"We're under a lot of pressure now!" Pharmaceutical companies are here, they have built thick barriers, so that consumers have no choice, you either spend a lot of money to buy my medicine, or just wait at home to die, if the supply to the country is reduced, and the pharmaceutical companies can't get enough drugs in a short time, then it will be troublesome.

"It's okay, Nova won't make up their minds so quickly, now they're just intimidating, we still have time." Shen Long comforted, but in fact this was not the case, he had already prepared for this, and had thought of a coping strategy, but this method was not suitable for Professor Ma Lin to know.

"That's best, let's hurry up and do trial production! As long as the drugs produced can meet the needs of patients, then Nova will not have a problem reducing supply. Professor Ma Lin and Director Qiao were a little relieved.

After they left, Shen Long turned on the computer and got ready to work, Nova has a lot of problems, the governments of other countries are dissatisfied with them, and the pharmaceutical giants are also entangled, Shen Long now intends to provoke conflicts between them to attract Nova company's attention, so that they can't take care of their own affairs for the time being.

This is the same as using other local governments to help him reduce pressure before, but the target is different, Shen Long carefully recalled the information he collected, and decided to put the target on Avastin, which is an anti-cancer drug developed by Roche Pharmaceutical, the chemical name is "bevacizumab", which is a drug that hinders angiogenesis, blocks the blood supply to the tumor by inhibiting the effect of vascular endothelial growth factor, inhibits the spread of the tumor in the body, and enhances the effect of chemotherapy.

The drug is very effective, and it has been very popular in the market since its launch, and its annual sales are about the same as that of Grenin, and it is an out-and-out blockbuster drug (the industry refers to drugs that sell more than a billion dollars a year).

At first glance, this drug may not seem to have anything to do with Nova Company, but some doctors have accidentally discovered that Avastin has a very good therapeutic effect on patients blinded by macular degeneration, and this use has gradually spread, and many doctors have begun to prescribe this drug to macular degeneration patients in the form of a label topical drug.

Off-label drugs refer to drugs that are not in the label for use in indications approved by regulatory authorities such as the FDA (Food and Drug Administration); For example, metronidazole was used to treat trichomoniasis at the beginning, but the doctor also prescribed you metronidazole when your gums hurt, and you were stupid when you saw it, so you quickly found a doctor, saying that the doctor I am a man, and the doctor said that it was okay, you just took it, go back and eat, hey, the tooth really doesn't hurt anymore, this medicine is really god!

The spread of Avastin's off-label drugs is very unfavorable to Nova because they also have their own products in the field of macular degeneration treatment, and the off-label drugs of these doctors have undoubtedly had an extremely negative impact on the sales of Nova drugs.

Nova didn't pay much attention to the situation, so Shen Long wrote an email analyzing the situation and sent it anonymously to Nova executives.

After they know about this, they will definitely sue those doctors who use topical drugs, and Roche Pharmaceutical will definitely take corresponding measures for their own interests, these two pharmaceutical giants fight, then it is interesting, compared to this matter, what is the trivial matter in China?

After all, China's economy is not developed now, Nova company's interests in China are far from being comparable to Avastin's influence on them, and Roche is not so easy to deal with, they have rich litigation experience, if this lawsuit starts, it will be long, and it can also take this opportunity to expose the greed of pharmaceutical companies.

After a period of litigation, Roche and Nova will understand that a war between pharmaceutical giants like them is not a good option, so they will definitely compromise and seek a more effective way to cooperate, such as establishing a community of interests like the vitamin C price alliance to monopolize the macular degeneration drug market and raise prices.

It stands to reason that Roche could re-conduct the clinical trial of Avastin, and if it is determined that it is effective for macular degeneration, this indication can be added to the label, but this drug is developed for cancer, and because of the amount of use, it is much cheaper for ophthalmic patients to use this drug than Nova's drug.

In this case, Roche is not happy, because it is against their principle to provide drugs that are cheaper than the market, and they have always sold as much as they can, so it is better to join forces with Nova to monopolize this market.

Historically, they have done the same, and instead of carrying out clinical studies on avastine for macular degeneration, Roche has initiated legal measures to prevent doctors from using avastin to treat patients with eye diseases.

This behavior caused an uproar in the academic community, and many governments were extremely unhappy about it, and the Italian government issued a fine of 1.6 billion US dollars to them, and the French government launched an investigation against them.

Shen Long's email seemed to help them and let Nova discover Avastin's threat in advance, but in fact, it dug a hole for Nova and caused them more trouble.

However, these are not enough, Nova is a behemoth after all, and they have every spare power to start two wars at the same time, so Shen Long began to write new emails.

This email is about Nova using bribes to pass the FDA review, pharmaceutical companies bribery is not uncommon in the world, and there are a lot of later generations, and there are even people who write articles to publish in the world's top journals and magazines such as "Science", and it is easy to find some black materials of Nova company.

In the email, Shen Long exposed the list of people who accepted bribes during Nova's new drug approval process, and these accepted bribes ranging from hundreds of thousands to millions of dollars from Nova to facilitate Nova's approval.

In addition to direct bribery, there are also indirect bribery, many officials in charge of new drug review work for a few years, then jump ship to a pharmaceutical company, get a high-paying position, if there is no cat in this no one will believe it, look at the audit projects they were responsible for during the FDA, and then look at the list of companies they go to in the future, people will easily find that there is a chain of interests in this.

Then there's Nova sponsorship of politicians around the world, who spend hundreds of millions of dollars a year to get them to sort things out, and if exposed, it's a real scandal.

Come on, hurt each other, see who can't stand it first!