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"A treasure trove!" Liu Feng knew the growth of Cordyceps underneath, one at a time, one at a time, and soon got hundreds.

After a day of delay in this meadow and a big bag, Liu Feng finally dug up and was about to vomit before leaving.

In the past, the cordyceps here were not allowed to be excavated by others, and it was usually the boss who took the hill to the top.

At night, he found a wooden house, which was prepared by the herdsman, Liu Feng put down his things, carried a bow and arrows, and a scimitar on his body.

A yellow sheep was shot in the eye, jumped up and fell to the ground.

Yellow sheep is the best delicacy.

Yellow sheep, also known as yellow antelope, Mongolian antelope, Mongolian gazelle, Mongolian antelope, etc., is not actually a sheep. The body is slender, but larger than the Tibetan antelope and the Przewalski's gazelle, and slightly thicker ~ strong, with a body length of 100-150 cm, a shoulder height of about 76 cm, and a weight of 20-35 kg, but the largest can reach 60-90 kg. The head is round and blunt, the ears are long and pointed, and they are densely hairy. It has a suborbital gland, which is different from the Tibetan and Przewalski's gazelles. It has slender limbs, slightly shorter front legs, and narrow, pointed hooves. Yellow sheep are good at jumping and running, and mostly inhabit the grassland areas of semi-desert areas.

The one in Liu Feng's hand is at least fifty catties, but it is not enough to eat.

The rest ran away all at once, Liu Feng didn't chase it, because it would expose his strength, although it was still far away from Ruxian County, but now Liu Feng was going to behave normally.

The yellow sheep was cleaned up on the spot, and the internal organs were thrown aside, and then Liu Feng took it to the wooden house, which had some daily necessities, Liu Feng directly cut the yellow sheep into small pieces, put them in a large pressure cooker, and then made a fire.

Then Liu Feng went out again, lurking near the discarded internal organs just now.

A fox was feasting, but it wasn't tasty, there wasn't much meat, and it smelled fishy.

Suddenly, the fox pricked up its ears, and then quickly left, and a leopard slowly came here, Liu Feng took a look.

Shaking his head, he felt that there was nothing left tonight, this was a female leopard, and it could be seen that there were offspring in the motherhood.

The female leopard quickly finished the entrails, then glanced into the distance and quickly left.

Back at the wooden house, Liu Feng did not feel discouraged, there was already meat in the hanging pot~ The fragrance was good, and the firewood was also ready-made.

Many of the empty houses in the pastoral area have basic daily necessities, lighters, salt, etc., and some have noodles.

The meat of this wild yellow sheep needs to be stewed for a long time, in fact, it is not suitable for general stewing in the plateau, and the barbecue is better.

Why do Tibetan areas eat tsampa?

This is going to talk about the production process of tsampa.

Tsamba is the Tibetan transliteration of fried noodles, it is the staple food that the Tibetan people must eat every day, as a guest in the Tibetan compatriots' homes, the host will definitely bring you fragrant milk tea and barley fried noodles with both hands, golden ghee and custard "qula" (casein), sugar stacked on top of each other all over the table. Ghee is a cream made from milk, and tsamba is a powder made by stir-frying barley and grinding it by hand. Tibetans have tsampa for three meals a day. Tsamba sounds fresh, and the name is actually barley fried noodles. The production method of tsamba is to dry and fry barley (belonging to barley, there are two kinds of white, purple and black) in the sun, grind finely, and sift it, so that the fried noodles made are edible tsampa. Tsamba is a bit similar to the fried noodles in northern China, but the fried noodles in the north are ground first and then fried, while the tsampa in Tibet is fried first and then ground without removing the skin. When eating tsampa, put some ghee in a bowl, pour in the tea, add some tsampa noodles, and stir it constantly with your hands.

In other words, this is actually fried, not stewed.

In addition, most of the meat is also made into grilled meat or jerky.

It is eaten directly by air drying, and there is no need to process it again at all.

Of course, with the modern society, life is different, and it can also be stewed.

The pressure cooker made a popping sound and the fragrance came out.

Liu Feng looked at his watch, and three hundred meters away, a bear was snorting over.

What is the most dangerous thing to say in Tibet?

Brown bear?

Liu Feng opened the door, although it was night, there was starlight, and the flashlight shot directly at the place where the bear was infested.

Brown bears are more ferocious than black bears, and this brown bear is larger, and it looks like a mutated creature.

The eyeball flashed with the information of the brown bear.

It is one of the largest mammals of the terrestrial carnivorous order, with a body length of 1.5-2.8 meters, a shoulder height of 0.9-1.5 meters, and a weight of 90-800 kg for males and 80-250 kg for females. The head is large and round, the body is muscular, and the shoulders and back are bulging~. The coat is coarse, up to 10 cm in winter; It comes in a variety of colors, such as gold, brown, black, and brownish-black. The forearms are very powerful, and the tips of the forepaws can reach up to 15 centimeters long. Since the tips of the claws do not retract into the claw sheath like in felines, these claw tips are relatively thick and blunt. The forearms are powerful when swinging, and the "thick" claws can cause great damage.

It mainly inhabits cold temperate coniferous forests, mostly active during the day, walks slowly, has no fixed habitat, and usually acts alone. Plants include all kinds of rhizomes, tubers, forages, grains and fruits, etc., like to eat honey, animals include ants, ant eggs, insects, rodents, ungulates, fish and carrion. Hibernation, during which body temperature, heartbeat and detoxification system stop functioning to reduce the loss of heat and calcium, and prevent hypothermia and osteoporosis. Running speeds of up to 56 km/h.

Brown bears have an excellent sense of smell, 7 times that of hunting dogs, and have good eyesight, and are able to see fish in clear water when fishing. The bulging muscles on the shoulders and dorsal shoulders give brown bears great strength in their forearms, and the tips of their forepaws can reach up to 15 cm in length. Since the tips of the claws do not retract into the claw sheath like in felines, these claw tips are relatively thick and blunt. The forearms are powerful when swinging, and the "thick" claws can cause great damage. Brown bears have long claws, but they are not very good at climbing trees, and their ears are small compared to their large heads, and when they change into thick long-haired winter clothes, the small ears can only be faintly visible. Brown bears have a wider snout and 42 teeth, including two large canines. Like other bears, they are also gimbal animals and have a short tail.

The specific stats of this brown bear are:

Shoulder height: 1.9 meters.

Length: two meters two.

Weight: 1600 kg.

Energy Level: Level 2.

The brown bear was shot by a flashlight, and suddenly confronted Liu Feng.

Immediately after that, more information appears on the eyeballs.

Hunger level: Very hungry.

Rumble!

The brown bear roared and rushed towards Liu Feng at once.

Collapse!

The compound bow shot out at once, and then Liu Feng ran quickly.

It is a forest edge with meadows and forest shrubs.

The arrow was directly inserted into the body of the brown bear, but the damage was limited, which only aroused the ferocity of the brown bear.

Roar!

Liu Feng was suddenly stunned, the roar of this brown bear actually had an attribute attack, a sonic attack.

Just now, he obviously felt a powerful sound wave impacting him, since he had such an attribute attack, Liu Feng would not kill and eat meat.

Attribute beasts, the value is very high, first study the energy purity, if the purity reaches the standard, you can stay.

Liu Feng jumped up a hillside, then picked up a big rock, and the brown bear behind him slapped him.

Rumble!

The big stone smashed directly on the brown bear's head, and Liu Feng landed on the brown bear's back in one leap.

Even a brown bear of one and a half tons was hit on the head by a large rock of hundreds of pounds, and it was a little dizzy, and it felt that there was someone on its back.

Annoyed, the brown bear opened its mouth and tore it back.

Then rolled on the spot, Liu Feng didn't expect this guy to be like this, he jumped, and then his eyes lit up, his mind moved, and a stone hit two eggs hard.

Roar!!!!!

The brown bear didn't expect to roll on the spot, and his biggest weakness was hit at once.

Roar!!!!

The brown bear felt that the back half of his body had lost sensation, and a pair of thick front legs supported the ground, roaring at Liu Feng.

Liu Feng himself also wants to break through the bottleneck, so he will not use telekinesis unless he has to.

Physique is the key, and the stronger the physique, the more energy you can reserve.

The brown bear's eyes were full of anger, but the heavy blow just now made the brown bear temporarily incapacitated.

Liu Feng is also waiting, waiting for the brown bear to recover.

The brown bear looked at Liu Feng, slowly stood up, and then slowly retreated.

The brown bear retreated not to say that it was leaving, but to observe Liu Feng's reaction and observe the reaction of its prey.

Liu Feng also took a step back, and the brown bear stopped all of a sudden.

"I just don't know if this watch can measure energy attributes, it would be great if it could." Liu Feng still had time to think about other things.

Liu Feng saw that the brown bear did not retreat, and he also stopped.

On the other side, the meat in the pressure cooker ~ the fragrance is stronger.

Li Feng tentatively took a step back again.

Roar!

The brown bear roared angrily and rushed towards Liu Feng with a leap.

Boom!

Liu Feng smashed a hard punch on the left side of the brown bear's face, and with the help of a force, the side of the body dodged the attack of the brown bear's right palm.

Liu Feng could even see that the left side of the brown bear's face was trembling.

Then separated, transposed, the brown bear's mouth cracked, and the bear's right paw was generally used as a means of attack, so Liu Feng hit the left cheek. Dodge to the right.

Liu Feng and Xiong are opposite, and Liu Feng's right is Xiong's left.

The brown bear felt that the guy in front of him was not easy to provoke, but he was unwilling and too hungry.

The brown bear looked at Liu Feng and slowly retreated, but Liu Feng not only did not retreat, but followed closely step by step.

The brown bear looked at Liu Feng with a pair of small eyes and found that he had actually become the prey.

The brown bear began to swim sideways~ away, and in the face of such a situation, Liu Feng had to turn his body.

Sou!

The brown bear ran out into the distance at once, and Liu Feng just jumped to follow, and the brown bear actually came up with a drag knife meter.

suddenly turned his head and pounced on Liu Feng.

Boom!

Liu Feng smashed his fist on the brown bear's left eye again, and with a strong foot, his body brushed the brown bear to dodge.

This brown bear actually opened its mouth and bit it, who knew that Liu Feng's strength was incomparably great, and his head was smashed off.

The brown bear felt that Liu Feng was very strong, and rushed into the bushes with a jump.

Liu Feng quickly followed, grabbed ~ the little tail, and pulled it upward, and the brown bear turned around and opened its mouth to bite it.

One foot lifted it up, and slammed it into the weak spot that had already been damaged.

Whoa, whoa, whoa!

The brown bear made a strange figure, and its whole body collapsed to the ground.

Liu Feng took out the thing that drew blood, drew ~ out~ blood, and tested his mental power.

"Purity is okay." Liu Feng nodded.

Directly tied up the brown bear, and then called someone to transport it away.

An hour later, a helicopter arrived, and several super-soldiers got off the helicopter and carried the brown bear away.

This brown bear is suitable for making attribute awakening potions, which have a certain chance of awakening attribute ~ power, which is the inspiration that Liu Feng got from eating electric eel brains.

The meat was so rotten that even the soup was drunk, and the next day continued on the road.

The entire plateau is a treasure trove, but Liu Feng has no more energy to continue to observe, because he has received news of the disappearance of livestock one after another.

Three days later, already approaching Ruxian County, about a few hundred kilometers away, Liu Feng saw a strange beast.

The original musk deer, a herd of original musk deer, numbered more than a dozen, one of which was the size of a yak.

The original musk deer has a small head, large eyes, long and erect ears, the upper part is nearly rounded, and the snout is bare ~ exposed. Both males and females have no horns, and males have well-developed canine teeth that expose their lips and form fangs. Females have small upper canine teeth that do not show out of their mouths. The limbs are slender, the hind limbs are longer than the forelimbs, more developed than the forelimbs, the height of the hips is greater than the shoulder height, and the back of the body is thick ~ strong. The main hooves are long and narrow, and the side hooves are prominent, and they can touch the ground. The tail is short and hidden in hairy bushes. Males have musk glands on their abdomen that secrete musk. The size of the glands varies from individual to individual, and the glands are sac-shaped.

The whole body of the musk deer is dark brown, and there are 4-5 longitudinal cinnamon-colored spots arranged on the back, abdomen and buttocks ~ part, the spots on the back are not obvious, and the spots on both sides of the waist and buttocks are more obvious, and they are dense and not branched. The mouth and cheeks are brownish-gray, and the forehead is darker. The back of the ear and the tip of the ear are brownish gray, the inner shell of the ear is white, the base of the ear is sometimes mixed with yellow spots, the jaw is white, and the neck has two white stripes extending from the sides to the armpits. The inside of the limbs, armpits and around the buttocks ~ are light brownish-gray, the outer sides of the limbs are dark brown, and the tail is light brown. The coat color varies depending on the region, season, age.

The proto-musk deer skull is narrow and thin, and the nasal bone is elongated, and its width is roughly equal anteriorly anteriorly. There is a depression in the anterior part of the frontal bone that connects with the nasal bone; The lacrimal bone is short, slightly triangular, and not connected to the nasal bone, and the frontal bone is separated from the maxilla, so that there is a gap between the four bones. There are no tear sockets in the eyes.

The maxillary incisors of the protomusk deer are missing, and there is a vacancy between the upper canine teeth and the first premolar; The upper canines of males are well developed, long and curved forward, flattened laterally, with sharp cues and sharp posterior margins, while in females the upper canines are small. The first premolars are small and laterally flattened, and the inner and outer margins of the second and third premolars each have a crescent-shaped tooth process; Molars have 2 pairs of crescent-shaped processes arranged in two rows. Mandibular canines are small, walking with the incisors, the tooth surface is oval, and the mandibular molars of the dentition have a similar process to the maxillary, but there is a horseshoe-shaped lobule behind the posterior molars.

"Musk!" Liu Feng thought of musk, what is the effect of the musk of the mutated roe deer.

"Catch it first." Liu Feng muttered in his heart.

Just when Liu Feng approached this group of original musk deer for 300 meters, this group of original musk deer was on the slope opposite the river valley, and it took Liu Feng more than an hour to approach.

Two hundred and fifty meters, two hundred meters.

One hundred and fifty meters.

Rumble!

The leading Yuan Musk Deer jumped up all of a sudden and rushed towards Liu Feng.

The rest scattered in a hurry, and as soon as Liu Feng stomped his feet, he rushed up.

Mental power coupled with strong strength, the leading original musk deer was thrown to the ground at once, and he was directly knocked unconscious.

Liu Feng grabbed a handful of stones, but it was too late, and he ran out a few hundred meters away.

Why not attack with energy?

Because Liu Feng is afraid of being exposed, this place is already close to Ruxian County, who knows where the top-level beast will be.

After looking up the relevant information, Liu Feng knew how to take musk.

Live musk deer incense is carried out in captivity. At present, the rapid incense method is generally adopted, that is, the musk deer is directly fixed on the leg of the musk deer, the hair covering the mouth of the sachet is slightly cut off, the alcohol is disinfected, the spoon is stretched into the bag and slowly rotated, and then the musk is pulled out ~ outward. After taking the incense, remove the impurities, put it in the dryer, and after drying, store it in a small brown closed glass to prevent moisture and mildew.

Liu Feng didn't find the glass bottle, of course, it was easier to take musk with his mind.

Remove the musk and test it directly with 10,000 votes.

A series of data came out, and Liu Feng looked big.

, water, muskone (musco

e), normuskone (

o

musco

e) and other macromolecular cyclic ketones. Also contains androsterane (a

d

osta

e) derivatives: 5α-androst-3,17-dione (5α-a

d

osta

-3,17-dio

e), 5β-androsteroid melt-3,17-dione (5β-a

d

osta

-3,17-dio

e), 3α-hydroxy-5α-refractory stane-17-one (3α-hyd

oxy-5α-a

d

osta

-17-o

e), 3α-hydroxy-5β-androstane-17-one (3α-hyd

oxy-5β-a

d

osta

-17-o

g), 3β-hydroxyandros-5-en-17-one (3β-hyd

oxya

d

ost-5-e

-17-o

E), androst-3,4,17-trione (a

d

ost

-3,4,17-t

io

e), 5α-androstane-3β, 17α-diol (5α-a

d

osta

-3β,17α-diol), 5β-androst-3α,17β-diol (5β-a

d

osta

-3α,17β-diol), androst-4,6-diene-3,17-dione (a

d

osta

-4,6-die

-3,17-dio

e) etc. In addition, it contains cholesterol (choleste

ol), cholestanol (cholesta

ol), cholest-4-en-3-one (cholest-4-e

e-3-o

e), proteins, amino acids, lecithin, fats, urea, ...............................

"Screening for substances that are different from ordinary musk." Liu Feng had to give an order to analyze, and his eyes were dazzled.

"No comparison samples." The watch gives this answer.

Liu Feng was speechless.

Musk is a precious Chinese medicine, Liu Feng took a closer look at how useful this musk was, Liu Qi decided to search for complete pharmacological data, and then use his watch to deduce.

Complete pharmacology, this makes Liu Feng feel very good, many people look down on traditional Chinese medicine, in fact, in his previous life, Liu Feng knew that after the mutation of traditional Chinese medicine, it is a really good thing, of course, it may also be highly toxic.

Liu Feng decided to take a closer look, in fact, many drugs have great benefits for people's good news and nerves.

The in vivo process of muskone was studied by tritium labeling tracer method, and it was shown that after 3 hours of intragastric and intravenous injection of muskone in mice, it could quickly penetrate the blood-brain barrier into the central nervous system. The distribution of the brain after gavage was the highest, followed by the brain, cerebellum and spinal cord. With the extension of time, the accumulation of each part gradually increases. After intravenous injection, the distribution volume is in the order of cerebellum, brain, brain and spinal cord, and it penetrates the blood-brain barrier quickly, reaches the peak time early, and accumulates for a long time. In addition, the distribution of different routes of administration in each major organ is also different. After gavage, it is mainly distributed in the intestine and liver, followed by the kidney, heart, spleen, lungs and muscles, and with the prolongation of time, the intestinal and liver accumulation can decrease rapidly, and other organs can increase. The order of distribution after intravenous injection is liver, lungs, kidneys, spleen, heart, intestines, and muscles. The mechanism of the difference between the dynamics of the two routes of administration in various organs and tissues in the body is not well understood. The two routes of administration of the drug are mainly eliminated from the liver and kidney, and the lungs may also be one of the routes of excretion~.

The drug-time curve and kinetics of a single intravenous injection of hour-muskone in 1 mouse were drawn, and the drug-time curve was drawn on semi-logarithmic coordinate paper. From the curve, it can be seen that the genus dynamics multi-chamber model is processed as a two-chamber model for the convenience of calculation. The approximate nonlinear regression method was used to process the 3-9 hour data to obtain an equation: C=e(-6.1169t+7.2914), and the elimination rate constant B and intercept B were obtained, and then the residual line was obtained by using the residual method and the approximate nonlinear regression method, so that the distribution velocity constant a and intercept A and other parameters were obtained according to the pharmacokinetic formula.

2. The drug-time curve and kinetics of a single 3-hour intragastric administration of muskone in mice, and the one-time curve of the drug was drawn on semi-logarithmic coordinate paper. It belongs to the kinetic single-chamber model, and the approximate nonlinear regression is performed at 3-9 hours, and the regression equation C=e(-0.068t+6.51) is obtained, so as to obtain the elimination rate constant K, and then the residual approximate nonlinear regression equation is obtained according to the residual method, and the absorption rate constant K2 is obtained, and the other parameters are according to pharmacokinetics.

3 Discussion hours of muskone single intravenous injection, its distribution t1/2 is 1.4 points, a single gavage absorption t1/2 is 12.6 minutes, indicating that the drug is quickly absorbed, the effect is rapid, and provides a theoretical basis for emergency use.

3.1 Compared with aromatic Chinese medicine borneol, its kinetic parameters are very close, because the fat-solubility of muskone is better than that of borneol, its absorption rate and distribution rate are faster, and its passage through the blood-brain barrier is also faster than that of borneol.

3.2 After a single intravenous administration of the product, the VB is 9 times that of VC, indicating that the distribution of muskone in the body is mainly concentrated in organs and tissues with rich blood flow, such as the heart, lungs, kidneys, and brain, and is rarely in the muscles.

3.3 The biological half-life of muskone is about 9 hours, which is longer than that of borneol (5 hours), so it should be considered in the dosage and interval between doses. The fraction of 4.3 hours-muskone gavage administration was 0.7, which was higher than that of borneol (F=0.25).

Seeing this, Li Feng looked at his detection of mutant longan, and his heart moved: "Could it be that it can be added to the telekinetic elixir?" ”

Liu Feng quickly sent an order to the base to detect the pharmacology of mutant longan.

Then Liu Feng continued to watch.

The first is the impact on nerves, in fact, drugs are aimed at nerves and cells, cardiovascular and cerebrovascular effects.

1.1 The effect of musk or musk ketone on the central nervous system, musk perfume agent, suspension intravenous injection of 50mg/kg or lateral ventricular injection of 2.5mg/kg, can make the cortical electroencephalogram (EEG) of quiet and awake rabbits desynchronize for a short time, some animals are mixed with agitation and are in a state of awake alert, indicating that it can stimulate the cerebral cortex and enhance cortical electrical activity; Musk perfume has a significant arousal effect on pentobal ~ than ~ sodium anesthetized rabbits, and lateral ventricular injection is more effective than intravenous injection, indicating that musk may directly act on the central nervous system through the blood-brain barrier.

1.2 Intragastric administration of 200 mg/kg of musk suspension or 5 mg/kg of musk ketone for 2 days (4 times) can significantly shorten the sleep time of pento~bi~ sodium butto, but has no significant effect on the sleep time caused by water and chloral and benzo~bi~sodium to. The experimental results showed that the concentrations of penta~bi~tosodium in the brain tissue, liver homogenate and blood of rats in the musk group were significantly lower than those in the control group after injection of pento~ bi~ sodium sodium. However, there was no significant effect on the blood concentration of penta~bi~tosodium in rats pre-given thioacetamide, which proved that the effect of musk and musk ketone on pentoba~bi~ sodium was caused by stimulating liver microsomal drug invertase. Musk gavage 0.018-0.03mg/piece can resist nicotinine-induced convulsions in mice, and reduce acute toxicity, but increase the acute toxicity of mangweed, shi~of~ning, etc.

1.3 Ketone also has anti-nicotinic toxicity similar to natural musk, reducing the number of deaths in mice by more than 2 times; Increase the toxicity of Shi ~ ~ Ning, so that the number of animal deaths increases by 2-7 times. Mice were intraperitoneally injected with musk 25-100mg/kg; Synthetic muskone or natural muskone 0.02-0.5mg/kg or natural musk 2mg/kg can shorten the sleep time caused by cyclohexanpa~bi~tosodium 100mg/kg or pentopa~bi~tosodium. The mechanism of action of musk and musk ketone antihypnotics is not fully understood. Rats were given musk suspension 200mg/kg or muskone 5mg/kg for multiple times, which could significantly shorten the sleep time of pentoba~bi~ sodium sodium, which was not directly excitatory center, but because they activated the effect of liver microsomal drug convertase and accelerated the inactivation of intrahepatic pentosis ~ bi~ sodium metabolism. Natural musk 1g/kg or synthetic musk ketone and natural musk ketone 100-500mg/kg can prolong the sleep time of mice caused by pento~ bi~ sodium to. Therefore, it is believed that musk excites the center in small doses and inhibits in large doses. Musk had no significant effect on the spontaneous activity of mice, so it had no obvious excitatory or inhibitory effect on the center.

1.4 It can significantly prolong the hypoxic survival time of mice in normal pressure environment; Musk 200mg/kg intraperitoneal injection can significantly prolong the hypoxic survival time of mice in normal pressure environment, without reducing the spontaneous activity of mice, and the synchronous recording of electrocardiogram and electroencephalogram in rats proves that this effect is due to the improved tolerance of the central nervous system to hypoxia. The synchronous recording of EEG and ECG in rats proved that musk could significantly prolong the existence time of EEG after acute respiratory arrest, but had no significant effect on the existence time of ECG and hypoxic ECG, indicating that musk enhanced the hypoxia tolerance of the central nervous system may be the theoretical basis for its aromatic opening.

1.5 Intraperitoneal injection of 60-200mg/kg has a significant antagonistic effect on atmospheric pressure hypoxia, which can significantly prolong the survival time of mice. In addition, the in vitro culture method of rat superior cervical ganglion was used to show that musk had the effect of promoting Schwann cell division and growth, suggesting that musk had glial maturation factor-like effect.

Seeing this, Liu Feng became short of breath and glia. What is this aromatic opening to the central nervous system?

This is the increase of mental power, how does mental power come about, and what is the basis of mental power?

It is the nerves, the brain, and the development of the brain is actually the development of the nerves, and only when the nerves are developed, can the brain be utilized.

Liu Feng took out a little musk, took out a can of milk, and then took it.

The smell is very big, and this smell rushes straight to the brain.

The spirit was shocked, and the telekinesis seemed to run much faster.

"It seems to have an effect on the physique, and it feels like the blood speed is increasing?" Liu Feng felt it first.

Then I looked at my watch and found that it has an additive effect on nerves, blood vessels, and blood.

Continue looking at the material.

1 musk 1mg/kg given to anesthetized cats can increase heart rate, blood pressure decrease, respiratory rate and depth also increase; The concentration of 10-4 g/ml can increase the contractile effect of isoproterenol on the mammary ~ capitate muscle of the cat heart by 3.8 times, and increase the effect of adrenaline by 1.5 times. Musk B ~ ether extract 150μg/kg or 300μg/kg intravenous injection can cause blood pressure drop and slightly slow down the heart rate of anesthetized dogs, but has no obvious effect on cardiac arteries, venous blood oxygen partial pressure difference and coronary venous sinus flow, and the effect of large doses is more obvious, and can counter the effect of isoproterenol to stimulate the heart. Experiments have also shown that musk does not block β-receptors in peripheral blood vessels. The concentration of 0.2 mg/ml musk had an inhibitory effect on the automaticity of cultured cardiomyocytes, slowing down the beating frequency, which was manifested as an incomplete competitive inhibitory effect on myocardial α-β-receptors, and had no effect on the acceleration of the pulsation frequency caused by calcium chloride.

Natural musk 0.5-2mg/ml can increase the systolic amplitude, contractility and cardiac output of isolated toads, while musk ketone 0.04-1mg/ml shows cardiosuppressive effect and does not have the cardiotonic effect of natural musk. The earliest experiments have also shown that both synthetic and natural musk ketone have an excitatory effect on the heart of the toad in vivo. Therefore, musk has a significant cardiotonic effect, while consistent results have not been obtained for the cardiac effect of muskone. There was no significant change in the coronary flow rate of musk perfume suspension on isolated rabbits and the coronary flow rate of musk injection ~ solution on dogs. Musk perfume suspension or aqueous extract can increase the coronary flow of isolated guinea pigs by 1 times, and the effect of muskone on coronary circulation has not been consistent, and various muskone emulsions have not increased the coronary flow in isolated guinea pigs. intravenous injection with muskone 3 mg/kg); It can increase the coronary flow of dogs by 34.8-56.1%, and the effect lasts for 30 minutes. Myocardial trophic blood flow was measured with 86Rb, and muskone was observed to increase myocardial trophic blood flow. The above different results may be related to different animals, preparations or experimental conditions, and need to be further validated. Acute animal blood pressure experiments showed that intravenous injection of musk preparations had a significant antihypertensive effect on anesthetized rabbits, cats and anesthetized dogs with and without ligation of the left anterior descending artery. The effect of muskone on blood pressure varies from one laboratory animal to another. Can raise blood pressure in cats; Causes blood pressure in the dog to drop or no effect.

"This is of great benefit to the awakened, it can increase the energy burst, and the energy burst is affected by the physical fitness."

1. Anti-inflammatory effect: natural musk suspension 500mg/kg, ethyl ~ ether extract 65mg/kg or 130mg/kg intraperitoneal injection, have a significant inhibitory effect on the auricular swelling ~ swelling caused by croton oil in mice. Different dosages and multiple administration methods of musk perfume extract had significant inhibitory effects on rat agar arthritis, yeast arthritis, adjuvant polyarthritis and cotton ball granulation tissue proliferation. It also has a very obvious inhibitory effect on the increase of scald vascular permeability in rats and the migration of abdominal leukocytes caused by carboxymethyl cellulose~; The 50% inhibitory dose of intravenous musk peptide powder on ear inflammation in croton oil mice was 0.63 mg/kg, which was 36 times the intensity of hydrocortisone. Intravenous injection of 80mg/kg of musk water soluble matter can reduce the content of vitamin C in epinephrine and increase the content of corticosterone in peripheral blood. The anti-inflammatory effect of musk disappeared after the resection of the adrenal gland in mice, while the anti-inflammatory effect of musk still existed after pituitary resection, indicating that its effect directly depended on the adrenal gland without the participation of the pituitary gland. The mustonol-soluble ingredient methanol in the extract of 400-1600 μg/ml can reduce the activity of rabbit kidney medullary epoxygenase, and significantly reduce the production of arachidonic acid metabolites prostaglandins E and F. Musk has a good anti-inflammatory effect on foot edema caused by injection of dead tuberculosis bacteria in rats, and has anti-inflammatory effects on granulocysts and formaldehyde-filter paper ball granuloma cysts caused by injection of croton oil in rats, and the half inhibitor dose (ID50) of the latter is 388mg/kg. It can also reduce the permeability of skin capillaries in mice, with a median inhibitor dose (ID50) of 4.2 mg/kg.

The results of anti-inflammatory experiments on a series of isolates with different doses of musk perfume solubility showed that the anti-inflammatory strength of musk-51 and -65 was 6 times greater than that of hydrocortisone. The inhibition rates of ear inflammation ~ swelling ~ swelling caused by mouse croton oil by intraperitoneal injection of 65-130mg/kg of musk B ~ ether extract and 500 mg/kg intraperitoneal injection were 29.7-33.7% and 27-29.4%, respectively, while that of hydrocortisone 12.5mg/kg was 39-60%. The musk perfume extract has a very significant inhibitory effect on mouse croton oil ear inflammation, rat agar arthrosma, yeast arthrosis and adjuvant polyarthritis. Increased vascular permeability to rat scalds. Carboxymethyl cellulose also has a very obvious inhibitory effect on peritoneal leukocyte migration~. The 50% inhibitor dose of intravenous injection of Musk No. 1 (a polypeptide with a molecular weight of about 10,000) on ear inflammation in mice with croton oil was 0.63mg/kg, which was 36 times the strength of hydrocortisone, and more than 500 times the strength of hydrocortisone when compared with the molecular dose in grams. The median lethality and 95% confidence limit of intravenous musk fragrance extract in mice was 848±104mg/kg. The musk perfume soluble substance can reduce the vitamin C content in the adrenal glands of rats, increase the content of peripheral blood corticosterone, and the anti-inflammatory effect of the resection of the adrenal gland disappears, but the anti-inflammatory effect of the pituitary gland resection still exists, indicating that the anti-inflammatory effect of the adrenal gland and the musk perfume soluble substance are closely related. Musk perfume soluble inhibits platelet aggregation. These effects of increasing plasma cAMP levels are similar to those of nonsteroidal anti-inflammatory drugs; However, musk water soluble substance can enhance the immune hemolytic response of 615 mice, suggesting that it may exert anti-inflammatory effects through immune regulation. The musk ketone contained in musk only has anti-inflammatory effect when intraperitoneally injected l00mg/kg, while the polypeptide extracted from musk has a half effective amount of 0.63mg/kg for inhibiting ear inflammation induced by croton oil in mice, which shows that musk ketone is not the main anti-inflammatory active ingredient of musk.

It has been reported that Anti-Inflammatory No. 1 (Musk-65), isolated from Musk, has approximately 40-fold greater anti-inflammatory effect on ear inflammation induced by croton oil in mice than hydrocortisone. And it is proven that musk has a negative effect on the whole process of inflammation. All have varying degrees of effect. In particular, the effect is most obvious in the transition between the early and middle stages of inflammation, which has the effect of inhibiting the increase of capillary permeability and strongly inhibiting the flow of leukocytes in mice, while the anti-inflammatory effect disappears when the adrenal gland is removed. At present, it is preliminarily confirmed that the soluble peptide part of musk is a component that has an inhibitory effect on the elution of white blood cells, and it is uncertain whether the effect of other active ingredients on each stage of inflammation is exactly the same. Musk 0.2mg/ml culture medium has an inhibitory effect on the autonomous rhythm of isolated cardiomyocytes, slowing down the beating frequency, can not slow down the cardiomyocyte exertional frequency caused by calcium chloride acceleration, cultured cardiomyocytes in the case of hypoxia and glucose, musk has accelerated cardiomyocyte release ~ lactate dehydrogenase, succinate dehydrogenase, acid phosphatase and accelerated the death of damaged cells and other toxic effects.

The rest is nothing, Liu Feng finally looked at toxicology.

The median lethal dose of mice injected with musk perfume extract intravenously was 6.0g/kg; The median lethal dose of muskone intraperitoneal injection was 290.7±20.76mg/kg, and the activity was reduced at larger doses. Poisoned dose animals fell on all fours, tremor, closed eyes, obvious respiratory depression and died; Rats were intraperitoneally injected with 55.56mg/kg of the product for 20 consecutive days, which had a certain effect on red blood cells and white blood cells, and made the liver and spleen of rats enlarge to a certain extent, and the edges were thick and blunt. The half lethal dose of intraperitoneal injection of musk perfume agent was 331.1mg/kg, and when the dose was increased to 600mg/kg, the erection hairs of mice were seen, and no special toxic reaction occurred. Another experiment proved that the half lethal dose of mice injected with musk perfume extract intravenously was 6g/kg. The median lethal dose of muskone mice injected intravenously was 152-172 mg/kg, and the half lethal dose of intraperitoneal injection was 270-290 mg/kg. Larger doses of musk ketone can make mice fall on all fours, tremor, closed eyes, respiratory depression and death, rats gavage musk 60mg/kg, rabbit gavage 62mg/kg, for 15 consecutive days or rats gavage musk suspension 2g/kg, for 16 consecutive days, body weight, blood, liver, kidney were not abnormal. The rat was intraperitoneally injected with 27.78mg/kg, and the body weight, various organs and blood were not normalized, and the dose was doubled, and the liver and spleen were enlarged, the edge was thick and blunt, and the pathological tissue section was not abnormal. Intramuscular injection of artificial muskone injection ~ liquid 400-800mg/kg for 14 consecutive days, the results showed that all animals had increased appetite, moved freely, and no abnormalities were found in liver and kidney function and blood image. Each monkey was injected with 1.2g for 2 consecutive days, and there was no poisoning, which shows that musk and musk ketone toxicity are very small.

The rest is clinical application, mainly cardiovascular and cerebrovascular diseases, for which Liu Feng feels that it can be used.

"Good stuff." Liu Feng found a positioning object, nailed it directly to the guy's ear, and then let it go.

After this guy was let go, he actually wanted to attack Liu Feng, but Liu Feng cleaned it up.

Then he hurriedly ran.

"The information just now is still the original musk, this mutated musk should be more effective, it seems that it is feasible to go back and get some mutated Chinese medicine." For cultivating mutant plants, Liu Feng has experience.

In addition, musk is not only the original musk deer, but also roe deer.

In the evening, Liu Feng had a deeper understanding of the musk project.

It was found that musk came more from muskrats.

The muskrat, the green-rooted marten, is the only member of the muskrat genus, a small and precious fur-bearing animal. The body shape is like a large mouse, with a length of 35-40 cm and a tail length of 23-25 cm, which is larger than that of a vole, weighing 0.8-1.2 kg. The muskrat has dense hairs all over the body, and the back is brownish-black or chestnut-yellow, and the ventral surface is brownish-gray. The tail is brownish-black, slightly flattened, with scaly patches on it and sparse brownish-black miscellaneous hairs. Mice that have just left the litter and live independently have inconspicuous lateral flattening of the tail. The muskrat has a small, slightly flattened head, a short, thick neck with no clear boundary with the trunk. The eyes are small, the ears are short and hidden in the long coat, and the ear holes are blocked by long hairs. The mouth is blunt and rounded, and there is a beard. The upper and lower jaws each have a pair of long, sharp front teeth that are light yellow or dark yellow and exposed outside the lips. The limbs are short, the forefoot has 4 toes, the claws are sharp, the toes are webbed, the hindfoot is slightly longer than the forefoot, the toes are semi-webbed, and there are stiff hairs.

Male muskrats can secrete ~ muskrat incense through the muskrat glands of the breeding system from April to September, which has a strong aromatic flavor. Muskrat incense can not only replace musk as a precious Chinese medicinal material, but also be a raw material for making high-end perfumes.

"Made in North America? Fortunately, it was discovered early, otherwise it would have been extinct. Liu Feng muttered in his heart.

It all starts with the environment in which the muskrat lives.

The muskrat is a land-dwelling mammal that can swim and dive in the water, and is a semi-aquatic mammal. Most of them live in reeds, cattails and other water-standing plants, gentle water flow, suitable for nesting in river bays, rivers, shallow small lakes and ponds (about 0.3-1 meters deep) and perennial water, ponds (commonly known as "water bubbles") in swamps. If the soil is suitable for the shore where the hole is built, the hole will be built; Nests are built in areas where it is difficult to burrow, such as reed ponds or swamps. [3]

Muskrats often inhabit low-lying areas, swamps, lakes, rivers, and ponds, where water and grass are abundant and the environment is quiet. Their holes~holes are mainly distributed on the shore, in the grass of reeds and cattails in shallow water, and some build nests on objects floating on water rafts. The holes ~ holes are branched, with many blind passages branching off, in which there are several granaries, where the feed is stored and there are several passages leading directly to the place where there is water.

"Rub, has it been artificially bred?"

Liu Feng directly issued a reward order on the watch, requiring 200,000 muskrats, one for an immune potion, but the other party needs to provide a cage and transport it to the base.

"Wangbu ~ Chief, I need a factory that breeds 200,000 muskrats, and you are ready to accept it." Liu Feng called Wang Jun and spoke.

"Okay." Wang Jun immediately carried out the order.

After checking the information of the muskrat, Wang Jun breathed a sigh of relief, this can be three-dimensional breeding, Wang Jun directly made a note on the cage of Liu Feng's bounty.

Here, a suitable space is directly established in the cave, and the cage is directly put on when it comes.

The base's bounty website, the long-term bounty is the beast, and the rest are almost none.

Now the muskrat is on offer.

"Boss Liu." Xiang Boss called Liu Feng.

"Boss Xiang, what's the matter?" Liu Feng asked.

"Does Boss Liu want to breed mutant muskrats, we just have them here, and there are two mutant musk deer, and mutant sika deer, do you need it?" Xiang Boss called Liu Feng beautifully.

How do you know that Liu Feng opened his mouth and said: "I'm sorry, Boss Xiang, I cultivated it myself, and the medicinal value of cultivation is higher." ”

"Do you need information, we have studied the musk of mutant muskrats? Have a complete pharmacology profile? Boss Xiang was very surprised when he heard this.

"Pass it to the base, I'll refer to it." Liu Feng was very surprised, this mainland was actually ahead of him.

Of course, Liu Feng did not underestimate the mainland, there are many people in the mainland, and he has mastered the method of making awakening potions.......

"It seems that we have to spread the method of making the awakening potion, otherwise it will be difficult to get it in the future." Liu Feng muttered in his heart.

"Okay." Give orders directly to the boss.

Half an hour later, Liu Feng received the information, and then ~ compared it and found that the toxicity had increased.

Frown!

"But the attributes are different, and the results are definitely different."

"The musk of this mutant muskrat can indeed relieve the pressure on the heart and brain, so you can study the outbreak potion."

Then there were the antlers of the sika deer sent to the Red Army.

Deer antler velvet is the young horn of the unossified dense hairy of the buck, mainly harvested from the heads of sika deer and red deer, the former is called flower deer antler velvet and yellow hair, and the latter is called green hair. When a buck reaches a certain age, it will grow horns on its head, and when it first appears, it is as tender as a spring shoot, and the young horns with a layer of delicate and fluffy hair on its surface are deer antler velvets. The young horns slowly grow and gradually age into antlers, and the fur falls off. When the young horns of a buck have not grown into hard bones, they are hairy and contain blood, which is called deer antler. Red deer antlers are large in size, but the medicinal quality of sika antlers is higher. According to the growth time, the size of the mushroom, the number of forks and the degree of age, the deer can be divided into many specifications, such as newborn mushroom, two bars, three forks, hanging horns, regenerated mushrooms, cut mushrooms, etc. The whole sawn antler velvet is cylindrical, with one branch called "two bars" and two branches called "three branches". Deer antler velvet can be divided into wax tablets, white ~ powder tablets, red powder tablets, blood tablets, and bone tablets from top to bottom. Deer antler velvet is a valuable traditional Chinese medicine used as a tonic and strengthening agent, and it is effective for weakness, neurasthenia, etc. Deer antler velvet contains phospholipids, glycolipids, gelatins, hormones, fatty acids, amino acids, proteins, calcium, phosphorus, magnesium, sodium and other components, of which amino acids account for more than half of the total components.

"Strengthen the kidneys and yang, replenish the essence, strengthen the muscles and bones, adjust the chong, and support the sores and poisons."

Then look at the details and store them in your watch.

Among them, the total amino acid content is 50.13%, including glycine, lysine (lysi

e), arginine, aspartic acid (ASPA

ticacid), glutamic acid, proline, alanine (ala

i

e), more than 17 kinds of leucine, etc. The active ingredient of deer antler velvet that inhibits MAO was separated, and 9 compounds were obtained from ether extract: (1) cholesterol meat ~ bean macroate. (2) Fertilizer alkyl oleate (choleste

yloleate)。 (3) Cholesterol palmorunate. (4) Cholesterol stearate. (5) p-hydroxybenzaldehyde. (6) Cholesterol (choleste

ol)。 (7) Cholester-5-en-3B-alcohol-ketone. (8) Cholest-5-en-3β, 7α-diol (cholest-5-e

-3β，7α-diol)。 (9) Cholesteric 5-ene-β,7β-diol. From the n-butanol extract, the urinary cataru (u

acil)。 Hypoasodic Yuanyin, urea (u

EA), uracil nucleoside (U

idi

e), niacin, muscle crisp (c

eati

i

e), in which Hypoagnosis has the effect of inhibiting MAO-B activity. In addition, fatty acids, triglycerides and monoglycerides were also isolated from the ether extract, of which the fatty acids were composed of lauric acid (lau

icacid), meat H macro acid (my

Isticacid), palmitic acid, palm oleic acid, oleic acid, and linoleic acid (Li

oticacid).

Deer antler velvet can enhance the tension of parasympathetic nerve endings, promote the restoration of the nervous system and improve the function of the nervous and muscular systems, and also have an excitatory effect on the sympathetic nervous system.

Large doses of deer antler velvet can lower blood pressure, make the heart contraction amplitude smaller, the heart rate slows down, and the peripheral blood vessels dilate. Moderate doses can cause a significant increase in cardiac contractions, with greater contractions and increased heart rate, resulting in an increase in cardiac output; Deer antler velvet is especially effective for tired hearts.

Deer antler extract has a strong anti-fatigue effect, can enhance cold tolerance, accelerate wound healing and stimulate adrenal cortical function. Therefore, deer antler velvet is a traditional tonic medicine, which is used to strengthen the body, tonify the kidney, and benefit the yang.

Deer antler velvet can increase hemoglobin in the blood, so it is extremely effective for the treatment of large amounts of ~ blood and patients with terminal infections, especially for elderly patients.

"Boss Xiang actually did a clinical trial." Liu Feng saw that in the end, the mainland had already used mutated sika deer for experiments.

"In the same direction comparative test, the warriors who took sika deer antler velvet increased their data by 30%."

Liu Feng was very surprised when he saw this.

"No wonder in the last life, many strange beasts will live, I seem to remember that there was a bloody case back then, it seems to be because of a mutated plant, what is it?" Liu Feng muttered in his heart.

"It seems to be the mother of Chuan?"

Liu Feng decided to look for information.

Sichuan fritillary is named because it is mainly produced in Sichuan, but it is produced in Tibet, Gansu, Xinjiang, North China and Northeast China.

Sichuan fritillary maternal slightly cold and sweet and bitter taste, cough and phlegm effect is strong, into the heart and lung meridian, function to moisten the lungs, clinically often with sand ginseng, wheat winter, asparagus, mulberry leaves, chrysanthemum ~ flowers, etc. However, those with cold phlegm and wet phlegm should be disabled. There have been reports of allergies to taking Fritillary Chuan, so people with allergies should use it with caution.

Modern pharmacological studies have confirmed that fritillary contains a variety of alkaloids such as fritillary sinensis, which has a variety of pharmacological effects such as lowering blood pressure and excitating children ~ uterus.

After reading it, Liu Feng felt wrong, it didn't seem to be this at the beginning.

What are the famous medicinal herbs near Higashiyama?

Liu Feng searched for it.

"Gastrodia, that's it, looking at the efficacy, it will also have an effect on the telekinesis." Liu Feng searched for it and soon found out what it was.

Gastrodia has the ability to calm the liver and calm wind. Gastrodia moistening ~ liquid, can nourish blood and relieve wind, can treat headache and dizziness caused by blood deficiency and liver wind, and can also be used for children's convulsions, epilepsy and tetanus.

Dispel wind and relieve pain. It is used for dizziness, migraine, limb numbness, and hemiplegia caused by wind and phlegm.

Gastrodia is suitable for dizziness caused by internal wind. There are three types of headaches caused by internal strokes: 1. Hyperactive liver yang, which manifests symptoms: headache and dizziness appear at the same time; 2. Phlegm turbidity and obstruction, showing symptoms: often feel that the head is heavy; 3. Patients with kidney deficiency, showing symptoms: headache and dizziness accompanied by symptoms of memory loss. Gastrodia is not suitable for headaches and dizziness caused by colds.

Gastrodia has sedative, analgesic, and anticonvulsant effects; It can increase cerebral blood flow, reduce cerebral vascular resistance, slightly constrict cerebral blood vessels, and increase coronary vascular flow; It can lower blood pressure, slow down heart rate, and have a protective effect on myocardial ischemia; Gastrodia polysaccharides are immunoactive.

"The main thing is gastrodin. That's it, but it's going to take a few years to find this thing in my last life, so I don't know if it exists now. ”

Liu Feng continued to look at the pharmacological effects, and then stored the information.

Entering the territory of Ru County, Liu Feng looked at the distribution of missing cattle and sheep.

"It's not going to do much." Liu Feng didn't expect this missing distribution to have any effect, after all, the mutant creatures ran hundreds of kilometers in one night, which was nothing.

Liu Feng found a high mountain, put on a single mecha, and then lurked on the mountain to turn on the armor detection function.

"Locked."

Liu Feng locked a pasture more than 20 kilometers away, next to a river under the snow-capped mountain of the pasture, it was summer, there were about 10,000 sheep, as well as hundreds of cattle and horses, this was a grazing point.

Now the pastoral area is basically herded by dozens of people, all equipped with weapons, satellite phones and so on.

Waiting for the rabbit, Liu Feng wished that the more little brothers under the beast, the better.

The more junior brothers, the higher the chance of exposure, and after the armor was locked, Liu Feng pondered whether to open the production of awakening potions to other forces.

"Open." Liu Feng thought about it for a while and decided to open up.

After editing the information, Liu Feng sent it to Antonio, Hudson, Abu, and Da Mao, the people of the Americas.

When these people received the news, they looked at the information in disbelief.

The name is very long, and the process and process of making awakening potions by electrolyzing the blood of the first generation of alien beasts with high voltage and low current.