Upload new books, ask for collections, ask for recommendations

At noon the next day, at Countess Isabel. Deneuve rode in a carriage to London with Dr. Blomstein. On the third floor of Deneuve's clothing store on Dover Street in London, Heroin has been successfully synthesized.

"Jason, these are ......" looked at two glass test cups with pale yellow and pale tachish brown blocks, and Roman was dressed in a bare-yellow skirt with a bare chest. Duran frowned slightly, and he was followed by the little French tailor, with an expectant expression on his face.

"This is morphine," Zhu Jishi said, pointing to the pale yellow powder, "This is extracted from opium, and its medicinal effect is several times that of opium, and it was successfully isolated from opium as early as 1806 by the German pharmacist Zetuna." However, this morphine is not ordinary morphine, but the hydrochloride of morphine, which has been further refined and synthesized, and its medicinal effect is 10 times that of opium. ”

"It's 10 times more than opium!" Madame Duran couldn't help but exclaim, and she said a bunch of French to the young man next to her, who immediately stared at the glass in Zhu Jishi's hand.

Zhu Jishi glanced at this kid who looked like Sven, and said in his heart: "This guy's big smoking addiction is estimated to be not small, it seems that there is still a market for the abuse of H loin in Europe!" However, thinking that most of the people who smoke big cigarettes here in Britain seem to be working people who don't have much money, Dr. Zhu's brows tightened.

"Jason, what's wrong?" Roman sneered, "Are you worried that Henry is in danger?" ”

Zhu Jishi shook his head, took another test cup with a gray-brown lump and said, "Wait a minute, and then look at this, this is Eryi Xian morphine!" This is my invention (Dr. Zhu is becoming more and more shameless now), and the medicinal effect is three to five times that of morphine hydrochloride! He paused, glanced at Mrs. Duran, and added: "Theoretically, it can be five times, but that refers to the high-purity diethyl morphine, and the purity of diethyl morphine in this test cup is not high, so the medicinal effect is not so strong, but it is still stronger than ordinary morphine hydrochloride." ”

Later generations of H heroin were also divided into No. 1, No. 2, No. 3 and No. 4 according to their purity. Zhu Jishi still can't make the high-purity H heroin of "No. 4", and the test cup in front of him contains "No. 2 H Loin", which is crude Diyi X morphine. Because the reaction between morphine hydrochloride and diethyl X is not sufficient, and the morphine hydrochloride refined by Zhu Jishi for the first time does not reach the highest purity, the purity of the further obtained diethylX morphine is only 30% at most, and the rest are morphine and various impurities.

"But...... How does this work? Madame Duran picked up a gray-brown lump and asked Zhu Jishi, "You won't let Henry swallow it directly, will you?" ”

"You can't swallow it, you can't swallow it that much, you will die if you take so many drugs!" Zhu Jishi waved his hand hurriedly, but then he was stunned.

You must know that Zhu Jishi, who made drugs in 1842, is a good boy in the 21st century! H Heroin, a drug, let alone manufactured, has never even seen it, and of course does not know how to use it - alas, this lesson is quite profound! A good young man of the 21st century Celestial Empire, who was born in New China and grew up under the red flag, stayed in Britain under the dictatorship of the bourgeoisie for less than two months, and actually engaged in such an evil deed as making drugs! It seems that the capitalist system is really very awesome in corroding people's hearts......

After condemning the evil capitalist system in his heart, Zhu Jishi still didn't figure out how to use such a whole piece of Erethyl X morphine. Zuihou had no choice but to take out a little powdered morphine hydrochloride, and then pinched it together with a small piece of opium paste and handed it to Mrs. Duran, who was eager to try it. Still a little uneasy, he instructed again: "Let Henry take small sips, but don't smoke them all at once." Speaking of this, he shook his head again, "Forget it, I'll watch him suck!" ”

"Well, Haode, let's go downstairs and try it." Madame Durán took the small piece of opium paste mixed with a little morphine hydrochloride and handed it to Henry, who flew down to the second floor and into his room, followed by Zhu Jishi. This room is very clean, the windows are bright and clean, and Zhu Jishi's messy kennel is simply the same thing, it seems that this French kid is not addicted to big cigarettes.

Henry took out a smoking gun from a drawer in a small cabinet and skillfully filled it with opium, but instead of using a cigarette lamp, he lit a candle and used it to light the opium smoke.

"Oh, God! This thing is so exciting! It's really a fairy medicine, I'm about to become an immortal, God, thank you for letting such a miraculous medicine come to the world, it's amazing......"

After a few puffs of cigarettes, this young man began to talk nonsense, although Zhu Jishi couldn't understand a mouthful of French, but seeing this kid's performance, he finally let go of his slightly hanging heart, he knew that his drug-making experiment had been successful, so he began to think about Jihua who would open a pharmacy next in his heart.

The most important thing is, of course, to apply for a patent.

The patent of diethyl X morphine must be won, but there is more than one patent that can be applied for. Through this period of time, Zhu Jishi knew that the most advanced pharmaceutical JISHU in Europe was still at the point of extracting alkaloids from plants. Morphine, for example, is extracted from opium. However, it seems that the jishu that further chemically treated these alkaloids has not yet appeared, so morphine and berberine in this era are directly oralized, and the effect is very unsatisfactory. Therefore, you can also apply for chemical synthetics made from alkaloids, such as diethyl X morphine, morphine hydrochloride, berberine hydrochloride, etc. Compared with direct oral alkaloids, the efficacy of chemical compounds that have been further processed and purified is significantly better, and they are also easy to make into injections for injection.

This is not a small step forward. Taking berberine hydrochloride as an example, this drug, which was called berberine by later Chinese, is actually a broad-spectrum antibacterial drug, which has antibacterial effect on hemolytic streptococcus, Staphylococcus aureus, gonorrhoea and Freund's and Shigel's dysentery bacillus, and has enhanced leukocyte phagocytosis, and also has different degrees of inhibitory effect on Mycobacterium tuberculosis and plague bacteria, and also has inhibitory effects on amoebic bacteria.

Of course, the antibacterial effect of berberine cannot be compared with most antibiotics in later generations. However, in the current era when there are no antibiotics that can be used, it is not too much to say that berberine is a "miracle drug"! In later generations of Chinese medicine for the treatment of tuberculosis, berberine was used in large doses. In the 50s, many hospitals in Chinese mainland even used berberine to cure tuberculosis patients - the effect of course can not be compared with streptomycin, but it can cure a handful, but also prolong the life of most tuberculosis patients, plus the addition of diethyl X morphine tuberculosis syrup, can make some rich tuberculosis patients more comfortable to survive.

Zhu Jishi estimated that as long as he has the patents of berberine hydrochloride, morphine hydrochloride, and diethyl X morphine, and then launches "special" patented drugs for the treatment of common diseases such as tuberculosis, cholera, and colds on the basis of them, he should be able to make a lot of money in this era.

As for antibiotics such as penicillin and streptomycin, Dr. Zhu also plans to secretly get some out of the laboratory for later use. However, mass production is exempt, and the level of the chemical industry in this era is too poor, and it is impossible to industrialize the production of penicillin and streptomycin on a large scale. And with berberine, which is very easy to produce, Zhu Jishi weishenme still has to engage in complex penicillin and streptomycin?

His purpose in opening a pharmacy is not really to benefit mankind, but to represent the Chinese people and earn back the silver lost in the Opium War!

Zhu Jishi, who studied basic medicine for more than 6 years in later generations, has a clear idea of how to make money with medicines. A drug with remarkable effects may not be more profitable than a drug with very ordinary or even inconspicuous effects -- because if the patient is cured all at once, the drug business will not be able to continue? If one day a miracle medicine is really invented, most of the pharmaceutical factories on the earth will have to go out of business, and most of the doctors will probably lose their jobs!

So on this shijie, drugs that are effective but difficult to really cure diseases are often more profitable than good medicines that cure diseases. Morphine hydrochloride, diethyl X, and berberine morphine obviously meet such conditions.

The first two are only symptoms but very addictive narcotics, while the latter, although broad-spectrum antimicrobials, only have a specific effect in the treatment of diarrhea. Berberine oral absorption is very poor, can only act on the gastrointestinal tract, if the time of residence in human tissues after subcutaneous injection is relatively short, must be injected in large doses, in order to have a certain effect on cholera, typhoid, diphtheria, puerperal fever, scarlet fever, dysentery and tuberculosis and other diseases. Therefore, in Zhu Jishi's jihua, berberine hydrochloride will be a drug with great sales, and because Zhu Jishi will have the patent for the drug, and it is the only effective antibacterial drug in this era, the price will definitely not be low...... Hehe, inventing penicillin and streptomycin to slaughter the white people of this era is not a skill, if you can use berberine to deceive millions of pounds, you can be worthy of the years of cultivation of the medical school of the Celestial Dynasty in the future!