Outside Nieyang City, among the Zhuangzi of Zhang Zhongjing's family, Zhang Zhongjing and his eldest son Zhang Yuan were very busy.

More than 20 days ago, after obtaining the method of pox from Zhuge Liang, the father and son immediately rushed to the Zhuangzi outside the city to verify it.

They were also cautious, knowing that this could not be done in the city.

If the experiment fails, smallpox is likely to spread to the whole city, and this is not the countless merits of the living, but the creation of evil.

Experiments were carried out in farms outside the city, and even if the experiment failed, even if this method was not feasible, the most smallpox could be infected was a farm; Timely isolation, blockade, and destruction are at most just a Zhuangzi.

Compared with the method of pox, this price is still bearable.

Similarly, before verifying the feasibility of the pox method, they did not report the matter to the clan elders.

Although they are a well-known family of doctors and Taoists, the elders of the clan are not only unwilling to hang the pot to help the world, but most of them are even more self-contained, they would rather be helpless about the symptoms than easily use those prescriptions that have not been verified.

If that's all they want, they don't even want to verify the feasibility of those new prescriptions!

In this way, how can medical skills be innovated?

In order to gain the support of the Chinese medicine practitioners, Zhang Zhongjing must first verify the feasibility of this method, and then invite the younger generation of doctors in the clan to benefit the world together.

Zhang Zhongjing knew that if the method of planting pox was feasible, it would not be possible to rely on their father and son alone to plant pox for the entire people in the world.

In this way, it is better to take this opportunity to take the younger generation of healers in the clan out for a walk, let them see the plight of the people, and let them know that the healers also need a benevolent heart, lest they also be taught crooked by those elders in the clan.

……

The experiment went well.

The first step of the experiment is to verify whether the Hu people on the grassland are really not afraid of the plague of smallpox.

Whether it is the Xianbei people or the Huns, they are all Hu people on the grassland. Hu slaves still have a huge market in the Central Plains, and although Zhang Zhongjing's family is not wealthy, it is enough to buy several Hu slaves.

Then, there is the search for smallpox patients.

Based on Zhang Zhongjing's doctor-patient relationship in the Central Plains, it is an exaggeration to say that the entire Central Plains is as long as he needs it, but in the entire Nanyang County, almost all patients are available for him to experiment. Even, most of the people took the initiative to send him to the door for experiments.

The Hu slaves needed for the experiment were there, and the source of smallpox was also available, and the first step of the experiment was immediately launched.

Zhang Zhongjing tried to infect those Hu slaves with smallpox under various circumstances, but none of them succeeded.

The source of the virus is pus extracted from smallpox patients.

In the past, normal people who had never been infected with smallpox, let alone smeared these smallpox venom on their wounds, were 100% infected if they came into contact with smallpox patients.

Now, when these pus are applied to the wounds of the Hu people, no one has contracted the disease.

This shows that the Hu people are immune to smallpox.

The word immunity is still said by Zhuge Liang, Zhang Zhongjing thinks it is very appropriate.

This first step of the experiment can be regarded as a verification that the Hu people on the grassland have actually been infected with smallpox.

This is because only people who have been infected with smallpox will be immune to the disease for life after they have recovered from the disease.

As for the Hu people on the grassland, why did they not die of smallpox on a large scale?

Zhang Zhongjing felt that it was very likely that as Zhuge Liang said, the Hu people were infected with bovine smallpox, that is, cowpox, and the toxicity of bovine smallpox was much weaker than that of human smallpox, and there was basically no fatality rate.

Of course, this needs to be further verified.

This first step of the experiment on the Hu people can only prove from the side that it is indeed feasible to plant cowpox on people.

……

The second step of the experiment was actually going on at the same time.

This step, the most crucial, is to infect normal people who have never had smallpox with cowpox.

Well, in Zhuge Liang's words, it is a kind of cowpox.

In this second step of the experiment, it is naturally impossible to use the Hu people, and in order to achieve accurate results, only the Han people of the Central Plains can be used.

Originally, for the experiment of planting pox, Zhang Zhongjing was still ready to buy slaves.

However, perhaps Zhang Zhongjing's reputation in Nanyang, especially in Nieyang, is too good, and when the nearby people knew that he was working to solve the great plague of smallpox, they were very supportive, and many people were stunned and volunteered to become his experimental materials.

This kind of doctor-patient relationship is only the same treatment as the divine doctor Hua Tuo.

In later generations, human testing was illegal. But this is in ancient times, not to mention that this move is to benefit the people of the world, that is, ordinary medical experiments, or any other experiments, can be carried out by living people.

In this day and age, human life is not valuable!

Not to mention anything else, Hua Tuo practices medicine all over the world, and his surgery is very famous, isn't it practiced?

Zhang Zhongjing selected ten people, both old and young, sick and disabled.

Then, with apprehension, Zhang Zhongjing made a cut on their arms.

Next, the pus from the cowpox is applied to their wounds.

Cowpox is actually very easy to find, in various villages, cows suffering from this disease are not uncommon, just look at the attention is not careful.

After applying the cowpox pus, it's time to wait anxiously.

If these 10 people had symptoms of smallpox, it would prove that cowpox and smallpox are of the same origin.

This point has been indirectly verified through the experiments of Hu slaves.

If these ten people were cured without medicine, and all of them were cured, it not only proved that the toxicity of cowpox was much weaker than that of smallpox, but also showed that the method of planting cowpox to prevent smallpox was indeed effective.

Of course, if all ten of them died from cowpox smallpox, then this approach would not be advisable.

However, Zhang Zhongjing just thought about this assumption and put it away.

Because, he is very confident in the method given by Zhuge Liang.

Moreover, the results of the experiments with the Hu slaves also convinced him that the method of planting cowpox should be feasible.

After two days of nervous waiting, the ten test subjects all had a fever.

Zhang Zhongjing's father and son were happy and a little worried.

The symptoms of the 10 people who had cowpox were the same as smallpox, only slightly milder. Even the old, weak, sick and disabled did not appear to be in a coma. This shows that cowpox and smallpox are the same source of disease, but the toxicity is much milder.

Next, it depends on whether these people can heal on their own.

Zhang Zhongjing recorded carefully, paying close attention to the symptoms of the ten patients.

He had been in the plague-stricken area many times, and had been infected with smallpox many times, so he was naturally not afraid of smallpox. As for the eldest son, Zhang Yuan, although he was not immune to smallpox, he was one of the ten people in this experiment.

This was not a mandatory order from his father Zhang Zhongjing, but Zhang Yuan, who is a doctor, took the initiative to ask for it.

……

Ten experimental patients had red bumps on their bodies one after another, and two days later, these bumps suppurated again.

This step, however, is a bit faster than normal smallpox.

After another two days, the pus had been cleaned and drained, and the pimples were scarred one after another.

At this point, according to Zhang Zhongjing's experience, these ten "smallpox patients" were basically cured.

It took less than 10 days before and after.

It must be known that in the past, even if smallpox patients could be cured, it would take half a month to say the least!

And the cowpox took less than ten days.

The toxicity of cowpox is indeed much weaker than smallpox, and the human body can easily withstand it.

Of course, depending on the person's constitution, this process lasts for a long or short time.

The three young men, including Zhang Yuan, were basically healed in only seven days, but there were still some scars on their bodies that had not yet fallen off. The old, weak, sick and disabled lasted two or three days longer, after all, their physique was weaker.

In any case, after planting cowpox, all ten patients were cured.

This proves that there is basically no life-threatening cowpox planted on the human body.

Admittedly, it would be too arbitrary to say that there is no danger based on the results of the experiments of ten people.

However, among the ten people who were experimented, there were several old, weak, sick and disabled!

Even the old, weak, sick and disabled can survive the sick period after planting cowpox, and it doesn't make sense that young and strong can't do it, right?

Smallpox, to put it bluntly, still has to rely on the patient's body to carry it!

The young and strong body is naturally much stronger than the old, weak, sick and disabled, and it is naturally no problem to survive the disease period of cowpox.

What's more, in the future, planting cowpox for the people will give priority to young and strong people.

……

The method of planting pox is feasible, and Zhang Zhongjing and his son are naturally very happy.

Even the few people who were used as experiments were equally happy.

Zhang Zhongjing is happy that with the method of planting pox, from now on, the people will no longer suffer from smallpox. Zhang Yuan is happy that he is about to follow his father and fully implement the method of pox in the whole world, and his name will not be far away in history.

As for the few people who participated in the experiment, they will be immune to smallpox for the rest of their lives, and they will no longer have to smell smallpox and change color!

Of course, after being happy, Zhang Zhongjing did not forget it, and he had to verify it one more step.

Verify whether the ten people who were vaccinated with cowpox were immune to smallpox.

While the results are clear, this step is important.

This is like a later generation of elementary school students doing math problems, and the results of vertical calculations come out, but they still need to check the calculations again.

Even in the hospitals of later generations, there are still clinical verifications for many drugs!

Although it is ancient, the wisdom and cautious attitude of the ancients are not as bad as later generations think!

However, this step is very simple, and it is exactly the same as the step of verifying the Hu slaves.

It was clear that the 10 people who had smeared the pus from smallpox patients did not have any symptoms of smallpox again.

Planting cowpox and preventing smallpox has been thoroughly proven to be feasible!

……

That night, Zhang Zhongjing rushed back to Nieyang overnight and summoned the elders of the clan to report the matter.

Since the method of planting pox has been proven to be feasible, if it wants to benefit the people of the whole world, in the final analysis, it must be practiced by doctors. Nieyang Zhang's family, almost all of the clan are doctors, and Zhang Zhongjing prefers to be their Zhang's doctor's hand and implement the method of pox cultivation to the world.