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Because our army in Shandong has captured Tianjin, occupied Qingdao and Jinan twice, and seized a large number of various industrial equipment, the pharmaceutical factory of the logistics headquarters of the Shandong Military Region, located in the depths of the Taiyi Mountains, is well-equipped and has a large number of talented people, and has a western medicine department, a Chinese medicine department, a materials department, a manufacturing department, a laboratory, a warehouse, and other departments; in addition to producing penicillin, which is an extremely precious medicine, it can also produce more than 40 kinds of injections, tablets, and more than 20 kinds of Chinese patent medicines such as pills, powders, ointments, and pills, as well as alcohol, baking soda, cotton wool, gauze, and so on, in addition to meeting the needs of our army in Shandong. It also undertakes the task of providing medicine supplies to our army in northern Jiangsu, southern Hebei, and central Hebei. In particular, the vaccinia vaccine successfully developed by the Xinhua Pharmaceutical Factory relieved the pain of smallpox in the Shandong base area after inoculating the children in the Shandong base area, and was well received by the masses in the base area.

After Liu Yimin arrived at the pharmaceutical factory, he listened to the reports of Li Weizhen, director of the pharmaceutical factory, and Liu Renbao, political commissar. When he heard that Cheng Wenzang, a pharmacist at a pharmaceutical factory, and Hu Jiamo, a chemist, were developing an inactivated cholera vaccine and a live attenuated vaccine against plague under the guidance of Chen Tong and American doctors, Liu Yimin was very excited.

Cheng Wenzang said in his speech that as early as 1883, scientists had isolated Vibrio cholerae, and immediately began to develop non-oral inactivated cholera vaccines, and in 1884, clinical trials were carried out in cholera-endemic areas in Spain, and the incidence of the inoculation group was significantly reduced. In the twenties, when a massive cholera epidemic broke out in India, inactivated cholera vaccines were used on a large scale, with an efficacy rate of 80%. Our army has seized a small amount of vaccines in Tianjin, Jinan, and Qingdao, and the pharmaceutical factory is in trial production through experimental analysis, and is in the stage of cultivation and proliferation of pathogens.

As for the live attenuated plague vaccines, Cheng Wenzang said that they had been used abroad since 1908, but due to repeated wars in our army, pharmaceutical factories often interrupted production and could not develop them. Now that the plague had appeared in the base area, they began to develop it.

Liu Yimin knew that he was not good at learning, and when he looked at the information before the crossing, he always thought that streptomycin did not appear at this time, and the plague vaccine would not appear, in fact, there was already such a thing.

Liu Yimin had precious time, so he indirectly led a few people to the laboratory to check it out, and felt that the development steps of the cholera extinguishing vaccine were the same as those he recalled, and the pathogen could completely lose its infectivity after inactivation and purification, and almost all the components of the pathogen could be retained, so as to produce a cholera inactivated vaccine with better epidemic prevention.

Because of his experience in guiding the development of penicillin, Liu Yimin is full of confidence in the successful development of streptomycin. However, he did not study medicine, and the reason why he was able to guide the development of penicillin was because penicillin was too famous, and there was a lot of information on the Internet in later generations. Streptomycin is not only a specific drug for the treatment of plague, but also a specific drug for the treatment of tuberculosis, and there is a lot of information on the Internet, but there is definitely not as much information as penicillin. Moreover, in order to disguise his identity as a traverser, it is impossible for him to indirectly tell the process of industrial production of streptomycin in later generations, so he can only lead Cheng Wenzang and Hu Jiamo to start with the pathological analysis of Y. pestis and try to extract Streptomyces step by step.

After the pathological analysis of Yersinia pestis, the bactericidal experiment was carried out with penicillin. In this experiment, Cheng Wenzang and Hu Jiamo discovered that the principle of penicillin sterilization is to "attack" the cell wall of the germ, resulting in its defect, so that the germ can obtain a protective barrier, and then rupture and die. However, Yersinia pestis is special in that in addition to the protection of the cell wall, there is also a capsule composed of polysaccharides on the periphery, which seems to put a layer of armor on Yersinia pestis. In this way, penicillin is not enough against Yersinia pestis.

Liu Yimin said his idea, that is, to develop an antibiotic with similar properties to penicillin, and the target of action is the ribosome of the plague bacterium, and the role of this organelle in bacteria is a protein processing plant, and the proteins necessary for the growth and reproduction of bacteria are produced by this processing plant. After the antibiotic occupied and destroyed the processing plant, the germs were like a poisonous snake that had been choked by seven inches, and there was no other way but to die obediently.

The most important thing to do is to have the right way of thinking.

You know, the inventor of streptomycin, Waxman, discovered Streptomyces as early as 1915 when he was in college, and at this time he was still leading dozens of students in the laboratory to study how to isolate a new species of Streptomyces that is less virulent!

Strictly speaking, Liu Yimin's practice is a very immoral plagiarism. However, in order to fight devils, it is not impossible to borrow the wisdom and hard work of predecessors. In the words of later generations, that is the golden finger of the start!

All the technicians of the pharmaceutical factory were mobilized, and under the guidance of Liu Yimin, Streptomyces was successfully detected from the soil microorganisms. After nearly a month of hard work, a species of Streptomyces that can inhibit Mycobacterium tuberculosis was successfully isolated from the soil and the throat of chickens. The new antibiotic streptomycin was secretly born in the pharmaceutical factory of the Logistics Department of the Shandong Military Region of the Eighth Route Army.

Liu Yimin couldn't suppress his joy, and couldn't wait to guide Cheng Wenzang and Hu Jiamo to extract streptomycin from the nutrient solution by activated carbon adsorption, dissolution, and precipitation, and ordered them to be sent to the field hospital for clinical trials.

Liu Yimin locked himself in the laboratory of the pharmaceutical factory to guide the manufacture of streptomycin, Tada Jun was not idle in Beiping, the Japanese army kept dropping plague bacilli in various parts of Shandong, and the Eighth Route Army was unable to defend against it. In more than a month, the plague spread in Shandong, and there was a phenomenon of the death of every household in a village. Although the troops were better, the number of infected people with the plague was increasing, and the battalion was full of wounds. Luo Ronghuan, who was in charge of the work, and Chen Tong, who was in charge of epidemic prevention, were so anxious that their heads were big.

may have felt that the toss was almost over, and the combat effectiveness of the Eighth Route Army must have dropped significantly, and Tada Jun once again mobilized his troops to attack Jiaoji Road.

This time, Tada Jun learned well, he used the North China Public Security Army as the main force, a Japanese army division commanded a North China Public Security Army group, and concentrated the second and third divisions of the chariot to use, once again formed a steel torrent, starting from Zhangqiu, attacking eastward. Luo Ronghuan and Cai Zhong commanded the troops to fight and retreat, resisting step by step, the Japanese army reoccupied Jiaoji Road, the 11th Division took over the defense of the original 32nd Division, and resumed the situation of heavy siege in central and southern Lu.

The situation of the Japanese army's reoccupation of Jiaoji Road, Luo Ronghuan and Cai Zhong sent several telegrams a day to Liu Yimin to inform him, and he naturally knew about it. It's just that the Japanese army's reoccupation of Jiaoji Road itself was expected by Liu Yimin, who had already made up his mind to eliminate as many elite Japanese troops as possible in Shandong and lay the foundation for the northeast to enter the northeast, and he didn't care about the Japanese army's reoccupation of Jiaoji Road at all, so he calmed down and buried himself in guiding the pharmaceutical factory to develop streptomycin.

As soon as the streptomycin sent by the pharmaceutical factory arrived, Chen Tong used it on the soldiers infected with the plague. This use is really immediate. Xide Chen Tong indirectly sent a telegram to Liu Yimin, saying that the new drug was symptomatic and had remarkable efficacy, and suggested that the commander order the pharmaceutical factory to produce it at full capacity!

At this time, Liu Yimin put his heart in his stomach, and simply sat in a pharmaceutical factory to guide the development of cholera vaccine and plague attenuated active vaccine.

After waiting until December, it was snowing heavily, and the two vaccines were successfully developed, Liu Yimin took the lead in vaccination, and notified the reporter of the "Dazhong Daily" to rush to the pharmaceutical factory and take a photo of his vaccination, so as to publicize and encourage the villagers in the base area to actively get vaccinated.

With streptomycin and vaccines, he was not afraid of the little devils fighting bacteriological warfare, so Liu Yimin rushed back to the Shandong Military Region Headquarters of the Eighth Route Army in Dadian with confidence.

As soon as Luo Ronghuan saw him, he said that there had been a major personnel change within the Japanese army, and that Prince Zaihito of the Imperial Palace, Lieutenant General Shigeru Sawada, deputy chief of staff, Major General Kyoji Tominaga, chief of operations, Lieutenant General Toshiyoshi Ando, commander of the South China Front, and Akito Nakamura, commander of the 5th Division, had all been dismissed, suspected of having something to do with the Japanese army's occupation of Vietnam. Sugiyama veteran Devil became chief of staff, Lieutenant General Tsukada became deputy chief of staff, Major General Tanaka Shinichi, chief of staff of the Mongolian Army, was appointed chief of operations, Lieutenant General Harem Jun was appointed commander of the South China Front, and Lieutenant General Matsui Taikuro was appointed commander of the 5th Division.

When Liu Yimin heard this, he said: "On the surface, it seems that the Japanese Fifth Division attacked northern Vietnam by force, which went against the original intention of the Japanese army to enter Vietnam peacefully as negotiated between the Japanese government and the French Vichy government. Emperor Hirohito was afraid that in the event of an unfavorable war, Prince Zaihito of the Imperial Palace would come to the trial seat to protect him, so he dismissed him from his post. The old devil of Shanshan didn't know whether he was alive or dead, and he regarded the hot potato as a fragrant dumpling. It seems that this Tada Jun is really a stupid marshal! ”

When Cai Zhong heard this, he said, "That's right! It is said that Terauchi Shouichi, Sugi Sugimoto, and Tada Jun have lost so many battles, not to mention that they have been dismissed, but it is normal to be shot several times. But Emperor Hirohito, the son of a turtle, did not remove them from their posts, and they were still singing on stage one by one! ”

Luo Ronghuan then reviewed, saying that the defensive operation of Jiaoji Road was not good, allowing the Japanese army to reoccupy Jiaoji Road, which led to a great reduction in the results of the Ludong War. Moreover, due to the large-scale bacteriological warfare of the Japanese army, the combat effectiveness of the troops has declined, the casualties have increased, and it is impossible to restore the combat effectiveness without a few months of rest and replenishment.

Liu Yimin said with a smile: "There is no need to review this, no one would have imagined that the Japanese army would continue to carry out bacteriological warfare on a large scale." However, I am not afraid in the future. With streptomycin and vaccines, it will be ineffective for little devils to engage in germ warfare. Moreover, we still have retaliatory measures, Li Lingfeng, didn't they go to the nest of the Japanese army's bacteriological troops? Next, it's time for Tada Jun to cry! ”

Cai Zhong then said in his speech that the New Fourth Army won the Battle of Huangqiao and eliminated Han Deqin's main force. Now, annoyed by Chiang Kai-shek, ordered the headquarters of the New Fourth Army to move north. The Central Committee is fighting a war of words with Chiang Kai-shek!

Liu Yimin was anxious when he heard this, and hurriedly asked Cai Zhong to bring all the telegrams from the Central Committee and the headquarters during this time, and he wanted to read them.