Chapter 84: Nutritional inhibition
"Human research on cancer cells has been going on for decades, and I have consulted a lot of cancer cell literature, combined with the biological characteristics of the "signaling" vectors emitted by tumor cells.
Finally, an organic chemical can inhibit the vector of this signal, thereby drastically reducing or even cutting off the nutrient supply to the tumor tissue. ”
Zhou Yi took Lu Yi to the mouse research area, pointed to the mouse in the glass box and said: "This is an experimental mouse with implanted tumors, and through microdose treatment, the growth rate of implanted tumors on its body has decreased significantly and has been effectively controlled.
When the dose is increased, the nutrients obtained by the tumor are further reduced, and the tumor cells begin to die in large numbers due to malnutrition, and the tumor begins to shrink.
Interestingly, the properties of this organic chemical are similar to those of the anti-cancer alkaloids found in paclitaxel, but the effects are more targeted and significant. ”
The so-called implantation tumor refers to the injection of living tumor cells into an organism that does not have cancer, and then the cancer cells will grow in the implanted organism, and the tumor that grows into shape is called an implantable tumor.
As for the specific rejection of the allogene, this is trivial for cancer cells, even on the protosome, cancer cells are "foreign substances" and are constantly attacked by white blood cells.
In addition to being more powerful in their own mutations, cancer cells are also deeply rooted in the essence of guerrilla warfare.
The strong and disgusting metastatic nature of the cancer cells, coupled with sufficient logistical supplies, leads to the fact that once the cancer cells are formed, they are almost irrepressible and can directly confront the white blood cells.
"What are the side effects of this thing?"
Lu Yi looked at the mouse lying there like a salted fish in the glass box, with a sluggish and energetic appearance, obviously this treatment is not without side effects.
"While inhibiting the nutrient supply of tumor cells, it can also inhibit the nutrient supply of normal cells."
Zhou Ying took several reports of experimental failures to Lu Yi and said: "This is the failure record of the previous 6 mice, which did not control the dose, resulting in the death of normal cells due to large-scale lack of nutrients, and eventually led to overall death."
The root cause of this side effect is that tumor cells signal their need for nutrients, and normal cells will send the same signal when they are deficient in nutrients.
The difference between the two is that the signal sent by the tumor cells is stronger, which will make the body think that there is a major "trauma" here, and if the injury is not supplemented in time, it will lead to serious consequences, so that the tumor cells will have a higher priority to obtain nutrients. ”
The organism is a rigorous system, and the cells need to send out the "hungry" signal before the cells will give you nutrients such as oxygen and sugar.
If you don't say "hungry", or if this "hungry" signal is suppressed and cannot be received by the body, then the body will think that you are not hungry and do not need to supplement nutrition.
It's like sleep, sleep is when the central nervous system signals sleepiness first, and then you feel sleepy and it's time to sleep.
If the central nervous system is defective and unable to send a signal of sleepiness, or if this signal is inhibited by substances such as caffeine and theophylline, then you will feel energetic all the time and can be happy for another three days and three nights.
"Tumor cells are more active, and strict dose control is not a side effect."
Lu Yi nodded and said, "Who else knows about this research except you?" ”
Tumor cells are more active, which means that they have higher nutrient requirements, and a serving of nutrient-normal cells can last for a day, but tumor cells are hungry after two or three hours.
Therefore, as long as the amount of inhibitor is strictly controlled, the tumor cells will definitely die before the normal cells.
It doesn't matter what type of cancer you have, whether you have lung, liver, stomach, lymphoma, squamous cell carcinoma, adenocarcinoma, or small cell undifferentiated carcinoma.
After inhibiting the "hunger" signal and implementing nutritional control, the same steamed bun, normal cells are like normal people, and they can stay up for two days after eating.
Cancer cells are like athletes with a very low body fat percentage, who have to go hungry to participate in the World Sprint Race after eating the only steamed bun, so that it is clear who will die first.
"The research on gene enzymes is studied by everyone, and the follow-up research is only carried out by me and two assistants, but they don't know the specific research data, and they are all recorded in my brain."
Zhou Ying also understands the importance of this research finding, so she is very cautious in this regard, not only does she know the specific data, but also simply keeps it in her mind, and does not keep realistic records.
"Okay." Lu Yi nodded, took out his mobile phone and called Li Yashan.
The three major laboratories are strictly controlled, and the security scanner at the gate stands there, and only he has the permission to bring his mobile phone in, and the rest of the people's mobile phones, any electronic devices and even watches cannot be brought into the laboratory.
"Lu Lu, what's wrong?" The phone rang for a while, and Li Yashan answered.
"Is there anyone else around?" Lu Yi didn't say it directly, but asked first.
"Wait a minute."
Li Yashan was stunned, waved her assistant to go out, and then took out the remote control to turn on the electronic shielding equipment in the office.
As for the phone, this is a confidential phone specially customized by Huawei, and the anti-blocking and confidentiality features are among the best in the world.
"That's it."
After seeing that the shielding equipment was working normally, Li Yashan said to Lu Yi.
Lu Yi glanced at the other researchers in the laboratory, stood to the side to prevent everyone from seeing the shape of his mouth, and said: "The biological laboratory has produced an achievement that can cut off the nutritional supply of cancer cells from the root......
After listening to Lu Yi's brief introduction, Li Yashan frowned slightly and said, "You first ask Zhou Ying to sort out the data of the inhibition drug, and I will arrange for the global patent registration first, and then go through the clinical trial process and production." ”
"Yes, your trip abroad should be canceled during this time."
Lu Yi understands that this kind of inhibitory drug will completely kill the interests of the world's major pharmaceutical companies in tumor drugs, and will even participate in the game of national interests as an important bargaining chip.
In such a situation, it is not very safe for Li Yashan to go abroad again.
"Understand, I'm not going abroad during this time." Hearing Lu Yi's concern, Li Yashan was in a somewhat happy mood,
"That's right."
Lu Yi suddenly said seriously: "Find a group of soldiers who have retired from the army and are more professional in protection, and the research involved in the follow-up laboratory is more sensitive." ”
"What research?"
Li Yashan was a little puzzled, the drugs that cut off the nutrition of cancer cells from the root just now were not so cautious as Lu Yi.
"This inhibitory drug can only be counted as a by-product, and the laboratory may have opened the door to genetic optimization."
Lu Yi talked about the gene enzyme in general, this research discovery can be regarded as a preliminary touch on the edge of gene transcription optimization, and then hand over the gene replication theory exchanged by the system to Zhou Ying, which is equivalent to officially opening the door to gene optimization.