Since the second year of Eiroku, there has been an epidemic of disease in Kai, and the scope and epidemic were not serious at first, so Takeda Shingen, as the leader, did not care too much. However, with the re-invasion of the Uesugi army and the increase in casualties in the territory, the epidemic gradually began to become serious.

Not only that, but there is also a drought in Kai Japan, and even Lake Kawaguchi has dried up for a time. This is a disaster for the Takeda family.

In addition, Takeda Shingenguang spent a lot of manpower, material and financial resources on pacifying the wealthy clans in various parts of the Koshin and two countries, helping the wealthy clans to resume production in their territories, and inviting the soldiers of the castle located on the border.

Due to the successive defeats of the Takeda family in Kita-Shinano, Nishi-Ueno, and Aimokuni in recent years, as well as heavy military service and hard labor, the wealthy families of the Takeda family in Shinano were born. Even the wealthy clans of the Kita-Shinano ancestors, such as Muroga, Mochizuki, Youzu, Tarogawa, Tahara, and Shimazu, began to secretly contact the Uesugi family, intending to fall in favor of the Uesugi family at the right time.

At the same time, as Takeda Shingen failed to rescue Saku-gun in time, it led to the fiasco of the influential Oi family and the Suwa Shokata who went to the rescue. This fiasco also caused complaints from the lords of the people in Kai and Minami Shinano, and important ministers such as Nobubo Baba, Masatoshi Hoshina, Yoshimasa Kiso, and Torakatsu Kohata once again explained to Takeda Shingen that "the soldiers of the two states of Koshin have died a lot, and the people of the country are overwhelmed and resentful." In addition, in particular, most of the relatives of Shinano's guardian Daidai Oi clan were killed in battle, which had a great impact on the wealthy clans throughout Shinano. As a result, the Takeda family's rule in Saku-gun was chaotic and shaken.

And Yamamoto Kansuke, the military advisor of the Takeda family, has seen the general trend of the eastern country, which is difficult to reverse, and the mountain fan (Yamauchi Uesugi, Ogiya Uesugi) is one, and its ambition is difficult to win. The Takeda family can only wait and see what happens, and in terms of national strength and strength, it is no longer possible to start a long-term tug-of-war with the Uesugi family. Although Kansuke Yamamoto repeatedly advised Takeda Shingen to dissuade him from suspending all hostile acts against the Uesugi family, Takeda Shingen did not accept it. Even Takeda Nobutora, who had come to Suruga from Kyoto, felt that the Takeda family would most likely be severed if they continued to fight with the Uesugi family, so Takeda Nobuta actively exchanged letters with Kenshin, hoping that Kenshin would retain the Kai Genji bloodline after defeating the Takeda family.

Although Takeda Shingen is naturally well aware of all this, there are some things that you still have to do even if you know that there will be strong opposition. He knew very well what the outcome would be if he continued to fight the Uesugi family, but if he did not continue to fight the Uesugi family, the development and living space of the Takeda family would be limited to Mikawa, Enoe, Suruga, and Koshin in Tokaido. And Kai is a large basin, from the basin flowing Fufuki River, Kamano River has become the most deadly disaster, almost every year wind and rain will be attacked by floods, today's Kai total stone is more than 200,000 stones, because of frequent wars and natural disasters and man-made disasters, the total population is only nearly 200,000 people. Generations of ancestors of the Takeda family have been pioneering and leading Kai warriors out of the backwoods of the countryside, and beyond Kai there is a rich land and beautiful landscapes, which has been proven countless times over the past decade or so. As the saying goes, from thrift to luxury, from luxury to thrift, after everyone has enjoyed the beautiful life outside the mountain, no one wants to continue to nest in Jiafei as a bitter mountain warrior.

At the same time, Miyoshi Nagakei, together with his retainer Matsunaga Xiu, and seventy-three others were baptized in the realm. Not long after, on August 20, the leader of Hosokawa Harumoto died of illness, and Miyoshi Nagakei also began to weaken rapidly under the blow of losing two younger brothers one after another. The state affairs are all controlled by Matsunaga Shu, Miyoshi Sanren (Iwanari Yudo, Miyoshi Nagayi, Miyoshi Masaysu) and others. Miyoshi Chokei's son-in-law, Miyoshi Yoshiko, was brave and brave, but due to the cause of jaundice, he died of illness in Akutagawa Mountain Castle on August 25 at the age of 20.

Miyoshi Changqing lost his brothers and eldest son one after another, and then became in a trance. Matsunaga then slandered Miyoshi Chokei, who was already in a trance, and falsely accused his brother Anzhai Dongyasu of intending to rebel. Miyoshi Changqing was furious and ordered his younger brother Anzhai Dongkang to commit suicide. On August 30, Miyoshi Changqing returned to the West in the midst of endless loss and loneliness, at the age of Chinese New Year's Eve eight, and his legal name was Eye Chamber Zongjin of Juguang Temple. The mighty Miyoshi and four brothers all went west in just a few years, and the rule of the Miyoshi family in the Gyeonggi area also came to an end, and the Miyoshi family was completely divided and withered.

With the death of Miyoshi Nagakei, Miyoshi Shigesu succeeded to the position of Miyoshi family governor with the support of the Miyoshi Sanzhong, Matsunaga Hide, Miyoshi Yasunaga and other important ministers of the Miyoshi family. And from the general of the Seiyi general, Ashikaga Yoshiteru, he received the word "Yoshitsugi", changed his name to Miyoshi Yoshitsugu, and was appointed as Doctor Sakyo because of Ashikaga Yoshiteru's request. However, Miyoshi Yoshitsugu was too young and became a puppet in the hands of the family's powerful ministers Miyoshi Sanzhong and Matsunaga Hide.

Not only that, but the sphere of influence of the Miyoshi family, which was originally unified under the banner of Miyoshi Changqing, has also undergone earth-shaking changes - the first territory of the Awa country, which actually became the territory of Nagaji, the son of Miyoshi Yoshiken, but Miyoshi Nagaji was not yet ten years old at the time, and the real power was in the hands of his important minister Shinohara Nagabo; In Hanoi Country, the real power is Miyoshi Changqing's uncle "Xiaoyan" Miyoshi Yasunaga, who occupies Gaoya Castle and is a veteran-level retainer in Miyoshi's family; Sanuki Province was also separated from the Miyoshi family, and the successor to the governor of the Tokawa family was another son of Miyoshi Yoshiken, who later became Tokawa Depository. The evil consequences of the division of the same clan in Miyoshi Changqing can be seen at a glance at this time, that is, once the core disappears, there will be no original cohesion.

Previously, when Miyoshi Nagakei was dying, the Miyoshi trio came to his sickbed with Matsunaga Tsutsumi (Matsunaga Hide's son) and applied to Nagakei to depose Ashikaga Yoshiteru, who was then the shogun of Seiyi, and supported the Sakai Gongkata (during the previous confrontation between the two Hosokawas, Awahosokawa and the Miyoshi family had supported Ashikaga Yoshisumi's second son, Yoshino, and established the shogunate in Sakai, and later transferred to Awataijima) Ashikaga Yoshiei as the new general. of the command. After all, at that time, Miyoshi Changqing was still the governor of the Miyoshi family, and the three of Miyoshi and Matsunaga Xiu did not dare to cut first and then play without authorization, so they went to get the permission of Miyoshi Changqing. Although Miyoshi Changqing was terminally ill, he had not yet reached the point where he had no ability to think at all, and immediately rejected the proposal of Miyoshi Sanzhong and Matsunaga Hide.

The intention of the Miyoshi Sanren and Matsunaga and others to depose the current Shogun Ashikaga Yoshiteru was not out of their selfish motives, but so that the Miyoshi family's hegemony in the Gyeonggi area could be as stable as a rock. When he learned that Miyoshi Chokeiichi was ill and dying, Ashikaga Yoshiteru took this opportunity to prepare to begin restoring the power of the shogun and driving the Miyoshi family out of Yamashiro Province in one fell swoop.

After Miyoshi Nagakei died of illness and Miyoshi Yoshitsu succeeded him as the governor of the Miyoshi family, they immediately 'requested' the new governor Miyoshi Yoshitsugu to depose the current shogun Ashikaga Yoshiteru. Miyoshi Yoshitsugu did not know what the result of deposing the current general of the Shogun, Ashikaga Yoshiteru, meant to the Miyoshi family, and after he nodded in agreement, he led an army of more than 10,000 with Miyoshi Sanshi, Matsunaga and others to swagger into Kyoto in the name of Kiyomizudera Temple.

On September 10, although Ashikaga Yoshiteru learned that the number of people led by the Miyoshi family to Shangluo was larger than the previous thousands, he did not think that they would do anything to him, and thought that the Miyoshi family was just to intimidate himself, so he did not mobilize the public in the Gyeonggi area to enter the Nijo Imperial Palace to assist in the defense. Even Akechi Mitsuhide, who occupied the area of Omi-ima-Katata Castle and Sakamoto, did not let him lead his army into Yamashiro Province.

The people around Kyoto found that the streets were crowded with the neat formation of the Miyoshi army, and the samurai of the Miyoshi family were very arrogant, and they did not give any reason to launch a siege operation against the Nijo Imperial Palace, and within half an hour, the Nijo Imperial Palace was surrounded in all directions, and the more than 3,000 Miyoshi troops who were originally stationed around the temple also left the temple to come to support, blocking all the streets leading to Kyoto in the Sakyo area. Miyoshi Sanren and Matsunaga and others immediately issued martial law, even if the edict of Ouchi did not go out of the city, the ministers were blocked at the door of their own houses and forbidden to go out, the people had to close the door and huddle in the corner of the room, praying to the gods and Buddhas that this war would not affect themselves, for a time the people in Kyoto City were panicked, and the atmosphere of the war was very strong.

At the same time, the Nijo Imperial Palace was built on all sides of the Castle Walls, and more than 100 public samurai were stationed inside and outside the Imperial Palace, and these forces were the only forces in the hands of the Shogunate at the moment, and seeing the weak samurai facing an enemy ten thousand times their own made them unconsciously think of this embarrassing scene similar to the decades after the Shogunate lost power, and the same embarrassment of being unavailable and overwhelmed by a large army.

Ashikaga Yoshiki sat in the Ohiroma of the Nijo Imperial Palace behind wearing the big armor, and on the left and right kneeled sat the samurai of the shogunate wearing the big armor. In just a few days, the anxiety and fear on the faces of the public warriors also became more and more intense, and the former high-spirited and high-spirited citizens were worried at this moment and did not know how to deal with it, more than 100 people against more than 13,000 people, unless they all had the ability of fierce generals such as Genyoshijing, Musashibo Benkei, and Heikyo Sutra. Otherwise, I really don't know how to repel the army of the Miyoshi family.