Not long after, Wu Youke walked out with a group of doctors. Pen, fun, pavilion www. biquge。 info

These people were wearing black boots, white high-necked tight-fitting gowns, specially made by the Royal Weaving Bureau, with extremely thin and impermeable silk threads, mouth and nose wrapped in a face towel, white high hats on their heads, and a pair of white gloves on their hands, like warriors fighting death, giving people a sense of awe.

Then, immediately afterwards, a white four-wheeled carriage drove by, and as soon as the healers entered the carriage, the carriage whistled incessantly, and it left the First Royal Hospital at great speed.

As soon as the officials and the people heard the sound of the whistle, they all knew that there were critically ill people who needed to be rescued, so they consciously moved out of the way.

At the same time, the Ministry of Health's squire Lang Yuanyuan, who was still staying at the First Royal Hospital, immediately ordered: "Immediately take out the high-powered microscope, open the isolation laboratory, within ten meters, non-official subordinates are not allowed to approach!" ”

Saying that, this Zhang Xuan hurriedly put on the protective clothing he was wearing and Wu Youke was wearing the same protective clothing and ran to Zhu Youxiao: "Please also ask Your Majesty to return to the palace quickly, this is the place where evil qi is concentrated, if the illness is on Your Majesty, Weichen will be unable to escape the blame." ”

Zhu Youxiao also knew that he would hinder other people's work here, so he nodded and said: "It's okay, Wang Chengen, pass the decree, the matter of the Royal Academy of Engineering is postponed and shelved, go back to the palace first and immediately summon the cabinet and the officials of the six ministries and the imperial history into the Xinuan Pavilion to discuss matters!" ”

Seeing that His Majesty the Emperor Zhu Youxiao had left, Zhang Miao immediately entered the isolation laboratory, the high-powered microscope had been placed on the laboratory table, the petri dishes and glass test tubes boiled in boiling water had also been prepared, and lime had been sprinkled all around.

Not long after, a healer galloped in, escorted by several heavily loaded soldiers: "The germs have arrived!" ”

As soon as they heard this, all the medical staff of the First Royal Hospital rushed to make their debut like a great enemy.

After the doctor gave Zhang Xuan a small porcelain bottle, he was sent to a nearby observation room with the soldiers for quarantine observation, and after three hours he had to leave if he had no fever or diarrhea.

After Zhang Miao took the small porcelain vase, he immediately entered the laboratory, and then the iron door that was a foot thick was directly closed.

Zhang Xuan was the only one who smeared a patient's diarrhea on a glass slide, added Gram stain solution one after another, dried it with an alcohol lamp, and then placed it in a high-powered microscope for careful observation.

About two quarters of an hour later, Zhang Xuan ordered: "Immediately report, it is not the plague bacillus, it is Vibrio cholerae, report to the imperial court, and enter the first-level epidemic prevention state!" ”

With that, Zhang Xuan took off his mask, put all the specimens into a glass jar, added lime, stirred quickly, and then threw them into the brazier.

Although he was already sweating profusely from the heat, he could not go out yet, so he could only honestly enter another confined space, and said to the outside world through a microphone connected by a wire: "Deliver the news to Shuntianfu, the pathogen has been confirmed, the infected person needs to be confined to solitary confinement, and those who have contact with the infected person must also be isolated, if there is a dead person who cannot be hastily buried, it needs to be dealt with in accordance with the epidemic prevention regulations of the Ministry of Health!" ”

One of the people outside answered and immediately ran out.

……

At this time, the cabinet ministers and ministers were also summoned by Zhu Youxiao, and Zhu Youxiao did not beat around the bush, and said directly: "It is reported that the plague in Shanxi is likely to have spread to Beijing, and the epidemic has always been something that should not be underestimated. ”

Zhu Youjiao said, and Wang Chengen hurriedly ran in: "Your Majesty, I just got the news from the First Royal Hospital, and the epidemic just discovered is not plague but cholera. ”

"Cholera!" Zhu Youxiao couldn't help but stand up, he didn't expect that Daming would have such a virulent infectious disease at this time, because according to Zhu Youxiao's understanding, cholera should only appear in India and Bangladesh, that is, in the Indian Ocean, but why did it suddenly appear in the suburbs of Beijing?

Zhu Youxiao thought that if there was a plague in Daming, it would be nothing more than smallpox and plague, among which smallpox was a viral infection, the most predatory, and the most difficult to eliminate, but fortunately, now with cowpox technology, most of the people of Daming can be successfully immunized, and once people are successfully immunized, they will no longer get this infectious disease.

Of course, in general, this acquired immunity is not permanent, and the recipient will be immunized for life, and it will be time-sensitive for many people.

Because of this, Zhu Youxiao also specially ordered officials in all prefectures and counties to ensure that every newborn baby in the territory under their jurisdiction is successfully vaccinated and that every unvaccinated person is successfully vaccinated, and that the second vaccination must be carried out regularly.

As a result, smallpox did not cause a rampant situation in the Ming Dynasty, and the smallpox virus, which should have spread more and more widely over time, began to show signs of extinction.

As for the plague, which belongs to the bacterial infectious disease, its harm is not less than that of the smallpox virus, but fortunately, the biology of the Ming Dynasty has been greatly developed, especially with the improvement of glass manufacturing technology, after the microscope was manufactured, the microbiology of the Ming Dynasty has been changed from scratch, and now it has been able to screen out hundreds of strains, and it is mainly used in military and medical treatment.

For example, gas-producing bacteria that produce methane and hydrogen sulfide gas, penicillin-producing penicillin-producing strains and their derivative strains.

Although these strains of Daming have not been changed by ultraviolet light radiation or chemical methods to cause their genetic mutations, so as to screen out new strains with more powerful secondary metabolism, they can basically meet the needs of the entire Daming.

In other words, the current Ming Dynasty cannot directly create species by physical and chemical methods, but at least it can find valuable species from nature.

Of course, it may be that in the future, when the Ming Dynasty can fully use electricity or produce electricity, it can use mercury vapor and high-frequency electric shocks to produce ultraviolet lamps, and then it may be possible to improve Penicillium strains or other strains and produce more types of antibiotics.

You know, the secondary metabolite of Penicillium strain, Penicillium strain, is only bacteriostatic and does not have bactericidal effect, and it is thought that the pathogenic bacteria in the entire human body have not yet developed tolerance to this bacteriostatic so that only one unit of penicillin can also survive an adult in a more serious bacterial infection.

If it is plague, Zhu Youxiao can also reduce the source of infection and link it with the plague epidemic in Changzhi, Shanxi, and expand the epidemic control area, but now it is cholera, which shows that with the development of maritime trade and the introduction of a large number of foreign countries and their pets or other animals, new pathogenic bacteria have appeared in the Ming Dynasty.

In other words, although the degree of virulent infection of Vibrio cholerae is not as severe as the plague, because the immune system of the people of Daming is unfamiliar with this new pathogenic bacterium, this Vibrio cholerae will cause a large-scale spread.

This is also an inevitable drawback after the opening of the sea, it will not only bring wealth and foreign culture to Daming, but also bring biological invasion and ecosystem destruction to Daming, Zhu Youxiao even regretted that he should let the customs establish a quarantine bureau as soon as possible, of course, this kind of thing can not be avoided sometimes.

"Spread my decree, all the foreign people who have recently come to Daming are not allowed to leave their current location, and order the officials in various places to immediately control their freedom of life, if there are no obvious symptoms of diarrhea or fever, they will be allowed to move freely, especially in the area of Beijing, not only the outer fan but also everyone is not allowed to leave the city, and those who have no obvious symptoms will be allowed to go after three days!"

As soon as Zhu Youxiao's decree was announced, he immediately ordered Yang Sichang, who was the governor of the Beijing camp, to mobilize the Beijing camp to assist the Shuntian Mansion in handling the matter, and at the same time ordered the Ministry of Engineering to immediately go to the place where the epidemic occurred to build a simple isolation area.

A large number of Chinese herbal medicines with antibacterial effects that had been hoarded in the past were also immediately distributed, and the fermentation production workshop of the Royal Industries Company was also required to increase the fermentation tanks for penicillin fermentation production.

Fortunately, because of the occurrence of plague in Shanxi, the Royal Industries Company has long been ready to put into production at any time, but despite this, it is impossible to produce a large amount of penicillin in the early stage, after all, the strain in a new medium is to go through a period of adaptation and rapid growth, only after the end of the rapid growth period will there be a large number of mature strains for secondary metabolism, not to mention that now the fermentation technology of Daming does not have constant temperature automatic control and computer monitoring at any time, so the cultivation of production bacteria is quite difficult.

But there is also a thing to be thankful for is that Daming's fermentation technology has mastered the factors that affect secondary metabolism such as the optimal carbon-nitrogen ratio summarized by later generations over several generations.

In other words, in the early stage, the only way to curb the spread of cholera is to cut off the source and route of transmission, which is of course the most effective way.

At this time, the Ming Dynasty did not need Wu You's response to the plague after the outbreak of the epidemic in large quantities, so he was able to quickly use administrative means to cut off the source of infection and the route of transmission. 、

The natural way to cut off the source of infection is isolation, and the patient is isolated from the person who is released from the patient, and this link can almost eliminate most of the pathogenic bacteria and prevent them from spreading to other organisms.

Of course, sometimes it is inevitable that there will be fish that slip through the net, or there are individual people with special genes who have natural immunity to this new pathogen or their autoimmune ability is indeed too strong, resulting in them being only pathogen carriers for a long time without symptoms.

At present, Daming has not been able to conduct antibody marker testing on pathogen contacts through biochemical indicators through medical testing tests, so there is no way to find out these carriers, so the only way to rely on the second link is to cut off the transmission route.

Although Vibrio cholerae is a new pathogen, its properties and characteristics have been mastered by the medical community, so it is easy to control its transmission route.

As a virulent infectious bacterium of the digestive tract, the transmission route and medium are naturally not airborne and human excrement and food and water are transmitted, therefore, the entire capital has also begun a large-scale rational disinfection work, fortunately, the city management has been improved, human and animal excrement has long been unified management, and now it is not difficult to sprinkle lime for strict disinfection.

The food and water were also strictly managed, and Zhu Youxiao personally issued a holy decree ordering that everyone in the capital should not eat any raw food or drink any raw water within half a month, and all food and water must be boiled at high temperatures.

Of course, because of this, it still caused panic among the people in the capital, because the transmission of the holy decree made many people think that the food was not clean, which caused a large number of restaurants to have their incomes plummeted or even closed down, and the prices of various foods also fell seriously, resulting in a large number of unsalable grains.

As a result, the imperial court's tax revenue also fell sharply, and the income of the Royal Bank also declined.

But at the same time, the price of various drugs has begun to soar, in this era when antibiotics are only a small amount or rely on Chinese herbal medicine to treat diseases, the frequency of various miracle drugs is higher, not to mention that at this time the Ming Dynasty also has an unprecedentedly developed media communication ability, when a famous imperial doctor said that Huoxiang or Banxia, Poria cocos and so on have an excellent effect on this kind of cholera or have a strong preventive effect, suddenly a large number of people to buy such medicinal materials in large quantities.

For a time, all kinds of "Chinese miracle medicines" appeared in newspapers and periodicals, and the prices of many ordinary Chinese medicinal materials that were originally low cost soared, and many of them even directly exceeded the prices of ginseng, Ganoderma lucidum, Panax notoginseng and other precious medicinal materials.

Of course, there are many people who take this opportunity to hoard, many people take out a large amount of savings to buy medicinal materials, the simple-minded may be to buy medicinal materials to survive, and the long-minded may want to take advantage of this to make a windfall, in short, the savings of the Royal Bank began to appear to be exhausted.

Before a large-scale outbreak of Vibrio cholerae began, it had already begun to shake the economic foundation of the entire capital and even the entire Ming Dynasty.

"Appoint Sun Chuanting as the governor of Shanxi 0, supervise the military affairs of Shanxi, and strictly prevent the spread of plague in the Changzhi area of Shanxi, and order Zhang Xuan to go to Shanxi immediately to assist Sun Chuanting, and tell Sun Chuanting to directly crack down on the Jin merchants who intend to hoard medicinal materials, and be sure to eliminate the plague in the area, so that it does not spread to the capital, making the capital even more panicked!"

Saying that, Zhu Youxiao ordered again: "For the capital, the East Factory secretly investigated, who called this hoarding of medicinal materials, and at the same time ordered the imperial pharmacy to sell the medicinal materials at the usual price over the years, it is necessary to curb this unhealthy trend, at the same time, the Royal Industrial Company further reduced the price of newly produced drugs, and its loss profits were filled by the state treasury, and if the treasury was not enough, it would be filled by the internal funds, in short, not because of a small cholera to directly drag down the economy of my Ming Dynasty!" ”

At this time, Zhu Youxiao desperately used his power as an emperor to administratively intervene in the fluctuations of the entire market caused by cholera, and tried his best to minimize the economic losses of the Ming Dynasty, so as to achieve the goal of surviving this difficulty as soon as possible, and leaving more capital for the future elimination of Lin Dan Khan and the battle against the Rakshasa Kingdom.