Chapter 127: Important News (2)
Everyone immediately became excited, although for the size of the United Group, 25 times the price-earnings ratio, 2.5 times the price-to-book ratio is not very cheap, but at least it is still below the market average, and more importantly, there is the bond qualification reservation - from July 1929, it will be opened at the point of annual repayment of principal and interest within five years, this situation of attacking and retreating, coupled with the joint and several guarantee that the United Group will take out other listed shares as collateral, makes the reporters think that the interests of investors are taken care of to the greatest extent.
Of course, the United Group itself has also benefited a lot: reducing the current general financing cost of about 4.5% to 1.5% will reduce the financing interest by three points per year, and can save $100 million in financing costs a year.
"Third, it is the first innovative, epoch-making antimicrobial drug of United Pharma that has passed the clinical validation of the hospital and the evaluation and approval of the FDA, and will be fully sold in the United States, which will help save the lives of thousands of patients.
Although at the end of the 19th century, all "drugs" were rampant, but the real doctors knew very well that only quinine, aspirin, morphine, these few things had a little effect, and the others could only wait for the patient to heal themselves, in this case, everyone was crazy looking for drugs that could fight the bacteria, Paul Ehrlich was the first to achieve limited success, and found 606 (arsenic vanamine) to effectively treat syphilis, thus creating the era of chemotherapy, but 606 side effects are very large, and it can only treat syphilis, As a result, chemists continue to rush in, and one of the lucky ones is called Domak.
As a medical student, he was wounded in World War I and then became a "medic soldier", witnessing countless wound infections, especially gas gangrene, and doctors had no choice but to cut it. Perhaps because of the doctor's weakness, Domac set his sights on scientific research and vowed to find a cure for the disease. But the fledgling "scientific research dog" is poor enough, so poor that he doesn't have the courage to propose to his girlfriend who has been in love for 9 years - he didn't make up his mind to get married until the second catastrophe.
After marriage, he worked and lived well, while finding a job in the pathology department of a university, insisting on the study of bacteria, immunity, and pathology, and giving birth to 3 children, but life was as stretched as ever, but good luck began to favor him, and the president came to the door, when Contini was looking for talents in all aspects of German universities, and offered higher salaries than Germany, and a large number of people went to Italy to work, and Domark also arrived in Italy with the crowd.
Originally, his ambition was to find a job in the medical department to support his family, and if he still had the means, he would engage in scientific research by the way, so he wrote this clearly in his job application, and later unsurprisingly obtained a teaching position and was assigned to work at the Roman Medical College. But it just so happened that this was also the school where Ida studied, and Contini once met Domark when he was looking for Ida, and he recognized Contini like countless opportunists, so he pounced on him like a moth to the fire to introduce his research ideas, hoping to be recognized - 99% of adventurers would be driven away by the bodyguards, because Contini knew whether their "invention" was reliable or not as soon as he heard it, but Domark was the lucky 1%, he told about his ideals, and described the fact that he had surgery on streptococcus - Anyway, the president is waiting for his girlfriend to get out of class, and he is idle when he is idle.
In this era, streptococcal infections are common and fatal, and once overcome, there will be a broad market prospect. But there are many types of streptococci and there are differences in pathogenicity between species, so it is impossible to try every streptococcus? On this issue, Domac made a decisive choice: no matter how many streptococcal species there are, I want the most virulent one! He took samples from patients who had died of streptococcal infection, cultured and isolated mice, and hoped to find strains that were 100% fatal — only indiscriminate infections and fatalities could be called "the most virulent." After several months of hard work, before he spoke to Contini, he had found a strain that could still kill all inoculated mice within two or three days after diluting the culture 100,000 times – and thus the animal model of streptococcal infection was successfully established.
Contini's first impression was that he thought he could engage in bacteriological weapons, but then he felt that it was wrong, this routine was too troublesome, the cost was too high, and he should find drug treatment in the opposite direction, so he blurted out: "You can try penicillin, even if you don't have penicillin, you can use sulfonamide, it is said that this thing can deal with streptococcal ......"
Now it was Domark's turn to be dumbfounded: "What is penicillin?" What is sulfonamides? ”
Contini then remembered that in this era, "penicillin" had not yet been found, and "sulfonamide" had not yet been invented, and he knew that penicillin was Fleming, but he couldn't figure out how sulfonamide came about, and finally coped with it, only saying that there were many people like Domak, all kinds of liars, and he was not sure whether it would be successful or not.
But within a few days, Domac came to him excitedly, saying that he had found a patent for sulfonamides, which had been patented 18 years ago, but it had no effect at all, and he was lying there quietly moldy, and he had come to ask the president how he knew about it, and how to get the follow-up - Domac did not dare to test it rashly, he thought that sulfonamides were just intermediate products or raw materials, and there must be other industrial procedures.
At this time, Contini could fully recall the whole event: Isn't it in history that Domak linked azo dyes and sulfonamides together, thus giving birth to the first antibacterial drug - Prontosil! So he immediately instructed Domac to suspend his class to do the experiment, and hinted that he could boldly find a patient to try, and he would be responsible for the bottom line if someone ordered him to do so—wouldn't it be to lose some money!
With the president's package ticket and good test conditions, of course Domac boldly started, this time sulfonamide does not need the intermediate of chemical dyes, and does not need Domark's daughter to undertake the test, and directly got the secret recipe for overcoming streptococcus from sulfonamide.
Coincidentally, the sulfonamide patent is about to expire, because it has been in a state of no one's interest, the original patent owner transferred it to the United Laboratory at a very cheap price, and under the activities of the United Group, the German Patent Office agreed to extend the patent protection period for another 5 years on the grounds of the new application of the original patent, forming a 20+5 pattern, that is, until 1933, the United Group can guarantee the exclusivity of the sulfonamide patent, which laid the foundation for the establishment of United Medicine. In Contini's view, these five years are crucial, and the extra five years are enough to unite the group to explore the follow-up of sulfonamides, while waiting for penicillin to mature.
In order to respect history, Contini still set the trade name of sulfonamides as Bailang Duoxi! After passing the registration of the US FDA, it means that the European and American powers have been completely opened here. Of course, now Bailang Duoxi has nothing to do with Bayer in Germany.
"Priced at $9.99 per box, this drug is widely available for streptococcal infections and has a special effect, and will be available starting tomorrow, and as a tribute to the American people, we have prepared 1,000 charity slots for those from poor families – all for free!"
The crowd began to applaud enthusiastically.
In fact, the production cost of United Pharmaceutical is very low, the cost of each box is less than 1 US dollar (including the cost of research and development, registration, promotion, and trial), this first batch of drugs was shipped from Italy by cruise ship after mass production a few days ago, in order to cause a sensation, Domac felt that the price was a little too high, but Contini persuaded him: "Your project is a success, but how many projects are being studied in the joint laboratory?" Every year I have to invest a lot of money and hire a lot of people, and the success rate is only 2-3%, which can only be supported by successful projects, so it is understandable to set the price a little higher; Moreover, the patent term of this product is only 5 years, and once the patent period expires, although we can continue to sell, I dare to guarantee that there must be a large number of imitations, and then you can only make a normal profit, and you have to consider the commercial appeal. ”
Domac was immediately convinced, the entire scientific research team of this drug has done a lot of work, before the film, the president has provided people with good conditions, and now it has just been invented, and the market effect has not yet been seen, the president has delivered a large set of houses and cars of United Real Estate, and from the position of the other party, it is indeed necessary to fully consider.
Now the scientific team is waiting for the options to be cashed in - Contini said that United Medicines is considering an IPO in March-April 1929, and if it succeeds, the team members may become millionaires - when he thinks of the time when he was so poor that he did not even dare to propose, Domark can't help but feel bitter, and now he wonders what Contini said - what is penicillin? Also, who said this to the president, this is either a crazy experiment, desperate madman - Domak knows that there are many scientific research experts who dare to test anything in order to develop drugs, regardless of life or safety, and are completely in a state of madness, or this is an unborn genius, similar to Tesla's, he really wants to get to know him!
Contini, who had an unusually bad headache, struggled to convince him that it was an inventor who had come to him for a casual chat, and that he couldn't remember who it was when he saw so many people every day. However, Domac did believe it, because there were too many people looking for Contini, and if he wasn't particularly lucky that day, he would definitely be forked out by the bodyguards. In fact, the joint laboratory has a special process for this kind of invention and creation of letters, and the summarized information will be read by Contini and the president's office, and many projects can eventually become the joint laboratory's key projects, similar to PVC, Bailang Duo is an inevitable result under the guidance of science.
Contini concluded: "The success of Bailang Duo Interest will promote the listing of United Pharma, and I look forward to sharing the joy of corporate growth and national development with tens of millions of investors in the United States." If the United States is good, Italy is good, if Italy is good, then the United Group is good, and vice versa! Long live the great friendship between Italy and the United States! ”