Chapter 369: Circle of Friends (43)

Swine flu: Pig, you have two holes in your nose, and you still have snot when you have a cold......

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10 minutes ago.

AIDS, Hepatitis B, Pertussis, Dengue, Measles, Rubella, Hemorrhagic Fever with Renal Syndrome, Typhoid, Rabies (I'm Crazy for Dogs), Xiaobu (Brucellosis), Plague, Cholera, Zika, Ebola, Influenza, Malaria, Hepatitis A, Schistosomiasis, Hepatitis B, Streptococcus suis, Legionella, Leptoplasmosis, Lyme Disease, Diphtheria, Monkeypox Virus, T-Cell Leukemia Virus, Monkey Foam Virus, Avian Influenza, SARS, Monkey Immunodeficiency Virus

Dengue fever: swine flu? Brother of the flu family?

Swine flu replies to dengue fever: Well, I'm an important member of the flu family, in fact, I also have a lot of swine flu.

AIDS: I know that the one that made a big fuss in the human world in 2009 was swine flu, which seems to be the H1N1 subtype of influenza.

Swine flu replies to AIDS: Oh, the 2009 influenza world pandemic, the pathogen is a member of the flu family, and it is barely my swine flu family.

AIDS replies to swine flu: barely counted? Isn't the happiest thing in 2009 your swine flu? What's going on with this reluctantly?

Swine flu back AIDS: In 2009, the influenza that began to break out in Mexico in the human world, the pathogen is the pdm/09 H1N1 influenza virus, this brother is a new type of influenza virus of human origin, poultry origin, pig origin, and three-source rematching, but it was convenient for humans to take the name at that time, and it was temporarily called "swine flu", which is different from the meaning of swine flu that is usually prevalent in pig herds.

AIDS reply to swine flu: It seems to understand that although there are many members of the influenza virus family, it is divided into many species according to different hosts, but there is a strict racial barrier between each species, and there is rarely cross-racial transmission, and swine flu exists in one of the races.

Swine flu responds to AIDS: Xiao Ai still knows a lot, and it is true that the influenza virus maintains a relatively stable balance because of the racial barrier between various hosts.

Hepatitis B: Wasn't the 2009 flu the result of an interracial rematch?

Swine flu responds to hepatitis B: Yes, every time the brothers of the flu family spread across races, they create a pandemic.

Hepatitis A: Swine flu, are you zoonotic? I often see your brothers and sisters in various animals, and the flu family is too big for the various members to tell the difference.

Swine flu reverts to hepatitis A: Swine flu is a zoonotic disease, which usually spreads mainly in pig herds, and occasionally exchanges gene fragments with brothers from poultry and humans, resulting in rematching.

Hepatitis A: There seem to be a lot of flu hosts.

Swine flu reverts to hepatitis A: Yes, type A in the flu family alone can infect many animals: primates, dogs, horses, cats, cattle, seals, whales, guinea pigs, ferrets, mink, giant pandas, tanuki, anteaters, camels, penguins, ...... And, of course, my favorite pig.

Ebola: I recently met two brothers from the flu family in bats, who claimed to be H17N10 and H18N11, and had never seen them before.

Swine flu replies to Ebola: H17N10 and H18N11 are new members of the flu family that live in bats and rarely come out.

AIDS: Wait, I remember that the autobiography of the flu in the circle of friends wrote that the flu family is divided into more subtypes according to the difference of surface hemagglutinin (HA) and neuraminidase (NA), with 16 subtypes of HA and 9 subtypes of NA. How can there be more subtypes in bats?

Swine flu responds to AIDS: The flu family is very large, there are always new brothers to be discovered, and now we have 18 subtypes of HA and 11 subtypes of NA in our big flu family, and there will be more in the future.

AIDS: I'll go! It's too fast!

Hepatitis A: If you don't support the wall, just serve you, brother flu! Too fast to mutate, too many classifications!

Hepatitis B: Ask for an autobiography!

Hepatitis A replies to hepatitis B: There is an autobiography of the flu family in the circle of friends who used to have flu.

Hepatitis B reverts to hepatitis A: The flu mutates so fast, the autobiography must be updated, and I want to read the autobiography of the swine flu, the more detailed the better.

Swine flu: Here's my autobiography.

My name is Swine Flu, which is a general name.

I'm the smallest of the flu family.

Because I mainly live in pig herds, it is collectively referred to as "swine flu".

According to the human classification of viruses, I belong to the genus Influenza Viruses of the family Orthomyxoviridae.

An outer membrane, plus the segmented single-stranded negative-stranded RNA inside, is my deity.

The single-stranded negative-strand RNA in my body is divided into 8 segments: PB2, PB1, PA, HA, NP, NA, M, NS, and each segment has a different function.

Human beings are divided into four types: A, B, C, and D according to the antigen characteristics and gene characteristics of our membrane protein MP and nuclear protein NP.

There are many brothers in the influenza family, especially influenza A, which is divided into more subtypes according to the difference in surface hemagglutinin (HA) and neuraminidase (NA), and currently there are 18 subtypes of HA and 11 subtypes of NA.

Compared with the previous autobiography of the flu family, there are two more subtype brothers, which were discovered from the bat's body.

The main members of our swine flu family are H1N1, H1N2, H3N2, H5N1, and H9N2.

I am endemic in pig herds and can cause acute and highly contagious respiratory diseases in pigs.

Pigs infected by me will have cold symptoms such as high fever, cough, and difficulty breathing.

Swine flu is endemic worldwide.

As early as 1930, the first strain of swine flu virus was isolated from humans and named it the classic swine flu virus.

In the decades that followed, multiple subtypes of swine influenza viruses emerged.

In 1979, an avian H1N1 subtype swine influenza virus was isolated from a European pig herd, and quickly replaced the previous classic swine influenza virus and became the dominant strain in the pig herd.

Although I have a high incidence in the herd, the fatality rate is low.

However, there is one exception – genetic reassortment and cross-ethnic transmission.

Because my host is a pig, and porcine respiratory epithelial cells have sialic acid receptors for both human influenza virus and avian influenza virus, they can be infected with both swine, avian and human influenza viruses.

So, pigs become "mixers" of influenza viruses.

Influenza viruses from different sources can infect pigs at the same time, and genetic recombination occurs in pigs to produce a new type of influenza virus.

The resulting new influenza virus can cross racial barriers and gain the ability to infect humans.

The population lacks immunity to the new reassortant influenza virus and is therefore likely to cause an influenza human pandemic.

The new influenza virus of the 2009 human influenza pandemic is the PDM/09 H1N1 new influenza A virus that has been reconfigured in pigs.

This is an example of cross-racial transmission of influenza.

What makes our brothers proud: every cross-racial spread of the flu can cause a pandemic.

Pig, my favorite, you are responsible for the genetic rematch and cross-racial transmission of the flu.

AIDS: Wow, pigs are to the flu what monkeys are to Xiao Ai, it's essential.

Swine flu responds to AIDS: Well, pigs are a mixer of the flu family.