After eating, Guo Xiang returned to the laboratory and received a call from Song Tingshen.

"Teacher Song?" Guo Xiang shouted.

"Guo Xiang, how is the progress of your HIV medication over there?" Song Tingshen asked.

"There's not much progress yet." Guo Xiang shook his head, he tried so many kinds of medicines, but the effect was not obvious, it may be that the ratio is wrong, or the dosage is wrong.

"The last time I was a liver cancer patient, there was an AIDS outbreak. It may be because the body's resistance to surgery is weaker, and the immune system will not work as soon as it is attacked. Now he has a persistent fever, swollen lymph nodes, and a red rash on his body. Song Tingshen said.

"That's the onset." Guo Xiang frowned, "You can let him take the medicine first, although the joint medicine we have here has not yet come out, but the ordinary medicine can still be taken first." ”

"Then we have no choice, we don't have a department for this disease in our country now, and there is no medicine, so we can only let him return to China for treatment." Song Ting sighed deeply.

Guo Xiang nodded, there is really no way, although they have medicine in the laboratory, it is also used for experiments, it is not a place to see a doctor, and there is no other treatment equipment, so there is no way to help him treat.

"Then let him go back to China, there is no way to do it." Guo Xiang said, "I also have to speed up the progress and make it earlier." ”

Song Tingshen hung up the phone and could only tell the patient the truth, there was really no way to treat it, and it was useless for him to be hospitalized.

The patient also understands that he went through the discharge procedures, and he has been in the liver cancer for more than a month and is also discharged, but he is now in such a poor condition that it is very likely to recur, but there is no way, this is something that no one can control.

Guo Xiang told Li Yuanhang about the patient, and he nodded, "We can only control it with medication first, and then talk about it when the drug resistance comes, we will also speed up the progress." ”

Guo Xiang nodded, looked at the data in the computer, and took a new set of formula drugs to the mice.

Mixing the medicine in rat feed and preparing to feed it to the mice, Guo Xiang noticed that some of the mice that had suffered from AIDS were still very energetic, while some were not in good spirits.

She suddenly realized a problem, Western medicine is generally relatively fixed, but it will be distinguished according to the age of the person.

For example, adults take three capsules each time, and children take half of them, and take one and a half capsules. This is generally the case.

The mice that do the experiment are small, and the dosage is generally recalculated according to the weight.

Just like some babies will use the weight to calculate the medicine, how many milliliters to eat within a few kilograms, and how many milliliters to eat more than a few kilograms, and so on.

However, they are not classified according to the severity of the disease.

If it is said that it is Chinese medicine that can do this, Chinese medicine generally feels the pulse to diagnose and prescribe medicine according to the differences in each person's constitution and different conditions.

Therefore, the prescription and dosage of medicine may be different for each patient, which is one of the reasons why Chinese medicine cannot be promoted like Western medicine.

However, the severity of the AIDS situation is very obvious, some may not be sick but just carry, some are serious, all kinds of symptoms appear, and some are mild, so can they all use the same medicine and the same dose?

Is it necessary to divide people according to their constitution and condition like traditional Chinese medicine?

Guo Xiang suddenly felt that he was right in this way, because the HIV virus attacked the human immune system.

Probably most people only have a very vague idea of the immune system, and they don't know what it is.

In fact, the human body is a very sophisticated system, with its own defense forces against foreign invaders.

And these defenses are a multitude of immune cells. For example, lymphocytes are immune cells that fight infections and tumors. The most important of these are Th cells containing CD4 molecules and Tc cells containing CD8 molecules. In other words, T cells are the defenders of disease.

CD4 cells are equivalent to sentinels and play the role of "ventilation and signaling", while CD8 cells are combat troops and have the effect of killing infected cells and cancer cells.

When HIV enters the body, it infects surface CD4 cells so that CD8 cells are unable to kill infected cells and cancer cells, leading to opportunistic infections and cancer.

Therefore, once a person is infected with HIV, there will be a progressive or irregular decline in CD4 cells, indicating that the immune system is severely damaged.

Generally, the CD4 cells of normal people are 500~1600 per cubic millimeter, which can be detected by blood drawing.

Therefore, the CD4 cells of each of these mice may be different, and the drug and dosage should also be different.

Guo Xiang suddenly realized that they might have done useless work in the previous month.

She immediately called Li Yuanhang over and said what she thought.

Li Yuanhang listened very carefully, nodding as he listened, "It's very likely that this is the case." ”

"Didn't you think about this when you were in the United States?" Guo Xiang couldn't help but ask, they had been studying for so many years.

"I entered the lab relatively late, and CD4 cells were also measured there, but at that time it was still a single medication, and now I don't think of this with a combination of drugs." Li Yuanhang said.

"I think our previous thinking was wrong, and it should be administered separately according to the number of CD4 cells in each mouse, so that it will have an effect." Guo Xiang said.

Li Yuanhang nodded, "Yes, we have tried so many drugs before, it is impossible that they all have no effect, it should be this reason, there is no right symptom!" ”

"Then we will immediately measure the CD4 cells of each mouse, and then adjust the medication and dosage." Guo Xiang said decisively, "Normal human CD4 cells are 500-1600, and setting more than 500 is a safe value, which may be positive, but within the safe range, it has not yet become ill, and it is still a carrier." ”

"Between 0~200 is already very serious, there are complications, and it is a serious patient; Between 200~500 people are mildly ill, although the onset of the disease is not serious. Guo Xiang continued, picking up the previous record book, "Then we will also divide the medication into groups, one group of tenofvi, zidovudine, and lamivudine, and the other group of efaviren, nevirapine, and Kelizhi, and use drugs differently for symptoms at different stages." ”

"Okay, we'll retest it right away." Li Yuanhang nodded, and at the same time admired Guo Xiang very much in his heart, he didn't expect this.

The two began to draw blood from mice and put them in a flow cytometer for testing, and these equipment were bought from the United States.

Each mouse was then numbered, indicating the number of CD4 cells they had, and then given a different drug and dose.

After doing this, both of them were a little excited, and they had a hunch that they might succeed this time.

After all the work was done, the two of them sorted out the laboratory, and the operating table was disinfected, before they left the laboratory and took off their protective clothing and changed into a white coat.

Guo Xiang suddenly found Gu Zhennan standing outside the window of his office.

She opened the window, "Why are you here?" ”

"What time is it? You don't look at the time, I thought something happened to you. Gu Zhennan complained a little.

Guo Xiang noticed that it was already dark outside, and when he looked at the clock on the wall, it was already past eight o'clock, and he was surprised, "It's so late?" ”

"We lose track of time as soon as we do experiments." Li Yuanhang said with a smile and looked at Gu Zhennan, this should be Teacher Guo's lover, right?