213 - Novel chimeric virus

For the next few days, Chen Chen did not leave the Spire Experimental Base.

The management of the Life Science City, Chen Chen simply handed it over to Cheng Chao, although Cheng Chao didn't know how to manage the city, but after all, with the help of Xiao X, nothing would go wrong.

Chen Chen, on the other hand, stayed in the laboratory, studying the Ancestral Virus with Hannibal and others.

Because Archaeopteryx is not perfect, although it has the ability to evolve life, the probability is extremely low, the lethality rate is extremely high, and the nature is unstable.

They want to upgrade the progenitor virus and transform it into a virus with a more stable nature and stronger evolutionary ability.

And this path, the Resident Evil plane has been paved for Chen Chen.

The Umbrella Company has spent more than a decade researching Archaeopteryx and finally found the brightest path - to merge some genes of Archaeopteryx and leeches together to form a completely new virus.

As an ancient annelid, leeches have superior environmental tolerance and adaptability, and the transcriptases of the two are homologous, and the adaptability of the progenitor virus can be enhanced by leech genes to improve the stability of the virus.

With all kinds of data from the Hive Laboratory, Chen Chen didn't need any new attempts, as long as he used those instruments from the Resident Evil Plane and used the methods that had already been successfully explored to chimerize the two genes together.

At this time, in the fourth-level laboratory, more than a dozen researchers wearing protective suits came and went, constantly busy.

"The fourth attempt is underway......"

A projector in the center of the lab projects an image from a microinjector.

In the translucent petri dish environment, a fixed straw is adsorbing a fist-sized blister, the blister is translucent, and you can faintly see a thin film on the outside, as well as various small particles and other strangely shaped substances inside.

And as the straw slowly moves forward with the blister, a transparent needle also appears in the frame.

Then, the two sides approached, and then the needle gently pierced the membrane, little by little, into the blister.

Finally, a few drops of a light blue substance are injected into the blister.

Chen Chen silently watched the operation on the screen, although it seemed that the picture on the screen was huge, but anything in the picture was smaller than the tip of a needle in reality.

For example, the blister, which is the fertilized egg of a leech, is only a few microns in diameter, and the smaller ICSI injection needle is only about 0.1 microns in diameter.

Through the implantation of this infection, coupled with the assistance of some chemical agents, the new leeches have the characteristics of the progenitor virus.

This is a heterophenotypic chimera.

After several complex processes such as reproduction, the virus is finally extracted from the leech.

After several failed attempts, the experiment was finally successful when the genes of the Archaeopteryx and leeches were completely chimeric to form a new viral substance.

"It has been extracted, and the genetically recombinant virus exhibits unique properties......"

In the laboratory, Hannibal took out a test tube from a low-speed centrifuge, sucked out all the liquid separated from it, and injected it into a test tube.

Suddenly, a blue liquid appeared in front of everyone's eyes.

"Don't be too optimistic, let's see the effect first."

Li Lei on the side urged.

"Okay." Hannibal personally walked to the side of the table, sucked up 0.1 ml of liquid from the test tube, and at the same time grabbed an SPF mouse from the cage and injected the virus into it.

"Squeak!"

The little mouse let out a scream of pain.

However, no one here took pity on it, and after injecting the virus, Hannibal put the mice back in the cage, and then took out the other mice in turn and injected them one by one.

Hannibal divided the animals into several groups, each given a different dose.

After doing all this, Hannibal looked at the time and said, "It's twenty-two thirty o'clock, and according to the information, it will take about three hours to take effect." ”

The assistant on the side hurriedly pointed an experimental recorder at this side to record the scenes of these mice infected with the virus.

At first, though, the injected mice seemed perfectly normal, and nothing happened.

But as time passed, after half an hour, the mice began to show a hint of restlessness, and the mice kept crawling around as if some predator was threatening them.

Then, for the next hour, the mice in each cage squeaked, and the higher the dose, the more painful it became.

After two hours, the mouse with the highest injection dose changed its usual docility and began to hit the cage wall, banging incessantly, while the mouse itself showed no signs of pain.

After two and a half hours, all the mice were extremely aggressive, constantly banging the cage and trying to break out.

But as it bumped into it, it slowed down and slowed down, and finally curled up in a ball, not knowing whether it was dead or fainted.

Three hours later, all the mice woke up again, but by this time they had returned to their previous state.

"They have survived the virus, they have not died, they have not become zombies, they have become carriers of the virus."

Seeing this scene, Li Lei on the side gasped, "Isn't it the same as asymptomatic infections, you can spread the virus wherever you go?" ”

"That's right, that's the horror of this virus."

Chen Chen looked at these rats and said thoughtfully, "There are multiple bacteria and viruses in the body of mice, which leads to the resistance of ordinary rats that are not inferior to bats, so it is normal to become the source of virus infection......

"But rats are not representative, so let's look at other animals."

Chen Chen suddenly thought of the bloodhounds infected with the virus in the movie, and suddenly said, "If you don't guess wrong, the virus has a different effect on cats and dogs and other creatures." ”

"Shall we start animal testing tomorrow?" Hannibal asked.

Chen Chen pondered for a while, and then said, "Okay, tomorrow we will start animal experiments, how many animals are there in the SPF breeding room now?" ”

"Now there are five kinds of animals: Kunming mice, SD rats, New Zealand white rabbits, macaques and chimpanzees." The assistant in charge of animal feeding replied.

"Then I'll try the last three tomorrow."

Chen Chen nodded and left the Spire Lab as he spoke.

When he left the laboratory after the complicated disinfection process, Cheng Chao had already received the message and waited outside the door, "Boss, do you want to go back to the research center today?" ”

Chen Chen waved his hand, "I won't leave, but I need you to make a trip, I remember that the Walvis Bay Harbor Police Department didn't set up its office and prison in Life Science City, you go to the police chief and ask him to provide me with five felons." ”

"Felons?"

"Yes, a murderer or a rapist."

Chen Chen nodded and said, "Then I will ask the Black Knight to cooperate with you to transport these five people in, and I must have one requirement, that is, these people must be in good health." ”

"I got it, I'll do it now."

Cheng Chao nodded and turned to leave.

The reason why human trials are going to be carried out so soon is because Chen Chen knows that the T virus is actually a virus with humans as the primary target, although many animals have the ability to carry the virus, but the real host of the virus has always been humans.

And it is an accident for a dog to become a zombie dog after being infected with the virus, and in fact not every animal does.

Watching Cheng Chao leave, he returned to his lounge in the minaret experimental base, but as soon as he lay down on the bed, he felt a wave of sleepiness hit him, and then he fell into a deep sleep.