"The accident is that this is the most wonderful thing in the world,

It's wonderful, it's hard to guess, it's hard to fathom.

Medical malpractice, traffic accidents, sudden illness, food poisoning, falling objects, falling from heights, fires, drowning, electric shocks...

Human life is so fragile,

A glass of water, an icicle, a chopstick, a fork, or even a nut is enough to kill someone.

There are too many tools that people have to face every day in modern life, and the possible ways to die are even more bizarre and bells and whistles than those shown in the movie "Death is Coming" or the TV show "1000 Ways to Die". ”

The boy spread his hands and smiled, "Death is the fate of all people, and it is also the fairest thing in the world."

If the murder case is shocking and angry, it will be recorded, and countless people will work together to track down the case and investigate the truth behind it.

Accidental death, then, is tinged with grief, helplessness, and sometimes a bit of black humor.

Similarly, no one will care much about the opposite of accidental death, not even the media that pursues traffic - this is an accident, a helpless fate.

I, on the other hand, am responsible for causing accidents. ”

Perhaps this passage was suspected of boasting, and the smile on the young man's face was a little shy, "As time goes by, I become more and more adept at this kind of thing,

Even if the whole accident process is completely shown to the world, no one can find the complete context of the story before the end of the matter.

Like a world-class magician, or a ruthless criminal conspiracy scholar in his reasoning. ”

——————

"Sister Lan, do you suspect that someone is chasing these criminals?"

"Hmm."

Wei Linglan nodded, looked at Chu Yin who was flipping through the materials, and nodded, "These cases are very ordinary, but I always feel that something is not normal."

I'm not an expert in this area, and the bureau's criminal investigation course doesn't score very high.

You're smarter, see if there's a problem here. ”

Hatsukin "um" the doctor, took a sip of the little Coke left on the ice, and stared intently at the information.

"Huang Yuanwei, male, 46 years old, driver, was a contact person in a criminal gang before that.

One morning in the summer of the previous year, while driving to Linshi, he suddenly felt that his breathing was becoming more and more difficult, and his throat and chest were tight.

There was a pinprick-like pain in his fingertips, his palms could barely hold the steering wheel, and the road scene in front of him began to ghost.

To be on the safe side, he drove off the highway and immediately went to the hospital.

By the time he arrived at the emergency department, he was in very bad condition, his face was sickly red, he was panting, his chest was heaving profusely, but the physical and neurological examinations were normal.

Considering that yesterday he ate local food on a business trip out of town, combined with his previous history of allergies,

The doctor thought that this was an ordinary allergy symptom, so he gave him the anti-allergic drug diphenhydramine - the drug has the effect of antihistamine H1 receptors, can inhibit the central nervous system, and is suitable for allergic diseases of the skin and mucous membranes, such as urticaria, hay fever, allergic rhinitis, etc.

Histamine is an active amine compound that is found in mast cells and also in mucosal tissues such as the lungs, liver, and stomach.

Histamine is released when the body finds an allergen,

Histamine, which is a chemical conduction, binds to the receptors on the smooth muscle of blood vessels, causing vasodilation and local edema.

It also causes the tracheal smooth muscle of the lungs to contract, causing narrowing of the airways and making it difficult to breathe.

Blood pressure decreases, and the heart beats faster.

Doctors used diphenhydramine to block histamine and gave Huang Yuanwei epinephrine to shrink his dilated blood vessels.

If he has allergies, then this should work.

But after hours of observation, Huang Yuanwei's condition did not improve, he still felt uncomfortable, and claimed that his stomach began to burn, even if he drank oral antacids, it did not help.

Then, he felt his throat swell and tight, unable to speak or swallow, his heart rate rising rapidly, and his eyelids drooping.

The doctor immediately performed various tests, including MRI, but the results showed no problems.

Huang Yuanwei's situation is deteriorating at a strange rate,

His facial and throat muscles were paralyzed, unable to speak, unable to move his hands and feet, his eyelids drooping and unable to open, and he had to use a respirator to help him breathe.

The most terrifying thing is that his will is still sober,

He could clearly feel that he was losing control of all his muscles little by little.

He could clearly feel that his body was constantly paralyzed.

He lost his life before the doctors could treat him further.

It wasn't until after his death that doctors understood the cause of his death.

The acute paralysis of his muscles was not a problem of the brain or spine, because the paralysis of his whole body was very balanced, average, and synchronized.

Nor can it be a viral infection of the nerves – viruses such as polio, which can paralyze the whole body, can leave patients with a fever for days before paralyzing their muscles.

So, it can only be a problem with the neuromuscular junction.

Motor neurons located in the anterior horn of the spinal cord and some nuclei in the brainstem send out nerve fibers to the muscles, and the nerve fibers branch into dozens or hundreds of branches at the muscle fibers.

Each branch terminates on the myofibers, forming a one-to-one neuromuscular junction,

The neuromuscular junction transmits signals from nerve fibers to muscle fibers, causing muscles to contract, and if the neuromuscular junction is interrupted, muscle atrophy and paralysis can occur. ”

Hatsuyin frowned and said, "And the one who caused the neuromuscular junction to malfunction is..."

"Botulinum toxin."

The boy smiled and said to the old woman, "You see, the whole process of muscle movement,

is an outgoing instruction from the nerve center,

Allowing nerve impulses to be transmitted to axon terminals,

As a result, the protruding cells in the presynaptic membrane are stimulated to release neurotransmitters such as acetylcholine, which diffuse into the synaptic cleft and bind to receptors on the muscle membrane, triggering muscle contraction.

Botulinum toxin binds to the presynaptic membrane of cholinergic neurons and undergoes intracellular endocytosis, forming an acidic vesicle that encapsulates the toxin molecule and stays at the end of the presynaptic membrane of motor neurons.

Blocks the release of the normal neurotransmitter acetylcholine,

This paralyzes the muscles.

I've been secretly observing, and sure enough, after the fact, the official was as I expected,

Following the botulinum toxin ingested by Huang Yuanwei, he found the food he ate in the restaurant yesterday - a ham that was originally packed in cans.

And the owner of that restaurant also happens to be a murder suspect who has been absconding for many years.

For botulinum toxin to be produced in canned food, the temperature and pH value of the external environment must be completely appropriate.

It was a perfect and unfortunate accident. ”