While Marin was busy planning the metropolitan area, Gaudard, who was in Panama, sent a ship back to Europe to report to Marin that several young men had died of malaria due to mosquito bites.

Although, Marlin provided Gaulard with a large amount of mosquito repellent toilet water. However, not everyone has a regular routine to apply toilet water to themselves every day. Some young men, relying on their youth, are not stable enough. When it was time to apply the toilet water, they simply didn't apply it because they were afraid of trouble. So, in the end, something happened, and several sturdy guys, because of mosquito bites, got malaria, and then they died.

This incident caused panic among the immigrants of Panama. Some people were so scared that they cried and wanted to go back to Europe. Ghoillard had no other way than to bounce and press. Right now, because of the panic in the hearts of the white immigrants, they don't even have the mood to drive the black people to cut down trees, which causes the road opening issue on the Panamanian side to stop. So, Ghoillard sent someone back to ask Marin for help. After all, he had heard that Marin had two miracle doctors, Mozhigen and Battle, and hoped that they could give a solution.

But where can Morrigan and Battle give a solution? Before cinchona cream was discovered, malaria was incurable. In China, malaria is thought to be caused by the introduction of miasma from the tropics. Therefore, the ancient Chinese people have always regarded the land of Lingnan as a dangerous place. Many officials who committed crimes were exiled to Lingnan as a very serious punishment.

In fact, if ancient China had found an effective cure for malaria, Lingnan would have been developed on a large scale. Even, Vietnam will become the target of the Central Plains Dynasty.

The reason why the Central Plains Dynasty abandoned Vietnam was because Vietnam was tropical and prone to malaria. Once you get malaria, it is easy to die, and the people of the Central Plains are naturally not happy to want it there. In addition, the chieftains of Vietnam like to hug their thighs with tribute and are good at patting horses, so the Central Plains Dynasty is even more reluctant to conquer Vietnam. Of course, when it comes to welcoming horses, the Vietnamese will not be able to catch up with North Korea. The ancestors of the stick would pat the horse and hug the thigh, and Zhu Yuanzhang was happy and directly listed North Korea as a country not to be conquered. But in fact, the climate in North Korea is much better than in Vietnam, and there is no miasma, which is actually very suitable for living. But the people were so good at shooting that they sent Goryeo beauties to the palace of the Ming Dynasty, and the emperor fell under the pomegranate skirt, how could he be embarrassed to conquer North Korea again? Even, it is rumored that Ming Chengzu Zhu Di's biological mother may be a North Korean concubine. Although this statement is unreliable, there is no doubt that there were Korean concubines in the palace of the Ming Dynasty. According to records, Yongle Emperor Zhu Di and his grandson Xuande Emperor Zhu Zhanji each accepted 8 Korean concubines...... fell for other people's beauty schemes, and are you embarrassed to ask for others?

Oops, I digress, but, anyway, if ancient China had obtained the miracle medicine for malaria, it is estimated that it would have conquered Vietnam a long time ago, and maybe it would have conquered Laos, Cambodia, Thailand and other places. However, because of the fear of "miasma", it did not continue to expand southward.

However, as a time-traveler in later generations, Ma Lin knew that ancient China was only one step away from curing malaria......

Before Ma Lin crossed, he knew that the Chinese god Tu Yo in later generations had discovered artemisinin, a miracle drug for malaria that was more effective than cinchona cream.

Because Tu Yoyo won the Nobel Prize in Medicine, the media gave a lot of coverage to Marin's previous life, which made Marin, a liberal arts student, also have a strong interest in artemisinin and consult relevant information.

The reason why it is said that ancient China is only one step away from the treatment of malaria is because of the particularity of artemisinin.

Artemisinin, as the name suggests, is naturally extracted from Artemisia annua. In ancient China, Artemisia annua was listed as a herbal medicine very early, and it should be said that it could cure malaria a long time ago.

But in fact, this is not the case, this is because the important thing is generally to be boiled for a long time with fire, which is called boiling medicine. The problem is in this boiling medicine......

Why? Because artemisinin is a substance that cannot be heated, once heated, it is easily converted into other substances and loses its function in treating malaria. Traditional Chinese medicine is boiled in a medicine pot for a long time, and when Artemisia annua is boiled, the natural efficacy disappears or is greatly reduced, and malaria cannot be treated. Therefore, ancient China did not know that Artemisia annua could treat malaria.

Of course, it's not that no one knows this. There were some powerful doctors in the Ming Dynasty who knew that Artemisia annua could be used to treat malaria if it was directly mashed. However, this method has not been widely disseminated. Traditional Chinese medicine naturally promotes medicine, so people cannot overcome the stubborn disease of malaria.

By searching for relevant information, Marin's later generations knew that the temperature of artemisinin extracted should not exceed 70 degrees Celsius to avoid the loss of medicinal efficacy.

And, it's important to note that artemisinin is insoluble in water. This makes it extremely difficult to extract.

If artemisinin dissolves in water, it's simple. Chop the artemisia annua grass directly and soak it in water. Artemisinin can be obtained without heating and directly air-dried.

But the problem is that artemisinin is insoluble in water......

When the god Tu Yo Yo was researching and developing, he heard that the ancients had treated malaria by taking Artemisia annua raw, so he tried every means to extract this substance. However, it never worked.

Until one day, she suddenly thought, is this substance insoluble in water? So, she used ether to soak the artemisia grass instead, and sure enough, artemisinin was extracted. Later, a production method for extracting artemisinin by gasoline immersion was also developed......

But Marin knows that artemisinin is soluble not only in ether and gasoline, but also in alcohol......

Because, alcohol and ether are both similar substances, and their properties are relatively similar. Of course, according to the summary of later generations, the extraction of artemisinin with alcohol may not be as effective as the use of ether and gasoline, but it can also extract artemisinin. Because, artemisinin is soluble in alcohol.

It just so happened that Marin now has a lot of wine made from grain, and he also extracts and produces a lot of medical alcohol. Moreover, as a liberal arts student, Marin did not know how to produce ether. Without oil, he couldn't get gasoline. Therefore, using alcohol to extract artemisinin has become Marin's only choice.

It just so happened that there was a very small amount of Artemisia annua in the herbal seeds brought by Mo Zhigen and Battle before. Although the quality of Artemisia annua in the northern grasslands may not be good, far less than the artemisinin content of Artemisia annua, it can also be used to extract artemisinin.

Moreover, now Marin's subordinates have planted hundreds of acres of Artemisia annua, which is located in a remote manor belonging to Marin near Aurich.

Gaudard didn't write from him, and Marlin almost forgot about the artemisia grass. But now, Marlin thinks about it—it seems that he can use those artemisia grass to extract artemisinin......

So, Marin sent someone to the manor and brought a large reserve of Artemisia annua......

At the same time, Marin went to the distillery, got a large amount of medical alcohol, and began the work of extracting artemisinin......

Marin first sent someone to chop up all the artemisia grass, then put it into medical alcohol to soak it, and cover it with a lid (alcohol is volatile).

After a long time, Marin had the lid open and gauze to filter out the crumbs of artemisia annua, resulting in an alcoholic solution that dissolved artemisinin.

Then, in order not to waste alcohol, Marin asked people to find a large cauldron for steaming wine, and began to heat the solution intermittently over low heat, trying not to exceed 70 degrees Celsius.

The alcohol then passes through a cooling tube, dripping little by little, and is recycled into a specific container, ready to be reused......

When the alcohol ran out, Marlin was taking that bit of base directly to the air to dry. Then, artemisinin, which is very mixed-colored, was obtained......

This is because Marlin did not use activated carbon to absorb some pigments and other impurities in the solution, resulting in the unsightly appearance of the extracted artemisinin.

But Marin doesn't care, as long as it works, what about his appearance?

It's just that the acquisition rate of artemisinin is really touching - it is less than one in a thousand......

Although there are problems with the extraction process, resulting in incomplete extraction, it is important to know that the artemisinin content of Artemisia annua in Youyang is more than 8 parts per thousand. Therefore, the artemisinin content of Artemisia annua is several times that of the ordinary Artemisia annua brought by Mozhigen and Battle...... This gave birth to a strong desire to go to Daming to find the seeds of the Youyang Artemisia annua variety......

But no matter what, Marlin still got a lot of artemisinin. The 10,000 pounds of Artemisia annua hay shipped in totaled nearly 10 pounds of artemisinin.

You know, on the manor, there are tens of thousands of pounds of artemisia grass, and if you extract them, you can extract dozens of pounds of artemisinin. To treat a malaria patient, the amount of artemisinin used is only 6 to 12 grams. Even at the maximum of 12 grams, 10 pounds of artemisinin can cure 378 patients. After that, dozens of pounds of artemisinin were extracted, which was enough to cure more than 1,000 malaria patients......

After getting these artemisinins, Marin was overjoyed and ordered a lot of oily paper bags to be made to pack these artemisinins. Moreover, Marin had people make small oiled paper bags weighing 12 grams to make them easy to use. If a strong man has malaria and it is severe, he is given a full packet of 12 grams of artemisinin. And if it is an elderly child with weak resistance, just pour out a part of the bag, and it will be enough to cure. In this way, it is also greatly convenient for doctors to use.

Marlin packed 10 pounds of artemisinin into 378 small oiled paper bags and sealed them to protect them from moisture. Then, it was planned to send a ship to Ghoillard. Of course, Tara on the island of Cuba also has to send some.

As for the other artemisia grass in the manor, the artemisinin extracted, Marin intends to distribute it to the people of the ocean-going fleet to carry it in order to deal with emergencies along the way. Moreover, artemisinin can not only treat malaria, but also treat kala-azar and lupus erythematosus, which is a miracle drug. Of course, because of its scarcity and preciousness, it is best used to deal with serious illnesses such as fatal malaria. It's a waste to treat minor ailments......