When the Martian Collar was in a hurry with the virus event, the new Keelung City base on the moon.

Huang Haojie is working with Michelle, Zhao Zhangdeok, and Takahashi Kenji to develop the solar ladder virus, and their research and development work has advanced by leaps and bounds.

"I didn't expect that allicin could inhibit the solar ladder, and the effect is so great, it is simply a natural inhibitor." Zhao Zhangde said as he stood outside the testing area.

On his side were Huang Haojie, Michelle and others.

Inside the test area, I don't know how many mice were injected with an improved version of the Sun Ladder, it was in pain, it wailed, it struggled, and the humans outside the shield turned a blind eye, obviously humans were more concerned about the success of the experiment.

After a fierce struggle, the mouse has turned into a large mouse full of muscles under the supply of nutrient solution, but although its strength has increased a lot, it still can't break free from the titanium alloy lock, and after the big mouse finds that it can't break free, it quiets down and stares at the humans outside.

"It worked!" Michelle clutched her hand excitedly.

"It's too early to say that it will be successful, check the test subject." Huang Haojie touched his chin and said.

Takahashi Kenji hurriedly operated the experimental platform and conducted a full-body examination of the successfully strengthened rats, and after a while, countless detection data on the holographic computer popped up, Huang Haojie looked at the data and shook his head: "Half the success." ”

Michelle and Zhao Zhangde also hurriedly looked at the data, and after a while, the two of them also understood why Huang Haojie said that he was half successful, because the gene mutation of the mouse was too powerful, and there was an obvious atavism, and the current gene series was 64% different from before, which is equivalent to replacing a body.

"It seems that the dose is too large, and we need to weaken the dose of the solar ladder and the rate of induced mutations." Zhao Zhangde said as he recorded some data and modified directions.

Huang Haojie looked at the experimental data, he knew that the use of the solar ladder would inevitably induce gene mutations, but if the solar ladder was used too much at one time, it would not only cause high mutations in the genes of the organism, but also produce a series of sequelae.

For example, the temperament changes drastically, becoming moody and aggressive, or atavistic phenomenon, or mutation and alienation, maybe one more hand or one foot, and so on.

The probability of this happening in the virus era is about 30%, and this kind of mutation can be accepted in that era, but in the 21st century, I believe that the vast majority of people are unwilling to become an outlier, especially the kind of outlier with obvious appearance characteristics.

"Michelle and Zhangde and I continue to modify the Sun Ladder, and Takahashi, you continue to test the remaining Sun Ladder Improvement Reagents." Huang Haojie commanded.

"All right, Führer." Kenji Takahashi hurriedly bowed and replied.

Inside the virus lab.

Huang Haojie, Michelle, and Zhao Zhangde are all inside, but according to the safety regulations of the biochemical virus laboratory, the three of them will not really contact the biochemical virus, but operate the virus through a stand-in robot or an auxiliary robot.

The experimental accidents of many science fiction movies are often not that the virus is too powerful, but that the experimenters are too dead, such as direct close contact with biochemical viruses or experimental subjects, or insufficient safety measures, or the experimenters do not follow the routine.

The alliance's laboratories, especially the biochemical laboratories, are strictly guarded, so that all experimental accidents can be eliminated.

For example, in Camp Zero, where they are now, there are three layers of condensed matter shields, once the virus leaks, under the layers of isolation, the possibility of the virus being leaked out is zero, unless it is deliberately spread by humans, but the alliance has very strict censorship for these people who can come into contact with the virus, and the laboratory has artificial intelligence monitoring around the clock, which basically eliminates the possibility of human intention.

"Michelle, modify the aberrant expression No. 35 sequence of exon 37-8-13 of the first strand of the solar ladder RNA to the aberrant expression No. 37 A sequence." Huang Haojie looked at the holographic gene spirochet of the Sun Ladder and commanded.

“OK。”

Michelle's ten fingers fluttered over the holographic projection, rapidly modifying the exome sequence of the solar ladder.

Zhao Zhangde, on the other hand, is modifying some non-structural genes of the solar ladder (a non-coding DNA fragment on both sides of the structural gene, also known as a flanking sequence, which participates in the regulation of gene expression), and he is adjusting and modifying while checking the simulation results of the supercomputer.

There are also a dozen researchers in the lab who are also modifying the solar ladder virus.

"Zhao Group, the promoter of the 9-6-15 sequence of the non-structural gene has crashed, and your modification has conflicted."

Zhao Zhangde looked at the situation of the non-structural genes 9-6-15 series, and re-simulated it again with supercomputing, and the result of supercomputing simulation was that [the promoter RNA polymerase specifically recognized the abnormal DNA sequence that bound and initiated transcription, and the transcription start site and the response element sequence produced conflicting reactions. ］

"Xiao Zhang, you can modify the sequence of the non-structural gene 9-6-15 and change it to a more stable sequence." Zhao Zhangde commanded.

"Okay."

Zhao also carefully studied the upstream promoter elements in the non-structural genes of the solar ladder, that is, some specific DNA sequences upstream of the TATA box, and trans agents can bind to these elements to regulate the transcription efficiency of genes.

RNA sequences transcribed through trans-acting factors and binding to specific cis-acting elements and influencing solar ladder genes.

After reading this part, he found two small problems and modified them, and then he asked Huang Haojie: "Führer, have you modified the 33-3-76 sequence of exons, is it still the previous version?"

"It's still the previous version, and this part has not been modified for the time being." Huang Haojie turned his head and replied.

"Okay." Zhao Zhangde hurriedly continued to look at the situation of exons and introns, he looked at the holographic gene spirochet, and modified one or two gene series from time to time, these modifications are regular and learned, if there is no gene programming technology of the Anluo people, they really dare not modify the genetic sequence of the Sun Ladder.

He glanced at the results of the supercomputer's Poly(A) tailing signal, and the conserved AAUAAA sequence at the end of the structural gene and the downstream GT or T-rich regions were recognized by the polyadenylation specific factor, adding 176 A to the 3′ end of the mRNA.

A non-directional enhancer was then combined with a trans-acting factor to enhance the transcriptional activity of the solar ladder, but Zhao Zhangde modified the sequence of the enhancer, because the general enhancer is effective at any position in the gene, but he now needs a directed enhancer.

A directional silencer is added after the enhancer to bind to the trans-acting factor to inhibit the transcriptional activity of some specific genes in the solar ladder.

After being busy for most of the day, Zhao Zhangde began to adjust the gene series of the response element of the solar ladder, which can bind to the activated information molecular receptor and regulate the specific DNA sequence of gene expression.

This part is related to the strengthening of the solar ladder after the combination of human genes, and there are many things that need to be paid attention to and adjusted.

Speaking of which, Anluo Xingren and humans are both carbon-based creatures, which makes it much more difficult for Zhao Zhangde and others to transform the Sun Ladder, after all, they are also carbon-based creatures, and many things are similar in nature, but Anluo Xingren's research on genes is more in-depth and comprehensive than that of humans.

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