The next day, in the Zhongzhou Academy of Sciences-Shangdu Institute of Life Sciences.

At around seven o'clock in the morning, five or six male and female employees were wiping tables and chairs in a conference room, while chatting about things on the Internet while taking advantage of their leisure time.

Because it was not yet time to go to work, the girl's crisp laughter came from the venue from time to time, bringing a touch of fresh air to the quiet and solemn research institute.

It wasn't until half past seven that the crowd wiped off the dust that had fallen in the venue and began to wipe down the windows and railings.

"Why haven't you finished yet?"

At this moment, a middle-aged man in a straight suit rushed in with an urgent face, "Hurry up, this venue will be used at eight o'clock!" ”

"Team leader, don't worry, it can be cleaned before eight o'clock." A young girl smiled and replied, "Why are you in such a hurry?" ”

"What do you know?"

The middle-aged man's expression became even more anxious, "I just received the news that there are deans and vice deans who came to this venue, don't you know that the dean is used to arriving ten minutes early?" ”

Everyone was startled and hurriedly accelerated the movements in their hands.

Just when the middle-aged man was in a hurry, and was even about to roll up his sleeves himself, there was a sudden sound of footsteps behind him.

The middle-aged man subconsciously turned around, but saw a young man in a white shirt walking over, "May I ask, this is Conference Room 3, right?" ”

"Yes, may I ask who you are?" The middle-aged man saw that the young man was a little angry, and realized that it was not a person in the hospital, so he subconsciously glanced at the work card on the other party's neck.

Chen Chen?

Haven't heard of it......

"I'm the speaker at this conference." The young man named Chen Chen glanced inside, "Can I go in now?" I want to prepare in advance. ”

"Oh, yes, please come in ......"

The middle-aged man hurriedly stepped out of the way, watching the young man skillfully walk onto the podium and start debugging the projection equipment, and he couldn't help but be a little surprised in his heart.

It was the first time he had seen such a young face standing on that podium, not to mention, this time it was the dean himself.

Everyone who cleaned the venue looked at the young man curiously, and they didn't dare to continue talking, and the movements in their hands sped up a few points, but the venue was cleaned up in about ten minutes.

The middle-aged man secretly breathed a sigh of relief, he took one last look at the podium, and saw that the young man was still checking the PPT with a serious face, so he made a gesture to everyone and prepared to leave the venue.

However, just as he was about to leave silently with everyone, his heart suddenly tightened.

I saw that in the corridor, the dean and a large number of academicians had already walked towards here from afar.

"Let's go!" The middle-aged man hurriedly yelled at everyone, and a group of people quickly left.

A few minutes later.

In the venue, a group of men in overalls with different expressions rushed in, although they had not yet started to speak, but these people were still sitting quietly in their seats, showing excellent quality.

This group of people is not students, but a group of middle-aged and elderly people over the age of 50, and some even over 60.

However, unlike ordinary middle-aged and elderly people, everyone here is at the top level in the academic world, and several of them are famous all over the world.

These people are basically academicians of the Chinese Academy of Sciences, and several others are also senior managers like Wang Luo.

What Chen Chen has to do is to convince this group of top elites in the academic world, because only when this group of people acknowledges the feasibility of Chen Chen's plan can they be regarded as giving an explanation to the official, and Professor Wang Xi will agree to go abroad for treatment.

Looking at the already full venue, Chen Chen bowed lightly and began to speak in a long breath:

"The so-called Alzheimer's disease is a devastating neurodegenerative disease that occurs in middle-aged and elderly people, with an average of 5 to 8 patients for every 100 people over the age of 60, and this number is increasing exponentially as the global aging population intensifies."

"Unfortunately, more than half of the world's population is unaware of the disease, and Alzheimer's disease has become the only disease with an increase in mortality in the last decade in the context of rapid medical advances around the world."

As Chen Chen spread his hands, the big screen behind him continued to show the reports intercepted from various newspapers and periodicals.

The reported data is staggering.

"Alzheimer's disease, here I will refer to it as AD, I believe some of you are already familiar with it, after all, there are only two major complications of it: Aβ protein deposition and tau protein aberration."

"But it wasn't until we investigated deeply that we found that the clues inside were extremely complicated, and behind the two complications were countless factors, like endless threads twisted together......

Chen Chen pointed to the screen behind him, "So far, the most in-depth discovery in the academic community is probably microglia, as a type of brain immune cell, experiments have proved that microglia can effectively engulf Aβ protein and abnormal Tau protein after being activated, inhibiting AD disease." ”

"But at the same time, this immune cell is a double-edged sword."

Chen Chen turned around, and the screen behind him displayed several research reports, "Recent studies have shown that microglia not only engulf abnormal proteins, but also secrete a substance called apolipoprotein E, which is ApoE. ”

"The gene responsible for secreting ApoE has three constructs, ApoE2, ApoE3 and ApoE4, and each person can only have one or two copies of this protein gene in their body."

A list automatically appeared behind Chen Chen, "In other words, in everyone's body, the probability of this kind of genetic combination in you is about one in six." ”

"ApoE was supposed to help remove Aβ deposits, but in subsequent studies, scientists found that E2 was more effective than E3, while E4 had the opposite effect and exacerbated Aβ deposits."

"Having an E4 gene will increase the risk of AD by 3 times, and if the gene sequence in your body is [E4/E4], then congratulations, your risk of AD is 12 times that of ordinary people."

With Chen Chen's words, a whispered conversation suddenly came from the audience.

"Microglia have an effect not only on Aβ protein deposition, but also on tau protein mutation."

Chen Chen spread his hands, "Tau protein phosphorylation abnormalities will cause neuronal fiber entanglement, which will cause nerve cells to die, but how did this death happen?" ”

"The current research suggests that this death may still be caused by microglia, which attack the tangles but harm nearby neurons, and that APOE4 secreted by microglia also amplifies the toxic effects of Tau on neurons."

"So, after genetic identification of a patient, can we restrict or activate microglia based on the patient's genes?"

Chen Chen was kind and inducing, "And my Black Light Biological Research Center is based on this. ”

Several old men in the audience glanced at each other and nodded approvingly.

Chen Chen uploaded the data photo in his hand to the projector, "AD complications always carry inflammation, and in recent studies, it has been found that an IL-1β cytokine can cause an inflammatory response, and the increase of IL-1β cytokines is due to a sharp decrease in TOM1 protein......"

"A paper published in PNAS confirms this view, and after the expression of TOM1 decreased, the Aβ protein did increase in the brains of the AD model mice, and the cognitive ability of these mice also declined."

"So, during my experiment, I used gene overexpression to activate the TOM1 protein gene, which greatly improved the subject's condition."

Chen Chen passed the experimental materials one by one, "You can imagine TOM1 as the brake structure of a car, and in the brain of AD patients, this brake fails, and what we need to do is to repair this brake at the molecular level." ”

Everyone was moved when they heard this.

"Through the first two ways, we have temporarily suppressed the condition of AD, but if we don't find a solution like this, the result can still only be a tragedy, so the next thing we need to do is to eliminate the sediment."

"So, the third project in our research center is Solaneuzumab, developed by Eli Lilly and Company, which is a monoclonal antibody that targets the Aβ peptide chain and prevents its deposition from polymerizing and can eliminate it from the human brain."

"Of course, this is not enough, so we have the last and most important process – to create autologous neural stem cells by 'inducing pluripotent stem cells' and at the same time activate G2 quiescent stem cells in the human brain."

"In this way, we can restore the brain of AD patients, even if it is not to its original state, but it can recover most of the time."

With Chen Chen's words, photos and evidence after animal experiments appeared on the screen, and everyone in the audience finally couldn't help it and discussed it in a low voice.

"I will publish these results in CELL in the future, if you are interested, you can contact me, I can provide you with detailed data."

With that, Chen Chen turned off the projector, turned around and walked off the podium.

Bang Bang ......

There was a round of applause.

Seeing this scene, Chen Chen couldn't help but think of the scene when Professor Wang Xi gave a lecture to him.

More than a year ago, I was sitting in a university class, listening to Professor Wang Xi driving a train with his mouth full of words, constantly instilling forward-looking remarks into his students.

At that time, the goal of many people's lives was to become an academic master like Professor Wang Xi twenty or thirty years later, right?

But I didn't expect that just over a year later, I would stand on an almost equal footing with Professor Wang Xi.

But that's just the beginning......

Chen Chen thought silently.

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