Chapter 145: Antigen-antibody hybridization

"As for the specific modification method, I suspect that the other party first extracts bone marrow stem cells from the modified people, and then uses genetic engineering to introduce the gene encoding the enzyme into these bone marrow stem cells. Pen @ fun @ pavilion wWw. ｂｉｑUｇE。 Finally, these genetically engineered bone marrow stem cells are delivered back into the body of the modified person. ”

"As for why I guessed that the other party was using bone marrow stem cells, there are several reasons. First, bone marrow stem cells can differentiate not only into various blood cells, but also into a variety of lymphocytes. And these cells will spread throughout the body with the circulation of blood and lymph, so the oxidative decomposition enzymes secreted by these modified cells will also spread throughout the body, as long as these enzymes are activated, the whole person will be turned into ashes in an instant! It is difficult for other cells to have such conditions! ”

"Second: bone marrow stem cells have the ability to self-proliferate and differentiate, and through self-proliferation, it can maintain its own number without much change; Through differentiation, it can compensate for the blood cells and lymphocytes that have died of aging, and then make the oxidative decomposition enzyme remain in the human body for a long time, and will not be eliminated by the immune system due to aging and deterioration, and finally disappear in the human body. ”

"Third, similar techniques have been used in human history, and it is easy for the other party to achieve technical success by drawing a scoop on a gourd. For example, in September 1990, American doctors used similar methods to perform the first gene therapy in human history on a four-year-old girl with ADA (adenylate deaminase) gene defect, and achieved good results. So I guess the other side will most likely use this technology to transform people! ”

"Fourth: this enzyme is not present in the human body, if they are introduced into the body alone, they will be eliminated by the immune system as antigens, but if this method is used, this enzyme is a substance produced by the body's own cells, and they will escape the recognition and removal of the immune system."

"The last step is the activation of the oxidative enzyme. I think the other side is using physical means to activate this oxidative enzyme! From what we know, we have verified that the enzyme is a protein that has been engineered using protein engineering. When proteins encounter many chemicals, biological bacteria, viruses, and physical rays, they are easy to denature and lose their original protein properties. And I guess that the activation of this oxidative decomposition enzyme is that the original protein has changed some parts of the protein under the action of these biological, chemical, and physical factors, forming an active site. Judging from the data obtained by the police, these criminals were suddenly reduced to ashes, and they were all killed at the most critical moment. And such a swift reaction could only be physical rays. Of course, the other party may also take some activated drugs in their mouths first. However, in this case, it will take a few hours for these drugs to activate oxidative decomposition enzymes to spread throughout the body, and it is difficult to achieve such precision in time. Most importantly, if you use this method, the oxidative enzymes throughout the body will not be activated in an instant! And the first to activate must be in the digestive tract. In this way, the other party will not be able to turn into ashes in an instant, but slowly rot from the inside out. Therefore, having a factor that activates the whole body's oxidative enzymes in an instant is only physical rays! ”

After Cheng Xiao said this, he paused for a moment, and finally said, "Teachers. That's all for me. Of course, these are just my conjectures and assumptions, and we need to practice to prove whether they are correct or not! ”

As soon as his words fell, there was a round of warm applause, and Professor Jiang stood up and said with a smile: "Xiaoxiao, your thinking and ideas are really different from ours. In the past, we all thought that this enzyme was an undiscovered enzyme in our body that was stimulated by an external factor to become an oxidative enzyme, but you think of protein engineering. It seems that we are about to make a breakthrough in our research! Hey! You're really good, kid! Cheng Xiao bowed to him and said with a smile: "Thank you, Mr. Jiang, for the compliment!" Several other scientists also laughed, and they said, "We also think that Xiaoxiao's words are very practical." Otherwise, our next research work will be carried out in the direction he said! Professor Jiang smiled: "I think so too!" ”

Next, other researchers also made some assumptions and additions. After six or seven hours, the little academic seminar finally ended. And the next step is to prove the truth with practice. In addition to working with these old professors, his focus is on how to remove oxidative enzymes and these modified cells from the body. During this time, he returned to the experimental base and took blood and bone marrow samples from the cat's body to develop an antidote to the control of MTH3 over her.

It is very easy for adults to remove oxidative decomposition enzymes, they only need to use oxidative decomposition enzymes as antigens to prepare corresponding antibodies, and finally use antigen-antibody hybridization to remove oxidative decomposition in the human body. (Antibodies are globulins that bind specifically to the corresponding antigen and lose their activity, which is called "antigen-antibody" hybridization.) ）

But to get rid of these modified cells is very nerve-wracking! If there is a chemical drug to use to get rid of it, but he is not a pharmaceutical student, he does not know what drug to use to get rid of it. In the end, all he could think of was cellular immunity!

He used these cells as target cells and created a corresponding batch of effector T lymphocytes. These effector T lymphocytes have the ability to activate the lysosomal enzymes in these modified cells, and finally cause these modified cells to lyse and die.

Cheng Xiao's experiment this time was really not smooth, after he developed these two drugs, it was already five days later, and he spent most of the day to test the feasibility of these two drugs. After determining that they were harmless to humans, he returned to his experimental base with two small bottles of potions.

At this time, it was already afternoon, and Mao Jin also returned from Golden State University.

As soon as Cheng Xiao entered the experimental base, he saw Mao Jin and Youxi sitting together, talking and laughing. Seeing this scene, he couldn't help but be stunned for a moment. Slightly surprised, to be honest, he is wary of the fox now. If it weren't for the fact that the fox and the moto were both in his experimental base, with Xiao Duo by his side, he would never let the puntus come into contact with the puxy.