New drugs, especially those with good effects on tumor treatment, are generally extremely expensive, which is something that cannot be helped, because the R&D cost of new drugs is extremely high, and the R&D investment of pharmaceutical companies for new drugs is huge, and the risk is also extremely high.

In the pharmaceutical industry, there is a "rule of 30" in the research and development of new drugs: the research and development of new drugs takes an average of 10 years, costs 1 billion US dollars, and has a success rate of less than 10%.

Taking the current most popular oncology and immunology drug R&D investment as an example, some people have calculated that in 20 new drug samples, the average investment is as high as 4.46 billion US dollars.

Since there is such a large investment, such a high risk, such a long R&D cycle, and there is not enough profit stimulation, no one is willing to do this kind of thing at all, once a new drug is launched, the price will inevitably be extremely high, and pharmaceutical companies need to recover their costs as quickly as possible, rather than making money slowly.

For example, when new anti-tumor drugs were launched, pharmaceutical companies didn't think about the poor at all, they just wanted to make money from the rich as soon as possible.

Although some pharmaceutical giants in Europe and the United States have been scolded all over the world, it is undeniable that without them in the lead, other companies do not even have imitation objects, and there are no original drugs, so how can there be any cheap generic drugs.

Although there are many shortcomings in the current market competition mechanism for new drugs and new medical devices, it is relatively reasonable, and there is no alternative mechanism at present.

This 1.2 million injections of the drug Axileucel injection belongs to CAR-T cell therapy, which is a cell therapy product produced in China by Fosun Kite Company with American technology, so the price is relatively cheap, and it is also the first cell therapy product in China.

There are currently five CAR-T cell therapy products on the market globally, namely Kymriah, Yescarta, Tecartus, Breyanzi and Abecma, and the most expensive of these drugs is Kymriah, which is priced at $4.75 million in the United States and $313,000 in Japan.

CAR-T is not a standardized assembly line preparation, but a personalized cell therapy that requires each patient to produce CAR-T cells individually.

Its preparation process is demanding, and the preparation process requires strict quality control and quality inspection, and the whole preparation process takes one month.

The laboratory uses genetic engineering technology to modify the patient's T cells to form CAR-T cells, which are expanded in large quantities, and after strict quality control and quality inspection, the CAR-T cells are sent back to the hospital through cold chain transportation and injected into the patient's body by injection.

CAR-T cells are in the patient's body, and once they encounter tumor cells expressing the corresponding antigens, CAR-T cells will be activated and expanded, exerting their huge specific killing power and destroying tumor cells.

The cost of training workers for the manufacture of CAR-T cells is also expensive, with an average training cost of 300,000 yuan per worker, which shows the high cost.

Yang Ping has his own ideas, his personal research and development ability is very strong, can rely on his own strength to drive the entire pharmaceutical industry forward, but he must not destroy the entire industry's benign competition mechanism, once this mechanism is destroyed, and the day he is old, the entire pharmaceutical market will be chaotic and incapacitated, if you want to rebuild this vitality mechanism will take a long time.

——

In the system space laboratory, Yang Ping's three experiments were carried out at the same time, thanks to the rewards given by 13 CNS articles and the creation of the "Medicine" journal system, and the huge amount of points allowed Yang Ping to carry out three surgeries at the same time.

The huge space laboratory is divided into three areas by Yang Ping, and the K factor research in the tumor laboratory is progressing smoothly, according to Yang Ping's experimental steps: find the K factor - analyze the K factor - synthesize the K factor - use the K factor, now the third step has been completed, and the fourth step has entered, and the K factor can be synthesized by artificial methods, and now the experiment is carried out to the fourth step, which is also the most difficult step, and after this step, the K factor is likely to enter the clinic.

This method of killing tumors was named K therapy, which is apoptosis therapy.

CAR-T therapy is a cell therapy that uses the principles of immunity to modify T cells in the human body.

Yang Ping's K therapy uses the apoptosis mechanism of human cells to start the apoptosis process of tumor cells and kill tumor cells by controlling the apoptosis mechanism of tumor cells.

If all previous targeted tumor therapies were to start from the outside, the tumor cells were precisely identified and then killed using various methods.

Yang Ping's K therapy starts from the inside of tumor cells, which is to let tumor cells wake up to themselves, start the self-explosion program, and commit collective suicide, which is a natural way for the human body to eliminate "rebellious" cells.

Yang Ping has made various modifications to K factors so that they can pass through the blood circulation smoothly and safely, and finally combine with tumor cells to start the apoptosis process of tumor cells.

The cost of trial and error is huge, Yang Ping modified it once, and then tried it once, so that it was repeated continuously, and no matter how much time the system space time consumed, the time converted into reality was already insignificant.

If in a real laboratory, this kind of trial and error is extremely labor-intensive and time-consuming, for example, in the initial molecular discovery of a monoclonal antibody drug, to find an antibody in a library of 1 billion, or even 10 billion, through a method to screen step by step, and finally screen out an antibody to make a monoclonal antibody into a drug, there are at least 1,000 steps in this process, and each of these 1,000 steps must not go wrong.

There is a pharmaceutical company in China that developed monoclonal antibody drugs, which took 7 years and more than 3,000 days and nights to successfully develop them.

Different from the real laboratory, in the system space laboratory, Yang Ping's trial and error cost is extremely low, because the system space has a huge time advantage, and also has countless robotic arms to assist work, so Yang Ping only needs to set the experimental program, everything is handed over to the system panel, he only needs to enter the system space regularly to check, once the problem is found, re-adjust, and if it is just a trial and error operation, Yang Ping does not even have to look at it, this road is not passable, the system panel will command the robotic arm to automatically enter the next route.

For example, to screen antibodies from the antibody library, the experimental steps are directly set, and the system panel directs the robotic arm to screen uninterruptedly, and Yang Ping only needs to lie down in the laboratory to rest.

The huge system laboratory has expanded to the size of several football fields, and with all kinds of instruments spread out on the plane, coupled with the high dome, Yang Ping felt for the first time that his space laboratory was so magnificent, those dexterous and delicate octopus hands worked tirelessly, and all the manual labor in the laboratory was borne by them.

The machines here never break down, never need to rest, and work smoothly all the time.

The system panel is like a faithful servant, managing the huge laboratory, processing massive amounts of data all the time, and the data of each instrument in the laboratory is transmitted back to the panel for various calculations.

The four walls of the laboratory are transparent glass, surrounded by magnificent natural scenery, there are mountain waterfalls, there are huge waves of the sea, there are boundless fields, there are mysterious forests, and now Yang Ping likes this laboratory more and more.

Yang Ping's "Medicine" journal is actually an online paper publication platform, it has no concept of time, no matter day or night, you can upload your own papers at any time, and you can publish them publicly after being reviewed by the editor, and the editorial department will turn the weekly paper collection into paper journals, which are only used as archives and do not need to be disseminated.

Since publishing 13 CNS papers, Yang Ping has never published papers in other journals, and all his subsequent papers have been published in Medicine, such as tumor apoptosis research and skin amplification research, all of which have been published in Medicine, so that he can make his scientific research results public as soon as possible, declare intellectual property rights, and disseminate them to the world at the same time.

——

Li Ruizhong appeared at Professor Zhang's door at 8 o'clock the next morning, he only believed Professor Zhang and was unwilling to go to any other department to continue his treatment.

Anyway, the Institute of Surgery can accept any patient, it is a clinical department with a research nature, and it is an entity that combines scientific research and clinical practice.

Li Ruizhong is the pillar of the family, and now that he finds out that it is this disease, he will definitely not be able to bear the blow in his heart.

Professor Zhang patiently explained the details of the disease to him, telling him not to worry and be afraid, and his condition has not yet reached the most serious stage.

To this end, Professor Zhang also contacted the Department of Hematology and Oncology to help contact the contact information of several patients who have been cured, hoping to let Li Ruizhong talk to these patients and strengthen his determination to overcome the disease.

After this "brainwashing", Li Ruizhong was much more open-minded and built up confidence, and he was very grateful to Professor Zhang.

"Professor Zhang, thank you very much, when you say that, this disease is really not a thing."

"Take good treatment, you are the pillar of the family, how can you say that if you faint, you will faint, you have to stand well, you know?"

"I can't accept it all at once, oh, I have to pay you back yesterday's room and lunch money." ”

"No, no, we are friends now, when I have a treat, and the Sanbo Hotel is from our hospital, and the lunch box is also from the hospital canteen, I am an expert, these can be reimbursed, it doesn't cost money, it's okay." ”

"Really?"

"Really."

"Professor Zhang, I will live in your building, you help me issue a hospital certificate, and you help me with treatment." ”

"Okay, we'll try our best to help you save money, but you still need to spend it, the money is earned by people, cure the disease, and then go to earn money in the future, so that you don't have to worry about running out of firewood."

Once this person's concept changes, the spirit and spirit are different, yesterday Li Ruizhong was still blind, today is full of confidence.

"Xiao Li, let me tell you, this person lives just one breath, you can't let go of this breath, everything is easy to do, is there a matter of expenses?"

"Professor Zhang, I called the factory director and advanced a part of my salary, and the factory director said to help me go to the factory to raise a part of the donation, plus medical insurance, I should be able to survive, right?"

"You still have a bit of status in the factory."

''I'm a welder, I started doing this at the age of sixteen, I've been doing it for more than 20 years, and my skills are still a bit, and the boss really hasn't recruited anyone better than me. ”

"You're a skilled worker!"

"It's a welder, what a skilled worker."

"You can't say that, you are now a skilled worker, the country is in short supply of talents, and you graduated from high school?"

"Junior high school, after graduating from junior high school, I came out to do this with people."

"Xiao Li, I speak more directly, don't mind, you are now an experienced skilled worker, but the theoretical culture is a little worse, you have to strengthen this aspect of learning in the future, find a way to learn on the job, improve the culture, improve the education, like you, if the theoretical culture comes up, the salary will be several times, now what shipyards and other large enterprises, everywhere to recruit powerful welders, you theory up, the understanding of welding technology is different, the technology will also improve, otherwise it will always stand still."

"Professor Zhang, when you say this, I really think it's like this, when I first came out, there was a worker who followed me as a welder, he just worked while applying for some on-the-job college study, and now he is working as a welder in a shipyard, I heard that it is tens of thousands a month."

That's the truth, to improve, learn to improve yourself, and plan things well, in fact, the money for smoking and drinking is also spent, and it doesn't cost much to sign up for a junior college. ”

''I'm 38, is it too late?'' ”

"It's too late, you start now, won't you be in your 40s in three years? If you are in good health after retirement, you can continue to work, you see me, I am eighty years old, I don't work to make money, and I am not afraid if I have technology. ”

"I saved money to study after I was cured, Professor Zhang, and I also worked until I was in my eighties."

In Professor Zhang's clinic, through this chat, Li Ruizhong not only established confidence in the disease, but also had a completely different view of his own life.

He felt that in the past 20 years, he had lived a chaotic life, completely following the crowd, and it would be good if he had someone like Professor Zhang to guide him when he was young, and he would not have been standing still.

''Thank you, Professor Zhang!'' ”

When the hospitalization certificate was issued, Li Ruizhong bowed and bowed, packed his things and prepared to go to the hospital.

''Come down and have a chat when you have time.'' ”

"Okay!"

Xiao Lin, a graduate student who has been sitting next to him, was stunned, yesterday Li Ruizhong was still stunned, and even had the idea of suicide, how can he be energetic today, or Professor Zhang is amazing, he can change the patient's mind, this is a powerful doctor.

After Li Ruizhong went away, Professor Zhang said to Xiaolin: "We are doctors who can not only treat diseases, but also help patients build confidence, that is, not only can they treat physical diseases, but also help them change their minds. ”

Dr. Kobayashi admired Professor Zhang's "brainwashing" technique very much, if it weren't for Professor Zhang's "brainwashing", Li Ruizhong would have been so happy to go to the hospital for treatment.

——

Li Ruizhong happily came to the ward of the Institute of Surgery to be hospitalized, and sometimes people need to be "brainwashed", so that they can have faith, goals, and motivation.

It is very rare for patients hospitalized at the Institute of Surgery to undergo medical treatment without surgery.

Diffuse large B-cell lymphoma is a type of non-Hodgkin lymphoma and the most common, and it is one of the few tumors that can be completely cured.

Non-Hodgkin lymphoma is the most common malignant tumor of lymphatic hematopoietic tissue, which can be triggered by infection, genetics, immunity and environmental factors, and the main symptoms are the major lymph nodes of the whole body.

Originally, the main symptoms of this disease were painless, progressive lymphadenopathy and local masses, but some people have atypical symptoms.

Li Ruizhong is atypical, his lymphadenopathy is not very obvious, the most prominent symptom is limb wandering joint pain, doctors generally examine, rarely carry out a systemic examination, such as will not palpate the lymph nodes of the whole body, and the whole body multi-joint wandering pain is so obvious, so the doctor must grasp this prominent symptom for examination.

When Li Ruizhong found Professor Zhang, Professor Zhang's examination was very detailed, and then almost the whole body was systematically palpated during palpation, and the lymph nodes in the groin were still swollen, because this slightly swollen lymph node was not painful, and Li Ruizhong didn't care, Professor Zhang gave him a color ultrasound of the lymph nodes and showed that they were still swollen.

Therefore, Professor Zhang gave him a lymph node puncture, and when the puncture was checked, it was actually diffuse large B-cell lymphoma, and then the pathological diagnosis was compared with all the symptoms, which basically matched, which is this disease.

Li Ruizhong's bedside doctor is Dr. Zhao Wenbo, a rotating master's student, and his academic performance and work performance are also very good, he and Li Guodong often argue over academic issues, but the private relationship is still okay, and the friendship between private colleagues is not affected because of academic disputes.

Under the guidance of Professor Zhang, Li Ruizhong did not eat breakfast when he was hospitalized, so that he could complete some routine blood tests in the hospital as soon as possible.

After the operation in the afternoon, Yang Ping checked the newly admitted patients and key patients with complex conditions individually, because Li Ruizhong needed internal medical treatment, and Yang Ping paid special attention.

Chemotherapy is the main conventional treatment for diffuse large B-cell lymphoma, and CAR-T cell therapy is generally used for relapsed or refractory diffuse large B-cell lymphoma because of its high price.

In fact, there are some diseases that are terminal diseases in the eyes of ordinary people, but they can be cured, but these cures are too costly, not popular, and cannot be accessed by ordinary people.

At the time of heart transplantation, there was no way for the average person to treat end-stage heart disease. But David Rockefeller, the American billionaire, has already begun to use heart transplants to save his life, and he has had his heart changed six times in his life and lived to be one hundred and one years old.

At that time, the technology for heart transplantation had just come out, and because the cost was too high, this cutting-edge treatment would not sink into the general hospital.

Yang Ping's ideal is to use his own system -—— reduce R&D costs, so that ordinary people can enjoy the latest and most cutting-edge medical treatment, and try to avoid the torment of illness.

He decided to do cell therapy for this patient, and he used his own inexpensive method.

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