That's right, it's that leaf god!

Speaking of which, Ye Han is really famous.

His reputation, people in the entertainment industry like Su Xingyan or Gao Yi don't know, and a policeman like Zhuang Wei who is so busy that he doesn't have time to pay attention to it, but as long as he rubs a little bit with the scientific community, or even doesn't have to rub the edge, he is just a little interested in this aspect, and he should have heard of it.

He is studying proteins, to be precise, proteomics, the frontier of life science.

Since the completion of the Human Genome Project, it has been discovered that the genetic mystery of life will be revealed when not all the bases are sequenced clearly—genetic information is not directly involved in life activities, but indirectly manipulates organisms by controlling the formation of proteins.

Therefore, when the framework map of the human genome was released, Nature published the news of the establishment of the human proteome research organization at the same time, telling people that from now on, the forefront of biology is proteomics.

That's how important it is!

The only Daben Frederick Sanger, who has won two Nobel Prizes in Chemistry, won the first prize for protein sequencing.

This situation reached its peak last year, in 2018!

This year's Nobel Prize, the Three Nature Prizes were impressively rounded by biology!

And proteomics occupies two more places in it!

The Physiology and Medicine Prize, given to the molecular brakes to inhibit immune cells to resist or kill cancer cells and pathogenic microorganisms by the mechanism of research, is related to proteins.

The Chemistry Prize is for enzymes, which are proteins with high catalytic efficiency.

As for the optical tweezers technique of the Physics Prize, it is also an important technical tool for studying the living state of biomolecules.

Some people may say, do you say that it is so lively, does it have anything to do with Ye Han's research?

It's really ......

His research interests are structural determination, the foundation of proteomics.

Protein sequence determination is to figure out the order of amino acid residues, which is equivalent to figuring out molecular expressions;

There is also structure determination, which is to understand the three-dimensional structure of protein space, because the way the long chain space is bent will greatly affect the function and expression of protein.

Sequences are not too difficult, but they are of little use; Structure determination is useful, but it is also more difficult......

How difficult is it?

The sort order is often referred to as a first-level structure.

On top of this, there is a secondary structure of the local spatial arrangement of the main chain atoms of the polypeptide chain; Adjacent secondary structures in the polypeptide chain are space-folded and close to supersecondary structures; On this basis, the three-level structure is further formed by twists and turns. and the quaternary structure formed by the combination of secondary bonds between polypeptide chains......

So, if the sequence determination is at the elementary school level, then the structure determination is at least undergraduate.

If the sequence determination is a univariate equation, then the structure determination is at least a unary quintat equation...... Such difficulty.

At present, the common practice is to predict the spatial structure through sequences, and there is also a homology modeling method. Threading method or string method, folding recognition method; and de novo prediction, which uses supercomputers or distributed computing to brute-force the problem.

There is also a difference in difficulty between the three methods.

It's the same as before - easy, more restrictive; If it's not restricted, it's harder.

Among them, the de novo prediction method is the most difficult, but it is also the most applicable.

Because it is based on molecular dynamics, it does not require homologous proteins, nor does it require a core folding database, except that it is computationally large and almost perfect.

Ye Han's paper optimizes the method through a purely mathematical algorithm, which greatly reduces the amount of computation for some steps while ensuring accuracy.

Although biologists don't need IQ so much, and more is wasteful, it is a profession that requires more physical strength, but when it comes to Ye Han's level, it is different.

His dissertation is hailed as another doctoral dissertation that can directly win the Nobel Prize after the Duke de Broglie! Or, take the Fields or Turing Award......

Among them, there must be unscrupulous touting by the domestic media, but it is indeed extremely good!

Because of this, he and Cao Yuan, who discovered the superconductivity of graphene magic horn, were known as "young geniuses", "twin stars of the University of Science and Technology", and "double pride in studying abroad...... Together with a senior from their school, they were on the list of the top ten scientific figures who influenced the world in 2018 by Nature.

There are also two scenes, and the exposure rate is extremely high.

Even now, many headlines and public accounts have shamelessly used his study experience and study abroad experience to demonstrate the gap between domestic and foreign education, and the success or failure of cramming education and quality education, of course, mainly to attract attention and attract traffic.

popularized Ye Han's achievements, and Hustan was pleasantly surprised, and bowed his head.

To be precise, it is to bow down and popularize science at the same time.

"Big guy! Leaf God! How did you get here? I even forgot that there are no master's and doctoral students here, "I am willing to study your doctoral students, I will follow you!" ”

Although this one is two years younger than himself, he ...... There is no order to learn, and the master is the first!

This is the legendary Nobel Prize in the palm of the hand of the Ye Shen, a proper future student valve Daben, if you don't hug your thighs now, when will you stay?

Ye Han moved silently to avoid it.

Poke the teacher's lung tube one after another, so that the students who deceive the teacher and destroy the ancestors, don't!

==========

Although Hustan did popular science......

Su Xingyan still timidly asked the doubts in his heart: "What are IMO and IPHO?" ”

What is IMO? What is IPHO? Su Baibai, you are so white!

Hustan's nose was about to smoke: "It's the Olympiad, haven't you heard of this?" ”

As soon as you say that, everyone understands.

IMO, the full name of the International Mathematical Olympiad; IPHO stands for International Physics Olympiad.

I think Hustan also participated in it back then.

Of course, it's not an international competition, it's not a domestic competition, it's a campus selection competition...... No, it was when he was 16 years old.

It can also be seen from this that Ye Han's strength has been consistent from small to large.

At the age of 11, he won the IMO silver medal, which is on par with the Australian Chinese mathematician, Fields Medal winner, and Tao Zhexuan.

It's a pity that he switched to IPHO in the second year and didn't participate in IMO, otherwise he would probably be the same as Tao, winning the bronze award at the age of 10, the silver award at the age of 11, and the gold award at the age of 12, leaving a good story.

Those present finally knew who Ye Han was.

I would also like to thank various public accounts for rubbing hot spots and brushing traffic, and reading reports repeatedly, so that everyone has more or less flipped over. It's just that this kind of academic report generally doesn't pay much attention to appearance......

In fact, there is no need to popularize science too much, and everyone doesn't understand academic things.

The IQ is one of the best, and Hustan, who is usually arrogant and stinky and can't do it, kneels down and hugs his thighs, which is enough to explain everything.

Let him bow his head and lick it like this, Duan Yan can't do it......

The crowd was stunned for a moment.

This guy, how old is this guy? Just a Nobel Prize-level scientist? You must know that it is as good as Sheldon, and it is also the Nobel Prize that was won at the end of the finale......

Ye Han helplessly kept the social laughter: Ordinary people also know Sheldon.