Chapter 629: Subtle Anatomy

After the introduction of Tang Shun was done, Yang Ping was much more relaxed.

In this way, the stem cell laboratory has a member who does basic research, and a lot of work is much easier to carry out.

In the laboratory of the system space, Yang Ping's experiments have been continuing, and he will use the right time to go in and continue the laboratory almost every day.

For the inducible substances of directional differentiation of stem cells, Yang Ping continued to collect, use cryo-electron microscopy to distinguish and record them one by one, and then conduct reverse experiments to confirm that a lot of work is trial and error, and it is difficult to do boring work without strong interest support.

Some repetitive work, such as the slicing of muscle monolayer cells, Yang Ping handed it over to the robotic arm to do, and the robotic arm could only do the work according to Yang Ping's arrangement, without any subjective initiative, and it was still good to be driven by coolies.

Muscle cells, also known as myofibers, are long cylindrical multinucleated cells, 1-40mm long, 10-100 Ξm in diameter, and a muscle cell contains dozens or even hundreds of nuclei.

How these muscle cells are organized into muscles, and then how the nerves, blood vessels, lymphatic vessels and other structures shuttle through them, how many layers of nerves, blood vessels, and lymphatic vessels are divided into, what cells are made of each layer, and how these cells are connected to each other.

This is the subtle anatomy of muscles that Yang Ping is currently trying to figure out.

In addition to the fact that time is very cheap in the system laboratory, these robots are also cheap labor, because they can be increased as needed.

The light and electron microscope pictures of these slices are all stored in the computer, and then the computer is used to reconstruct the three-dimensional subtle anatomy of the whole muscle.

These basic tasks are extremely tedious, but they are particularly important, and each link must not be sloppy in the slightest.

A single cell layer slice of a muscle, considering the muscle cells alone, the sagittal plane and the coronal plane can make more than 20,000 slices, but considering the blood vessels, nerves and lymphatic vessels, three sections can make millions of slices.

How to do a good job of muscle slicing of monolayer cells, Yang Ping explored a very good method through a large number of slices, he summarized this set of methods, and then applied them to real-life experiments, so as to reduce the time of trial and error.

In scientific research, a lot of time is wasted on trial and error, but trial and error is a process that must be experienced.

The most important reason why some senior companies in each technology industry can form a monopoly, for example, why some of the world's pharmaceutical giants can form a monopoly that is difficult for latecomers to surpass, is that their scientific research database includes countless success and failure data, and emerging companies have invested heavily in developing drugs, and it is likely that these large companies have tried and made mistakes decades ago.

Therefore, the longer the company is and the more experiments there are, the data of success or failure is extremely valuable and belongs to the core secret.

There are also some companies, such as some high-end steel manufacturing companies, the formula of manufacturing materials is the data accumulated by decades or hundreds of years of trial and error, which cannot be surpassed in a short time.

Therefore, materials, chemicals, pharmaceuticals and other high-tech industries, it is difficult for the chasers to surpass the former, unless there is a scientific and technological revolution and a change of track, otherwise there is no corner overtaking.

Coming out of the system space, Yang Ping relied on his memory to write down the method of slicing muscle monolayer cells by himself, and then sorted them out a little, these are extremely valuable things, and he has been tested by countless trial and error.

The digital medicine laboratory of Nandu Medical University is currently responsible for the slicing of muscle monolayers, and they have gained a lot of experience in building digital humans, so they are handy when receiving muscle slices.

When the digital human was completed, the body of a young man was selected from the 20 donated remains, and the body was cut into thin slices of less than 0.2 mm from head to toe using sub-millimeter grinding technology, and a total of 8972 pieces were cut, and more than 20 scientific researchers, day and night, processed more than 200,000 pictures, with a resolution of 4040*5880 for each picture, and used these pictures to build a digital human.

The difference is that the current muscle slices, to achieve a single layer of cells, require very high technology, and process more pictures, just one direction of slicing processing is hundreds of thousands.

And in each picture, the cells should be distinguished, and if they are known cells, they should be figured out which category they belong to; If it's an unknown cell, find out what it is.

The task of directional cultivation of stem cells into muscle cells is completed by the stem cell laboratory of Sanbo Hospital, which not only differentiates into muscle cells, but also differentiates into cells that make up nerves, blood vessels, and lymphatic vessels.

After completing these two tasks, the next steps began to differentiate into two routes, one is biological 3D printing technology and the other is gene expression regulation technology.

The bio-3D printing technology is in charge of the laboratory of Ruixing Medical, and the expression regulation of the fund is in charge of the genetics laboratory of Nandu Medical University.

The whole process requires the division of labor and cooperation of multiple units, and if it were not for the cooperation of Sanbo Hospital and Nandu Medical University, it would take a year and a half to contact and coordinate the cooperation units.

Chen Zhi of Ruixing Medical, a master's degree graduate in bioengineering, this outstanding graduate student uses his spare time to study for a doctorate in Nandu Institute of Technology, he is very talented in the research and development of medical instruments and medical devices, under the instruction of Huang Jiacai, he is organizing a team to develop a new type of biological 3D printer.

The existing bioprinters in the world cannot complete the printing of a real muscle, and the muscles printed in the United States are only a pile of muscle cells, which have some functions, it has no nerves, no blood vessels, and the connections between cells are not simulated.

Every link starts with basic research, which is very difficult, and the manpower, material and financial resources invested are huge.

But only then can it be truly successful.

---

"Professor, what projects can you and I work on?"

Robert has been following this for a long time.

Yang Ping knows in his own heart that he must not be allowed to participate in the core projects, and the relationship is good, and some things involve the foundation of the country in science and technology in the future.

At present, many cutting-edge biological technologies in the United States, including stem cell research projects, are denied access to foreigners, and strict confidentiality is implemented.

For example, the directional differentiation technology of stem cells, how to obtain induced proteins, what are the induced proteins, and how to match the proportions are all absolute secrets in the laboratory.

Just like the engine technology of the aviation industry, it will never be sold or opened.

However, the branch project can allow Robert to participate.

"Analyze the structure of articular cartilage, sectioning a single layer of cells, and then construct the three-dimensional anatomy of cartilage after slicing."

Yang Ping assigned Robert a task.

"What about me?"

August also wanted to get involved.

"You do the microstructural analysis of the intervertebral discs."

Yang Ping also played the role of August.

These projects are the peripheral research of Yang Ping's project, and Yang Ping cannot distract himself from doing it for the time being, so he can not only maintain contact with the world's top scientific research forces, but also not lose control of the core technology of the project.

Just like building an airplane, you can focus on building the engine yourself, and you can give other projects to others appropriately, so you don't have to research and manufacture everything yourself.

Whether it is the study of cartilage or the study of intervertebral discs, once successful, it is also a huge breakthrough.

Robert and August were more than happy to take on this task, and they were confident that under Professor Yang's guidance, they would succeed.

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