Chapter Eighty-Seven: M1 in vivo experiments

This part of the experiment needs to be carried out at the animal level. Pen | fun | pavilion www. biquge。 The results of info cell experiments and live animal experiments can sometimes be very different. The purpose of this step is to determine the effectiveness and safety of the drug.

"Are you sure that the results of your new drug on live animals are exactly the same as those on cells?"

"Definitely agree, how could I make such a mistake? Okay, Lao Zhao, we have to declare as soon as possible, the Shangsheng Institute is also doing a tough job on the versatility of the M1 virus, one minute late, the cooked duck will fly! ”

"I said Pan Yan, this is not a trivial matter, scientific experiments ......" Zhao Changming was still a little hesitant, the fight against cancer was easily solved by this female doctoral student who relied on her body? It's just that because of the situation, he can only persuade, not reprimand.

"Peace of mind! Isn't it just a virus? Let's start the acceptance. Rest assured, the animal in vivo experiment report will be handed over to you at the time of acceptance. ”

Pan Yan looked a little impatient, took out a few report sheets and swiped them, the header was the animal in vivo experiment report, she didn't do it at all, the first one she felt was unnecessary, the experience of many experiments told her that the difference between in vivo experiments and cell experiments would not be very big. There is another rhesus monkey that costs about 10,000 yuan, and a mobile phone without a headphone plug has recently been released, and the rest of the research funds can just buy one.

"The acceptance personnel are from the General Hospital, you can't make any mistakes!" Zhao Changming gave an ultimatum.

When the acceptance work was carried out in an orderly manner, Zhu Cheng naturally got the news that this cancer had been conquered.

Is this woman really doing something serious? He looked at the paper with questions, and with the intuition and questioning nature of a scientific researcher, he always felt that there was a big problem with the paper.

M1 virus, he naturally knows that if the direction of treatment of the winger is the normalization of cancer cells, then the M1 virus is the direction of clearance, and these two directions are also the main points of contention now.

In the history of mankind, there is only one virus that mankind has truly defeated and eliminated, and it is called smallpox. And it was the smallpox vaccine that Edward Cenner discovered from cowpox that killed smallpox. After several improvements, smallpox was finally eradicated.

Without immunity, how can it be considered eradication? He is more optimistic about the winger's plan, this time it is a one-and-done method, for the universal M1 virus of the 320 Institute of Biochemistry, in Zhu Cheng's view, it is more of an auxiliary means. The radical cure still depends on the research of the protease inhibitory of the wing.

Not only Zhu Cheng is anxious, but the winger is also anxious. Inhibitors of proteases that can degrade cellular viscosity have not been found for a long time.

"Mentor, I have a question, we have a big project called the International Human Proteome Project."

A cadet walked up to the gloomy-faced winger, who was bold when the winger was in a bad mood and there were few people around him.

"Something to say!"

The student continued to say timidly: "Then why do we want to inhibit proteases, can we solve this problem from another way?" Looking for proteins that increase the viscosity of cell membranes......"

He stopped halfway through his speech, for he saw that the winger's face was even more gloomy, and he secretly wondered whether he should continue to speak.

"Excellent! What is your name?! The winger asked, nodding his head.

"Suo Yunfeng." It's not going to be fired! This is really lifting a stone to shoot yourself in the foot, and the gains outweigh the losses. His mood was as gloomy as the winger's face in an instant.

"Well, very good, Suo Yunfeng, you will be my experimental assistant in the future." The winger gave a cold order, but the joy on his face could not be concealed. He gave a pretty good advice!

Pan Yan is now submitting a paper to the journal Nature and hopes that her paper on the universal M1 virus will be published in the special issue of Nature Life Sciences.

In the domestic acceptance work, Zhao Changming naturally discovered that Pan Yan did not conduct live animal experiments and falsified the report! It's just that the acceptance procedure has been opened, just like the water that has been spilled, if it is forcibly stopped, it is a major scientific research accident, and this responsibility is likely to make him stop at the deputy director in the future, and there is no possibility of moving forward.

Even if it is published, acceptance is completed. The subsequent new drug development process is also a fairly long process, and animal experiments can be supplemented!

This is Zhao Changming's plan, and he also ordered Pan Yan to carry it out, but he didn't expect that the scientific research funds had been misappropriated by her, and there was an extra rhesus monkey on the list of the laboratory.

Zhu Cheng called Zhang Youlin and asked for some samples of the universal M1 virus, which is not a lot at present, but without Zhang Youlin's relationship, he can't get it at all, he always feels that this universal M1 virus is a little strange, and the performance of this virus far exceeds the valuation of the data.

He took the general-purpose M1 virus sent by Zhang Youlin and walked into the biological laboratory.

WingFeng divided the biology laboratory into several large groups, namely the microbiology laboratory, the cell biology laboratory, the molecular biology laboratory, the tissue culture laboratory, and the living laboratory.

The experimental animals in the living laboratory are all kept on the 3rd floor and specially taken care of, Zhu Cheng put on a chemical protective suit, went through a long disinfection channel, and entered the living laboratory.

Turn on the scanning tunneling microscope, the two inventors of which won the Nobel Prize in Physics in 1986. Scanning tunneling microscopy is often used to observe the internal structure at the NDA base pair level, using the tunneling effect in quantum effects to probe the surface structure of matter.

Although people have not yet understood quantum mechanics and quantum effects, it does not prevent people from using these phenomena. He needed to pry open the protective shell of the universal M1 virus and observe the DNA of the virus.

I turned off the ultraviolet disinfection lamp on the ultra-clean bench, turned on the blower, opened the fuse box of the universal M1 virus, rows of blue injections, and used a low-bright pipette to remove a little sample.

It's just that nothing has been found from this observation. He couldn't read the genetic code any more than assembly language was like a mother tongue. He shook his head, turned on the communication of the wisdom eye, and ordered the keeper on the third floor to take a tree shrew down.

He's going to do his own experiments to verify the virus. It is different from the experimental animals of the 320 Institute of Biochemistry. The experimental animal he used was a tree shrew.

Rhesus monkeys, India is no longer ready to sell! The price has soared, and it costs one to do a virology, immunology, and pathology experiment, which has soared from 1,000 yuan to 10,000 yuan.

Although mice are genetically close to humans, they are generally not used for research because their physiological structure is too different from humans, and with the increasing use of non-human primates represented by monkeys, the domestication and wild number of monkeys is becoming less and less, and it is difficult to buy.

Therefore, the tree shrew has entered the eyes of people, as an animal that is closest to humans in anatomy and physiology in addition to primates, and has officially become the new favorite of human biochemical laboratories, and some people have analyzed a large number of characteristics of the skull, teeth, muscle groups, gastrointestinal tract, nervous system and reproductive system of different species of tree shrews, revealing that tree shrews and lemurs have many common characteristics, so the tree shrews are classified into the suborder Protomonkey.

Regardless of the provenance, the tree shrew is a non-rodent omnivorous laboratory animal with high motility and extreme sensitivity to social and environmental stress, making it an ideal laboratory animal for research on nutritional metabolism, exercise physiology, the effects of acute and chronic stress, and stress.

Open the constant temperature air bath shaker and start the culture of the universal M1 virus, the sample is just a little bit, about the culture of the virus, as a biology doctoral student, he naturally knows it by heart.

Gently inject the universal M1 virus into the experimental tree shrew.

Zhu Cheng carefully observed the numbers on the scanner, observed the changes of various numbers, and occasionally drew some blood to observe the content of cancer cells in the blood.

Rapid reduction! As a cancer-stricken and advanced tree shrew, the reduction of blood cancer cells in the body naturally means that M1 is successful!

He was testing for lymphoma.

Is it really okay? Zhu Cheng is still a little skeptical, although there seems to be some gap between the current experimental data and the experimental data provided by Pan Yan, but this little gap cannot be used as an argument for the ineffectiveness of this generic M1 virus.

"When did you come here? The big boss personally did the experiment. What happened?" Qi Shuli has not received the news of the universal M1 virus. Naturally, I don't know what experiments he is doing.

Zhu Cheng told Qi Shuli about Pan Yan's recent attack on cancer.

Even through the thick protective clothing, he also felt the change in Qi Shuli's mood, this feeling of only one step apart from others is really maddening!

They're going to succeed soon! A new way has been found! But there are people who are the first to get there! How could Qi Shuli not be distressed? She was not for the Nobel Prize, but for the winger, who finally produced some results, and I don't know if the winger can withstand such a blow.

"Pan Yan's data is obviously anomalous! I don't think she's really done it, but I can't find a loophole where the values of the live experiment match her report. ”

Zhu Cheng is ready to accept the fruits of this woman - to overcome cancer.

"You can keep an eye on this tree shrew, I just injected him with m1, if the trial is successful, this tree shrew is expected to recover." He was ready to leave, and there were too many people who had been pioneered in this kind of scientific research, and only the first person went down in history.

People only remember that the father of the atomic bomb was Oppenheimer, and who remembers that the famous German physicist Heisenberg deliberately miscalculated the decimal point and delayed the process of the German nuclear bomb explosion?

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