"Let's sort out the existing information first." Guo Xiang said.

"I have the data here." Li Yuanhang handed over a floppy disk.

Guo Xiang turned on a computer that Li Yuanhang had brought back and was ready to use it.

This computer uses windows3.0 system, which is much better than the domestic DOS system.

And this computer is all in English, which is relatively difficult to operate, but it is also safer and will not be too easy for others to use.

Domestic computers will be left for others to use in the future, and some students may be recruited at that time.

Insert the floppy disk into the floppy disk slot to read the data.

The data is very complete, mainly the virus data and current drugs that Dr. Hua and they have studied.

"Can I use this?" Guo Xiang was a little worried.

"Yes, with the permission of Mr. Hua, and many drugs are available on the market, and some are used in clinical practice, as long as you have the intention to collect them." Li Yuanhang said.

"That's good!" Guo Xiang copied the data to his computer.

There are four main categories of medicines.

Nucleoside reverse transcriptase inhibitors (NRTIs): These drugs are similar in molecular structure to natural deoxynucleotides and can be added to the DNA strand instead of deoxynucleotides, terminating DNA synthesis. Zidovudine, lamivudine, tenofovir, and emtricitabine all belong to this class of drugs.

Non-nucleoside reverse transcriptase inhibitors (NNRTIs): This drug has a completely different molecular structure from nucleosides. It binds to other parts of the reverse transcriptase enzyme and makes the reverse transcription process impossible. Nevirapine and efavirenz belong to this class of drugs.

Protease inhibitor (PI): binds to protease and inhibits the activity of protease.

Integrase inhibitor (INSTI): binds to integrase to inhibit the activity of integrase.

"We're mainly going to treat AIDS with three antiretroviral drugs, like a cocktail mixing different liquors together, let's call it cocktail therapy." Guo Xiang said.

"Cocktail therapy? It's kind of interesting! Li Yuanhang nodded, "You are very creative." ”

Guo Xiang laughed humbly, in fact, this was proposed by Dr. Hua Hongmin in his previous life, and he just borrowed it in advance, but the specific dispensing still has to go through a lot of experiments to get it.

When the time comes, if you can really succeed, you will write Dr. Hua's name in front, and you will not dare to monopolize the credit.

"These three drugs are not a random combination, they must contain two nucleoside reverse transcriptase inhibitors and one other type of drug. In this way, the problem of monodrug resistance can be overcome. Guo Xiang continued.

"You're quite right." Li Yuanhang nodded, "Now we have more than a dozen kinds of drugs here, which two nucleoside drugs are matched with another, and what is the ratio, we have to go through many experiments to know." It's not something that can be done just a few times. ”

"That's nature, it's not that easy." Guo Xiang nodded, while making a rough drug type ratio on the computer.

Li Yuanhang saw her make a chart, he was very curious, the various types of drugs in the chart were proportioned to other drugs, and then just follow this to experiment one by one.

"What is this?" Li Yuanhang was very surprised, this watch is really well done.

"It's a mind map." Guo Xiang smiled, this is very widely used in later generations, and she often uses it, and it can be used in various fields, which is very useful.

"It's clear at a glance, it's clear, it's good." Li Yuanhang praised.

"Thank you." Guo Xiang laughed, "If you want to learn, I can teach you." ”

"Really? That's great! Li Yuanhang couldn't wait to sit next to Guo Xiang, originally thinking that he had a lot to teach Guo Xiang when he came back from studying abroad, but he didn't expect that he would have to learn from her first.

And she knew far more than he thought, he thought it was incredible, where did she learn it?

"You see, there are many types of mind maps that you can use as needed. There are tree-like, fishbone-shaped, map distribution type, bubble diagram, flow chart, bridge diagram, etc., like our experiments, as well as class preparation, process flow, etc. ”

Guo Xiang's subordinates kept explaining to Li Yuanhang, Li Yuanhang was very surprised, and listened to it with relish, with this mind map, it would be much easier to do some analysis.

Guo Xiang spoke for a long time, Li Yuanhang listened carefully, and started to do it himself.

At this time, there was a knock on the door outside, and the two looked up to see that it was Principal Lin coming, and they both stood up, "Principal Lin!" ”

"Busy?" Principal Lin smiled and nodded, looking at Li Yuanhang, "Teacher Li, what do you think of our laboratory?" ”

Now Li Yuanhang is a member of Beijing Medical University, so he can naturally be called a teacher, although he only graduated with a master's degree, but he is a world-famous school, and his status is a little different.

"Good, unexpected." Li Yuanhang said with a smile.

"Yes, I was shocked when I came to see it two days ago, it was a world of difference from before, you look at this, it is not an exaggeration to say that modernization has been achieved." Principal Lin said with a smile.

"Today, the biological experiment cabinet and computer have been installed, Principal Lin, take a look again, is it more progressive?" Guo Xiang said with a smile.

Principal Lin was surprised, "So you all use computers here?" It's too advanced. ”

"How come there are four?" Principal Lin asked.

"I bought two of them, and Li Yuanhang brought two more from the United States, so there are so many. However, President Lin, don't worry, it will never be wasted, it will definitely be used in the future, our laboratory will definitely have to recruit students, and the two of us can't do experiments. Guo Xiang said with a smile.

"That's right. Teacher Li, then you have to teach Xiao Guo more. Principal Lin said.

"Principal Lin, you are joking, Teacher Guo is more skilled than me, she taught me just now, you look at this picture, she taught me to do it." Li Yuanhang said modestly, and he had to admire, he was really powerful.

"Really?" Principal Lin was very surprised, looking at the things on Guo Xiang's computer is indeed more complicated than that in Li Yuanhang's computer, this student is actually more powerful than returning from studying abroad?

But it's not surprising to think that her family has so much money and may have used a computer a long time ago.

He doesn't understand this anyway, so that's how it should be.

"Are there any other difficulties?" Principal Lin asked.

"We also need small animals for experiments, mice and rabbits." Guo Xiang said.

In the future, the virus should be implanted into the animal, and then the drug can be used to see the effect.

"Yes, these are essential." Li Yuanhang also nodded.

"That's no problem, the school also has other laboratories, and there are specially fed experimental animals, just go over there and catch them when the time comes." Principal Lin replied.

"That's great." The two replied.

In this way, you can start the experiment now, catch a few mice first, implant the HIV virus first, and then start testing the drug when you have AIDS.

(PS: The relevant drugs are all quoted from the relevant knowledge on the Internet.) ）