German Confederation, Berlin.

Robert Koch Institute RKI.

The institute has just completed the construction of a BSL-4 laboratory this year. Note: Internationally, biosafety is divided into four levels, Bio-Safety-Level 1-4, and BSL-4 is the fourth level laboratory, also known as P4 laboratory.

The Robert Koch Institute's P4 laboratory is dedicated to studying the molecular properties and modes of transmission of a variety of pathogens, including not only bacteria and viruses, but also fungi, parasites and prions like BSE BSE BSE pathogens.

According to the original plan, the Robert Koch Institute planned to upgrade the BSL-3 laboratory to the BSL-4 laboratory in 2020.

However, the outbreak of the rice plague in 15 years frightened the whole world, and no one expected that a rice plague would indirectly kill more than 50 million people.

No one can guarantee that there will be no untreatable wheat plague, avian flu, swine flu, or even human plague in the future.

Therefore, major powers have upgraded their domestic biological laboratories to prevent the emergence of super viruses in the future.

The German Confederation, which originally had only one BSL-4 laboratory at the Institute for Tropical Diseases in Hamburg, invested heavily in upgrading the BSL-3 laboratory at the Robert Koch Institute last year.

Don't think that BSL-4 and BSL-3 are one level apart, in fact, the cost and maintenance cost of the two are hugely different.

For example, the most advanced high-risk virus laboratory, the Jean Merrieux BSL-4 laboratory in Galloli-Lyon.

The laboratory was launched in March 1999 with the aim of conducting in-depth research, documentation, and treatment of the most virulent and up-to-date viruses, as well as the oldest and most recent viruses.

The 600-square-meter laboratory cost 40 million francs, of which 10 million francs were worth the instruments and equipment, and the annual cost of operation and maintenance and experiments was 1.9 million dollars. Seven or eight Chinese fastest ^ mobile terminal:://

Considering inflation, the cost could now be about 10 times higher.

The most advanced BSL-4 laboratory is because of the Qinghai Lake Life Research Institute, the Qinling Institute of Virology, and the Daxinganling Institute of Genetics in Huaguo, which are more powerful than the Lyon laboratory.

……

At this time, Dr. William Z. Baker, the head of the Robert Koch Institute's BSL-4 laboratory, was leading a group of researchers to study the cerea and rice searella obtained from Tianzhu and Southeast Asia.

After browsing the genetic analysis map data, William Z. Baker couldn't help frowning, turned his head and instructed his assistant: "Kalia, immediately conduct a genome-wide assay of the genes of Rice Pear in 15 regions. ”

The squinting eyes of Kalia Schneider with glasses asked with some hesitation: "Doctor, it's 15 regions of Rice Pear Bacteria."

"Do as I tell you to." William Z. Baker said solemnly.

"Yes, Doctor."

Looking at the back of his assistant leaving, William Z. Baker turned his head and looked at the report on the table with some silence.

As a veteran virobacteriologist and geneticist, William Z. Baker had clearly seen some terrible problems.

Among the samples collected in Tianzhu and 15 rice regions in Southeast Asia, there was a significant difference between C. crisea and S. oryzae.

Both Cinerea and Rice Pear are fungi that can cause rice blast, and both belong to different states of the same species.

In general, there is no significant genetic difference between C. cinerea and N. oryzae.

But here's where the problem arises, the case of Pear Cinerea is very normal, and the results of whole genome assays are not much different from previous data; However, the whole genome assay on the side of Rice Pear has yielded results that William Z. Baker has not believed.

2015—There was a huge difference of 34.6% between the genes of Lycopia oryzae and Pyrrhosa oryzae.

Obviously, no matter how powerful the mutation of viruses and bacteria is, it is impossible to mutate 34.6% of the genes in a short period of ten years.

What's more, he checked the genetic data of Rice Research Institute of the Chinese Academy of Sciences in 2014, and compared with Paleo-Rice Pear Mushroom, the mutation rate of the two is only 0.00064%.

Such a huge mutation can no longer be said to be a mutation, it can be said to be a variant, 2015-Rice Pear Bacteria and Palaeo-Rice Pear Mushroom, are already two different biological species.

This situation made William Z. Baker very uneasy, because there was only one condition that matched this level of genetic mutation, and that was "genetically modified".

2015—It is highly likely that the bacillus oryzae is the product of man-made modification, which is why he asked his assistant to arrange for a whole genome assay of all samples.

If someone really does such a bottomless thing, it is absolutely unforgivable.

As a scientist with discipline and a bottom line, William Z. Baker could not tolerate the use of biotechnology to make biological weapons, which is why he refused the invitation of several biological laboratories in the United States.

He is a political novice, but it does not mean that he is a fool, and whoever is the biggest beneficiary of the outbreak of the rice plague may be the mastermind behind it.

The 2015 rice plague incident directly crushed the economy and society of Tianzhu, Bangladesh, and the Thousand Islands of the South Seas, and seriously affected Southeast Asia and Northeast Asia.

So who is the biggest beneficiary, the answer is self-evident.

……

In the following study, they found that 2015-Pear Rice Bacteria has a large number of signs of artificial modification.

At present, among the genes that can be matched, 11.2% of the 34.6% of the mutated genes belong to the gene sequence of HIV, 12.6% of the genes belong to the gene sequence of Staphylococcus aureus, and the remaining genes are still being matched.

"God, the guy who made this fungus deserves to go to hell." William Z. Baker angrily slammed the report on the table.

The restless William Z. Baker walked about, and at last he made up his mind to write a paper to expose the matter, and instructed his assistant: "Kalia, you go and make arrangements, we are going to write a paper." ”

"Writing a dissertation...... Okay, Doctor. Kalia Schneider turned, a twinkle of struggle in his eyes.

……

Ruta Schneider, the general manager of the institute, immediately changed his expression after listening to his nephew's report.

He didn't care about the coffee spilling on his shirt, and while rushing to the virus laboratory, he called the research institute's network security department, asking the network security department to immediately cut off the research institute's external communication.

If William Z. Baker's paper is sent out, William Z. Baker doesn't know if there is anything going on, but he, the general manager, is probably at an end.

The paper must not be sent out, or it will be over, Ruta Schneider thought madly to himself.

Rushing into the outer office of the virus lab, he shouted loudly, "Tell Dr. William to stop the experiment and come out to see me immediately." ”

"Uh...... Good. The person in charge of contact was not taken aback, and quickly grabbed the internal phone and told William Z. Baker to come over.

More than an hour later, William Z. Baker, who had passed through 10 isolation doors and had been thoroughly disinfected, belatedly appeared in front of Ruta Schneider.

Before the other party could speak, Ruta Schneider said in a serious tone: "Doctor, the study of the rice plague is now suspended, this is not a request, but an order. ”

"Schneider, why?" asked William Z. Baker, somewhat angrily.

Ruta Schneider stared at each other and replied, "Why don't you die because I don't want to die, I don't want you to die, understand?"

"I am willing to die for truth and morality!"

"Enough!" Ruta Schneider was furious.

He then gave up arguing with William Z. Baker and used his authority to erase all experimental samples and data, deleting the paper by William Z. Baker and others about the artificial modification of Oryza oryzae.

Have security personnel temporarily restrict the freedom and external correspondence of William Z. Baker and others.

William Z. Baker watched all this in silence, and finally he said only one sentence:

"When science is exploited by Lucifer, all silence fuels darkness, and hellfire will eventually burn on everyone."