Diphtheria: Ahem, ahem, ahem, the ancient voice is coming to earth again.

——

10 minutes ago.

AIDS, hepatitis B, whooping cough, dengue fever, measles, rubella, hemorrhagic fever with renal syndrome, typhoid, rabies, brucellosis, mumps, cholera, Zika, Ebola, influenza, malaria, hepatitis A, schistosomiasis, hepatitis B, Streptococcus suis, Legionella, leptoplasmosis, Lyme disease, plague

Flu: Wow! Brother Diphtheria, long time no see.

Rabies: Woohoo, diphtheria has nothing to do with me.

Plague: Brother Diphtheria, I finally see you again in the world.

Diphtheria replies to the plague: The great god praises me, I am very honored.

AIDS: Who is diphtheria? Never seen it before.

Flu replies to AIDS: Xiao Ai, you are too ignorant, when diphtheria was epidemic in the world, you didn't appear yet.

AIDS:??? Does diphtheria have such a long history? Longer than the history of the old god like the plague?

The plague reverted to AIDS: Yes, the plague began its first world pandemic in the 6th century AD, and the diphtheria brothers began to circulate as early as the 2nd century BC.

AIDS: Back in BC? It's true?

Diphtheria replies to AIDS: Well, there are human history books to prove it. In the "Yellow Emperor's Neijing", there is a record of "throat paralysis" in the "Su Wen" chapter. There is a "throat lock wind" in "Jingyue Quanshu", and there is a "white throat" in "Chonglou Jade Key". These are my former names.

AIDS: Listening to the bull roar, the diphtheria autobiography is pasted.

Diphtheria: Here's my autobiography.

I'm diphtheria.

My pathogen is Corynebacterium diphtheria, or diphtheria for short.

I'm a gram-positive bacterium, which is the largest in the bacterial family.

I'm 2-4 microns long, 0.5-1 microns wide, slightly thicker at one or both ends, typical rod-shaped.

The diphtheria family has many brothers, one of whom can produce an exotoxin called diphtheria toxin.

This toxin is unstable and easily inactivated by heat and light.

However, this toxin can damage any tissue of the animal, especially heart muscle and nerve tissue.

My toxin-producing diphtheria bacillus brother likes to parasitize the nasopharynx of susceptible people.

I multiply here in large numbers and produce exotoxins.

The toxin is absorbed by the local mucosa, causing tissue necrosis.

Necrotic tissue provides me with abundant nourishment, and I produce more toxins.

These toxins then cause host inflammation and exudation.

Together with the flora of the host's pharynx, I form a white "pseudomembrane", which is where my name "diphtheria" comes from.

Once the host is infected by me, he will have fever, stuffiness, hoarseness, and a dog-like cough.

In severe cases, symptoms of systemic poisoning may occur, and myocarditis and peripheral nerve paralysis may also occur.

Once upon a time, I was on a rampage.

I like to infect children, it can cause acute infections in the population, and the mortality rate is very high at that time.

However, humans later invented multiple ways to deal with me.

Two microbiologists, Emil Adof and VonBrhring, invented antivenom therapy, which greatly reduced my lethality.

Humans also use antibiotics against me.

Erythromycin, penicillin, I hate you.

What's even more terrifying is that humans invented a vaccine against me, and combined it with whooping cough and tetanus to form a diphtheria-tetanus-pertussis vaccine.

Soon after the birth of human children, they will be vaccinated with this diphtheria-pertussis triple vaccine, which has caused me to be almost extinct in the world.

Whooping cough: I deeply understand that the human vaccine blocks my way through the world.

Tetanus: Well, the vaccine is a barrier between us and us.

Hepatitis B: The vaccine is a human canopy.

Measles: Hey, this Tiangang hood is our brother of the weakened strain.

Diphtheria: Vaccine, vaccine, a barrier that I can't cross.

AIDS returns to diphtheria: Your bacteria mutate too slowly, so they will be limited by vaccines, like me and the flu, and the vaccines are helpless against us.

Diphtheria Responds to AIDS: ??? There's a vaccine for the flu, right?

Flu replied to diphtheria: Well, Xiao Ai doesn't understand, humans have a vaccine against influenza, which greatly reduces the symptoms and lethality of my flu, but I mutate very quickly, and humans need to change the epidemic strains in the vaccine every year to barely keep up with my mutation speed.