NO: 99 exonuclease
At this time, a middle-aged man with a typical western face stood up, with a full beard and hair as if he hadn't been washed for several days, messy, he spread his hands with an indifferent look and said: "You can't blame us, we only have so many people, and the workload is so huge that it is too large to be overcome, believe me that you have to take your time, I suggest you take a look at the report!" ”
Thomas Boothby, who spoke, was the first biological expert to sequence tardigrades, from the University of North Carolina at Chapel Hill, USA, he was "invited" by Lin Feng with a lot of money, I don't know if the life in this undersea base made him a little unhappy, and he spoke in a very bad tone.
Of course, Lin Feng had read the report, for the research of the elixir,. For more than a year, there were no results to speak of, not even a by-product, and their main research target was the creature tardigrades.
This creature, the most tenacious creature on earth, has a normal lifespan of several months, but has a recessive lifespan of up to 200 years, and it can be dried in the sun, and it can still be resurrected if thrown into water, and even survive in space.
All organisms can survive in extreme environments of the four hidden states, it all have, namely: low humidity temperature cryptophytic, low temperature cryptophytic, metaosmotic cryptophytic, hypoxia cryptophytic, if it can be studied, and can be applied to the human body, then the human physical fitness will become extremely strong.
Swimming in boiling water, sunbathing in the North Pole, without fear of deadly radiation, if you want to sunbathe in Antarctica, you can also do it, but the temperature in Antarctica is much lower than that in the North Pole, and you can be resurrected after freezing into popsicles and throwing them into the water.
However, the genes are particularly complex, and a significant part of the resulting gene sequences do not belong to them, and because they can be dehydrated, they can easily absorb foreign genes, and these biologists estimated that the genome of the tardigrade contains 250 million bases, but after removing potential bacterial contamination, they obtained a much smaller genome - only 135 million bases.
The results are not necessarily accurate, they need to be calculated through a lot of experiments, and there are more than 900 kinds of tardigrades, and they are only studying one of them, really to completely unravel the mystery of the tardigrades, this is a huge and desperately large bioengineering, and finally these biologists told Lin Feng that it is impossible within a hundred years.
He was advised to shift his research, and of course the legendary lighthouse jellyfish immortality was just pseudoscience, and in fact it was no different from other jellyfish, so they suggested that it might be more reliable to study turtles, which is what they came to for more than a year.
And most importantly, solving the mystery of the tardigrade does not necessarily mean that it can be applied to the human body, why do we have to study the tardigrade, because it can still survive in an extremely harsh environment, and humans are destined to go into space in the future.
However, the vitality of human beings is too fragile to adapt to the harsh environment on the earth. Therefore, at present, human beings need to improve their genes to adapt to the extremely harsh climate and atmospheric environment, and the information left by Gao Daquan can only be used as some reference, because without biological samples, many things are impossible to talk about.
Lin Feng looked at the biologists below who were drooping their heads, and had a headache,
"Tell me how long it will take you to study the tortoise! How to solve it technically. ”
Standing up and speaking was a middle-aged man with an Asian face, his name was Shinya Yamanaka, the 2012 Nobel Prize in Physiology and Medicine, and unlike Mr. Thomas Boothby, who was scruffy and unkempt, Shinya Yamanaka wore a crisp suit, and the two men were in stark contrast.
"We can't say for sure when the boss is, but it's certainly simpler than a tardistilla, we know that human embryonic cells can be cut 50 times, while turtle embryonic cells can be cut 110 times, which is why turtles live so long.
According to the material given to us by the boss, technically it would not be a problem, and we found a DNA-protein complex called "telomere", which maintains the integrity of chromosomes and manipulates the fragmentation cycle of cells.
And this telomere is the goal of our research. Cells are unable to fully replicate their chromosomes due to DNA polymerase dysfunction during each division, so the last replicated DNA sequence may be lost, eventually causing cell senescence and death, which is why humans will age and die.
What we need to do is to allow the cells to fragment and replicate without losing information or slowing down the process.
I think we've found some ideas, although immortality can't be done, but on the basis of the current one, extending the life span of human beings by 50 to 100 years, I think it should be no problem, or that sentence, we need time. ”
"Okay, you're all experts in this area, but I want to see the results sooner, and in the next few months, I'll be more idle, and I'll do research with you, and I'll meet all your needs!"
In the next time, Lin Feng didn't go anywhere, the gold exhibition center in Xin'an City was opened, Lin Feng didn't care, and Lin Feng didn't have to worry about the fluctuation of the gold exchange rate, so he concentrated on doing research in this undersea base.
This time, Lin Feng did not arrest people everywhere, and let the cabinet directly issue an order to move dozens of Japan's most cutting-edge biologists to this undersea base, first of all, it was secret biological research and a major project needed to be tackled, which was related to the future of the country, and in the face of the country's righteousness, all personal honor and disgrace must be abandoned.
Then the world's turtles suffered, turtles from all over the world, turtles, turtles, have become the object of study, why so many species, not only the longest-lived turtles should be caught, of course, not so simple, no comparison, you will never know the differences between the species.
And the most important thing for Lin Feng is to consult the relevant information, and check it in the vast amount of information, there is no way, because Lin Feng is the only one who knows multiple alien languages, and many scientific and technological materials cannot be translated at all.
2 months later
Lin Feng and a group of biologists were discussing some academic issues, dozens of people were gathered in a small conference room, and in the middle of the round table, three-dimensional images showed the state of some DNA.
"The ends of chromosomes are coated with telomeres, which are highly compressed strands of DNA that can cause problems if they become very short, such as chromosome breaks, which then fuse with other chromosomes."
"The main culprit of telomere shortening is exonuclease, through the comparison of various turtles, we found that some turtles have a special exonuclease cell named Exo1p, which is slightly different from what our body carries, and it belongs to the restriction exonuclease, if it can be implanted into the human body, then the effect of prolonging life is not easy to say, but I think there should be no problem to solve these diseases of cancer."
Listening to their eloquent conversation, Lin Feng interrupted: "These situations do not need to be described, there are more than 100 kinds of restriction exonucleases, and our research results tell us that we need to change the most important 5 kinds, but the characteristics of restriction exonucleases, we all know that after the foreign DNA enters the human body, it will be cut off by the restriction exonuclease, and now the question is how to implant it?" ”
Then came the voice of the scruffy Thomas Boothby: "I think I can answer that question." ”