Chapter Seventy-Eight: An Antidote That Is Difficult to Make
"Ladies and gentlemen, although the plague is terrible, as long as it is dealt with properly, it will inevitably be eliminated, please give your full help, have confidence in the future, control the epidemic within half a month, as fast as January, slow as March, and the plague will be eliminated!"
Ma Qiang said and saluted everyone.
An old man got up and replied, "The Ma County Order is so heroic, and the old man is not false, the old man has contributed 500,000 yuan, 100 stones of grain, 100 pieces of cloth, and 100 strong men to help the Ma County Order!" ”
"This is someone from the Lu family in Jixian County." Xian Yufu whispered on the side.
Ma Qiang asked Xian Yufu to come for these families, Xian Yufu is actually a child of the family, with him, Ma Qiang can get more information.
"Okay, our Zhang family pays millions! Three hundred stone of grain! Two hundred pieces of cloth! Three hundred strong men! ”
Needless to say, Yuyang Zhang's family.
"The Gongsun family also paid 800,000 yuan! Two hundred cloths, one hundred strong men! ”
As soon as you say it, I say it, Ma Qiangmao estimated it, and these people present contributed more than 10 million dollars and food.
No wonder Yuan Shao, who has the support of the family, can be like that, these families are too rich.
Otherwise, I'll ask the Mi family if they want a son-in-law, and I don't want to struggle...
Ma Qiang asked Jian Yong to connect with the money and food, and asked each family to send their children to Li Jue to learn how to deal with the plague, and he returned to the room to prepare to check the information.
Back in the room, let Xian Yutong guard the door, Ma Qiang immediately took out the mobile phone in the wooden box.
The familiar boot screen made Ma Qiang feel a little distracted for a moment.
I shouldn't be able to see the new model of my phone again....
I don't know what 6G will be like.
XX with no signal appeared in the upper right corner, and Ma Qiang directly turned on the airplane mode and lowered the brightness in order to maximize power saving.
And 53 percent of the battery.
Ma Qiang looked at the games he downloaded, Ma Qiang did not have the popular chicken and king in later generations, he played all the games that could be played in fragmented time.
For example, Lianliankan.
For example, the Magic Tower.
Ma Qiang shook his head, expelling his desire to play mobile games, he didn't have this electricity to consume, opened the e-book, and Ma Qiang directly found Encyclopedia Britannica.
This encyclopedia of more than 40 million words is much easier for Ma Qiang than Baidu.
Of course, these 40 million words are not the largest encyclopedia in history, the encyclopedia with the largest number of words should be the "Siku Quanshu" compiled by me in the Qing Dynasty, 800 million words can make a person read for a lifetime, but unfortunately, this book has no effect on Ma Qiang, who is engaged in scientific research, just occupies memory, so it is not downloaded, otherwise it can be taken out in the future to scare people to death...
Wait, this mobile phone Ma Qiang will only use it himself, do you want to copy 800 million words by yourself...
Forget it, future generations will definitely write it.
Ma Qiang began to look for the symptoms that Li Jue had mentioned earlier, and soon, a record appeared on the screen.
"Hemorrhagic fever... Hemorrhagic fever with renal syndrome, also known as hemorrhagic fever with epidemic hemorrhagic fever virus (hantavirus), is a natural epidemic disease with rodents as the main source of infection. The main clinical manifestations are fever, hemorrhage, congestion, hypotensive shock and renal damage. In the 19th century, there was a large-scale contagion in Northeast China..."
Ma Qiang's eyes rolled, this black plague is actually the same as the Black Death, it is also a type of plague.
Because the Black Death is so famous, Ma Qiang also looked up this information and knew that the Black Death was actually a virulent infectious disease caused by Yersinia pestis, and it was the only Class A infectious disease in later generations.
Because he knew the symptoms of the Black Death, Ma Qiang knew that it was not the Black Death when he saw the patient.
"How to cure it, did you say it?"
Ma Qiang flipped down.
"Blood transfusion... Without this condition, diuretics, this ask Li Jue, to maintain electrolyte balance... Within four days of the onset of the disease, taking ribavirin... Ribavirin is the only antiviral drug for the treatment of hantavirus, but it is only effective for prophylaxis and in the early stages of the disease, and is not effective for hantavirus pulmonary syndrome."
It turned out to be ribavirin.
Ma Qiang's eyes lit up, yes, why didn't he think of this panacea for the virus.
As I said before, most diseases are caused by bacteria and viruses, if in the face of bacteria, sulfonamides and penicillin are panaceas, then in the face of viruses, ribavirin can also be called a panacea.
Ribavirin appeared very late, it was not invented until the seventies, it is a drug that deals with the spread of the virus, but it also has flaws, it has certain side effects, and may even cause cancer and fetal malformations, which is why this drug has been restricted in European and American countries in later generations.
It is worth mentioning that this drug is one of the drugs that has been abused in China in later generations.
"Mannitol... This is useful in the oliguric phase, and the sodium bicarbonate solution is given intravenously... This is used in the shock phase, this one is simple, syringes... Can think of a way... That's it, you can only respond to emergencies first. ”
Now that we know the antidote, the next step is to make this medicine.
Ma Qiang began to take out a pen and paper and write down the equations.
Thanks to chemistry, ribavirin is not a chemical compound that must be cultivated like penicillin, it is a chemical compound that can be synthesized directly by chemical means.
"The chemical equation for ribavirin is C8H12N4O5, which is riboside... In this way, there can be many kinds of chemical synthesis formulas, well, there should be four categories of halogenated sugar method, inosine method, adenosine method and nucleotide method, and there are one or twenty kinds of equations... It's a pity that there are too few materials that can be used. ”
If outsiders come in, they will definitely hear it in the clouds, and what Ma Qiang said is not human words in the eyes of people in this era.
Ma Qiang felt like he was back in his lab, with words in his mouth, writing and drawing, and he had to rely on the known chemical equations to work backwards to make it.
What's more, in this era, most of the chemical raw materials are not available, and more and more people are sick, and it is useless if they cannot be produced quickly and in large quantities.
In addition, Ma Qiang can only use two chemical reactions, heating and self-reaction, and he can't use electrolysis or microwave, which further limits the chemical equations he can use.
Ma Qiang felt the limitations of this era for the first time, without the level of science and technology in the sixties and seventies, even if it was the level of science and technology of the Anti-Japanese War, he could easily find a way to make ribavirin, but now it is really not possible.
At least at that time there was electricity.
"First put the limestone, coke. Nitrogen gas to make aminonitrile, and then the amino nitrile as the raw material, and carbon dioxide in the environment of sodium hydroxide can be used to generate cyanodithiocarbamate sodium salt, cyanodithiocarbamate sodium salt and water and hydrazine reaction to form triazole sodium salt, and then adjust the pH of the reaction system to obtain triazole...."
Ma Qiang has stopped writing here, it is easy to write, but it can't be done in a month just to prepare all kinds of equipment and materials.
One month... No, there's not so much time to waste...
The mortality rate of hemorrhagic fever can reach 90 percent, and the reason why there are no large numbers of deaths is because it is not yet time, as long as it is a few days, I am afraid that hundreds of corpses will be carried out from Jixian County every day.
There are no four or five thousand people killed in a month, and the entire Youzhou is afraid that there will be tens of thousands, and Ma Qiang must find a plan that can be used in a short time.