Chapter 136: Preparing for the Exit Sulfonamide Antimicrobials

This Gonggong Li is a ghost, he knows that now it is the people of Yaogang who want to go out of the Mongolian steppe, as for what they are going to do, the ghost knows, but they want to report the information of the danger in the north to the emperor, and they know that the emperor has no soldiers to send when he gets the news, and if they don't get it, they will invite them to soldiers. They also made a half-push, half-done, and asked the emperor to receive their love. couldn't help but scold in his heart, "Fuck it!" ”

Gonggong Li, who has been weathered for a long time, still smiled and said with a pun: "However, if the emperor gives you an order, you can't refuse." The people of Yaogang know this from top to bottom. ”

"What the emperor's decree requires, we will do as much as we can. What you can't do will be tried to do. There's no way to do it, I think the emperor can understand it. Zhang Zhimu also replied neither soft nor hard.

The banquet in the evening is still indispensable to Gonggong Li, except for Gonggong Li, who is loyal to the emperor, Gonggong Li and Yaogang are still very good. Zhang Zhimu knew that as long as he reported the crisis in the north to the emperor, the emperor would reply soon. Since the beginning of the Ming Taizu, the Ming Dynasty's prevention of the north has always been regarded as the top priority. Although Li Zicheng had posed a great threat to the Ming Dynasty, Emperor Chongzhen did not dare to move the hundreds of thousands of border guards in the north. The threat of the north, that is the threat of extermination, the emperor does not dare to ignore it. Therefore, Zhang Zhimu and Gonggong Li both knew that the emperor would definitely react.

During the banquet, Father-in-law Li did not forget to play tricks. With the strength of the wine, Gonggong Li said: "Zhang Dongjia, you said that you are loyal to the emperor, but why can you send the telegram to Ningwuguan and Datong, but not to the capital?" ”

Zhang Zhimu also said with the strength of wine: "You only know one but you don't know the other." You know that telegraphs cost a lot of silver and a lot of copper. This telegram to Datong and Ningwuguan was that Zhou Yuji and Jiang Zhu, the two general soldiers, spent a lot of silver, and the silver was not enough, and the prince also spent some silver. They also sent a lot of copper. Sending troops to help erect electric poles again. Do you think it's easy to get through the telegraph? ”

"Not all of you in Shanxi have telegraphs, but a little less to Beijing." Father-in-law Li is still very persistent.

"Such a big Shanxi, we are such a small number of people. Without fast means of communication, can we keep it? So we just smashed the pot and sold iron, and we also had to fix the telegraph. Zhang Zhimu said.

Chen Yufeng also borrowed the strength of wine and said unceremoniously: "What's the use of us going to Beijing, in addition to borrowing money from us, the imperial court is to let us do this and that." I can't see better. ”

Zhang Zhimu should also say: "Yes! Even the emperor agreed that we would not set up a branch in Beijing, just because he wanted us to have as little contact with the imperial court as possible. ”

For the first time, Gonggong Li heard that the emperor also agreed that Zhang Zhimu would not set up a branch in the capital. He thought about it, too, the Yaogang people opened branches in the north and south of the river, but they didn't open stores in the capital. It seems that the emperor agreed, otherwise the emperor would be dissatisfied. What is the relationship between this Zhang Dongjia and the emperor. I can see that I don't get involved in it. If you don't get anything done, you don't know what's going on, so you're going to be a scapegoat.

"I know that the emperor is very kind to you. Last time, you sank two ships of the official army in Poyang Lake, Zuo Liangyu sued you to the imperial court, and the emperor pressed them down. "Father-in-law Li seems to know a lot of things, and today I also want to inquire about what is going on with that matter.

"That's what you said. We have already explained the misunderstanding to General Zuo Liangyu. Zhang Zhimu said, "I'm afraid you also know that General Zuo's military discipline is really not flattering." Our merchant ships went to Jingdezhen to buy things, and when we met their warships, we showed the bronze medal given by the emperor, but they didn't care, saying that the emperor couldn't control this and had to detain our ship, isn't this a rebellion? We fought. Later, how dare these officers and soldiers tell the truth of the matter to General Zuo, so they went back and talked nonsense. I think he reported it to the emperor at that time and told him about it. Later, we sent someone to explain it well. After General Zuo knew the truth, he punished the perpetrators, and we are now good friends. Meet together to deal with the thieves. ”

When Gonggong Li heard this, this was terrible. That Zuo Liangyu didn't even pay attention to the emperor's holy decree, and these kiln people sank Zuo Liangyu's ships, not counting, but also became good friends. I don't know if this is a good thing or a bad thing for the emperor.

Gonggong Li responded: "So that's the case, I said that the emperor still understands you." But there's one more thing. It is reported that you are doing business with the thief Zhang Xianzhong, but there is such a thing. If there is, it is a big deal to collaborate with the enemy. "Gonggong Li didn't use the big crime of collaborating with the enemy, but the big thing of collaborating with the enemy.

"Yes!" Zhang Zhimu was very serious and said to Gonggong Li: "To tell you a big secret, we need to add a special thing to the musket we produce." This thing is only available on Zhang Xianzhong's side. Nor are we collaborators. The first time we went to the vicinity of Wuchang, we fought a battle with Zhang Xianzhong's navy, which sank two of their large warships. In the future, when we go over there, they will hide far away, and we know that as long as we don't push them too hard, they will turn a blind eye when we buy what I need. They can't afford to fight us. In this way, we solved the problem of producing muskets. You don't think that's going to be done? ”

"Ou! That's right. Father-in-law Li said: "Do it, do it." ”

"Yes! If we don't buy that thing, why should we defeat Li Zicheng and lead the army. Zhang Zhimu knew that it would be easier to open a branch in Hankou, Nanchang. Gong Li reported everything he talked about today to the emperor, including why he did business with Zhang Xianzhong.

However, Gonggong Li also felt that today's wine was not in vain, because he had a lot of things to report to the emperor.

The people in Yaogang also felt that this meal was worth drinking, because many things could be reported to the emperor through the Li Gong Communiqué, which was much better than reporting directly to the emperor himself.

During this time, there are many happy events in Yaogang, and after the grand opening ceremony of the Prime Meridian Memorial Tower and markers, Yaogang Hospital is unveiled.

For the construction of Yaogang Hospital, the two masters and apprentices of 'God Hand Zhang' Zhang Bengui and Zhang Bingchen have done too much work. A four-story building, at the suggestion of Zhang Zhimu, was temporarily divided into surgery, internal medicine, orthopedics, gynecology, and pediatrics, with more than 200 beds in the inpatient department. Each department is equipped with advanced equipment of this era, including stethoscopes, blood pressure monitors, and thermometers. The rescue room contains oxygen bags and cylinders. There is a shadowless lamp inside the operating room, and there is a disinfectant potion outside, and a sterilization pressure cooker.

The medicines that can be available in this era are basically complete. Zhang Bengui of each department invited the chief doctor of the department with a high salary, and each of them also had general doctors and interns. Nurses are also trained. Zhang Bengui himself served as the president, and Zhang Bengui served as the vice president. There is also an emergency doctor on call at night. At night, there are two large calcium carbide lamps in front of the hospital, which illuminate the front of the door. The hospital outpatient clinic also has wheelchairs and stretcher beds with four wheels. There are wheelchairs and stretcher beds at the entrance of the hospital that can be pushed up the gentle slope.

The hospital is also equipped with an ambulance and is manned day and night. The hospital phone is manned day and night. Of course, the ambulance is a four-wheeled rubber wheel steel spring carriage, and when the ambulance goes out, there will be doctors and nurses to follow the visit.

Zhang Bengui also asked the doctors in the hospital to go to the college to give lectures to the students. According to Zhang Zhimu's suggestion, the hospital and the college are also preparing to jointly organize a monthly magazine "Medicine". Doctors write articles on medical issues and provide health care knowledge.

The setting of the hospital is also very user-friendly, and patients will be guided as soon as they enter the door. Tell the patient which department to go to.

Before the opening, Zhang Zhimu personally held a meeting with Zhang Bengui and them.

Zhang Zhimu was very modest and said: "I am a layman for curing diseases and saving people, and in the future, we Yaogang people and even us Shanxi people, after we have a disease, whether we can be cured or not depends on everyone's medical skills." I know that Dean Zhang, with his prestige in the apricot forest, has invited many experts. These experts are all masters of the apricot forest. I also heard a lot of stories from experts who saved lives and treated many incurable diseases. But I know that we are dealing with many more patients that we cannot treat. There is no one-size-fits-all doctor. A doctor who can cure all diseases must not be cured. ”

Zhang Zhimu's words caused a burst of laughter from everyone.

Zhang Zhimu continued: "So I suggest that we have so many good doctors together, there must be an atmosphere of consultation and even a requirement. For those diseases that cannot be diagnosed by a doctor, we need to use the method of consultation. Because something that is difficult for one person may be as simple as something for another. We must not think that I, a patient, will lose face if I don't see what is wrong with it, and if others see it. Because everyone has limitations. What I would like to say more is that everyone's life is more important than our face. ”

Zhang Zhimu didn't expect that his words received a round of applause from everyone, which made Zhang Zhimu feel very pleased.

Zhang Zhimu finally said: "We have gathered a group of excellent doctors here who take saving lives and helping the wounded as their own responsibility. I believe that through everyone's efforts, we will be able to make Yaogang Hospital the best first-class hospital. Bring good news to the majority of patients. ”

After the opening ceremony of the hospital, Zhang Zhimu came to Zhang Bingchen's laboratory. In the laboratory, there were a few disciples sent by Qingfengzi. Together with Zhang Bingchen, they developed Penicillium extraction.

Seeing Zhang Zhimu coming, everyone stood up together. After Zhang Zhimu sat down, he also asked everyone to sit down. Seeing everyone's expressions, Zhang Zhimu knew that the preparation of Penicillium was not going well. Zhang Zhimu said: "What's the matter, I see that your mood is not high!" ”

Zhang Bingchen said: "Alas! Experimented many times, but it just didn't work, and we didn't have confidence anymore. ”

"Don't be without faith. Your result is that you've found that there are many ways to make Penicillium that don't work. You are a little closer to success. Zhang Zhimu encouraged everyone.

Zhang Bingchen said: "Yes! At the very least, the Penicillium we have cultivated has been very successful and can be multiplied and cultivated in large quantities. ”

Zhang Zhimu deeply felt that people without antibiotics were very fragile, and if there was a little infection that could not be controlled, a person would die. You can't help him at all. That feeling of helplessness stung Zhang Zhimu deeply, so he had to support Zhang Bingchen and the antibiotics they developed no matter what. However, the development of penicillin is not a simple matter, and it is difficult to make a breakthrough for a while. Suddenly, Zhang Zhimu remembered that he was allergic to sulfonamides when he was a child, and his face was swollen at that time, and it took a long time to get better.

Once, when I was at a party with a friend, when talking about which line of trade has high profits, a friend who is engaged in medicine said: "No line of trade is as profitable as medicine, and the cost of a few cents or even a few cents can be sold for a few yuan, or even a dozen yuan." ”

Zhang Zhimu asked him what kind of drugs he was engaged in, and he said that he was engaged in sulfonamides. Zhang Zhimu also laughed and said: "I am allergic to sulfonamides. Now they are all using penicillins, who still use sulfonamides. ”

"You don't understand, some drugs are still widely used," he said. In the past, no antibiotics such as penicillin were found, and sulfonamides were relied on to treat diseases and save lives. In fact, there are many categories of sulfonamides now. But you can't use either, as long as you have a sulfonamide allergy, there will be many sulfonamide allergies. It's weird that as long as one bacterium is resistant to one sulfonamide, the bacterium will be resistant to many sulfonamides. ”

The table was full of people who were very amateurs in the medicine and listened to him with relish. He saw that he wanted to hear him, and he also came to the spirit. He said, "This medicine is the most fucking simple." Let's talk about sulfonamides, which were first discovered. We all know that benzene can be extracted from petroleum or coal tar, and then nitrated into nitrobenzene with nitric acid and concentrated sulfuric acid, and then ammonia can be added to nitrobenzene to generate aniline, and the aniline and excess glacial acetic acid are placed in the glass reactor, and acetanilide can be made into acetaminobenzene sulfonide after *** sulfonation, and acetaminobenzene sulfonyl chloride can be generated by concentrated ammonia water in acetaminobenzene sulfonyl chloride. Acetaminobenzenesulfonamide can be added to concentrated hydrochloric acid to produce p-aminobenzenesulfonamide, which is what we often call sulfonamides. In fact, acetanilide itself can be used as an analgesic and antipyretic. ”

At that time, because the names such as acetaminobenzene sulfonyl chloride were too long, no one could remember them clearly. It's just that Zhang Zhimu went back and read some information and remembered the name only after knowing the molecular formula of *** and the molecular formula of acetanilide. Because acetanilide is so important in medicine.

But after listening to him, everyone said that it was no wonder that the drug was so expensive, and that it was too fucking complicated to produce. This guy wanted to say how easy it is to produce drugs, but the effect is the opposite. He was so angry that he said, "You stupid people, these things are pediatrics for chemistry." ”

This thing may be interlaced like a mountain, and afterwards, because of his interest in these things, Zhang Zhimu read a little bit of the book suggested by that buddy. However, I didn't dig deeper.

Zhang Zhimu thought that maybe it would be faster for them to study sulfonamides first. Anyway, although I don't know how to make this thing, I still have ideas. It's better than this penicillin doesn't understand at all. In fact, many things are not successful or not in one way of thinking.

Thinking of this, Zhang Zhimu said to Zhang Bingchen and them, penicillin has no idea to put it first, and then do it after a while, scientific research is like this, now you may feel that there is no way, and after a while, there will be a way. There's also an antibiotic, so you might as well give it a try. However, you can't start developing this thing until Master Qingfengzi extracts benzene from coal tar, and this thing is based on benzene. However, there is one point, the antibacterial effect cannot be seen in the test tube when this thing is developed, and only in the human body can it have an antibacterial effect. You can also experiment with animals.

Then Zhang Zhimu gave them an afternoon class, and first carefully explained to them the production process of sulfonamides. These disciples of Qingfengzi who followed Zhang Bingchen to do the experiment were happy.

One said: "Mr. Zhang, we can make a lot of effort in this matter." It's all about our chemistry. Unlike penicillin, we don't know what to do. ”

Zhang Zhimu said: "But this time is different from the past, the things in the production process are much more toxic and dangerous, you need to pay special attention." ”

After Zhang Zhimu's words were finished, Qingfengzi's disciples all laughed. One boldly said: "Mr. Zhang, we are not beginners in chemistry. The losses we have suffered and the lessons we have encountered have long tempered us. We all know how to protect ourselves. You can rest assured. Just tell us what you think. The rest is up to us. ”

Another said: "That's how to do experiments, if it doesn't work once, we will try again in a different way or ratio, and we will always get the best results." ”

Zhang Zhimu said: "Practice without theoretical guidance is blind practice. You need to digest the principle before you experiment. ”

Several of Qingfengzi's disciples smiled and didn't speak, Zhang Zhimu liked their confidence very much.

Suddenly, one of them asked, "What is that *** thing, we haven't used it before." ”

Zhang Zhimu said: "This may also need to be made by yourself. I just know that they are synthesized directly from dry hydrogen chloride with sulfur trioxide inside the synthesizer. ”

"Okay, Mr. Zhang! With you in mind, we'll do the rest. ”

"Some people are allergic to these drugs, but the reaction is not too violent. Taking this medicine requires drinking a lot of water because they have a low solubility in the urine and are prone to urinary tract stones. If necessary, it can be taken with sodium bicarbonate. It is a broad-spectrum antimicrobial that can treat many diseases, such as meningitis, pneumonia, and various infections. ”

Just as Zhang Zhimu and the others expected, Gonggong Li came back not long after leaving.

Gonggong Li, who was smiling all over his face, said to Zhang Zhimu: "Zhang Dongjia, this time you got your wish." The emperor replied that now the officials and troops of the imperial court are fighting against the Manchu army at Shanhaiguan with all their might, and they cannot spare any military strength, and I hope that you Yaogang people can share the worries of the imperial court and find a way to stop the situation on the Mongolian steppe from deteriorating further. If necessary, please send troops to help. The emperor has given an order to the defenders of Hukou and Zhangjiakou to allow your troops to enter and exit the pass. ”

"Father-in-law Li, what you said is not right. How did we get what we wanted? Zhang Zhimu said, "I told you, we have no troops to go out now. You better tell the emperor about our situation. ”

"I've said everything I need to say." Gonggong Li said, "I don't need to say, the emperor has no soldiers and no food, grass and military salaries. And you know that it will befall you. ”

"Tell me, Grandpa Li. We got the news from the northern grasslands, can we not report it to the emperor? Zhang Zhimu was helpless, "Why has this become our business again?" ”

"That's the case," Grandpa Li smiled, "Hehe! If you don't send troops, then watch the situation worsen! ”

"We don't have soldiers, and besides, it's the Mongolian steppe, so it's useless to go less." Chen Yufeng looked at Zhang Zhimu and said, "If it doesn't work, let's take advantage of the fact that the grassland hasn't snowed yet." Send some food weapons to Prince Tori's tribe and support them. Their tribes have all retreated to the mountains, and we don't need to help, no one needs to fight, and they are trapped to death. ”

Ouyang He twisted his beard and said slowly: "It's not easy to send grain and grass over. In the savannah, the convoy is easy to spot. I'm afraid I won't be able to reach Prince Tori's tribe, so I'll send it to someone else. ”

"Can you ask the defenders of Datong and Biguan to help send it?" Zhang Zhimu asked.

"Zhang Dongjia, don't you understand?" Gonggong Li said: "When our officers and troops go out of the customs, it will be a war. It's useless to go out and fight without soldiers and horses, you can't beat others, and it's annoying. ”

Zhang Zhimu said: "We can't ignore the affairs of the northern grasslands. The so-called lips are dead and the teeth are cold. When the northern steppes were completely unified by the Manchus. We were more passive back then. ”

"Gather the cavalry in Tongguan as soon as possible, and the Tongguan side will be completely on the defensive." Ouyang He said, "Let's organize some more cavalry, and then organize a fast-moving rubber wheeled carriage, and let Prince Torrey cooperate." We can sneak out of the customs and send food supplies to them. As long as we keep this thing a secret, we can succeed. None of them could have succeeded in intercepting our large convoy of cavalry escorts without adequate preparation. ”

"Then, in the name of transporting materials to the Killing Tiger Mouth Branch, first concentrate the material vehicles at the Killing Tiger Mouth, and then our cavalry quietly move to the Killing Tiger Mouth, and then suddenly assemble and set off. I can also use the evening time to get out of the customs, because the gates are usually closed at night. This makes it more sudden. "What Chen Yufeng said was actually discussed in advance, and today I said it to Gonggong Li.

"I think so!" Zhang Zhimu said, "Gonggong Li, you told the emperor, let us send troops now, we really don't have troops to send out." But we cannot afford to watch the situation in the northern steppes deteriorate. We would like to give some material support to the tribes in the north that are inclined to us first. As for fundamentally solving the problem, the imperial court still needs to take measures first. We will continue to work hard. ”

"Alright! I will report your intentions to the emperor as soon as possible. Gonggong Li said, "I think the emperor will definitely be interested in your further efforts." ”

"Forget it!" Zhang Zhimu said, "You can save this sentence for us." ”

"Quack!" Gonggong Li laughed a few times and said, "Zhang Dongjia, you have phones everywhere, so let's install a phone for us!" ”

"Oops! I'm sorry, Grandpa Li. Zhang Zhimu said, "Blame us for forgetting about you." We will arrange for you to install the phone right away. ”

Two days after Gonggong Li left, Chen Yufeng and Ouyang He were busy preparing for the customs and delivery.

Prince Tori hurried to the command center.

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Five-line scores, oscillating circuits, caesarean sections. Guo Shoujing made alloy cannons, and Guan Hanqing created "Journey to the West". --Progress of "Memories of the Southern Song Dynasty".