Chapter 710: Development of new drugs
"Because the gastrointestinal function of chemotherapy is already very weak, it is difficult for patients to absorb the effective ingredients in traditional Chinese medicine, so the role of traditional Chinese medicine is not large, and it is only an adjuvant." Xu Yan said.
Jiang Nan was thoughtful, it was true.
"And what is the new method you are working on?" Jiang Nan asked.
"It is to transform cancer cells into ordinary cells to achieve the control and conquest of acute promyelogenous leukemia!" Xu Yan said.
Jiang Nan nodded, it was really a good way, and it was also very bold.
"Didn't work out?" Jiang Nan asked.
Xu Yan sighed and nodded.
"At present, the new drugs researched abroad are mainly 13-cis-retinoic acid, which has been able to phagocytose cancer cells with T cells, but it has not yet been able to achieve the reversal of cancer cells to normal cells, and I have searched all the pharmaceutical factories in China, and we can't even produce 13-cis-retinoic acid." Xu Yan sighed.
"13 cis-tretinoin?" Jiang Nan's heart jumped, is this a kind of tretinoin? She knew that the medicine in her previous life was tretinoin, but she didn't know the specific ingredients, so in fact, Mr. Xu, the direction of their research was right, but she didn't know what was wrong, so she was stuck here?
"So what kind of similar drugs can we produce in China now?" Jiang Nan asked quietly.
"There's only all-trans tretinoin, which is a little bit different from how we think about it." Xu Yan shook his head.
Another retinoid? Jiang Nan thought to himself, so there is still hope, right?
She now knows that medical physics, inorganic chemistry, and cell biology, which medical students must learn, are very useful, especially for pharmaceuticals, and there is no way to make medicines without knowing the chemical composition of drugs.
"So let's try all-trans retinoin?" Jiang Nan asked.
Xu Yan shook his head, "I'm afraid not, my research abroad is not like this, don't waste that time." ”
"It's okay Teacher Xu, let's try, maybe it's okay, or let me try, anyway, I have time." Jiang Nan looked at Xu Yan, his eyes were bright and his attitude was resolute.
Xu Yan still wanted to say something, but he didn't want to dampen Jiang Nan's enthusiasm, so he nodded, "You can try, tell me if you need anything, and you can ask me if you don't understand." ”
"Thank you, brother!" Jiang Nan said happily. In the absence of outsiders, she still feels that it is more cordial to call her senior brother.
On Saturday, Jiang Nan called Yang Zhengang, he really didn't have time to go home, it just so happened that Jiang Nan was also very busy, and she was now shaved her head, she was really embarrassed to let him see it, I don't know if he would dislike it.
So I told him that she wouldn't go to the base, she was going to the hospital to see a child with leukemia, and Yang Zhengang didn't say anything.
On Sunday, Jiang Nan and Xu Yan went to the hospital together, and later Ren Bin also came, and the other three did not come, because it was a rest day Xu Yan did not ask them to go, after all, they were usually very busy, and finally on the weekend, he didn't want to deprive them of their rest days.
However, seeing Jiang Nan and Ren Bin coming over by themselves, I was still very relieved.
"Mr. Xu, I want to collect some samples and start experiments." Jiang Nan said.
Xu Yan nodded, since Jiang Nan wanted to try, let her try it, the new drug was successful in continuous experiments.
When Jiang Nan arrived at the ward, she took off the hood, and the children were very happy to see her coming, and Sister Jiang Nan screamed.
Jiang Nan saw that the children were not as lifeless as before, and his mood became relaxed, and he walked to the children's side to check their conditions one by one.
"My sister is now working on a new drug, and she wants some virus samples, which is to draw a little blood from you, which of you would like to?" Jiang Nan asked.
Originally, this did not require the consent of the patient, and the doctor said that the patient's family would cooperate with the blood test, but Jiang Nan wanted the children to also participate, so that they were highly motivated, and felt that they were still useful, not waiting for death, and this change of mentality also helped the condition to a certain extent.
"Me!"
"Me!"
"Me!"
Everyone shouted and raised their hands.
Jiang Nan looked around, and among the four children, only the boy named Xiaohu was fatter, and his condition was slightly milder, so it was not a big problem for him to draw a little more blood.
"This time, let's draw Xiaohu first, okay? Xiaohu is our great hero! Jiang Nan said.
"Okay, okay, smoke me first." Xiaohu cried out happily.
Jiang Nan carefully drew blood on his arm, pressed to stop the bleeding before letting go of his hand, their leukemia patients have worse blood clotting function than ordinary people, so they should be very careful.
A blood sample was taken, and Jiang Nan added anticoagulants to prevent the blood from clotting.
"Teacher Xu, where can we do the test?" Jiang Nan asked.
Xu Yan thought for a while, "You better go back to school, you are not official interns, and it is not good to use the equipment of the hospital, but we have relevant equipment in the laboratory." ”
"Yes!" Jiang Nan nodded, and went back to school with Ren Bin first.
When he arrived at the research room, Jiang Nan took out a blood sample, walked to the microscope, took a straw to suck a drop of blood and put it on a slide, and put it under the microscope for observation.
After reading it, Jiang Nan asked Ren Bin, "Ren Bin, do you want to come and see it too?" ”
"Good!" Ren Bin nodded, and Jiang Nan stepped back for Ren Bin to see.
I saw that some of the originally red flat and red thin breasts in the microscope had turned into half-white and half-purple cells, as if the red blood cells had been whitened, and they all became cancer cells.
Ren Bin couldn't help but sigh, "The energy of cancer and thin chest is really big, and the red blood cells have changed beyond recognition." ”
"Not really, so what we're going to do now is get the red blood cells back." Jiang Nan said.
"Can you do it?" Ren Bin was skeptical.
Jiang Nan told Ren Bin about Xu Yan's ideas for their research abroad, and said that he wanted to give it a try.
"But didn't the teacher say that 13 cis-tretinoin can't be made in China, so how can cancer cells be transformed into ordinary cells?" Ren Bin frowned.
"Of course it's not that easy, that's why we have to experiment. Now we can only produce all-trans retinoic acid in China, so let's try it with all-trans retinoin. Jiang Nan said.
"But I'm afraid it's useless." Ren Bin shook his head.
"So what's the matter, whether it's successful or not, we can learn from it." Jiang Nan said.
"That's just as well." Ren Bin nodded, just like this cancer cell, if it weren't for Jiang Nan saying that he wanted to study it, he wouldn't know that the cancer cells of leukemia look like this, wouldn't this be insightful? It's always useful to learn it.
"Then I'll be with you!" Ren Bin said.
"Okay!" Jiang Nan nodded happily, she was naturally willing to have like-minded friends.
The two discussed the possibility of transforming cancer cells into ordinary cells, and Xu Yan also came back.
"I've brought you some all-trans retinoin, and you're going to experiment here in the future. Don't be afraid of failure, failure is the mother of success! ”
"Yes, Mr. Xu!" Jiang Nan and Ren Bin replied in unison.