"Forget it, I prefer money and credibility to saints. This medicine will be manufactured by my company, shipped to you, and then you will conduct clinical trials. Eventually, this medicine will be discovered by you and the church...... Don't interrupt, listen to me. The church has to be involved, and you have to be one of the inventors. Because it's up to you to test the suitability of the drug, it's very risky. If you have cured many sick people to death, and the church will come out and speak ill of you, the prestige and reputation you have accumulated over the years will be lost in an instant. People are always easy to remember your bad and not easy to see the good. ”

"In addition, according to my philosophy of life, you will get as much as you give, and more or less means unfairness. You don't give a lot, and your reputation, prestige, and throne will all be tied up with it, so you deserve this honor. It's the same with the problems of the church, they don't necessarily help much, but they can cause you a lot of trouble. It pays to give them a little credit and avoid possible trouble. And this is also a matter that the Pope has to pay attention to, he certainly doesn't want to see you directly become St. Friedrich II, right? Even if he can't stop you, he and the church have to progress with you. Hong Tao believed that Friedrich II was telling the truth and that he could really become the savior of Europe, but after thinking about it, he refused. Prestige and wealth can be both, but you can't ask for too much of one thing, which will harm the other.

You don't need to be a saint yourself, especially European. Because in a few years, he may become a mortal enemy of the Europeans, and maybe there will be war. Getting along too well before this will affect your judgment of things.

In addition, there is a more important point, quinine, a drug, I have not yet been sure of purification. The original intention was to use Friedrich II and the Europeans as living guinea pigs. If it succeeds, then let them continue to be guinea pigs, and when they have figured out all the medicinal properties, side effects, and details of use, the new safe quinine will be sold in large quantities to the Jinhe Empire and the Great Song Dynasty, where they need to be their own saviors.

People always have a conscience, let people be guinea pigs, and lick their faces to be saints for others, this kind of thing Hong Tao can't cross the threshold in his heart. If you talk about things more vulgarly and more vulgarly, you will feel much better. Buying and selling, you and I are willing. I will treat you with medicine, if you die, you will be unlucky, and if you live, you will be lucky, and it has nothing to do with morality and character.

As for how to purify quinine, Hong Tao knows a little bit, and this is thanks to the fat Pavi from Toronto. He grows hand-rolled tobacco leaves at home, and at the same time refines some alkaloids, and he has worked with him a few times, so he probably understands the process and doesn't learn. Now this little knowledge is very useful, quinine is an alkaloid, it is the same kind of thing as belladonna, nicotine, cocoaine, morphine, and chlorophylline (berberine), and the purification process is similar.

Purifying alkaloids, if the purity is not too high, don't use the medical and health standards of later generations, in fact, it is not difficult, you can do it at home with simple laboratory equipment. There are only three main raw materials: ethanol, dilute hydrochloric acid, and caustic soda.

Quinine is chemically called cinchonamine, which is a free base that is not hydrophilic, that is, it cannot be fully dissolved with water, but it can be dissolved with ethanol. It is precisely because of this characteristic that ethanol can be used to extract it from many alkaloids, and some of the remaining impurities can be removed by acid and alkali neutralization, and the result is relatively pure cinchonaline.

The approximate step is to dry the bark of the cinchona tree, grind it, soak it in ethanol, and soak all the free alkaloids in the bark. First, the solution is concentrated by the thermal reflux method, dilute hydrochloric acid is added to acidify, and then alkalized with caustic soda solution to obtain relatively pure cinchonaline. Of course, it is only relatively pure, far from meeting the medical standards of later generations, and in addition to quinine, there are some free alkaloids. But as a special medicine, it can almost be used. It's better than chewing the bark and drinking the water soaked in the bark.

Today, a book friend said, you can purify alkaloids, why don't you use the soil method to get penicillin out, that thing is not simpler and more efficient than quinine? Personally, I think penicillin is really not simple. It is different from quinine, which is a raw material that is easy to find, but it is a bit troublesome to purify. However, it is difficult to find the raw materials of penicillin, and it takes countless tests to accurately find out the penicillin strains among dozens or hundreds of molds.

If there is mold and hair, it is not necessarily penicillin, and even if there is penicillin in it, the content cannot be determined, and most of it may be other molds. They are not antibiotics and may be harmful when they enter the human body. How to find a pure penicillin strain, but also to ensure that it is not infected by other strains, this requires a relatively high level of technical means. At least you have to get a constant temperature, constant humidity, relatively pure air in the culture room, and you have to have a culture medium, and you have to have skilled personnel to do the cultivation observation work, which means that you have to use another instrument, the microscope.

In the nineteenth century, penicillins could be discovered, purified, and cultivated, because of these conditions. Anyway, Hong Tao can't figure out how to find and cultivate these squeamish strains, even if he makes a microscope, there are still many problems, and they can't be made by a few people, fiddling with test utensils, and relying on chemical experiments. Hong Tao can write down these thoughts and remind future generations, so that they can ponder this technique if they have time, but after all, they have limited time, so don't play this kind of difficult thing.

"Carl is right, you are a combination of angel and devil, why do you always want to make a good thing into a business, are you really short of money? Your little lover is already rich, and what she did may not be clear to others, but I can see that there is still your shadow behind it, right? Hong Tao's explanation did not convince Friedrich II, who really couldn't figure out what kind of person Hong Tao really was and why his ideas were always so strange.

"You brothers are dishonorable, and always like to slander me behind my back, as well as my beautiful Baron. I don't think the same way as you, I think it's a natural thing to rely on your own skills to make money, and even God can't stop it. But there is no need to use one's own skills to forcibly gain the respect of others, these are two completely unrelated issues. You can respect me, but you can't give me a penny less when you buy medicine. ”

"Unfortunately, most people don't think so, they think that because I have a lot of money, I should give them free medicine. I can't convince them, and I don't want their respect, so I'd better do it as a deal, which is more worry-free. By the way, I'd like to say hello to you in advance, and I can give away some of this medicine as a trial when it first starts. If it is easy to use, the price behind it will definitely not be cheap, and not everyone can afford it. When the time comes, you are not allowed to talk nonsense about me like angels and devils, I am just a very capable businessman, neither a god nor a fool. No matter what Friedrich II said, Hong Tao will not change his original intention, he can think whatever he likes.

"Well, you have your point, I can't convince you. But I also have to thank you, a very skilled businessman, not only for the sake of convincing the Pope, but also for the sake of my people. In the eyes of Friedrich II, Hong Tao is still an emperor regardless of whether he abdicates or not, and he has always regarded the two as friends, so he will not force Hong Tao to change his mind, and he must try to respect each other's choices, which is part of their culture.

"Don't be in a hurry to thank you first, I still have one condition to say, your thanks make me embarrassed to open my mouth." That's why Hong Tao is reluctant to get too close to the Europeans. There are also many good people among Europeans, who are worth associating, and if you are too familiar with them, you really can't bear to harm them in the future.

“…… Talking to you sometimes makes me ...... Awkward! Friedrich II couldn't help himself, he felt that Hong Tao had been making fun of himself all along.

"Seriously, I need to hire His Majesty the Emperor's navy to protect the ports of the Count of Tripoli. Carl's son is going there to inherit his grandfather's domain, you and Carl are my best friends, of course I can't watch little Philip being bullied in the past, let alone let his safety not be guaranteed. You are little Philip's uncle, and no one can say anything if you come forward to support him. Your Majesty still has a friendship with the Sultanate over there, and it is most appropriate for Your Majesty to do this matter. I know that Your Majesty is not very wealthy, and since I am so rich, I naturally have to think more about my friends, and I can't make my friends embarrassed. Therefore, the military expenses will be paid by me, and it will not take too many people and ships to pass, as long as it is enough to show the attitude of His Majesty and the Empire. How's that, isn't this condition harsh? I'm not a stingy Venetian, am I? "Quinine is not easy to come by, and I have to send people to Central America and South America to find cinchona trees, just to fool the Pope, the old immortal Hong Tao must not be happy, you must hug the grass and beat the rabbit to carry something, little Philip's matter is just right.

"If you don't say it, I'll send someone to protect him...... Count me in debt to you once" A penny is hard to beat a hero! When it came to large expenditures, Friedrich II immediately lacked confidence.

"No one owes anyone, you give money for your nephew, I pay for my friends, the two of us have the money to contribute, and we have the strength to contribute, and it is also a good story to spread it, hahahaha!" Spent some money to fulfill his promise to Karl, and also obtained the great favor of the emperor, and solved the safety problem on the oil transportation route, killing three birds with one stone! Hong Tao smiled very happily, but he was very unhappy in his heart. It's so dishonorable, and the feeling of deception isn't always wonderful, and it's often impossible to tell which is more than what is gained and what is lost.

(To be continued.) )