weak.

John was a little weak-hearted, but Ehrlich was shocked.

Ehrlich naturally knew very well how influential the disease was diphtheria, and if John's words were true, it meant that he had probably found a cure for diphtheria! For 1888, this was enough news to stir up the entire medical community!

"Hoo ......"

After exhaling heavily, Ehrlich fell silent for a long time before asking, "John, this is an experiment you did when you were in Berlin?" That...... Why didn't you publish it back then? ”

"This ...... Ha ha. ”

After laughing awkwardly, John could only explain helplessly: "At the beginning, because I was too busy with study and work, I had too little free time, and I didn't have time to do a few more experiments, so I ......"

After hearing this explanation, Ehrlich was speechless.

As a physician and scientist, Ehrlich knew very well that John was lying, because the results of such an experiment were extremely important to anyone, how could it be easy for someone who did not have time to deal with it? However, looking at John's somewhat embarrassed expression, Ehrlich did not continue to ask, because he knew that some things did not necessarily have to be answered......

After the embarrassment in his heart lasted for a few seconds, John shook his head and smiled, "How is it?" Mr. Ehrlich, is there any interest in this experiment? ”

"Absolutely!"

Without any hesitation, Ehrlich immediately nodded heavily!

Looking at the other party's impatient look, John suddenly smiled, and then gently opened the drawer next to him, took out a stack of materials and handed it to Ehrlich......

Diphtheria antitoxin serum, destined to appear in advance.

In the history of the development of medicine, there is a famous story called Christmas Salvation, specifically on Christmas Day, in the pediatric ward of the University Hospital of Berlin, a girl is dying and is afraid that she will die soon. She suffers from diphtheria, a discoloring form that not even the best university hospital in the world in Berlin can save her life. And at this time, a man in his thirties came to the ward. When the desperate parents learned of the man's intentions, they didn't hesitate for long to accept his suggestion: to inject their daughter with a new medicine that had never been used in the human body!

This man is the emir. Adolph. Feng. Behring!

Is Behring the famous Robert? Professor Koch's subordinate, a name that is almost a household name in Germany, gave the girl's parents a lot of confidence, so the girl with diphtheria was injected with immune goat serum, recovered and discharged from the hospital a few days later, and this incredible miracle combined with the timing of Christmas made the matter a huge sensation, which is the very famous Christmas Salvation.

Whether this dramatic story is true is unquestionable, but there is no doubt that the world's first case of passive immunity came from Berlin, which won Behring the first Nobel Prize in Physiology and Medicine, and made a fortune as a result, founding Deling, one of the world's largest clinical diagnostic companies.

In real history, Behrin and Kitasato Shibazaburo published their research in 1890, only two years after now. Now that there is detailed theoretical support, and there is Ehrlich, who plays an important role in this process, John is very sure that he and Ehrlich can get ahead of Behring and Kitasato Shibazaburo!

That is, John wants to allow himself and Ehrlich to rob Behring of the honor.

Behring's exclusive Nobel Prize was actually controversial in later generations, because in the process of discovering the antitoxin serum, not only Kitasato Shibazaburo was his collaborator, but Ehrlich also gave great help, but in the end, both honor and money were enjoyed by Behring alone. In the end, the scientist even fell out with Koch and left Koch's institute......

The truth of history has long been unexaminable.

However, for John, there is no point in exploring the truth of history, he only knows that he has no relationship with Behring and Kitasato Shibazaburo, and Ehrlich is now one of his generals.

That's enough.

In the director's office at Heinz General Hospital, Ehrlich watched intently as John wrote out the detailed experimental plan, and directly across from him, John? Mr. Huntelaar's mind had long since withdrawn from the experiment itself. The development of medicine can prove that antitoxin serum is only suitable for a few infectious diseases such as diphtheria and tetanus, but as an important event in the history of medicine, it itself has irreplaceable significance in this era...... (To be continued......)