"APOPTOXIN, a combination of apoptosis (apoptosis) and TOXIN, is a drug that unconditionally causes the self-death of human cells, the details of which are unknown."

"Traditionally, cell death is considered to be "cellular necrosis", and self-death is just a form of necrosis. Cell necrosis is a word that indicates the death of a cell due to some external cause. For example, cuts, burns, etc., block cell functions, damage cell membranes, and cause internal cytoplasm and ions to be lost to the outside of the cell. In other words, there is some kind of destructive external force that causes the cells to "die accidentally", causing edema, fever and even purulent bleeding. Such obvious phenomena can be directly observed, so they have been known for a long time, and it has long been thought that this is how cells die. ”

On the other hand, cell self-death is a phenomenon in which cells are automatically destroyed and absorbed by surrounding cells. For example, the transformation of a tadpole into a frog is a phenomenon of the disappearance of the tail. In the early stages of finger formation, the webbed-like part between the fingers disappears, and the cells in this part die, forming the fingers. In other cases, if it is not the metamorphosis stage of such a life, the process of occurrence stage, the abnormal self-death of cells caused by radiation or drugs, the increase in excessive cell division, and the self-death of cells at the end of their lifespan are the phenomena of cell self-death caused by daily life. ”

"Unlike cell necrosis, which is greatly affected by surrounding cells, the phenomenon of self-death is very "smart". Careful analysis of the DNA in the nucleus of self-dead cells can confirm very small fragment changes, a phenomenon known as "coagulation necrosis". This fragment is quickly absorbed by the surrounding cells, and the posthumous form becomes the nutrients of the surrounding cells.

”

"It has been found that self-death is a phenomenon in which the cells themselves choose to die in order to remove unwanted cells that have proliferated excessively, or to make unexpected sudden mutations of somatic cells threaten life. Hence the "self-death". That is, APTX. ”

"APTX4869 is a drug that causes explosive self-death of somatic cells, why can it cause rejuvenation, how is it explained in today's technology, as the main researcher of this drug, you should not understand, right?"

Lin Zhengyang threw the topic to Xiao Ai again, who clasped his hands to his chest and replied indifferently:

"THE LIMIT OF SOMATIC CELL DIVISION IN THE HUMAN BODY, KNOWN AS "HEAFLICK", IS DETERMINED BY THE NUMBER OF BASES ATTACHED TO THE END OF THE DNA CALLED "TTAGGG". Beyond this value, the cell will not be able to divide and proliferate. ”

"A "c-myc" gene that has been reported as a cancer-related gene—this gene promotes cell proliferation, so removing the activated cells from the cause of proliferation is equivalent to inducing cell self-death, which means that the process of "c-myc" promotion is the opposite of the process of cell self-death. ”

The process of APTX4869 is speculated to be that cells that should have died of their own aging are activated by the C-Myc gene. However, on the basis of a certain degree of cell self-death, the reactivated c-myc promotes the proliferation of young cells through base stretching, thus causing the overall rejuvenation of somatic cells and producing "smaller". ”

"Of course, there are still big problems·······"

Xiao Ai paused, and said in a somewhat low tone:

"After studying the samples provided by Conan from the guinea pig, I found a lot of suspicions."

"First of all, no matter how many young cells proliferate, there is no phenomenon of "rejuvenation". ”

"Theoretically, this process of cell proliferation is the same as the proliferation of cancer cells, which is a disordered proliferation, and obviously produces cells that impairs the body's functions."

"In the human body, the shape and function of the body need corresponding command signals, and it is very strange that this command signal can be transmitted normally when the cell is dying and the cell is proliferating in parallel. It's amazing how the body's cells can function normally under this command. ”

She lowered her head, and her little face seemed to be clouded.

"Secondly, there is the problem of nerve cells."

"Nerve cells are formed during the months of fertilization and do not divide and multiply after that, so APTX4869 do not work.

However, it is a fact that an average of 100,000 brain cells die every day, which is a normal "cell death", that is, death at the end of life. ”

"Of course, this process is also formed through intracellular activity, and the APTX4869 that unconditionally induces cell self-death, except for this process, is quite unnatural."

"That's something I can't understand."

"In addition to nerve cells, there are other cells that are formed after fertilization and do not divide or proliferate, that is, heart cells."

"If the heart cells are the same as the nerve cells, and there are no changes, it is equivalent to a 7-year-old child having a 17-year-old heart, which will cause serious damage to the circulatory system."

"And if the heart cells and the body have the same changes that degenerate to the level of a seven-year-old child, there will be a problem: it is difficult to imagine that the cells will still be normal after such drastic changes, and it is likely that the heart will die due to severe cardiac insufficiency."

"However, in Conan and me, these drawbacks and side effects were so minimal that it was as if we were really back to the state of being seven years old······ This is unconscionable! ”

"Conan experienced unimaginable pain several times when he used the drug, mainly in the form of bone changes and a heart that accelerated and beat violently, and I thought he would have a blood vessel burst, and his heart function would be severely impaired, or even completely collapsed, leading to death········· However, no, it is no coincidence, neither me, nor Conan, is special! ”

"This can't be a coincidence!"

She jerked her head up, got up from her chair, and suddenly realized:

"Do you know something?"

"It's just a guess."

Lin Zhengyang's right hand made a downward motion, signaling her to pay attention to her surroundings.

At this time, the waiter in the distance came over:

"Sir, ma'am, please be quiet."

"Sorry, my daughter is here for the first time and it's a bit noisy."

Lin Zhengyang was like a father who came out to play with his wayward daughter, and smiled helplessly.

The waiter, who was also a young man, smiled and said:

"Your daughter is lovely."

Xiao Ai's face brushed, flushed red, and kicked him hard under the tablecloth.

When the waiter walked away, she lowered her voice and yelled viciously:

"Who do you say is your daughter!"

"A man and a woman in this café are almost all couples······· If I don't say father and daughter, believe it or not, the patrol should be here now! ”

"Humph!"

was taken advantage of, Xiao Wai was very unhappy, picked up the menu resentfully, and ordered the most expensive dozen desserts in one go.

It seems that her body has become smaller, and she has been with a group of children for a long time, which has made her mentally younger, and she has made such a childish appearance.

Of course, it is more likely that because of the identity of "sister's friend", she let her down her guard.