Chapter 399: Endogenous retroviruses
After a moment of silence, Ashford said again: "Professor Pang, I have another reluctant request. ”
"Please."
Ashford said, "Professor Pang, I hope you can help me get Angela back before I tear my face with Spencer." I know that you and that Lady Alice are no ordinary people, and that with your abilities, there is a way to get Angela back from Spencer's hands. ”
Pang Xuelin smiled faintly and nodded: "Don't worry, Dr. Ashford, since I can save Angela once, I can save her a second time." ”
Ashford said gratefully, "Professor Pang, thank you then." ”
Then, Pang Xuelin chatted with Ashford about other issues, and it was not until nine o'clock in the evening that Ashford pushed his wheelchair and slowly returned to the villa.
Pang Xuelin smiled, waited until Ashford's back completely disappeared at the door, and said: "Come out, everyone is gone, there is no point in hiding any longer." ”
The night wind blows the branches and leaves of the green belt, and from time to time the yellow fallen leaves fall.
After a while, a black figure stood out from behind a plane tree.
"How did you find me?"
Alice said with some curiosity.
"I hear your breathing."
Pang Xuelin smiled faintly.
A hint of surprise flashed in Alice's eyes, after the transformation of the T-virus, her control over her body can be said to have made a qualitative leap.
On weekdays, his breathing is extremely soothing, and tonight is a windy day, in this case, Pang Xuelin can still distinguish his breathing from the noisy environment around him, which is enough to show the strength of the man in front of him.
Alice no longer dwelled on this topic, her beautiful eyebrows furrowed slightly, and she wondered: "Do you think the method that Ashford said can really help us find a way to deal with the T virus?" ”
Pang Xuelin shook his head and said, "I don't know, but what Ashford said about starting with non-coding RNA does have a certain degree of feasibility." ”
Alice said: "I don't understand academic things, I only kill people, if you want to kill someone or save someone, I can help you." ”
Pang Xuelin smiled slightly and said, "Thank you, but there's no need to kill people, I have another important task for you." ”
"What task?" Alice said with some curiosity.
Pang Xuelin said: "Although the Umbrella Company still hopes to get the manufacturing method of the new virus from me, the Kempten base cannot always rely on the material support of the Umbrella Company, and I hope that you and Jill can lead a team to sweep the surrounding towns and collect useful materials to transport over." This includes food, fuel, machinery and equipment, vehicles, and more. In the next year, in addition to building a base, our main work is to stock up on various materials. ”
Alice was slightly stunned, nodded and said, "No problem." ”
Pang Xuelin hesitated for a moment and said, "There is another thing that needs you to come out. ”
"What's the matter?"
"I talked to them a little earlier, and the weapons and equipment we have now are mainly light weapons, and the reserves are limited. I need someone who can lead a sweep of Hill Air Force Base in Utah......"
"Hill Air Force Base?"
Alice seemed a little puzzled.
"The Hill base is located about 30 kilometers from Salt Lake City, Utah, and is home to the 419th Fighter Wing, the 388th Fighter Wing, and the 34th Frontline Combat Squadron, the first U.S. military equipped with F35A," Pang said. In addition, it is an important base for the U.S. Air Force Logistics Center to provide engineering and maintenance services for F22, F16, A10 and C130 transport aircraft deployed around the world. It also provides support and maintenance for weapons systems such as the B-2 and B1B bombers and the Minuteman III intercontinental missile. Therefore, it is one of the three major logistics centers for the equipment of the US Air Force and one of the five major maintenance bases. There may even be a nuclear bomb ...... in this base."
Alice's eyes narrowed suddenly: "Are you going to use a nuclear bomb against the Umbrella Company?" ”
Pang Xuelin shook his head with a smile and said, "Just in case, even if the nuclear bomb is found, I won't get it to the Kempten base." ”
Alice nodded thoughtfully and said, "Sweeping the matter of Hill Air Force Base, you let Jill organize candidates, there should not be too many people, and I will lead the team when the time comes." ”
"Okay, then it's hard for you."
"You're welcome. I hope you remember the promise you made before. ”
After speaking, Alice no longer paid attention to Pang Xuelin, turned around and quietly disappeared into the darkness.
Pang Xuelin smiled faintly and didn't say anything more.
Early the next morning, Pang Xuelin began to find Jill and Claire to assign tasks.
At present, the Kempten base relies on the umbrella company for food, oil and material consumption in all aspects.
Moreover, there is no airport at the Kempten base, so the umbrella company can only dispatch a tiltrotor similar to an osprey to provide material support for the Kempten base.
Therefore, if he wants to completely control this base in his own hands, Pang Xuelin must let the army in the base move as soon as possible and collect materials from the outside world on a large scale.
After arranging the tasks of Jill and Claire, Pang Xuelin found Spruce, Berkeley, Huang Yu and others and introduced Ashford to them.
There was something unexpected for Pang Xuelin, these people actually knew Ashford.
From their mouths, Pang Xuelin learned that Ashford is also a well-known figure in the life sciences industry, and has made several quasi-Nobel Prize-level achievements.
Just because of the relationship of working for the umbrella company. Ashford is not very active in academia.
But since everyone knows each other, it couldn't be better for Pang Xuelin.
The base's underground lab was soon set up to devote itself to the study of the T-virus.
Xiao Dongbei, as a doctoral student in medicine, was also pulled into the research group by Pang Xuelin.
……
Half a year has passed in a flash, and in the past six months, Pang Xuelin has spent most of his time and energy on the laboratory and the study of biology.
Previously, when Pang Xuelin was in the world of "District 9", he had studied theoretical knowledge of biology.
But at that time, he had not been modified by genetic optimizers, so although he had studied hard in the world of "District 9" for three years, Pang Xuelin's level was not so high, at best, he was only in terms of knowledge, a little wider than the scholars of the Resident Evil world, but in terms of research depth, it was far less deep than that of Sprus.
And now, after genetic modification, Pang Xuelin's memory, learning ability, and thinking reaction speed are much beyond ordinary people.
Moreover, the study of biology is not like mathematics, and many things in biology are more biased towards memorization and experimentation.
Therefore, Pang Xuelin is relatively easy to learn.
The only trouble is that the biological theories are scattered and not very related to each other.
For example, the interaction between different protein molecules, non-transcribed RNA molecules, physiological functions, etc., are all independent systems.
Moreover, there are thousands of protein molecules and RNA molecules, and even in the human body, there are many life phenomena that have not yet been discovered or cannot be explained by existing theories.
For example, why can a DNA molecule only replicate once in a cycle?
How does the conception of the DNA molecule affect gene expression?
What is the intrinsic relationship between protein dynamics and their function?
How do gene regulatory networks deal with noise?
How the nuclear genome is coordinated with the extranuclear genome and so on.
……
The absence of these theories can only further illustrate that human beings' understanding of life is quite limited.
And because the study time is relatively short and the coverage of biology is too wide, Pang Xuelin mainly focuses on the fields of virology, genetics, biochemistry, biophysics, molecular biology, computational biology and bioinformatics.
In less than half a year, Pang Xuelin's understanding of the T virus has far surpassed that of Spruce, Berkeley and others, and he is not even under Dr. Ashford, who has been immersed in the field of T virus for decades.
In the past six months, under the leadership of Dr. Ashford and Pang Xuelin, the Kempten base has conducted very in-depth research on the T virus.
Thanks to Alice's cooperation, Pang Xuelin and Ashford compared the evolution of the T virus in the dead body with the evolution process in Alice's body, and they found that the T virus in Alice's body turned out to be an endogenous retrovirus.
The so-called endogenous retrovirus starts with the pathogenicity of the virus.
Viruses are the smallest living organisms discovered by human beings so far, and they have no cell structure and must rely on the infected host cells to provide the material and energy they need to complete their life activities.
So far, diseases such as AIDS, rabies, avian influenza, influenza A, SARS, coronavirus, smallpox, Ebola, etc., have all been caused by viruses.
Therefore, in many people's minds, viruses are always associated with illness and death.
But in reality, not all viruses cause disease.
Among the viruses that infect the human body, some viruses enter the host cell without causing significant damage to the infected cells or organs.
Some viruses can coexist with host cells for a long time without affecting the host's daily life activities, and some viruses can even benefit from giving the host the ability to cope with environmental stresses.
For example, adeno-associated virus (AAV), which the vast majority of people have been infected with, but did not cause any disease.
Adeno-associated viruses replicate and multiply in the human body, but do not affect the daily life activities of host cells.
It is with this characteristic that scientists remove the part of the gene encoding AAV to construct a recombinant AAV viral vector, which can insert some therapeutic genes and introduce them into the human body through AAV, so that it can be stably expressed in the human body for a long time, and then treat some genetic diseases or cancer.
As for the other type, it is the so-called endogenous retrovirus (ERV).
In the process of evolution, this virus has formed a very close relationship with human cells, and it can be said that the normal operation of the human body is inseparable from the help of ERV.
After analyzing the whole human genome sequence, scientists found that at least eight percent of the human genome originated from ERV.
Studies have shown that 1743 genes in the human body are transcribed from the promoter sequence of ERV, and the promoter sequence of some ERV can even determine that its downstream genes can only be expressed in certain tissues and organs or at certain specific time periods.
Because of this, to some extent, ERV sequences can affect gene expression in humans to a large extent, which in turn has a very significant impact on the regulation and evolutionary direction of the human genome.
……
That night, the underground laboratory.
"Professor Pang, the genetic test report on you is out."
Xiao Dongbei came out of the laboratory excitedly, waving a report in his hand.
"Take it and have a look."
Before Pang Xuelin could speak, Ashford, Spruce and others on the side were a little impatient.
Previously, they had completed genetic testing on Alice, and found that part of the T virus in Alice's body had been converted into ERV sequences.
This is also the reason why Alice did not become a zombie after being infected with the T virus.
The T virus transformed into the ERV sequence strengthened Alice's cell life activities, but did not make the cells out of control like zombies, but greatly improved Alice's physical functions.
That's why Alice is like Superman.
After completing the test on Alice, Ashford and the others began to turn their attention to Pang Xuelin.
They couldn't wait to see what had happened to the T virus in Pang Xuelin's body.
The test report fell into Ashford's hands for the first time, but after carefully reading it from beginning to end, Ashford's brows couldn't help frowning deeply.
Subsequently, he handed the test report to Spruce on the side, and after reading it, Spruce handed it to Berkeley, and then transferred it from Berkeley to Huang Yu, and finally, the report appeared in Pang Xuelin's hand.
Pang Xuelin skimmed through the report roughly, a little disappointed and relieved at the same time, he said lightly: "What do you think of this report?" ”
The report showed that Pang Xuelin was not infected with the T virus, and even the ERV sequence homologous to the T virus was not detected.
In this way, even on the side of the umbrella company, it is difficult to find the specific formula of the genetic optimizer through Pang Xuelin's genetic analysis.
Ashford was a little curious: "Professor Pang, isn't the virus you injected yourself in the Hive Lab T virus?" ”
Pang Xuelin shook his head and said, "To be honest, the situation was urgent, and I only temporarily thought of injecting the mutated T virus into my body, and as for the sequence of that virus, I didn't have time to test it at all." ”
Ashford frowned slightly, and said: "You and Alice should be infected with two completely different viruses, the T virus is in Alice's body, converted into an ERV sequence, but in your body, what has become of it, because there is no gene sequence of the original virus, it is difficult for us to figure it out, unless your genes are analyzed by large-scale sequencing, but the workload in this is ......"
Ashford gave a wry smile.
Even the umbrella company has limited research on human genes, so what if all the genetic sequences in Pang Xuelin's body are detected?
I don't know which part of the gene is working, but it's still versatile.
As for transcribing these genes one by one, cell tests are carried out to find out which gene fragments are working.
This is basically impossible.
The amount of work involved is so huge that even if you give the umbrella company a hundred years, it may not be able to complete such a job.
()