021 - End of Experiment

Time flies like a white horse, whether it is leisure or busy, it can pass quickly without people's inadvertentness.

In the blink of an eye, the New Year has passed, and the time has come to the year 2221 of the Earth Federation.

Although the school has not yet started, many graduate school entrance examination parties have already returned to school early.

With the return of students, the originally deserted campus has become lively again.

However, in the past month, Chen Chen's trio has been in the dark and need to work in the laboratory for more than ten hours a day.

Every morning I eat breakfast at 8 o'clock in the morning, enter the laboratory at 9 o'clock, except for the lunch at noon, I will go out of the laboratory for lunch, and then come out after 9 o'clock in the evening.

Sometimes they were so tired that Chen Chen and Wang Wei didn't go back to school and went straight to the lounge for a night.

Xia Yin's work is more logistical, such as buying food, delivering water, and taking care of experimental animals, which is much easier than the two of them.

With three days left after leaving school, the last batch of eggs and cells were finally born with cloned cubs, and the preliminary work of the experiment was successfully completed.

So, Chen Chen divided the cloned mice into three groups.

The first group was the brain injury model group, which was divided into two teams: AB.

Among them, Team A will be treated with artificially cultivated autologous stem cells, and Team B will be treated with cloned autologous stem cells, with the number of each of the two teams being four.

The second group is the spinal injury model group, as above, Team A is treated with artificially cultivated autologous stem cells, and Team B is treated with clonal autologous stem cells, with four animals in each of the two teams.

The third group was the most numerous, with a total of 20 individuals, all of which were specially selected for the elderly SD rats, which were used to rebuild the immune system.

All of the mice in this group have been cloned and have cloned stem cells corresponding to their own.

They will be used in the form of radiotherapy and chemotherapy to kill most of the hematopoietic stem cells and mesenchymal stem cells in the body, and then inject the clonal stem cells to test whether they will regain their youthfulness.

This is also known as a bone marrow transplant.

As for why there are so many third groups?

That's because just the process of chemoradiotherapy can kill and injure most of these mice.

Radiotherapy and chemotherapy are treatments that use radiation and chemical agents to kill clusters of cancer cells in a certain part of a patient's body.

However, this treatment method has always hurt the enemy and self-harmed, after all, while killing the cancer cells, the normal cells in the patient's body will also be overwhelmed.

This is why patients undergoing chemotherapy and radiotherapy have hair loss.

In fact, many patients with advanced cancer do not die from the spread of cancer cells, but from the chemotherapy process that destroys the patient's body, which has to be said to be a tragedy.

Since the official discovery of cancer in 1911, mankind's war against cancer has been going on for hundreds of years.

In this protracted war, human beings have gone from being helpless against cancer, to the radiotherapy and chemotherapy that appeared later, and then to the various targeted drugs that have now been used, and have gradually regained the lost life position.

The advent of bone marrow transplantation as a treatment marked the first victory in the war between mankind and cancer.

This victory will continue until one day in the future, when humanity will completely defeat the disease of cancer and let cancer disappear from the human race.

It's like smallpox back then.

Of course, not every bone marrow transplant will be successful.

Today, the success rate of bone marrow transplantation, which is clinically recognized by the medical community, for the treatment of leukemia is only 60%.

Of these 60 percent, half of the patients will relapse after six months.

Therefore, bone marrow transplantation is still a journey full of thorns in the fight between human beings and diseases.

If there is an improper operation in the intermediate link, resulting in the death of all these mice, it is equivalent to a month of manpower and material resources have been wasted.

After all, even the body is gone, so what is the use of these corresponding clonal stem cells?

Therefore, in order to accumulate experience in radiotherapy and chemotherapy for mice, Chen Chen deliberately took other mice to test the waters.

It's just that rats are different from humans after all, and these chemotherapy methods are still too intense for mice, and Chen Chen can only guarantee a survival rate of 40%.

However, with the birth of the last batch of cloned rats, the preliminary preparations for Chen Chen's three experiments were finally completed.

Next, it's time for the official experimentation period.

Another five days have passed, and it is officially the day of school.

Chen Chen and the others submitted an application to the school to delay their return to school, and continued to stay in the laboratory day and night.

At the same time, with the use of stem cell treatment, both the first and second groups began to show signs of recovery.

The third group is in a bad situation, out of 20 SD rats, five have died, and the remaining rats are still alive, but they are also dying, and even no longer eat.

Two days later, the chemotherapy was completely overwhelmed, and some of the rats that were already dying were completely overwhelmed, and eight or nine died in succession, leaving only six alive.

But six is enough.

Chen Chen now only hopes that two or three of the six can only hold out until the end of the experiment.

In this tense atmosphere, another month and a half passed.

The three-month trial period that had been planned has finally come to an end.

At this moment, the three of them gathered in front of a group of guinea pigs, and everyone had an excited look on their faces.

"Final Result Verification ......"

Chen Chen said into the recorder, "The number of Team A of the first group of brain injury model groups is 3, the survival is 3, and the degree of healing: No. 1 is better, No. 2 is significantly better, and No. 3 is slightly better......"

"The number of B team in the first group of brain injury model group is 3, survival is 3, and the degree of healing: No. 1 has significantly improved, No. 2 has significantly improved, and No. 3 has significantly improved."

"Summary: The cure effect of group A cultivated with artificial stem cells is significantly worse than that of group B using cloned autologous stem cells."

"The second group of spinal injury model group A has a team of 4...... The number of Team B is 4, as above, both in terms of recovery speed and effect: Team A is inferior to Team B. ”

"In the third group of experiments, 3 animals survived in the end, and the fundamental CT showed that the physical functions of the subjects who were already in a state of aging were greatly enhanced in all aspects......

"I really didn't expect that the three experiments were really successful!"

Wang Wei patted Chen Chen's shoulder excitedly, "In other words, the cloned young stem cells are far more effective than the artificially cultivated autologous stem cells?" ”

"Moreover, the third set of experiments also showed that the replacement of bone marrow can really make people rejuvenate?"

Xia Yin also muttered in a low voice, with a look of disbelief, "Chen Chen, we're going to be famous......"

Although Chen Chen was also smiling, his eyes were very calm, "I will write two papers next, as I said before, Xia Yin's first work, Viagra Second work, and my corresponding author, there is no problem, right?" ”

"No, I'm stained with the light of the two of you, if it weren't for you in Chenzi, the experiment wouldn't have gone so smoothly."

Wang Wei looked calm, and suddenly wondered, "By the way, why are there two articles?" Isn't it three experiments in three groups? ”

"One article is about the difference between the efficacy of artificially cultivated stem cells and cloned autologous stem cells on the human body, and this article automatically covers the first and second sets of experiments."

Chen Chen explained, "The other one is the experiment of bone marrow transplantation. ”

"Also, the first group and the second group are put together, which is more convincing."

Xia Yin smiled and nodded, "What about the submission?" Definitely vote for a zone, right? ”

"Of course, the first of these two research results may be a bit suspenseful, but the second one is definitely no problem to invest in one area."

Hearing this, Xia Yin and Wang Wei cheered again.

"Which journal are you going to apply to?" Xia Yin asked.

"There are only a few TOP journals in the field of biology, of course, I voted for "Cell"!"

Wang Wei replied first, "Didn't your mentor teach you?" The shorter the journal name, the better it is! ”

"Cell", also known as "Cell", is a journal about the latest research discoveries in the field of life sciences, and it is undoubtedly the TOP in the field of biology.

People engaged in scientific research often say "CNS papers", and CNS here is the abbreviation of the three top journals of "Cell", "Nature" and "Science", and no one will not be proud to be able to publish papers in these three journals.

Chen Chen looked at the two of them who were extremely excited, and said with a smile, "Viagra is right, it must be voted for "Cell", after all, it is faith." ”