(The new book "Back to the Ming Dynasty to Open a Factory" has been released, ask for support)

In fact, Zhu Mingzhong is not the only one who is studying streptococcus and other bacteria, in fact, in this era of "secret recipes", many scientists are also engaged in this research, but they are often trying to find a "panacea" in traditional herbal medicine.

Drugs such as artemisinin, quinine, and morphine have given people too much inspiration in the past 100 decades, and it seems that as long as the effective ingredients in traditional Chinese medicine are refined, highly effective modern drugs can be made.

Perhaps, people are too paranoid about extracting Chinese medicine and ignoring chemical synthesis. Just like in another time and space, Western medical companies focused on synthesis and neglected the extraction of natural medicines for a long time.

Both planes and planes are at one point in the other.

However, the occurrence of deviation does not mean that there are no scientists working hard to overcome the disease, the largest pharmaceutical company in the Ming Dynasty - Ankang Company has been conducting streptococcal research in the laboratory, but there is a big problem in the study of streptococcus: there are many types, and there are differences in pathogenicity between species, so you can't try every streptococcus, right? On this issue, the researchers in the laboratory have long made a decisive choice: no matter how many streptococcal species there are, I want the most virulent one! They collected samples from patients who died of streptococcal infection, cultured and isolated them, and infected mice, hoping to find a strain with a 100% infection and lethality rate, because only indiscriminate infection and death can be called "the most virulent". Years ago, they found a strain that could kill all inoculated mice within two or three days after diluting the culture solution 100,000 times.

It is not difficult to obtain such a highly virulent strain, and you don't even need to go through the company, you only need to go to the academy to get the strain, after all, the academy is also studying this germ.

With this highly lethal streptococcus, animal models of infection are easy to set up.

But for the experiment on animals, Qian Le and Li Meihong are all laymen, but this is not difficult, and that day Qian Le hired a few biology students to start inoculating those mice with deadly strains of streptococcus.

"For each dye, a control should be made, and the dosage should be ......"

When they injected dyes into the infected white mice, Zhu Mingzhong specially reminded them.

Sulfonamides are ineffective in vitro and are only released by enzymes in living organisms. So it is necessary to test with mice.

Unlike the DoMark team in another time and space, Zhu Mingzhong chose azo dyes at the beginning, instead of trying more than 3,000 compounds like them, and in the end they all failed.

Where is the light of hope?

Zhu Mingzhong couldn't remember clearly, for him, the light of hope was not just those dyes, but the "Dictionary of Chemistry", when he was busy there in the laboratory, he continued to look through the dictionary there.

"Sulfonamides...... There must be a process of sulfonation and amination, so the first thing to look for in the raw materials containing sulfur is to look for,"

Zhu Mingzhong muttered to himself.

Because of the development of chemistry, especially the naming has been biased, so in the "Dictionary of Chemistry", Zhu Mingzhong saw many unfamiliar words, fortunately, from the dictionary explanation, you can also analyze some names, just like "泍", if you don't look at the explanation, you can't guess that it is "benzene" in another time and space.

Like many things written by Zhu Mingzhong during the Xingqian period, people at that time would collapse when they saw words such as "chlorine, hydrogen, nitrogen, ammonia", and even if they searched through the Yongle Dictionary, they could not find any valuable references, which were basically the masterpieces of Chinese chemists in the 20th century.

After Xingqian, with the development of chemistry, there will inevitably be a new phenomenon of word-making in the field of chemistry, which is the epitome of science and technology, but there are not as many words in any other discipline as in the field of chemistry.

"Maybe it's because it's liquid......

In his own words, Zhu Mingzhong continued to look at it, and slowly he still found some patterns.

For example, solid metal elements use gold characters, solid non-metallic elements use stone characters, and gaseous non-metallic elements use gas words. The use of "three points of water" for liquids is probably the same, and of course there are many words, which were left by Zhu Mingzhong. That's why he was able to find azo dyes.

Even after guessing, Zhu Mingzhong finally found some clues.

"Huh? This is...... Sulfonate ...... Glacial acetic acid ...... Could it be ...... That's it? ”

Despite some changes, Zhu Mingzhong felt that he had found what he needed, so he immediately asked.

"Song Mingjie, do you know what this sulfonate is for?"

"Sulphur?"

Song Mingjie, who was conducting a comparison test, thought for a while, and then said.

"It seems that attaching a sulfonamide group to a dye increases the coloring effect on wool, well, because it is only released by the action of enzymes in living organisms. Wool...... Bacterial ......"

Suddenly, Song Mingjie's eyes lit up and said.

"Can we put sulfonate on the chain of azo dye, can this increase the affinity for bacteria?"

Doubt it no more!

"Sulfonamide" is the "sulfonamide" you need, it's just a word difference!

Now, there is nothing left to doubt. It's just a literal difference, it's not a big deal. The tech tree of this era has not been distorted. But literally, there has been a slight change.

Taking a deep breath, Zhu Mingzhong smiled, and then said.

"Then try it......"

In fact, there is no need to test at all, when adding sulfonamide groups to the red dye, Zhu Mingzhong looked at the remaining white crystal powder, and suggested.

"It's a pity that there are any of these sulfons left, so let's try it together. Anyway, it's still put. ”

At Zhu Mingzhong's suggestion, they prepared a batch of mice, a group of 4, a blank control, a group of red dyes with sulfonamide groups, and a group of sulfonamides, but it was a matter of a few mice, but "everyone" did not expect such a "saving" to rewrite history, because in the last few groups of mice, only the two groups of red dye and sulfonamide survived, which shows that it is not the dye that Zhu Mingzhong has been obsessed with since the beginning, but the colorless sulfonamide!

Of course, he already knew about this result.

"This ......"

Looking at the guinea pig that had recovered its health in surprise, Qian Le and Li Meihong were all dumbfounded, they couldn't have imagined that the originally dying guinea pig would be healed so quickly.

After swallowing his saliva for a long time, Qian Le looked at the boss and said.

"Old, boss, me, we made it!"

It worked!

Zhu Mingzhong smiled and didn't speak, and only after a moment did he ask.

"Has the patent expired for that sulponium? ”

Obviously, it's okay to directly test "sulfonamides"!

Okay now, all that's left is to buy its patent and ...... Just when Zhu Mingzhong just started to conceive, he heard Song Mingjie say with some disappointment.

"Boss, this substance was discovered more than thirty years ago, and now the patent has long expired, and it is completely unprofitable for us,"

"How unprofitable, it's a miracle medicine that can save lives!"

Li Meihong obviously disagrees with Song Mingjie's opinion.

"Isn't that right, boss, didn't you also want to save your friends in the beginning? Well, now with it, your friend will be saved! ”

In fact...... That's my money-making plan!

Zhu Mingzhong thought to himself in his heart, but at this time, he didn't mind showing his benevolent side to others.

"Of course, the most important thing is that it can save people, but we need to conduct further trials on it, after all, this is a chemically synthesized drug, and it is very likely to cause harm to people, if the dosage is not right, and we can develop new drugs based on it."

"Sulfon" may not make money, but at least it can save people, and it can also develop new drugs.

Although it was already the fourth day since the discovery of the "sulfonate", Zhu Mingzhong still made a phone call to Nanjing, and when it was determined that Zhao Guowei was still in a coma, he immediately took a plane to Nanjing.

The aircraft of Yongping 50 years is a bit like an aircraft in the thirties of another time and space, with a single wing, a star engine, and a propeller, and the cruising speed does not exceed 500 miles per hour, and the top speed can reach more than 700 miles, which is exactly the technical level of this era. But on the other hand, televisions have been popularized, and even color TVs have entered thousands of households.

"Really, an airtight cabin should have been invented."

Muttering softly, Zhu Mingzhong, who felt a little cold, shrank his shoulders, and just as he was about to put up his collar, the beautiful flight attendant lady walked up to him and asked softly.

"Sir, do you need a blanket?"

"Yes, of course ......"

Zhu Mingzhong nodded again and again, flying at an altitude of more than 3,000 meters, he already felt a little cold.

Putting the blanket on your lap immediately warmed up, but that didn't mean comfort, and the roar of the engines in the cabin made it impossible to enjoy the journey quietly.

All in all, for Zhu Mingzhong, who took a plane for the first time in this time and space, the experience of flying for the first time was not wonderful at all, and it could even be said that he suffered a little.

"When I get back, I'm going to start an airplane company too...... Not for anything else, just to make yourself more comfortable. ”

2000 hp ...... No, it should be a jet, the Boeing 707 has the kind of specifications that can cross the ocean...... Of course, all this only exists in fantasy, and for Zhu Mingzhong now, the most important thing is to go to Nanjing and save his friend's life with the "sulfonium" that has just been successfully tested......

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