Since the visit of Prince Zhu Yi to European countries, the Ming Dynasty has become increasingly close to Europe, not only establishing diplomatic relations with each other's embassies, but also encouraging commercial trade and cultural exchanges. In this context, the Ming Dynasty launched a top-down movement to learn from the West to the East, taking the initiative to absorb the knowledge of natural sciences in Europe, and many scholars of the scholar clan have begun to explore the real material world, revealing the camouflage of natural mysteries one by one.

During this period, some European works were also translated, such as Li Zhizao's "Hun Gai Tongxian Diagram", Li Zubai's "The Theory of the Long Mirror", Lu Zhongyu's "Sun, Moon and Stardial Style", and Xu Guangqi and the Italian Jesuit Matteo Ricci's "Geometric Original".

Whether a country is strong or not depends first on its military strength, and only those who say it with a fist can be listened to, and the strength of the military depends on science and technology, and science and technology depend on the level of education, and the direct embodiment of education is academic works. The essence of this foreign knowledge was quickly mastered by the Ming elite, which directly promoted the progress of the Ming Dynasty in mathematics, physics, chemistry, astronomy, etc., which is why Li Zubai dared to use celestial knowledge to refute the retribution of the Ministry of Rites in the Imperial Palace.

In fact, pneumonic plague is a very common disease, but the mortality rate is extremely high, and the Black Death, which once spread to Europe, was one of them. With the help of Matteo Ricci, John Tang and others, some information about the plague began to be sorted out, and with some of the results of the "Treatise on Plague", the epidemic in Gansu was quickly controlled. Among them, Wu Youxing, a master of air communication, has the greatest credit, and Zhu Youxiao has long wanted to see his honor, so he summoned him to the Qinzheng Palace. After greeting the two monarchs and ministers, Wu Youxing leaned over and said:

"Qi Song Sheng, thanks to the grace of the heavenly family, although he works in the Tai Hospital, he has been able to visit the disaster areas in various places to check the epidemic. Over the years, he has gained a lot, and he has studied the source of the disease, devoted himself to research, and wrote all his efforts into the book "On the Plague".

In Weichen's humble opinion, every time after a catastrophe, there will be a plague, and it is ferocious, easy to be infected, and the harm is great. Although these plagues are different, they are mostly caused by the decomposition of human or animal corpses, which are transmitted through contact in the early stage and through the air in the later stage. ”

The ancients said that entering the soil is safe, and you can have a good future in the next life, Wu Youxing's insight into cremation surprised Zhu Youxiao, and admiration came spontaneously from the bottom of his heart, and he sighed at the intelligence of the Ming elite. By this time, he had already discovered that the germs could be transmitted through contact and air, and accordingly proposed to prevent cross-infection between patients, which alone was more than 200 years ahead of the West.

In 1644 AD, the national scum Wu Sangui abandoned the pass and surrendered to the enemy, and Dolgon led the Eight Banners into the Central Plains. Wu Youxing was brutally murdered by Qing soldiers for refusing the notorious "shaving order", and his wife and young son were martyred by throwing themselves into the river.

In order to promote this famous person in history, so that the plague theory can benefit mankind as soon as possible, and also let him have a happy ending, Zhu Youxiao is determined to take the opportunity to carry out a medical reform. First of all, the Royal Academy of Medicine was established, and Wu Youxing was appointed as the first president, who was responsible for recruiting famous doctors from all over the world, collecting Chinese and foreign medical works for research, and shifting from the traditional "looking, smelling, asking, and cutting" to focusing on practical medicine such as human anatomy, studying organ mechanisms, and eliminating pathogenic factors.

It can be said that this is a subversive reform, in order to ensure that the theory of traditional Chinese medicine occupies a dominant position, Zhu Youxiao did not hesitate to spend a lot of money to publish the four traditional medical classics, in addition to the "Outer Classics", "Qianjin Fang", "Bai's Inner and Outer Classics", "Bian Que Inner and Outer Classics", "Side Chapters" and so on. Holding these treasures of the Chinese nation, Zhu Youxiao burst into tears of excitement. From 1644 to 1949, the Chinese nation experienced a catastrophe like broken bones, and Westerners not only squeezed out the achievements of 5,000 years of civilization, but also looted and burned many cultural relics and ancient books, resulting in the interruption of our cultural inheritance.

On the day of the establishment of the Royal College of Physicians, Zhu Youxiao, as the monarch of a country and the initiator and investor of the college, was unanimously elected as the honorary dean by everyone. Zhu Youxiao thought that a layman could not lead an insider, so he hurriedly waved his hand with a red face and excused himself:

"There is no end to the development of medicine, I have only read a few medical techniques, and I am not even as good as a Western doctor, where do I dare to take on this important responsibility. Moreover, the original intention of the Royal Academy of Medicine was to rely on collective wisdom to explore medical knowledge and alleviate the suffering of disease and death for the common people in the world. The so-called benevolence of doctors, I have decided to let a medical master of this dynasty receive this honor. ”

After saying that, he ordered someone to uncover the red cloth behind him, and a huge bronze statue of Li Shizhen shone brightly under the sun, looking at everyone's puzzled eyes, Zhu Youxiao continued:

Li Shizhen, who was born in the Zhengde period, tasted all the strange flowers and herbs in order to collect medicine, and almost died of severe poison several times, and finally wrote the book "Compendium of Materia Medica" with his life. The value of this book is far from being understood by our generation, and it may benefit the entire human race thousands of years from now, so I have decided not only to appoint him honorary president of the Royal Academy of Sciences, but also to build an ancestral hall in his hometown, where incense and candles can be worshipped at all four o'clock. ”

At this time, Li Shizhen's name had already been widely circulated in the medical community and among the people, and the "Compendium of Materia Medica" became a medical dictionary for printing, and was even translated into foreign languages and circulated overseas. Although everyone felt a little unbelievable about the emperor's admiration, they had nothing to say if they really did it. Li Shizhen was hired by Zhu Yingyi, the king of Chu, as the temple of the palace when he was in Jiajing for 30 years, and five years later he entered Beijing to serve as a judge of the Tai Hospital, which can be said to be famous at a young age, and has a bright future, but the pond of the Tai Hospital can not support Li Shizhen, the dragon, and it will not take long for him to resign and return to his hometown, and devote himself to writing, only referring to 925 books. During this period, he left home many times to investigate, footprints all over Huguang, Anhui, Henan, Hebei and other places, after 27 cold and summer, recorded tens of millions of words of notes, revised the original manuscript three times, and finally completed the 1.92 million words of medical masterpiece "Compendium of Materia Medica".

About Li Shizhen, there are anecdotes about the legend of the rain lake. Legend has it that on the day he was born, his father was fishing in a rainy lake. Usually luck is good, but this time he didn't even get a few nets, and his father was very frustrated. The last net felt heavy when it was pulled up, and I was secretly happy in my heart, thinking it was a big fish, but when I lifted it, I found that it was a big stone. Father Li sighed: Stone, stone, I have no grievance with you, why are you playing tricks on me today? It makes me more sorrowful. The stone suddenly spoke: Stone, stone, don't worry about coming to congratulate. Mr. and Mrs. are about to fall on the moon, I don't know what Mr. wants? It turns out that this stone is the god of the rain lake.

Li's father hurried home, and it happened that Li Shizhen gave birth to the ground, so he named him Shi Zhen. That night, Li's father had another dream, and he dreamed that the immortal Tie Guan Li came to say goodbye and said: "Shi Zhen Shi Zhen, all diseases can be diagnosed." Be my high disciple and pass on my reputation", so he changed his name to Li Shizhen.