Leon glanced at the Asgardian Heavenly Father in the glass jar, and said indifferently, "As I said before, there are two explanations for the reason why living forms 'age and die'.

One is that the living body automatically evolves the death mechanism, and the other is that the living form is lost in the process of operation.

In response to the first theory, the Department of Urban Regenerative Medicine at Gakuen under the leadership of Dr. Strange believes that the goal of delaying the limit of physiological lifespan can be achieved by artificially intervening in the aging process. ”

With that, he raised his hands, and above his left hand was a projection of a healthy spindle cell, and above his right hand was a bloated projection of a spindle cell.

"On the left are normal cells, and on the right are senescent cells."

Leon raised two phantoms and asked Thor and the others, "Do you see the difference?" ”

Thor scratched his head, it was okay to carry a hammer into battle to kill the enemy, and it was really difficult for him to let the god of thunder identify the cell map.

Instead, Rockie raised her hand slightly and said, "Senescent cells have more damaged DNA in them. ”

"That's right."

Leon nodded and said: "According to common sense, multicellular organisms, especially senescent cells in the human body, will be replaced by new cells, but over time, senescent cells will begin to occupy the pit and not, which is retained, promoting the aging of multicellular organisms."

This anomaly is due to the stagnation of the p53 protein in the human body.

The P53 gene is a tumor suppressor gene mapped to human chromosome 17p13.1 and encodes a 53 kD intranuclear phosphorylated protein composed of 393 amino acids, known as p53 protein.

It is responsible for cell cycle regulation, DNA repair, cell differentiation, and apoptosis.

Once the p53 protein is stopped, the senescent cells cannot be targeted to die, and eventually congestion the body, accelerating the aging process of the body. ”

Speaking of which, Leon glanced at Odin's family and found that only Rogie and Queen Freya could understand, while Thor and Odin were in a state of bewilderment.

The queen Freya can understand,It's because she's quite studious.,After selling herself in the school city.,Shame and courage.,Absorb knowledge like a sponge.。

And Loki can understand it, completely because she was too deeply injured in the last "Frost Giant Sex Chromosome Disorder Incident".

For this god of lies and cunning, it was hard for her to endure the feeling of ignorance and complete lack of control of the situation.

Therefore, in addition to becoming an idol, Rogie also made up for a period of genetic biology.

From this point of view, she is many times stronger than a certain Thor who only likes to think with his muscles.

Li Angwan smiled and said, "On this basis, Dr. Strange has done further research.

They found that a transcription factor called FOXO4 binds to p53 and prevents p53 from functioning and preventing senescent cells from dying.

This FOXO4 transcription factor is quite overbearing, and can force p53 to have a relationship with it, and the solution is to inject a substitute for FOXO4, FOXO4-DRI short peptide.

This short peptide is a D-retro inverso isomorphism, which simply means that the L-type amino acids in it are replaced with D-types, and the direction of the skeleton is also reversed.

FOXO4-DRI short peptide has a higher priority than FOXO4, and is more domineering than the overbearing president, and can deprive FOXO4 of its 'mating rights' and preferentially bind to P53 without preventing the latter from continuing to function.

From a macro point of view, the short peptide can cause targeted apoptosis of senescent cells, thereby promoting the replacement of old cells by new cells, thereby delaying or even preventing the overall aging process of individual life. ”

I have to say that the queen of heaven, Freya's brain is spinning fast, and she has already guessed Li Ang's intentions in this way, and said with some excitement: "Then if this FOXO4-DRI is injected into Odin's body, his divine body, which is already on the verge of aging and collapse, will start metabolism again, destroy old cells, and produce new cells,

My husband doesn't have to die?! ”

As soon as these words came out, not only did Thor's face flash with excitement, but even Odin in the glass cylinder showed a trace of emotional fluctuations.

He just saw through the essence of some things and looked down on the world, but it didn't mean that he wanted to die.

If you can extend your life for another minute, a minute, or even a month, a year, who wants to die?

Unexpectedly, Li Ang shook his head and poured a basin of cold water on the excited Freya and the others, "It's not that simple.

FOXO4 - DRI short peptide is just an experimental product, even if Altron joins later, the computing power of the entire scientific research project has been qualitatively improved.

It is only a few transcription factors that have a similar effect to this short peptide.

Odin's divine body has long been on the verge of its limit, similar to the realm of the five decays of heaven and man, where every part of his body begins to decay and decay.

These transcription factors are tied together to make a 'senescent cell targeted apoptosis agent', and if it is directly fed into Odin's body, it will only cause the cells in his whole body to collapse in an instant, becoming a puddle of ignorant cell soup. ”

Freya and the others wilted in an instant, from hope to disappointment, the span difference between this is too great.

This is actually Odin's own reason, if he is not the god king of the Aesir God Clan, but just an ordinary, ordinary old man on the earth, then it can be solved by relying on the primitive cells of the underground base of the school city.

The primitive cells, which have long been able to multiply indefinitely, can invade the host's body, attack the city between the cells and tissues, replace most of the host's body, and allow the host to achieve another degree of immortality.

However, the powerful divine body of the Aesir Protoss can block the erosion of the primordial cells, so that the latter cannot help the former to extend his lifespan. You must rely on the life mechanism in your own body to fight aging.

Just when Freya and the others were disappointed and desperate, Leon said slowly: "In the first explanation of the death of a living being. Senescent cell targeting apoptosis agents containing FOXO4, a short DRI peptide, can indeed play a part.

However, targeted apoptosis agents are like a double-edged sword, which will disrupt the dynamic balance of cells in Odin's body.

At this point, we can turn our attention to the second explanation of the death of living beings. ”

The second explanation?

Rogie and Freya hurriedly shook their spirits, according to what they didn't know much about Leon, this second explanation was the main thing.

Sure enough, Leon said slowly: "The second explanation for the cause of death of living organisms is the 'principle of wear'.

Free radicals produced during mitochondrial metabolism can damage DNA, allowing abnormal damaged cells to gradually accumulate and form senescence.

This is almost an unavoidable thing, and the thermal movement in the human body and the regular metabolism will inevitably lead to the gradual breaking of chemical bonds in proteins.

It is this chemical bond break that accumulates more and more, so that the more necrotic cells are generated, and the human body gradually ages.

To put it more technically, it is 'the gradual decrease in molecular fidelity and the gradual increase in molecular disorder, resulting in changes in molecular structure, leading to changes in the overall function of cells, and ultimately leading to aging'. ”