Jia Daoshi introduced a prescription to Sun Yi: water-containing stones, gypsum stones, and talc can defeat fire, and three kinds of stones are ground into powder, called "Sanshi San", which can be used to treat fever. Pen, fun, pavilion www. biquge。 info It is recommended to leave some for the wounded and can be taken in case of fever.

Sun Yi couldn't help but think of the "Wushi San" that was popular among the literati in the Wei and Jin dynasties, which was also made of stone powder, which is said to be at the same level as the drug.

Sun Yi had the heart to refuse Jia Daoshi's suggestion, but there was no medicine in the Ironwood camp.

Looking at the red willow trees in his eyes, Sun Yi sincerely regretted that if he had kept his backpack tighter at that time, the medicines in the first aid kit would not have been stolen.

In addition to the usual diarrhea medicine, there is also an all-purpose aspirin in the first aid kit. Aspirin is an over-the-counter drug that is analgesic, antipyretic, anti-inflammatory, and has few toxic side effects. If you have a headache, you can eat a slice; If your brain is hot, you can eat a slice; For joint pain and low back pain, you can eat one tablet; If there is inflammation in the body, you can eat one tablet; If the heart is not good to prevent blood clots, you can eat one tablet. It is really a must-have medicine for field trips.

Aspirin is a foreign brand name, the scientific name is acetylsalicylic acid, and the common name is acesalicylic acid.

The so-called salicylic is the willow tree.

Looking at the red willows in his eyes, Sun Yi was excited, and immediately took out his mobile phone to check aspirin.

Aspirin, also known as acetylsalicylic acid, is a salicylic acid drug commonly used as an analgesic, antipyretic, and anti-inflammatory. It is one of the most widely used medicines in the world, with an annual consumption of about 40,000 tons.

Aspirin is derived from chemicals found in the bark of willow trees. Willow bark was used to cure diseases as early as 2,400 years ago, and Hippocrates used it to cure headaches. At Wardham College, Oxford, Edward Stone first discovered that the active ingredient of aspirin was salicylic acid from willow bark. In order to reduce the irritation of the human stomach and intestines by taking salicylic acid directly, Felix Hoffmann, a chemist from Bayer in Germany, successfully synthesized aspirin for the first time in 1897.

That said, the ingredient in aspirin that really works is salicylic acid from willow bark!

Sun Yi was ecstatic, and then checked salicylic acid.

Salicylic acid, also known as salicylic acid, o-hydroxybenzoic acid, 2-hydroxybenzoic acid. Aspirin is hydrolyzed in the human body into the active ingredient salicylic acid.

Salicylic acid is soluble in ethanol, ether, and not easily soluble in water.

Salicylic acid is found in willow bark, white bead leaves and sweet birch.

The industrial production of salicylic acid is the synthesis of sodium salt of salicylic acid by phenol and carbon dioxide at high temperature (390 K) and high pressure (100 atmosphere) under high temperature (390 K) and high pressure (100 atmosphere) through the Kolber-Schmidt reaction, and then acidification of sulfuric acid to obtain salicylic acid.

In the 19th century, salicin, an extract of willow bark, was used to produce aspirin

Sun Yi's head tightened, one salicylic acid is not enough? Another salicin? Is it sour or sweet? Sun Yi gritted his teeth, persevered, and checked salicin.

Salicin, or salicin, has a bitter taste of "quinine" and can be metabolized into salicylic acid in the human body, so salicin is considered to be the main cause of pain relief and anti-inflammatory of willow bark in herbal medicine. Salicin is slower than aspirin for pain relief, but its effects last longer.

In fact, in the 19th century, salicin was used to produce aspirin.

Salicin is soluble in water, soluble in boiling water, insoluble in ethanol, insoluble in ether.

Salicin in nature is widely found in the bark and leaves of a variety of Salix and Populus plants. For example, the bark of the purple willow tree contains up to 25% salicin.

Sun Yi slapped his thigh excitedly, this is what kind of "salicin"!

Forget it, it will be easier to call it "Liusu" in the future.

Since the data shows that saliin is widely found in a variety of willow bark, especially in purple willow bark, which is easily soluble in boiling water, it is just that saliin can be extracted by boiling in boiling water!

Sun Yi looked up at the large area of red willow trees in front of him, and immediately felt that they were red and purple, and purple was so cute.

Sun Yi shouted: "Someone! Chop willow branches and peel willow bark for me! ”

A group of Ming Dynasty people were carefully surrounding and observing Sun Yi.

Just now, when Lord Lidel was talking and talking, he suddenly closed his mouth, took out the "Book of Heaven", lowered his head, and pointed.

Sometimes the master frowned, sometimes he suddenly realized, sometimes he stroked his face and thought, and finally the master slapped his thigh and shouted.

The general army did not hesitate when the sun fell, and he went up the tree with a machete and slashed with a knife!

The others didn't know what to do, and they didn't dare to slack off, and in just a moment, a layer of red willow bark was piled up on the ground.

Sun Yi asked people to cut these barks into small pieces and boil them in boiling water, and after a while, the water in the pot was dyed red.

Sun Yi tasted it, bitter.

Sun Yi commanded, and continued to boil, until the water turned brown-purple.

Sun Yi tasted it, bitter, so bitter that Sun kept grinning.

The brownish-purple willow bark sap is strained several times through boiled old clothes, and the color of the willow bark sap fades. Sun Yi instructed to change the pot and continue to boil, evaporating all the excess water.

A pot of red soup thickened into a pot of bottom, and Sun Yi didn't dare to cook it anymore, he was worried that without water, the temperature would rise and lose its medicinal effect.

Sun Yi took a willow stick, dipped it in a little "willow concentrate", and put it in his mouth, bitter! Nothing else, just bitterness! It was so bitter that Sun Yi was in tears.

This "Lycin Concentrate" is so bitter that no one can drink it.

Since you can't drink it, you have to find a way to swallow it.

Just now when making gypsum gauze, only a little bit of fried aqueous stone powder was used. Now Sun Yi mixes raw and cooked aqueous stone powder together like making chalk, and pours "willow concentrate" into it and mixes well.

The baby's eyesight is accurate, and Sun Yi asked the baby to use a simple spoon made of willow sticks to quickly divide the "willow concentrate with aqueous stone powder paste" into small balls of the same size.

The others washed their hands and quickly kneaded the "small balls" into round balls.

The fried cooked water-containing stone powder absorbs water quickly, and after a few minutes, the balls solidify and form, and the red ones are neatly placed together.

――This is Sun Yi's homemade "aspirin"!

Red pills are rich in stringin, which is slowly and steadily metabolized into salicylic acid in the human body, which is as effective as aspirin.

The main ingredient of aqueous stone powder is calcium sulfate, which is a food and drug additive in later generations, which is non-toxic and harmless.

The calcium ions in calcium sulfate also play a role in calcium supplementation, and red balls have invisibly become calcium tablets.

And the people of the Ming Dynasty just thought that water-bearing stone powder could dispel fire and detoxify, regardless of whether there was actually this curative effect or not, there was no harm.

As for the dosage of red pills, how many lycin are in one pill and how many pills should be taken at one time, no one knows.

――The only way to do this is to try slowly from less to more.

Sun Yi took a pill himself. With the water, he raised his neck and swallowed it in one gulp.

Later, Sun Yi explained to the Ming Dynasty the three major indications of this pill: analgesic, antipyretic, and anti-inflammatory, which is basically a cure for all diseases.

Sun handed over all the pills to Jiang Laojun and instructed Jiang Laojun to carefully observe the efficacy and pay attention to increasing or decreasing the dose.

At this time, Hu Donkey already firmly believed in Lidel's "grafting theory", the master grafted his belly, and also grafted his leg bones, as long as he wanted to grow like a crop, he would naturally recover.

Hu Donkey'er watched as Lord Lidel personally tested the alchemy for them.

When Jiang Laojun gave him a red elixir, Hu Donkey couldn't wait to swallow it in one bite.

Suddenly, Hu Donkey felt that the true qi in his abdomen was rising, and his vitality was surging!

-- This little life of his own, Lord Lidel has saved it alive!